標(biāo)題: Titlebook: ; [打印本頁(yè)] 作者: Grant 時(shí)間: 2025-3-21 20:03
書目名稱Growth Hormone and Somatomedins during Lifespan影響因子(影響力)
書目名稱Growth Hormone and Somatomedins during Lifespan影響因子(影響力)學(xué)科排名
書目名稱Growth Hormone and Somatomedins during Lifespan網(wǎng)絡(luò)公開度
書目名稱Growth Hormone and Somatomedins during Lifespan網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Growth Hormone and Somatomedins during Lifespan被引頻次
書目名稱Growth Hormone and Somatomedins during Lifespan被引頻次學(xué)科排名
書目名稱Growth Hormone and Somatomedins during Lifespan年度引用
書目名稱Growth Hormone and Somatomedins during Lifespan年度引用學(xué)科排名
書目名稱Growth Hormone and Somatomedins during Lifespan讀者反饋
書目名稱Growth Hormone and Somatomedins during Lifespan讀者反饋學(xué)科排名
作者: 漸變 時(shí)間: 2025-3-21 20:52 作者: BRAWL 時(shí)間: 2025-3-22 03:39 作者: 立即 時(shí)間: 2025-3-22 04:49 作者: CHIDE 時(shí)間: 2025-3-22 12:24
,Vorbedingungen für die Planung, the authors’ laboratory using several transgenic and genetic strains of mice and rats with altered function of the individual axis components. These functional changes all produce profound effects on growth as well as on other components of the hypothalamic-pituitary axis.作者: monologue 時(shí)間: 2025-3-22 15:26
Studies on Peptide 23: A GHRH-Regulated Protein of the Pituitary and Gastrointestinal Tractbe paracrine regulators of GH secretion. However, as pointed out by O’Halloran et al. (1991), a number of conditions must be met to establish a paracrine role for any of the putative regulatory factors. As well the influence may not only be on secretion of GH but also on GH cell proliferation or differentiation.作者: monologue 時(shí)間: 2025-3-22 20:10
Insulin-like Growth Factor Binding Proteins: Biochemical Characterization these proteins, both in their primary structure and resulting from post-translational modification, which contribute to their unique biological functions. Of necessity, the review cannot be comprehensive, but will be illustrated by selected examples, including studies conducted in the author’s laboratory.作者: Hypomania 時(shí)間: 2025-3-22 22:56
Autocrine and Paracrine Effects of Insulin-like Growth Factors and Their Binding Proteinss are devoid of IGF-I receptors (Caro et al. 1988). If the liver is the major producer of IGF-I, the lack of IGF-I mitogenic effect on hepatocytes is a support for the endocrine hypothesis of IGF-I mode of action.作者: 割讓 時(shí)間: 2025-3-23 04:14 作者: 扔掉掐死你 時(shí)間: 2025-3-23 09:35
https://doi.org/10.1007/978-981-13-2242-6ters whose dual effect on GH secretion can be explained by the action of the same molecule either at the level of GHRF- or SRIF-secreting neurons (Fig. 1). This is well exemplified by catecholamines, where α. and α.-β. adrenoceptors exert respectively stimulatory and inhibitory influences on GH secretion (Müller et al. 1991).作者: Banister 時(shí)間: 2025-3-23 11:36
Economic halophytes — a global reviews now generally recognized that somatomedins are synthesized in a number of tissues, and autocrine/paracrine functions of these peptides have been suggested. The present review will mainly focus on recent studies of IGF-I and its relevance in tissue growth and regeneration.作者: Hamper 時(shí)間: 2025-3-23 17:29
Growth Hormone: Neural Mechanisms of Control at Neonatal and Aged Periodsters whose dual effect on GH secretion can be explained by the action of the same molecule either at the level of GHRF- or SRIF-secreting neurons (Fig. 1). This is well exemplified by catecholamines, where α. and α.-β. adrenoceptors exert respectively stimulatory and inhibitory influences on GH secretion (Müller et al. 1991).作者: 貪婪地吃 時(shí)間: 2025-3-23 19:58
Tissue Expression of Insulin-like Growth Factor Is now generally recognized that somatomedins are synthesized in a number of tissues, and autocrine/paracrine functions of these peptides have been suggested. The present review will mainly focus on recent studies of IGF-I and its relevance in tissue growth and regeneration.作者: Digitalis 時(shí)間: 2025-3-23 22:13
Problemstellung und Aufbau der Arbeit,es. Barker and associates have recently presented considerable evidence linking abnormal fetal and/or placental growth to the subsequent development of hypertension, ischemic heart and cerebrovascular disease in adulthood (Barker and Martyn 1992). At particular risk are infants who are disproportionately small relative to their placentae.作者: Lipoma 時(shí)間: 2025-3-24 04:36
Mechanisms of Intrauterine Growth Retardation: Role of Fetal and Maternal Hormoneses. Barker and associates have recently presented considerable evidence linking abnormal fetal and/or placental growth to the subsequent development of hypertension, ischemic heart and cerebrovascular disease in adulthood (Barker and Martyn 1992). At particular risk are infants who are disproportionately small relative to their placentae.作者: 演繹 時(shí)間: 2025-3-24 07:07 作者: 憤慨一下 時(shí)間: 2025-3-24 13:33 作者: 貝雷帽 時(shí)間: 2025-3-24 17:33 作者: 場(chǎng)所 時(shí)間: 2025-3-24 20:36 作者: 委屈 時(shí)間: 2025-3-25 00:32 作者: Alcove 時(shí)間: 2025-3-25 05:09 作者: 遠(yuǎn)地點(diǎn) 時(shí)間: 2025-3-25 07:36
Biosynthesis and Biological Role of Insulin-like Growth Factors in the Nervous System ensuring the optimal development of the CNS and its later function. In recent years it has become increasingly evident that these processes are regulated by the complex interaction of several growth factors, such as fibroblast growth factor (FGF), nerve growth factor (NGF) and the insulin-like grow作者: BOOR 時(shí)間: 2025-3-25 12:36
Growth Hormone Treatment of Children with Intrauterine Growth Retardationerform clinical trials in a large variety of patients who are growing poorly. A growth response to treatment with GH has been obtained in children with short stature and normal growth hormone secretion, the most prominent example being the treatment of children with Turner syndrome (Rosenfeld et al.作者: Synapse 時(shí)間: 2025-3-25 17:59 作者: Affable 時(shí)間: 2025-3-25 22:35 作者: Eulogy 時(shí)間: 2025-3-26 02:44
Adel Moustafa,Ahmed G. Fahmy,Rim S. Hamdyto study GH action is further motivated by the fact that several cell lines lose their GH receptors under in vitro conditions. For example, the liver is a major GH responsive tissue where GH receptors are abundant; however, in many hepatoma cell lines we have studied the receptor levels are low. Thi作者: sphincter 時(shí)間: 2025-3-26 06:58 作者: ASTER 時(shí)間: 2025-3-26 11:53 作者: 假 時(shí)間: 2025-3-26 15:52
Bulent Armagan,Nurettin Besli,Deniz Ucaracterization has also shown that numerous post-translational modifications of these proteins can occur. Specifically IGFBP-1 through 5 have been shown to be proteolytically cleaved. These proteases exist in a variety of physiologic fluids and therefore are capable of modifying binding protein activi作者: Entropion 時(shí)間: 2025-3-26 20:18 作者: Anticoagulants 時(shí)間: 2025-3-27 00:44
https://doi.org/10.1007/978-3-322-88015-4erform clinical trials in a large variety of patients who are growing poorly. A growth response to treatment with GH has been obtained in children with short stature and normal growth hormone secretion, the most prominent example being the treatment of children with Turner syndrome (Rosenfeld et al.作者: aesthetic 時(shí)間: 2025-3-27 03:42
https://doi.org/10.1007/978-981-13-2242-6c neuropeptides, GH-releasing hormone (GHRF) and somatostatin (SRIF), control in an opposite way the pituitary somatotrophs and are the final mediators of the neural, hormonal, metabolic and environmental stimuli that affect GH secretion. GHRF and SRIF are in turn regulated by numerous neurotransmit作者: 無能力 時(shí)間: 2025-3-27 08:43 作者: 受人支配 時(shí)間: 2025-3-27 11:27 作者: myocardium 時(shí)間: 2025-3-27 13:51 作者: Ascribe 時(shí)間: 2025-3-27 18:46
https://doi.org/10.1007/978-94-017-2693-1laxin (Blundell et al. 1983). As shown in Fig. 1, the IGF-I and IGF-II precursor peptides are similar to insulin in that they contain B and A domains which are homologous to the B and A chains of insulin, and which are separated by a C domain which, in contrast to the C peptide of insulin, is not re作者: 文字 時(shí)間: 2025-3-27 22:05 作者: SPURN 時(shí)間: 2025-3-28 03:30 作者: concentrate 時(shí)間: 2025-3-28 06:52
Stefan Mayr,Peter Schmid,Barbara Beikircheris structurally related to insulin (Daughaday and Rotwein 1989 Humbel 1990; Rechler and Nissley 1990). IGF-I is produced in most organs (D’Ercole et al. 1984; Han et al. 1987), but the liver is the major source of the circulating peptide (McConaghey et al. 1970; Schwander et al. 1983; Miller et al. 作者: Junction 時(shí)間: 2025-3-28 12:59
https://doi.org/10.1007/978-94-010-1961-3tructurally distinct binding proteins (IGFBPs; Drop et al. 1992). These proteins bind IGF-1 and IGF-II with varying affinities in the range 10.-10.1/mol two of them, IGFBP-2 and IGFBP-6, have a strong preferential affinity for IGF-II, whereas none appears to show a marked preference for IGF-I. An in作者: CLAY 時(shí)間: 2025-3-28 18:32
Bulent Armagan,Nurettin Besli,Deniz Ucarructurally distinct forms of IGF binding proteins have been cloned and their cDNA sequences determined (Shimasaki et al. 1991). Although all six share structural homology many of their features appear to be distinct. Structural characterization and purification of these proteins has made it possible作者: LAP 時(shí)間: 2025-3-28 20:59 作者: frozen-shoulder 時(shí)間: 2025-3-29 01:15 作者: 沙文主義 時(shí)間: 2025-3-29 05:29
Planung der Anlageninstandhaltungrapid proliferation of the stem cells, migration and differentiation into neurones and glia, and the establishment of synaptic connections as well as the selective death of specific cells. Disturbance in this growth process can often result in permanent and irreversible defects in CNS structure and 作者: palliate 時(shí)間: 2025-3-29 09:22 作者: 步履蹣跚 時(shí)間: 2025-3-29 14:14 作者: subacute 時(shí)間: 2025-3-29 17:48
Growth Hormone: Neural Mechanisms of Control at Neonatal and Aged Periodsc neuropeptides, GH-releasing hormone (GHRF) and somatostatin (SRIF), control in an opposite way the pituitary somatotrophs and are the final mediators of the neural, hormonal, metabolic and environmental stimuli that affect GH secretion. GHRF and SRIF are in turn regulated by numerous neurotransmit作者: commonsense 時(shí)間: 2025-3-29 21:55
Studies on Peptide 23: A GHRH-Regulated Protein of the Pituitary and Gastrointestinal Tractne (GH) secretion. There are other hypothalamic factors that influence GH secretion both directly and indirectly. As well there is a growing body of evidence indicating that intrapituitary factors influence GH secretion through paracrine or even autocrine effects. The list of putative paracrine regu作者: commute 時(shí)間: 2025-3-30 02:55
Biochemistry and Cellular Distribution of the Growth Hormone Receptor interactions of GH with its receptor, not surprisingly the receptor has been the focus of much attention. When we reported the cloning of the human and rabbit GH receptors (Leung et al. 1987), the GH receptor was structurally unique, and its sequence gave no mechanistic clues. Subsequently, when Bo作者: 使更活躍 時(shí)間: 2025-3-30 05:45
Cellular Transfection of GH Receptor cDNA to Study GH Actionprogress is now being made towards a deeper understanding of the mechanism of GH action. In vitro systems are essential tools for studying signal transduction by hormones and different GH responsive cell systems such as primary liver cells (Toilet et al. 1991) and preadipocytes (Catalioto et al. 199作者: Density 時(shí)間: 2025-3-30 09:00 作者: Verify 時(shí)間: 2025-3-30 12:29
Tissue Expression of Insulin-like Growth Factor Ie growth factors (IGFs) which are subsequently released into the bloodstream to exert anabolic effects on peripheral tissues such as cartilage and skeletal muscle. During the last decade, our knowledge and understanding of the mechanism of action of somatomedins have undergone dramatic changes. It i作者: 長(zhǎng)矛 時(shí)間: 2025-3-30 18:38 作者: 健談 時(shí)間: 2025-3-31 00:26 作者: allergy 時(shí)間: 2025-3-31 02:15
Insulin-like Growth Factor Binding Proteins: Biochemical Characterizationtructurally distinct binding proteins (IGFBPs; Drop et al. 1992). These proteins bind IGF-1 and IGF-II with varying affinities in the range 10.-10.1/mol two of them, IGFBP-2 and IGFBP-6, have a strong preferential affinity for IGF-II, whereas none appears to show a marked preference for IGF-I. An in作者: Resign 時(shí)間: 2025-3-31 07:59
Role of Insulin-like Growth Factor Binding Proteins in Modulating Insulin-like Growth Factor Actionructurally distinct forms of IGF binding proteins have been cloned and their cDNA sequences determined (Shimasaki et al. 1991). Although all six share structural homology many of their features appear to be distinct. Structural characterization and purification of these proteins has made it possible作者: CLEFT 時(shí)間: 2025-3-31 09:19
Autocrine and Paracrine Effects of Insulin-like Growth Factors and Their Binding Proteinsble for such mode of action. A support for this hypothesis is that liver accounts for most of the circulating IGF-I (Schwander et al. 1983) and that it is insensitive to its action. At variance with EGF, IGF-I is unable to stimulate thymidine incorporation on isolated adult rat hepatocytes in cultur作者: 同義聯(lián)想法 時(shí)間: 2025-3-31 15:07
Use of Transgenic and Genetic Models to Study the Neuroendocrine Regulation of Growth Hormone Secretimals and after destruction or removal of key components of the hypothalamic-GH-IGF-I axis have given considerable insight into the individual components, the ablative procedures all give rise to other neuronal and/or hormonal deficiencies that complicate interpretation of the results. The recent av作者: Catheter 時(shí)間: 2025-3-31 21:12
Biosynthesis and Biological Role of Insulin-like Growth Factors in the Nervous Systemrapid proliferation of the stem cells, migration and differentiation into neurones and glia, and the establishment of synaptic connections as well as the selective death of specific cells. Disturbance in this growth process can often result in permanent and irreversible defects in CNS structure and 作者: 網(wǎng)絡(luò)添麻煩 時(shí)間: 2025-3-31 23:59
Mechanisms of Intrauterine Growth Retardation: Role of Fetal and Maternal Hormones perinatal morbidity and mortality. Fetuses with IUGR are more likely to be stillborn or die in the neonatal period. Neonates with IUGR have greater risk of asphyxia induced encephalopathy with the consequent risks of neurological dysfunction. Infants who are born small may either show catchup growt作者: 抱負(fù) 時(shí)間: 2025-4-1 04:08
Growth Hormone Treatment of Children with Intrauterine Growth Retardationstnatal growth (Davies 1981; Fancourt et al. 1976; Fitzhardinge and Steven 1972; Fitzhardinge and Inwood 1989). Intrauterine malnutrition alters the potential for postnatal growth, accounting for the lack of catch-up growth in a significant number of children. Several groups in the past have been co
