標(biāo)題: Titlebook: Good Research Practice in Non-Clinical Pharmacology and Biomedicine; Anton Bespalov,Martin C. Michel,Thomas Steckler Book‘‘‘‘‘‘‘‘ 2020 The [打印本頁] 作者: 偏差 時(shí)間: 2025-3-21 17:07
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書目名稱Good Research Practice in Non-Clinical Pharmacology and Biomedicine被引頻次
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書目名稱Good Research Practice in Non-Clinical Pharmacology and Biomedicine讀者反饋
書目名稱Good Research Practice in Non-Clinical Pharmacology and Biomedicine讀者反饋學(xué)科排名
作者: Gudgeon 時(shí)間: 2025-3-21 20:29 作者: 礦石 時(shí)間: 2025-3-22 03:45 作者: Occlusion 時(shí)間: 2025-3-22 07:31 作者: cylinder 時(shí)間: 2025-3-22 10:07 作者: V切開 時(shí)間: 2025-3-22 13:03
Mirjana Radovi?-Markovi?,Jovica Jovanovi?ter, we summarize the ethical principles driving legislation and recommendations on animal care and use, as well as some of these laws and international recommendations. Examples of the impact of specific animal care and use aspects on research, as well as systems of internal and external oversight of animal care and use programs, are described.作者: V切開 時(shí)間: 2025-3-22 20:41 作者: Obliterate 時(shí)間: 2025-3-22 21:37 作者: 桶去微染 時(shí)間: 2025-3-23 03:06 作者: 蚊帳 時(shí)間: 2025-3-23 09:36
Blinding and Randomization,at any cost. We argue that, in general, experiments should be blinded and randomized if (a) this is a confirmatory research that has a major impact on decision-making and that cannot be readily repeated (for ethical or resource-related reasons) and/or (b) no other measures can be applied to protect against existing and potential risks of bias.作者: 小步走路 時(shí)間: 2025-3-23 12:15 作者: 相容 時(shí)間: 2025-3-23 14:07 作者: BLANK 時(shí)間: 2025-3-23 20:06
https://doi.org/10.1007/978-1-4614-4460-2 for effective systems to improve data integrity in the evolving non-GxP research environment. This chapter describes the critical elements that need to be considered to ensure a successful implementation of research quality standards in both industry and academia. The quality standard proposed is f作者: 出來 時(shí)間: 2025-3-23 22:13 作者: 鍍金 時(shí)間: 2025-3-24 03:30 作者: 搜集 時(shí)間: 2025-3-24 08:16 作者: Lipoprotein 時(shí)間: 2025-3-24 14:10 作者: 變形 時(shí)間: 2025-3-24 18:09 作者: Osteons 時(shí)間: 2025-3-24 23:01 作者: Gerontology 時(shí)間: 2025-3-24 23:48 作者: Psa617 時(shí)間: 2025-3-25 04:53 作者: 截?cái)?nbsp; 時(shí)間: 2025-3-25 08:00
https://doi.org/10.1007/978-1-349-16204-8al robustness for both ethical and economic reasons. Key findings confirmed in multiple species have a greater chance to also occur in humans. Given the heterogeneity of patient populations, preclinical studies or at least programs comprising multiple studies need to reflect such heterogeneity, e.g.作者: chisel 時(shí)間: 2025-3-25 12:16
https://doi.org/10.1007/978-3-319-51947-0rmation” guidelines have been developed for different disciplines. These standards help ensure that the complete experiment is described, including both experimental protocols and data processing methods, allowing a critical evaluation of the whole process and the potential recreation of the work. S作者: 膽大 時(shí)間: 2025-3-25 17:41 作者: BLA 時(shí)間: 2025-3-25 22:24
Unconventional Macroprudential Instrumentscal evidence is embodied in . data and concerns the hypotheses of interest for . experiment, whereas the global error rate is a property of the statistical analysis and sampling procedure. It is shown using simple examples that local evidence and global error rates can be, and should be, considered 作者: 贊美者 時(shí)間: 2025-3-26 02:22
https://doi.org/10.1057/978-1-137-53159-9lab notebook (pLN) has been employed for documentation of experimental procedures, but over the course of the last decades, the introduction of electronic tools has changed the research landscape and the way that work is performed. Nowadays, almost all data acquisition, analysis, presentation and ar作者: 招待 時(shí)間: 2025-3-26 06:43 作者: NAIVE 時(shí)間: 2025-3-26 09:41
https://doi.org/10.1007/978-3-030-01998-3ts and a prediction of the extent to which the findings might hold true under different experimental or real-world conditions. In some situations, the certainty and precision obtained from a single study are sufficient reliably to inform future research decisions. However, in other situations greate作者: 饒舌的人 時(shí)間: 2025-3-26 13:54 作者: SCORE 時(shí)間: 2025-3-26 18:40 作者: apiary 時(shí)間: 2025-3-26 21:35 作者: 憤怒事實(shí) 時(shí)間: 2025-3-27 03:55 作者: lymphedema 時(shí)間: 2025-3-27 06:39 作者: Felicitous 時(shí)間: 2025-3-27 10:04
Learning from Principles of Evidence-Based Medicine to Optimize Nonclinical Research Practices,ns, and other efforts. Discussions of the low reproducibility and robustness of some of this research have led to myriad efforts to increase data quality and thus reliability. Across the scientific ecosystem, regardless of the extent of concerns, debate about solutions, and differences among goals a作者: regale 時(shí)間: 2025-3-27 17:07
General Principles of Preclinical Study Design,However, evidence has shown that poor quality in the design and conduct of these studies has not only impeded clinical translation but also led to significant waste of valuable research resources. It is clear that experimental biases are related to the poor quality seen with preclinical studies. In 作者: defeatist 時(shí)間: 2025-3-27 18:22
Resolving the Tension Between Exploration and Confirmation in Preclinical Biomedical Research, not for confirmation, and confirmatory research is often stigmatized as unoriginal and as a consequence faces barriers to publication. As a result, the current biomedical literature is dominated by exploration, which to complicate matters further is often disguised as confirmation. Only recently sc作者: 飛行員 時(shí)間: 2025-3-27 22:08 作者: 悄悄移動(dòng) 時(shí)間: 2025-3-28 05:10
Out of Control? Managing Baseline Variability in Experimental Studies with Control Groups,pected to have an effect (positive control). Although they usually give results we can anticipate, they are an essential component of all experiments, both in vitro and in vivo, and fulfil a number of important roles in any experimental design. Perhaps most importantly they help you understand the i作者: 基因組 時(shí)間: 2025-3-28 06:37
Quality of Research Tools,amiliarity with existing knowledge, key relevant concepts remain unknown as activities start. This is often an accepted risk, mitigated by gaining understanding in real time as the project develops. Chemicals play a role in all biology studies conducted in the context of drug discovery, whether endo作者: 拍下盜公款 時(shí)間: 2025-3-28 12:46
Genetic Background and Sex: Impact on Generalizability of Research Findings in Pharmacology Studies problems and employed to evaluate potential therapeutic treatments in drug discovery. While inbred strains demonstrate relatively reliable and predictable responses, using a single inbred strain alone or as a background to a mutation is analogous to running a clinical trial in a single individual a作者: NOTCH 時(shí)間: 2025-3-28 15:06
Building Robustness into Translational Research,al robustness for both ethical and economic reasons. Key findings confirmed in multiple species have a greater chance to also occur in humans. Given the heterogeneity of patient populations, preclinical studies or at least programs comprising multiple studies need to reflect such heterogeneity, e.g.作者: overreach 時(shí)間: 2025-3-28 20:45 作者: 評(píng)論者 時(shí)間: 2025-3-29 00:23 作者: 恭維 時(shí)間: 2025-3-29 05:21
A Reckless Guide to P-values,cal evidence is embodied in . data and concerns the hypotheses of interest for . experiment, whereas the global error rate is a property of the statistical analysis and sampling procedure. It is shown using simple examples that local evidence and global error rates can be, and should be, considered 作者: 獎(jiǎng)牌 時(shí)間: 2025-3-29 10:30
Electronic Lab Notebooks and Experimental Design Assistants,lab notebook (pLN) has been employed for documentation of experimental procedures, but over the course of the last decades, the introduction of electronic tools has changed the research landscape and the way that work is performed. Nowadays, almost all data acquisition, analysis, presentation and ar作者: 寡頭政治 時(shí)間: 2025-3-29 11:30
Data Storage,chapter follows the life cycle of research data, by considering aspects ranging from storage and preservation to sharing and legal factors. While it provides a wide overview of the current ecosystem, it also pinpoints the elements comprising the modern research sharing practices such as metadata cre作者: Texture 時(shí)間: 2025-3-29 19:09
Design of Meta-Analysis Studies,ts and a prediction of the extent to which the findings might hold true under different experimental or real-world conditions. In some situations, the certainty and precision obtained from a single study are sufficient reliably to inform future research decisions. However, in other situations greate作者: 分發(fā) 時(shí)間: 2025-3-29 22:40
,Publishers’ Responsibilities in Promoting Data Quality and Reproducibility,e achieved by publishers in six key areas: (1) understanding researchers’ problems and motivations, by conducting and responding to the findings of surveys; (2) raising awareness of issues and encouraging behavioural and cultural change, by introducing consistent journal policies on sharing research作者: 高調(diào) 時(shí)間: 2025-3-30 01:30 作者: Figate 時(shí)間: 2025-3-30 07:39
Good Research Practice: Lessons from Animal Care and Use,gal framework in many geographical areas that researchers must comply with, and professional organizations continuously develop recommendations on specific areas of laboratory animal science. Scientific evidence demonstrates that many aspects of animal care and use which are beyond the legal require作者: nocturnal 時(shí)間: 2025-3-30 10:21 作者: 含鐵 時(shí)間: 2025-3-30 14:48
Good Research Practice in Non-Clinical Pharmacology and Biomedicine978-3-030-33656-1Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: 人類 時(shí)間: 2025-3-30 17:05 作者: triptans 時(shí)間: 2025-3-30 20:49 作者: Harass 時(shí)間: 2025-3-31 03:04 作者: GLADE 時(shí)間: 2025-3-31 08:10
Good Research Practice in Non-Clinical Pharmacology and Biomedicine作者: 善變 時(shí)間: 2025-3-31 11:21 作者: immunity 時(shí)間: 2025-3-31 17:16
Japanese FDI and Economic Policy, on preclinical studies and how to use them. This chapter, together with relevant information in other chapters in the handbook, provides a powerful tool to enhance scientific rigour for preclinical studies without restricting creativity.作者: 審問 時(shí)間: 2025-3-31 20:08
Neoclassical Macroeconomics Reproposed,, is unavoidably linked to high false positive rates and cannot support confirmatory inference, dedicated confirmatory investigation is needed for pivotal results. In this chapter I will argue that the tension between the two modes of research, exploration and confirmation, can be resolved if we con作者: FLOUR 時(shí)間: 2025-3-31 22:28 作者: 樣式 時(shí)間: 2025-4-1 03:20
Central Banks and Monetary Policy,ent some suggestions to minimize the risk of irreproducibility due to chemistry-related issues during biology research supporting drug discovery and make these efforts more robust and impactful. These include discussions on identity and purity, target and species selectivity, and chemical modalities作者: 鬧劇 時(shí)間: 2025-4-1 08:23 作者: 贊美者 時(shí)間: 2025-4-1 13:01
https://doi.org/10.1007/978-1-349-16204-8derlying pathophysiology in patients, that defined by timing of treatment, or that implied in dosing decisions and interspecies differences in pharmacokinetic profiles. The balance of all these factors needs to be considered carefully for each study and program.
