作者: Mobile 時(shí)間: 2025-3-22 00:00
Molecular Control of HIV and SIV Latency,ncy virus (SIV) infection and the use of nonhuman primate (NHP) models that recapitulate many aspects of HIV-associated latency establishment and disease progression are essential tools since they allow extensive tissue sampling as well as a control of infection parameters (virus type, dose, route, and time).作者: 的是兄弟 時(shí)間: 2025-3-22 01:53
0070-217X n-depth analyses of current concepts, paradigms and ideas th.This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Speci作者: minimal 時(shí)間: 2025-3-22 08:07 作者: Colonoscopy 時(shí)間: 2025-3-22 12:28
Role and Function of Company Lawyers,odels have been used to predict the efficacy of potential HIV cure strategies, such as latency-reversing agents, early treatment initiation, or gene therapies, and to provide guidance for designing trials of these novel interventions.作者: 踉蹌 時(shí)間: 2025-3-22 15:41
Mathematical Models of HIV Latency,odels have been used to predict the efficacy of potential HIV cure strategies, such as latency-reversing agents, early treatment initiation, or gene therapies, and to provide guidance for designing trials of these novel interventions.作者: 吞下 時(shí)間: 2025-3-22 20:53
Book 2018ng targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex inte作者: OGLE 時(shí)間: 2025-3-23 00:55
The Antiviral Immune Response and Its Impact on the HIV-1 Reservoir,he HIV-1 specific immune response, nevertheless the size and composition of the reservoir is influenced by the immune system. In this chapter, we review the different components of the HIV-1 specific immune response and discuss how the immune system can be harnessed to eradicate the virus.作者: AROMA 時(shí)間: 2025-3-23 05:13 作者: craving 時(shí)間: 2025-3-23 09:24
HIV-1 Latency978-3-030-02816-9Series ISSN 0070-217X Series E-ISSN 2196-9965 作者: 萬花筒 時(shí)間: 2025-3-23 13:31 作者: intrigue 時(shí)間: 2025-3-23 16:24 作者: 巧思 時(shí)間: 2025-3-23 21:46 作者: 有毒 時(shí)間: 2025-3-24 02:10 作者: Immortal 時(shí)間: 2025-3-24 03:20 作者: Absenteeism 時(shí)間: 2025-3-24 07:40
Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antireed cART regimens for use in NHPs, new viruses, a wider array of sensitive virologic assay approaches, and a better understanding of pathogenesis should allow even greater contributions from NHP models to this important area of HIV research in the future.作者: 格子架 時(shí)間: 2025-3-24 11:10
SIV Latency in Macrophages in the CNS,growth assay (QVOA) designed to evaluate latently infected CD4+?lymphocytes, a similar protocol was developed for the assessment of latently infected myeloid cells in blood and tissues. Using an SIV ART model, it was demonstrated that myeloid cells in blood and brain harbor latent SIV that can be re作者: scrutiny 時(shí)間: 2025-3-24 17:58
Residual Immune Activation and Latency, immunological non-responders, fails to reconstitute the immune system despite optimal treatment and viral suppression (Kelley et al. Clin Infect Dis 48(6):787–794, .; Robbins et al. Clin Infect Dis 48(3):350–361, .) and remains at high risk for opportunistic infections and non-AIDS-related events (作者: Muscularis 時(shí)間: 2025-3-24 21:45
Immune Interventions to Eliminate the HIV Reservoir,r dual-affinity re-targeting molecules to direct cytotoxic T lymphocytes to virus-expressing cells and broadly neutralizing antibody infusions. Methods to steer immune responses to tissue sites where latently infected cells are located need to be further explored. Ultimately, strategies to induce HI作者: 橢圓 時(shí)間: 2025-3-25 02:46 作者: 善辯 時(shí)間: 2025-3-25 06:06
Book 2018 subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public. .作者: certain 時(shí)間: 2025-3-25 08:05
Food System Lessons from Vermontservoir may underestimate reservoir size because not all replication-competent proviruses are induced by a single round of T cell activation in this assay. Therefore, this assay is best regarded as a definitive minimal estimate of reservoir size. The best approach may be to measure all of the provir作者: DEFER 時(shí)間: 2025-3-25 14:08
Varieties of Mathematical Experienceed cART regimens for use in NHPs, new viruses, a wider array of sensitive virologic assay approaches, and a better understanding of pathogenesis should allow even greater contributions from NHP models to this important area of HIV research in the future.作者: 有其法作用 時(shí)間: 2025-3-25 19:51 作者: 不能平靜 時(shí)間: 2025-3-25 20:39 作者: 盡忠 時(shí)間: 2025-3-26 02:19
,Coaching — the route to top performance,r dual-affinity re-targeting molecules to direct cytotoxic T lymphocytes to virus-expressing cells and broadly neutralizing antibody infusions. Methods to steer immune responses to tissue sites where latently infected cells are located need to be further explored. Ultimately, strategies to induce HI作者: 任命 時(shí)間: 2025-3-26 06:25 作者: 記成螞蟻 時(shí)間: 2025-3-26 10:09
The Community Manager‘s Playbook at the transcriptional and post-transcriptional levels. A better understanding of latency is needed in order to ultimately achieve a cure for HIV. The mechanisms underlying latency vary between patients, tissues, anatomical compartments, and cell types. From this point of view, simian immunodeficie作者: Tempor 時(shí)間: 2025-3-26 15:56 作者: 偽書 時(shí)間: 2025-3-26 20:39 作者: IDEAS 時(shí)間: 2025-3-26 21:54
Varieties of Mathematical Experiencet in the setting of suppressive combination antiretroviral therapy (cART) and to develop and evaluate novel strategies for more definitive treatment of HIV infection (i.e., viral eradication “cure”, or sustained off-cART remission). Multiple different NHP models are available, each characterized by 作者: zonules 時(shí)間: 2025-3-27 03:12
Interviewing Perpetrators of Genocide,SIV are lentiviruses that infect CD4+?lymphocytes in addition to myeloid cells in blood and tissues. HIV infection of myeloid cells in brain, lung, and heart causes tissue-specific diseases that are mostly observed during severe immunosuppression, when the number of circulating CD4+?T cells declines作者: Guaff豪情痛飲 時(shí)間: 2025-3-27 08:00
Role and Function of Company Lawyers,blishment, maintenance, and potential clearance of latent infection are complex dynamic processes and can be best understood and described with the help of mathematical models. Here we review the use of viral dynamics models for HIV, with a focus on applications to the latent reservoir. Such models 作者: 離開就切除 時(shí)間: 2025-3-27 11:21 作者: Altitude 時(shí)間: 2025-3-27 16:57 作者: 繞著哥哥問 時(shí)間: 2025-3-27 19:54
Matt Kaeberlein,Lara S. Shamieho emerging. Cell and gene therapy strategies are connected with human pathologies at a fundamental level, by delivering DNA and RNA molecules that could correct and/or ameliorate the underlying genetic factors of any illness. The history of HIV gene therapy is especially intriguing, in that the viru作者: 破裂 時(shí)間: 2025-3-28 00:39
Molecular Control of HIV and SIV Latency, at the transcriptional and post-transcriptional levels. A better understanding of latency is needed in order to ultimately achieve a cure for HIV. The mechanisms underlying latency vary between patients, tissues, anatomical compartments, and cell types. From this point of view, simian immunodeficie作者: dapper 時(shí)間: 2025-3-28 02:49
Assays to Measure Latency, Reservoirs, and Reactivation,ently infected resting CD4. T cells carrying an integrated copy of the viral genome that is not expressed while the cells remain in a resting state. Targeting this latent reservoir is a major focus of HIV-1 cure research, and the development of a rapid and scalable assay for the reservoir is a rate-作者: EXUDE 時(shí)間: 2025-3-28 08:32
The Antiviral Immune Response and Its Impact on the HIV-1 Reservoir,HIV-1 infection unless these cells are eliminated. Latently infected cells probably do not express viral antigens and thus may not be susceptible to the HIV-1 specific immune response, nevertheless the size and composition of the reservoir is influenced by the immune system. In this chapter, we revi作者: 注意到 時(shí)間: 2025-3-28 13:12
Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiret in the setting of suppressive combination antiretroviral therapy (cART) and to develop and evaluate novel strategies for more definitive treatment of HIV infection (i.e., viral eradication “cure”, or sustained off-cART remission). Multiple different NHP models are available, each characterized by 作者: Esalate 時(shí)間: 2025-3-28 15:04 作者: 天真 時(shí)間: 2025-3-28 22:07 作者: 觀點(diǎn) 時(shí)間: 2025-3-29 00:55
Residual Immune Activation and Latency,or both AIDS- and non-AIDS-related events. Cancers, cardiovascular disease (CVD), liver and kidney disease, neurological disorders and frailty have become of great importance lately in the clinical management as they represent the principal cause of death in people living with HIV who receive cART (
