作者: Ascribe 時(shí)間: 2025-3-21 21:23 作者: Hemiparesis 時(shí)間: 2025-3-22 02:24 作者: neologism 時(shí)間: 2025-3-22 04:47
Endocrine Regulation of Glycoprotein Hormone Alpha Subunit Gene Expression in Transgenic Micedistinct beta subunits that confer biological specificity (1). The common alpha subunit and each of the beta subunits are encoded by unique single copy genes that are expressed in specific cell types (gonadotropes: LH and FSH; thyrotropes: TSH) of the anterior pituitary gland (1, 2). LH and FSH are 作者: Adornment 時(shí)間: 2025-3-22 09:51
Coordinate Regulation of the Gonadotropin Subunit Genes in Pituitary and Placentadinately expressed with an individual β-subunit gene to form each hormone (2). The . (CG) β-subunit gene is coexpressed with the α-subunit gene in placental trophoblasts, while the thyroid stimulating hormone β-subunit gene is coexpressed with the α-subunit gene in pituitary thyrotropes. In pituitar作者: LIMIT 時(shí)間: 2025-3-22 15:06
Role of Helix-Loop-Helix Proteins in Gonadotropin Gene Expressiones can occur at almost any point along the pathway from DNA to protein. The most common method that cells use to express specialized genes is to regulate the level of transcription of these genes (1). Combinations of transcription-enhancing and -repressing DNA binding factors can determine the level作者: LIMIT 時(shí)間: 2025-3-22 17:10 作者: 柏樹 時(shí)間: 2025-3-22 22:29
Regulation and Expression of Thyroid Stimulating Hormonen common with the gonadotropins, luteinizing hormone, and follicle stimulating hormone; and the unique beta subunit, which confers biological specificity to the intact hormone and is expressed exclusively in the thyrotropes of the anterior pituitary (2). Previous studies have indicated that the tran作者: 流出 時(shí)間: 2025-3-23 03:36 作者: NEG 時(shí)間: 2025-3-23 05:34
Evidence for Altered Splicing in Two Members of the Chorionic Gonadotropin β Gene Clusterng the . (FT). CG is a member of the glycoprotein hormone family that includes the pituitary hormones . (LH), follitropin, and thyrotropin and consists of an α.β heterodimer. The α-subunit is encoded by a single gene (1) and the β-subunit is encoded by a cluster of six genes (or pseudogenes [2, 3]) 作者: TOXIN 時(shí)間: 2025-3-23 11:57
Delineation of Subunit and Receptor Contact Sites by Site-Directed Mutagenesis of hCGβa species, the single α-subunit binds to distinct β-subunits to form bioactive holoproteins, which exhibit specificity for three G protein-coupled . (r) (2), LH/CGr (3), FSHr (4), and TSHr (5). Since the glycoprotein hormones contain a common α-subunit, and since both subunits are believed to partic作者: Antioxidant 時(shí)間: 2025-3-23 17:33 作者: rectum 時(shí)間: 2025-3-23 19:09 作者: BACLE 時(shí)間: 2025-3-23 23:36
https://doi.org/10.1007/978-3-322-87545-7re working on the purification of the glycoprotein hormones in the 1960s. There is little question that the isolation of highly purified gonadotropins (and thyrotropin) in the late 1950s and the 1960s, and the preparation of their subunits, provided a powerful stimulus to physiological and clinical 作者: Emasculate 時(shí)間: 2025-3-24 05:41 作者: –FER 時(shí)間: 2025-3-24 10:30
Lehrbuch der Mathematischen Physiksful series published in . for the 75th anniversary of The Endocrine Society. I know one of my fellow honorees, Harold Papkoff, contributed a remembrance to that series (1) that I much admired, and I am sure he can do it again. The other fellow honoree, Robert J. Ryan, can always be counted on for t作者: NOVA 時(shí)間: 2025-3-24 11:19
https://doi.org/10.1007/978-3-7091-6646-8distinct beta subunits that confer biological specificity (1). The common alpha subunit and each of the beta subunits are encoded by unique single copy genes that are expressed in specific cell types (gonadotropes: LH and FSH; thyrotropes: TSH) of the anterior pituitary gland (1, 2). LH and FSH are 作者: consent 時(shí)間: 2025-3-24 16:40 作者: 無節(jié)奏 時(shí)間: 2025-3-24 20:42
Analysis auf Mannigfaltigkeiten,es can occur at almost any point along the pathway from DNA to protein. The most common method that cells use to express specialized genes is to regulate the level of transcription of these genes (1). Combinations of transcription-enhancing and -repressing DNA binding factors can determine the level作者: 責(zé)問 時(shí)間: 2025-3-25 02:19 作者: concubine 時(shí)間: 2025-3-25 07:06 作者: 沒血色 時(shí)間: 2025-3-25 11:20
https://doi.org/10.1007/978-3-662-34530-6eptide hormone and a larger globular protein. As noted by Dyson and Wright (1), the active conformation of a small hormone or bioactive peptide may be imposed predominantly by the shape of the receptor, while regions of interest within a protein are inevitably involved in interactions within the mol作者: 荒唐 時(shí)間: 2025-3-25 14:38 作者: infelicitous 時(shí)間: 2025-3-25 16:29 作者: 沙草紙 時(shí)間: 2025-3-25 21:25
https://doi.org/10.1007/978-3-642-91188-0lt, uncombined α- and β-subunits, as well as α-β heterodimer, are secreted (1–3). Efficiency of α-β assembly in vitro, using purified urinary forms of the subunits, has also been reported to be low, with a kd of 0.6 μM (4).作者: sclera 時(shí)間: 2025-3-26 01:34 作者: 細(xì)胞學(xué) 時(shí)間: 2025-3-26 07:49 作者: 填料 時(shí)間: 2025-3-26 10:57
https://doi.org/10.1007/978-3-642-91188-0lt, uncombined α- and β-subunits, as well as α-β heterodimer, are secreted (1–3). Efficiency of α-β assembly in vitro, using purified urinary forms of the subunits, has also been reported to be low, with a kd of 0.6 μM (4).作者: 殺菌劑 時(shí)間: 2025-3-26 13:05
Where to from Here?however, the answers are apt to be biased by what you judge to be salable to a review committee. I think better answers come after the application has been submitted. This allows time to obtain data and make the goal salable at the next application three to five years later.作者: 天文臺(tái) 時(shí)間: 2025-3-26 16:51
Folding of the β-Subunit of hCG and Its Role in Assembly of the α-β Heterodimerlt, uncombined α- and β-subunits, as well as α-β heterodimer, are secreted (1–3). Efficiency of α-β assembly in vitro, using purified urinary forms of the subunits, has also been reported to be low, with a kd of 0.6 μM (4).作者: 軍械庫 時(shí)間: 2025-3-26 22:07
Regulationszentren visceraler FunktionenIn humans, maintenance of pregnancy requires extending the lifetime of the corpus luteum, which produces essential steroids. The signal for this maintenance is provided by . (hCG), a dimeric glycoprotein hormone produced by the trophoblast cells of the early embryo. The absence of hCG would result in rapid termination of early pregnancy.作者: flaunt 時(shí)間: 2025-3-27 01:55
Die Kristalle und ihr Stoff bestandThere appears to be only a single gene for the gonadotropin α-subunit in humans (1, 2), but the α polypeptide may combine noncovalently with any of several β-subunits to form one of the heterodimeric hormones, LH, FSH, TSH or hCG. Less commonly appreciated is the notion that substantial quantities of α are secreted in uncombined or “free α” forms.作者: 朦朧 時(shí)間: 2025-3-27 05:43
Human Chorionic Gonadotropin: Progress in Determining Its Tertiary StructureIn humans, maintenance of pregnancy requires extending the lifetime of the corpus luteum, which produces essential steroids. The signal for this maintenance is provided by . (hCG), a dimeric glycoprotein hormone produced by the trophoblast cells of the early embryo. The absence of hCG would result in rapid termination of early pregnancy.作者: 車床 時(shí)間: 2025-3-27 12:50 作者: Decongestant 時(shí)間: 2025-3-27 17:14
978-1-4613-8388-8Springer-Verlag New York, Inc. 1994作者: 弄臟 時(shí)間: 2025-3-27 18:07 作者: 調(diào)色板 時(shí)間: 2025-3-28 01:35 作者: 颶風(fēng) 時(shí)間: 2025-3-28 02:44 作者: 老巫婆 時(shí)間: 2025-3-28 09:23 作者: 異端 時(shí)間: 2025-3-28 13:59
Coordinate Regulation of the Gonadotropin Subunit Genes in Pituitary and Placenta and nuclear protein purification in cell culture model systems, several of the transcriptional regulatory proteins involved in controlling expression of the CG genes in placental trophoblast cells (JEG-3 cell line) and the LH genes in pituitary gonadotrope cells (αT3-1 cell line) have been identifi作者: strain 時(shí)間: 2025-3-28 15:11 作者: Common-Migraine 時(shí)間: 2025-3-28 20:24
Glycosylation and Glycoprotein Hormone Functionhese transferases is hormonally regulated, and the sulfated oligosaccharides produced play a key role in the expression of LH bioactivity in vivo by controlling its circulatory half-life following release into the blood.作者: 圣歌 時(shí)間: 2025-3-29 01:46
Conference proceedings 1994Pamela Mellon, James Hoeffler, John Nilson, Bruce Weintraub, and Joel Habener. These presentations reflected major advances from the in the understanding concepts offered at the last meeting. Other advances of hormone structure/function included the continuing work by Joyce Lustbader on the determin作者: exhilaration 時(shí)間: 2025-3-29 06:20
sented by Pamela Mellon, James Hoeffler, John Nilson, Bruce Weintraub, and Joel Habener. These presentations reflected major advances from the in the understanding concepts offered at the last meeting. Other advances of hormone structure/function included the continuing work by Joyce Lustbader on the determin978-1-4613-8388-8978-1-4613-8386-4作者: Indolent 時(shí)間: 2025-3-29 10:56 作者: Cardiac 時(shí)間: 2025-3-29 14:16
Lehrbuch der Mikrobiologie und Immunbiologie, particularly those responsible for conferring specificity. The absence of a crystallographic structure for any member of the glycoprotein hormone family has, however, prevented a detailed understanding of these contact regions.作者: 認(rèn)為 時(shí)間: 2025-3-29 16:37
Receptor Binding Regions of hLH and hCGβ-Subunit: Structural and Functional Propertiescule remain largely uncharted. They must, however, be considered an important factor in the alignment and relative contributions of the multiple receptor binding sites revealed in all four glycoprotein hormones by assays of individual synthetic peptides (2–8).作者: 到婚嫁年齡 時(shí)間: 2025-3-29 20:11 作者: 歡笑 時(shí)間: 2025-3-30 01:22 作者: gerrymander 時(shí)間: 2025-3-30 07:53
Cyclic AMP-Mediated Hormonal Regulation of Gene Transcriptiontor serves as the communicative link between the outside and the inside of the cell. In response to the binding of hormone, receptors activate one or more signal transduction pathways, resulting in the generation of the important second messengers, such as cAMP and . (DAG), that in turn activate the protein kinases A and C, respectively (1–5).作者: 古代 時(shí)間: 2025-3-30 10:59
Evidence for Altered Splicing in Two Members of the Chorionic Gonadotropin β Gene Clusters of an α.β heterodimer. The α-subunit is encoded by a single gene (1) and the β-subunit is encoded by a cluster of six genes (or pseudogenes [2, 3]) (see Fig. 11.1A). Linked to this cluster is the single gene encoding the related LHβ-subunit.作者: 變色龍 時(shí)間: 2025-3-30 13:09
Lehrbuch der Mathematischen Physikought I decided that rather than simple remembrances, I might best interest the readers in some of the things I have not forgotten, but for one reason or another I have foregone. Perhaps these things may strike an interested listener who still has laboratory and grant support at his disposal.作者: Yag-Capsulotomy 時(shí)間: 2025-3-30 18:34
Remembrance of Things Foregoneought I decided that rather than simple remembrances, I might best interest the readers in some of the things I have not forgotten, but for one reason or another I have foregone. Perhaps these things may strike an interested listener who still has laboratory and grant support at his disposal.作者: Pde5-Inhibitors 時(shí)間: 2025-3-30 23:33
https://doi.org/10.1007/978-3-322-87545-7studies of these hormones. Thus, it became possible to establish specific, sensitive, and reliable radioimmunoassays and, later, radioreceptor assays, the results of which provided the groundwork for the spectacular gene-related studies of recent years.作者: 善辯 時(shí)間: 2025-3-31 01:53
Lehrbuch der Mathematischen Physikscription of the TSHβ gene is stimulated by . (TRH) (3–6), phorbol esters (5, 7), and the adenylyl cyclase activator, forskolin, or the cAMP analog 8-bromo-cAMP (4–6, 8), and is inhibited by thyroid hormone (9–15).作者: BOLUS 時(shí)間: 2025-3-31 09:06
Reflections on Purifying Gonadotropins in the 1960sstudies of these hormones. Thus, it became possible to establish specific, sensitive, and reliable radioimmunoassays and, later, radioreceptor assays, the results of which provided the groundwork for the spectacular gene-related studies of recent years.作者: eczema 時(shí)間: 2025-3-31 10:37
Regulation and Expression of Thyroid Stimulating Hormonescription of the TSHβ gene is stimulated by . (TRH) (3–6), phorbol esters (5, 7), and the adenylyl cyclase activator, forskolin, or the cAMP analog 8-bromo-cAMP (4–6, 8), and is inhibited by thyroid hormone (9–15).作者: Thymus 時(shí)間: 2025-3-31 16:50 作者: Bucket 時(shí)間: 2025-3-31 17:34
