書(shū)目名稱Growth Factors and Alzheimer’s Disease影響因子(影響力)學(xué)科排名
書(shū)目名稱Growth Factors and Alzheimer’s Disease網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱Growth Factors and Alzheimer’s Disease網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱Growth Factors and Alzheimer’s Disease被引頻次
書(shū)目名稱Growth Factors and Alzheimer’s Disease被引頻次學(xué)科排名
書(shū)目名稱Growth Factors and Alzheimer’s Disease年度引用
書(shū)目名稱Growth Factors and Alzheimer’s Disease年度引用學(xué)科排名
書(shū)目名稱Growth Factors and Alzheimer’s Disease讀者反饋
書(shū)目名稱Growth Factors and Alzheimer’s Disease讀者反饋學(xué)科排名
作者: Injunction 時(shí)間: 2025-3-21 21:19 作者: Anguish 時(shí)間: 2025-3-22 00:27
,Nerve Growth Factor Induces Differential Splicing of β-Amyloid Precursor mRNAs in the PC 12 Cell Li) transcripts. In particular there was reduced expression of the transcript coding for the longest precursor form (APP.) and a concomitant increase in the shortest (APP.) transcript following NGF treatment. These observations may have important implications in relation toβ-amyloid processing in Alzheimer’s disease.作者: 排名真古怪 時(shí)間: 2025-3-22 08:10
Part C: Qualities and Performance of Place) transcripts. In particular there was reduced expression of the transcript coding for the longest precursor form (APP.) and a concomitant increase in the shortest (APP.) transcript following NGF treatment. These observations may have important implications in relation toβ-amyloid processing in Alzheimer’s disease.作者: convert 時(shí)間: 2025-3-22 11:19
Das rechtwinklige Koordinatensystem, the cerebellum was detected. The ability to obtain specific expression in transgenic mice opens the possibility of directed expression of heterologous genes in specific neuronal cell types and of understanding the regulation of NGF and its receptor in the cholinergic septal-hippocampal pathway.作者: 人工制品 時(shí)間: 2025-3-22 13:06 作者: 人工制品 時(shí)間: 2025-3-22 17:45
,Streckenverh?ltnisse. Proportionalit?t,ergic neurons in the basal forebrain. Available information suggests that other, more recently discovered neurotrophic factors have a different spectrum of action than NGF. There are various pharmacological strategies to utilize neurotrophic molecules for the development of effective therapy of neurodegenerative diseases.作者: Trypsin 時(shí)間: 2025-3-22 22:21 作者: 祖先 時(shí)間: 2025-3-23 01:46
Neurotrophic Factors and Neurodegenerative Diseases, of adult neurons. Administration of neurotrophic factors can attenuate age-related and experimentally induced degeneration and behavioral deficits in animals, suggesting that such molecules may become useful in the treatment of diseases involving structural disintegration of nervous tissue. In part作者: 共同時(shí)代 時(shí)間: 2025-3-23 08:24
Survival, Regrowth, and Reconnection of Injured Retinal Ganglion Cells, graft that changes the nonneuronal substrate of the RGC axons and provides a link between the eye and the superior colliculus (SC). As a result of this axonal regrowth, RGCs can form well-differentiated synapses that excite or inhibit postsynaptic neurons in the SC. Because the potential source of 作者: 不愛(ài)防注射 時(shí)間: 2025-3-23 09:44
Localizing Expression of the Three Members of the Nerve Growth Factor Family to Neurons in the Brair “relatives,” forming a fascinating family of factors now known as the NGF family (see Ebendal et al. 1991). This new development began with the landmark report of Barde and colleagues (Leibrock et al. 1989), in which they showed that brain-derived neurotrophic factor (BDNF) had a remarkably high s作者: 一瞥 時(shí)間: 2025-3-23 16:06
Nerve Growth Factor: Studies Addressing Its Expression and Actions in the Central Nervous System,d significance of their actions it will be important to identify specific candidate molecules, link their expression and actions with the development of specific neuronal populations, and examine the effect of blocking their actions on neuronal development. The studies reported herein address the po作者: 條街道往前推 時(shí)間: 2025-3-23 18:23
Nerve Growth Factor Gene Expression in Actively Growing Brain Glia, on distant, projecting perikarya. To define the basis of local action, we used a sensitive nuclease protection assay to identify cells expressing the NGF gene in vivo and in vitro. In addition to neurons, glia from a variety of developing brain areas synthesized NGF mRNA, suggesting that CNS glia e作者: bourgeois 時(shí)間: 2025-3-23 22:21
Human Nerve Growth Factor Receptor Expression in the CNS of Transgenic Mice, Alzheimer’s disease. Cholinergic cells of the basal forebrain express NGF receptors and carry out retrograde axonal transport of .I-NGF. We have generated transgenic mice that express human NGF receptors. Distinct neuronal expression in cholinergic cells of the basal forebrain and Purkinje cells of作者: decode 時(shí)間: 2025-3-24 05:05 作者: landfill 時(shí)間: 2025-3-24 07:42
,Distribution and Characterization of β-Nerve Growth Factor Receptors in Alzheimer’s Disease, treatment of Alzheimer’s disease (AD). If β-NGF is used as a therapy, the presence of receptors on functioning neurones will be required. We have therefore examined the number and size distribution of neurones expressing β-NGF receptors in the nucleus of the diagonal band and the anterior, intermed作者: quiet-sleep 時(shí)間: 2025-3-24 12:51
Regulation of Nerve Growth Factor Synthesis in the Central Nervous System by Cytokines and Implicattage of the disease, and that the consequences of these degenerative changes are predominantly responsible for the impaired cognitive functions. Although there is no evidence that Alzheimer’s disease results from a reduced production of nerve growth factor (NGF), potential beneficial therapeutic eff作者: 為敵 時(shí)間: 2025-3-24 15:00 作者: Gobble 時(shí)間: 2025-3-24 21:39
Nerve Growth Factor and Behavioral Recovery After Brain Damage in Rats,ions. Since the late 1970s, evidence has accumulated indicating that nerve growth factor (NGF) acts as a neurotrophic factor for cholinergic neurons of the basal forebrain. There are conflicting data concerning the action of this protein on cognitive functions, particularly in animals with lesions a作者: STAT 時(shí)間: 2025-3-24 23:28
Functional Impairments that Develop in Nerve Growth Factor-Sensitive Neuronal Projections in the PNem, the collateral sprouting of undamaged nociceptive nerves into adjacent denervated skin. This new growth leads to an expansion of the surviving nociceptive fields. We now find that the . effect, a (reversible) ., particularly of the heat-nociceptive fields, is produced by the antibody-induced chr作者: 安定 時(shí)間: 2025-3-25 04:55
Morphological and Behavioral Effects of Basic Fibroblast Growth Factor and Heparin on Transplanted in vitro as a trophic factor for certain fetal CNS cells and for survival of fetal astrocytes. In vivo bFGF has a preserving effect on damaged adult septal cells. The present experiments were performed to investigate the effect of heparin and the combination of heparin with bFGF on the functional re作者: enterprise 時(shí)間: 2025-3-25 08:20 作者: 出處 時(shí)間: 2025-3-25 12:52
Synthetic Peptide Agonists and Antagonists of Basic Fibroblast Growth Factor: Increasing Cellular Sntial as a therapeutic agent in Alzheimer’s disease or other neurologic diseases. Unlike nerve growth factor (NGF), bFGF is a multifunctional growth factor with additional effects on glial cells, endothelial cells, and fibroblasts. The actions of bFGF within a tissue are probably determined by a com作者: 組裝 時(shí)間: 2025-3-25 17:57 作者: choleretic 時(shí)間: 2025-3-25 23:06
Effects of Neurotrophic Factors on the Secretion and Metabolism of the Alzheimer Amyloid Precursor,egenerating and regenerating neuntes. The main component of the plaque amyloid is a small protein (βA4 protein) which derives from a larger amyloid precursor protein (APP). It has been proposed that the neuritic regeneration associated with the neuritic plaques takes place in the presence of a milie作者: 獨(dú)輪車 時(shí)間: 2025-3-26 00:11 作者: choleretic 時(shí)間: 2025-3-26 07:09
,The Role of Misdirected Plasticity in Plaque Biogenesis and Alzheimer’s Disease Pathology,or cell loss. This process may represent the plasticity by which the brain can modify its circuitry and compensate for neuronal or synaptic loss after trauma and in a variety of disease states. Lesions of the entorhinal cortex in the rodent brain and degenerative cell loss in this region in Alzheime作者: URN 時(shí)間: 2025-3-26 10:16
,Streckenverh?ltnisse. Proportionalit?t, of adult neurons. Administration of neurotrophic factors can attenuate age-related and experimentally induced degeneration and behavioral deficits in animals, suggesting that such molecules may become useful in the treatment of diseases involving structural disintegration of nervous tissue. In part作者: CEDE 時(shí)間: 2025-3-26 12:47 作者: 不能逃避 時(shí)間: 2025-3-26 17:41 作者: 摘要 時(shí)間: 2025-3-26 21:38 作者: 引起痛苦 時(shí)間: 2025-3-27 03:52 作者: Analogy 時(shí)間: 2025-3-27 05:42 作者: 偽善 時(shí)間: 2025-3-27 10:47 作者: consent 時(shí)間: 2025-3-27 15:05 作者: Albinism 時(shí)間: 2025-3-27 20:51 作者: 詞匯記憶方法 時(shí)間: 2025-3-27 23:43
Plankosten, Deckungsbeitr?ge und Budgetso various degrees during development and, in some cases, in mature organisms. Deficits in the NGF responsiveness of basal forebrain cholinergic neurons may contribute to pathological changes in the aged central nervous system. One gene whose expression appears to be regulated by NGF is the amyloid p作者: Misgiving 時(shí)間: 2025-3-28 03:50
Die flexible Plankostenrechnung,ions. Since the late 1970s, evidence has accumulated indicating that nerve growth factor (NGF) acts as a neurotrophic factor for cholinergic neurons of the basal forebrain. There are conflicting data concerning the action of this protein on cognitive functions, particularly in animals with lesions a作者: Indigence 時(shí)間: 2025-3-28 07:57 作者: 無(wú)政府主義者 時(shí)間: 2025-3-28 11:23 作者: Brochure 時(shí)間: 2025-3-28 16:03
https://doi.org/10.1007/978-3-642-78804-8tions of some growth factors could be involved in the degeneration of retinal ganglion cells and their axons in the optic nerve. Among growth factors, acidic and basic fibroblast growth factors (aFGF, bFGF) are polypeptides which could be good candidates. They possess neurotrophic effects which have作者: 希望 時(shí)間: 2025-3-28 20:10
Flavio E. Paparazzo,José L. Estevesntial as a therapeutic agent in Alzheimer’s disease or other neurologic diseases. Unlike nerve growth factor (NGF), bFGF is a multifunctional growth factor with additional effects on glial cells, endothelial cells, and fibroblasts. The actions of bFGF within a tissue are probably determined by a com作者: BURSA 時(shí)間: 2025-3-29 00:38 作者: gonioscopy 時(shí)間: 2025-3-29 05:03
Slums and the Postcolonial Uncannyegenerating and regenerating neuntes. The main component of the plaque amyloid is a small protein (βA4 protein) which derives from a larger amyloid precursor protein (APP). It has been proposed that the neuritic regeneration associated with the neuritic plaques takes place in the presence of a milie作者: Perigee 時(shí)間: 2025-3-29 10:14 作者: Lucubrate 時(shí)間: 2025-3-29 13:09 作者: Infect 時(shí)間: 2025-3-29 18:20
Survival, Regrowth, and Reconnection of Injured Retinal Ganglion Cells,nection appeared to diminish the loss of RGCs. Studies of axonal transport after ON injury revealed a selective decrease in the rate of slow transport of neurofilaments and tubulin. This change contrasts with an enhanced rate of transport of these cytoskeletal proteins when RGCs regenerated into the作者: 窗簾等 時(shí)間: 2025-3-29 21:07
Localizing Expression of the Three Members of the Nerve Growth Factor Family to Neurons in the Braial. 1990). In this chapter we shall use HDNF to denote this third factor and will review recent data on the expression of NGF, BDNF and HDNF in the central nervous system, as demonstrated by in situ hybridization.作者: 鍵琴 時(shí)間: 2025-3-30 00:47 作者: Factual 時(shí)間: 2025-3-30 06:39 作者: CHAR 時(shí)間: 2025-3-30 11:18 作者: 藕床生厭倦 時(shí)間: 2025-3-30 16:09
Regulation of Nerve Growth Factor Synthesis in the Central Nervous System by Cytokines and Implicattigated the changes in NGF synthesis which occurred in cultured rat astrocytes and in the hippocampus after intraventricular injection of various growth factors and cytokines. We found that in particular, interleukin-1 (IL-1) and transforming growth factor β (TGF-β) enhanced the synthesis of NGF bot作者: 聚集 時(shí)間: 2025-3-30 18:07
Nerve Growth Factor Expression and Function in the CNS,sed into aged and young rats. In young adult rats, chronic NGF infusion produces robust increases in APP mRNA hybridization, NGFr mRNA hybridization, NGFr immunoreactivity, ChAT mRNA hybridization, and hypertrophy of ChAT immunoreactivity and mRNApositive neurons. NGF treatment also increases the ra作者: 耐寒 時(shí)間: 2025-3-31 00:38
Nerve Growth Factor and Behavioral Recovery After Brain Damage in Rats,gle intrahippocampal injection of NGF made at the time of lesion surgery. Behavior was measured in a test battery including spontaneous alternation and radial maze performance. The results were as follows:作者: discord 時(shí)間: 2025-3-31 02:20
Functional Impairments that Develop in Nerve Growth Factor-Sensitive Neuronal Projections in the PNged animal constitutes a partial model of this disease. Therefore, we have looked for evidence of a naturally occurring deficit in NGF utilisation in aged rats both in the PNS, by measuring cutaneous sensory fields, and in the CNS of the same animals, by using the Morris water maze to reveal possibl作者: 談判 時(shí)間: 2025-3-31 06:54 作者: Custodian 時(shí)間: 2025-3-31 10:29 作者: Isthmus 時(shí)間: 2025-3-31 16:26 作者: mechanism 時(shí)間: 2025-3-31 20:11 作者: ANA 時(shí)間: 2025-4-1 01:26 作者: 無(wú)瑕疵 時(shí)間: 2025-4-1 04:57
Das rechtwinklige Koordinatensystem,nection appeared to diminish the loss of RGCs. Studies of axonal transport after ON injury revealed a selective decrease in the rate of slow transport of neurofilaments and tubulin. This change contrasts with an enhanced rate of transport of these cytoskeletal proteins when RGCs regenerated into the作者: INCH 時(shí)間: 2025-4-1 06:07 作者: fixed-joint 時(shí)間: 2025-4-1 12:29
,Aufgaben über das rechtwinklige Dreieck,In contrast, expression was essentially undetectable in adult optic nerve. Transection, which induces rapid and transient glial proliferation, elicited transient, de novo appearance of NGF mRNA in the adult nerve. Our observations suggest that active glial growth is associated with expression of the作者: CUMB 時(shí)間: 2025-4-1 14:29
,Die ?hnlichkeit und der Kreis,-tetradecanoyl-phorbol-13-acetate (TPA). This mechanism may be altered in neuropathological disorders such as Alzheimer’s disease or diabetes-associated peripheral neuropathy, where impaired or decreased protein kinase C activity is thought to take place.作者: demote 時(shí)間: 2025-4-1 19:34 作者: 道學(xué)氣 時(shí)間: 2025-4-2 01:12
,Beispiele zur Fl?chenbereehnung,tigated the changes in NGF synthesis which occurred in cultured rat astrocytes and in the hippocampus after intraventricular injection of various growth factors and cytokines. We found that in particular, interleukin-1 (IL-1) and transforming growth factor β (TGF-β) enhanced the synthesis of NGF bot
