標(biāo)題: Titlebook: Glutamine Metabolism in Mammalian Tissues; Dieter H?ussinger,Helmut Sies Conference proceedings 1984 Springer- Verlag Berlin Heidelberg 19 [打印本頁(yè)] 作者: Levelheaded 時(shí)間: 2025-3-21 18:29
書(shū)目名稱(chēng)Glutamine Metabolism in Mammalian Tissues影響因子(影響力)
書(shū)目名稱(chēng)Glutamine Metabolism in Mammalian Tissues影響因子(影響力)學(xué)科排名
書(shū)目名稱(chēng)Glutamine Metabolism in Mammalian Tissues網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱(chēng)Glutamine Metabolism in Mammalian Tissues網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱(chēng)Glutamine Metabolism in Mammalian Tissues被引頻次
書(shū)目名稱(chēng)Glutamine Metabolism in Mammalian Tissues被引頻次學(xué)科排名
書(shū)目名稱(chēng)Glutamine Metabolism in Mammalian Tissues年度引用
書(shū)目名稱(chēng)Glutamine Metabolism in Mammalian Tissues年度引用學(xué)科排名
書(shū)目名稱(chēng)Glutamine Metabolism in Mammalian Tissues讀者反饋
書(shū)目名稱(chēng)Glutamine Metabolism in Mammalian Tissues讀者反饋學(xué)科排名
作者: Preamble 時(shí)間: 2025-3-21 21:55 作者: Onerous 時(shí)間: 2025-3-22 00:58 作者: PACK 時(shí)間: 2025-3-22 07:33 作者: Nebulous 時(shí)間: 2025-3-22 10:51
https://doi.org/10.1007/978-3-322-88319-3e synthesis [1], cumulative feedback inhibition by metabolic effectors [2], and by metabolite controlled chemical interconversion of the enzyme [3,4]. This highly sophisticated regulation seems to be necessary to adapt these organisms to substrate dependent alterations of energy and nitrogen metabolism [5].作者: 證明無(wú)罪 時(shí)間: 2025-3-22 13:36
https://doi.org/10.1007/978-3-662-36520-5, but when absorption ceases, internal sources must be called into play. Because free amino acids are not stored in mammalian cells or extracellular spaces to any significant extent, this supply (or its nitrogen equivalent) can only come from the degradation of endogenous proteins.作者: 證明無(wú)罪 時(shí)間: 2025-3-22 21:02
https://doi.org/10.1007/978-3-7091-4738-2ll 1970). Thus, the enzymes involved in the primary pathway of renal glutamine metabolism should exhibit properties consistant with a role in this process. The enzymology of renal glutamine metabolism has been most extensively characterized in the rat. Therefore, this review will be limited largely to this species.作者: photopsia 時(shí)間: 2025-3-22 22:11 作者: BRIDE 時(shí)間: 2025-3-23 05:27 作者: gene-therapy 時(shí)間: 2025-3-23 06:56 作者: 整理 時(shí)間: 2025-3-23 10:59
Enzymes of Cerebral Glutamine Metabolismford et al. 1978, Hamberger et al. 1978, Reubi et al. 1978). Since brain lacks a complete urea cycle, ammonia is largely detoxified by formation of the nontoxic Gin, whereby nitrogen is also saved for synthesis of important compounds, such as proteins.作者: A簡(jiǎn)潔的 時(shí)間: 2025-3-23 14:26
Liver Glutaminasend Knox [8] showed that 90% of the glutamine hydrolysing activity was phosphate-de- pendent and located in the mitochondria and was thus catalysed by the enzyme now classified as glutaminase (EC 3.5.1.2)作者: 善于 時(shí)間: 2025-3-23 21:51 作者: Alveoli 時(shí)間: 2025-3-23 23:04
Mechanism and Control of Deprivation-Induced Protein Degradation in Liver: Role of Glucogenic Amino , but when absorption ceases, internal sources must be called into play. Because free amino acids are not stored in mammalian cells or extracellular spaces to any significant extent, this supply (or its nitrogen equivalent) can only come from the degradation of endogenous proteins.作者: 譏諷 時(shí)間: 2025-3-24 05:23
978-3-642-69756-2Springer- Verlag Berlin Heidelberg 1984作者: 種類(lèi) 時(shí)間: 2025-3-24 10:03
Overview: 978-3-642-69756-2978-3-642-69754-8作者: 全部 時(shí)間: 2025-3-24 12:59
https://doi.org/10.1007/978-3-642-69754-8Amino acid; Glutamat; Glutamin; Glutamins?urestoffwechsel; Mammalia; Tissues; cells; enzymes; metabolism; ske作者: Cantankerous 時(shí)間: 2025-3-24 16:59
https://doi.org/10.1007/978-3-642-72405-3al nervous system for removal of ammonia and of glutamate, a neurotransmitter. Glutamine is a major energy source in kidney [2], small intestine [3], bone [4], and in certain cells grown in tissue culture [5,6J. Hydrolysis of glutamine by renal glutaminase plays a key role in acid-base balance. Glut作者: 松軟無(wú)力 時(shí)間: 2025-3-24 19:58
Lebensdauerprüfung von Zahnradgetrieben[23], showing that glutamine was vigorously oxidized to C0. by incubated ileal tissue from several laboratory animal species, appears to be the first reported indication that glutamine may be a preferred substrate for intestine. These studies seem to have attracted little attention, however, perhaps作者: 協(xié)議 時(shí)間: 2025-3-25 00:47 作者: Palate 時(shí)間: 2025-3-25 06:52 作者: SUE 時(shí)間: 2025-3-25 08:06
https://doi.org/10.1007/978-3-662-36521-276, Burch et al. 1978a). Thus, in the species whose kidney contains both glutaminase and glutamine synthetase, the possibility exists that renal degradation and synthesis of glutamine occur simultaneously.作者: Neutral-Spine 時(shí)間: 2025-3-25 11:41
https://doi.org/10.1007/978-3-662-36516-8dipose tissue. Thus, glycerol may also be viewed as being, in part, a product of glycolysis of glucose. Amino acids, principally alanine and perhaps glutamine, represent the most important sources of de novo carbon available for glucose production. Skeletal muscle is the predominant site of amino ac作者: EXCEL 時(shí)間: 2025-3-25 19:37
https://doi.org/10.1007/978-3-642-94505-2led despite high levels of glutamine synthetase activity in brain and glutamic acid is the only established immediate precursor of glutamine. In recent years increasing evidence pointed to the probability that glutamic acid also functions as an excitatory neurotransmitter in the central nervous syst作者: 牛的細(xì)微差別 時(shí)間: 2025-3-25 23:13 作者: Intractable 時(shí)間: 2025-3-26 01:24
Enzymology of Glutamineal nervous system for removal of ammonia and of glutamate, a neurotransmitter. Glutamine is a major energy source in kidney [2], small intestine [3], bone [4], and in certain cells grown in tissue culture [5,6J. Hydrolysis of glutamine by renal glutaminase plays a key role in acid-base balance. Glut作者: 拱墻 時(shí)間: 2025-3-26 06:12
Metabolism of Vascular and Luminal Glutamine by Intestinal Mucosa in Vivo[23], showing that glutamine was vigorously oxidized to C0. by incubated ileal tissue from several laboratory animal species, appears to be the first reported indication that glutamine may be a preferred substrate for intestine. These studies seem to have attracted little attention, however, perhaps作者: comely 時(shí)間: 2025-3-26 12:15
Renal Glutamine Metabolism and Hydrogen Ion Homeostasiserves; acidosis due to nonvolatile acid production is termed metabolic acidosis. During uncontrolled diabetes the incomplete oxidation of fats accelerates nonvolatile acid production inducing life threatening metabolic acidosis. In both physiological and clinical circumstances cellular H. homeostasi作者: 真實(shí)的你 時(shí)間: 2025-3-26 12:38
Effects of 2-Oxoglutarate and Glutamate on Glutamine Metabolism by Rat Kidney Mitochondria enzyme for 2-oxoglutarate was decreased at acid pH values. Moreover, additional studies from our laboratory demonstrated that renal glutamine metabolism was accelerated by hydrogen ions in the presence, but not in the absence, of 2-oxoglutarate, suggesting an important role for this metabolite in t作者: recession 時(shí)間: 2025-3-26 16:58
Role of Fatty Acids in Simultaneous Regulation of Flux Through Glutaminase and Glutamine Synthetase 76, Burch et al. 1978a). Thus, in the species whose kidney contains both glutaminase and glutamine synthetase, the possibility exists that renal degradation and synthesis of glutamine occur simultaneously.作者: CEDE 時(shí)間: 2025-3-26 23:09
Cyclic Nucleotide Regulation of Glutamine Metabolism in Skeletal Muscledipose tissue. Thus, glycerol may also be viewed as being, in part, a product of glycolysis of glucose. Amino acids, principally alanine and perhaps glutamine, represent the most important sources of de novo carbon available for glucose production. Skeletal muscle is the predominant site of amino ac作者: Mawkish 時(shí)間: 2025-3-27 03:42
Cerebral Glutamine/Glutamate Interrelationships and Metabolic Compartmentationled despite high levels of glutamine synthetase activity in brain and glutamic acid is the only established immediate precursor of glutamine. In recent years increasing evidence pointed to the probability that glutamic acid also functions as an excitatory neurotransmitter in the central nervous syst作者: 訓(xùn)誡 時(shí)間: 2025-3-27 05:17
Glutamine Metabolism in Lymphoid Tissues bodies (3-hydroxybutyrate and acetoacetate) and long-chain fatty acids (oleate and palmitate) (Table 1) and the effects of these fuels on oxygen consumption by lymphocytes. Of these fuels glutamine may be quantitatively the most important.作者: Indicative 時(shí)間: 2025-3-27 10:54
https://doi.org/10.1007/978-3-642-72405-3nsport form of both glutamate and ammonia. Glutamine is more effectively transported across the blood-brain barrier and across certain cell membranes than glutamate. Ammonia is toxic to many animal tissues, whereas glutamine serves efficiently as a nontoxic source of ammonia for many reactions. Glut作者: cortisol 時(shí)間: 2025-3-27 16:34 作者: Affiliation 時(shí)間: 2025-3-27 21:00 作者: 鋸齒狀 時(shí)間: 2025-3-27 23:18
William Bradford Shockley (geb. 1910),ginally proposed the existence of two distinct transport systems with overlapping specificity in the Ehrlich ascites cell. These were termed System A and System L. System A catalysed the Na.-dependent accumulation of amino acids with short, unbranched side-chains, e.g., alanine, glycine and serine. 作者: hypotension 時(shí)間: 2025-3-28 04:59 作者: 小隔間 時(shí)間: 2025-3-28 09:45 作者: Commentary 時(shí)間: 2025-3-28 11:17
https://doi.org/10.1007/978-3-322-88319-3of nucleic acids and proteins. Consequently, glutamine synthetase is regulated by a complex control system, including repression/derepression of enzyme synthesis [1], cumulative feedback inhibition by metabolic effectors [2], and by metabolite controlled chemical interconversion of the enzyme [3,4].作者: 衣服 時(shí)間: 2025-3-28 17:19 作者: 證實(shí) 時(shí)間: 2025-3-28 18:51 作者: 言行自由 時(shí)間: 2025-3-29 02:04
https://doi.org/10.1007/978-3-662-36515-1and accelerates cellular autophagy. Most animals, including man, are faced with a surfeit of acid. The daily metabolic CO. production obligates the formation of some 15 mol of carbonic acid; normally expiration matches cellular CO. production so the H. homeostais is not threatened by this volatile a作者: 無(wú)表情 時(shí)間: 2025-3-29 03:52
https://doi.org/10.1007/978-3-662-41127-8acidosis. A perplexing problem has been the observation that despite an increase in renal ammoniagenesis from glutamine known to occur in acidosis in vivo, glutamine metabolism in vitro was depressed by acid pH [1–3], probably by inhibition of phosphate-dependent glutaminase [4]. Although glutamine 作者: Explosive 時(shí)間: 2025-3-29 10:09
https://doi.org/10.1007/978-3-662-36521-2he only important enzyme thought to initiate renal degradation of glutamine (Tannen 1978), the main precursor of the urinary ammonia needed to serve as a buffer for excess protons (Van Slyke et al. 1943, Pitts et al. 1965), has been shown to be present in the kidney of all the species that have been作者: 小說(shuō) 時(shí)間: 2025-3-29 12:45 作者: 言行自由 時(shí)間: 2025-3-29 19:23 作者: 有常識(shí) 時(shí)間: 2025-3-29 20:07
https://doi.org/10.1007/978-3-662-00847-8igh biochemical activity which initiates production of various mediators of immunity including antibodies if they are B-lymphocytes and the mediators of cellular immunity (e.g., lymphotoxin, chemotactic factors, mitogenic factors) if they are T-lymphocytes. To perform this activity lymphocytes requi作者: companion 時(shí)間: 2025-3-30 01:54 作者: blister 時(shí)間: 2025-3-30 05:34
Enzymes of Renal Glutamine Metabolismsis (Tannen 1978, Kovacevic and McGivan 1983). The amide and amine nitrogens of glutamine are released as ammonium ions. The increased ammoniagenesis provides an expendable cation which facilitates the excretion of anions and titratable acids without depleting the body’s supply of sodium and potassi作者: Neutropenia 時(shí)間: 2025-3-30 10:12 作者: 雇傭兵 時(shí)間: 2025-3-30 15:17 作者: depreciate 時(shí)間: 2025-3-30 17:48 作者: Neolithic 時(shí)間: 2025-3-31 00:01 作者: 省略 時(shí)間: 2025-3-31 01:58
Cellular Distribution and Regulation of Glutamine Synthetase in Liverof nucleic acids and proteins. Consequently, glutamine synthetase is regulated by a complex control system, including repression/derepression of enzyme synthesis [1], cumulative feedback inhibition by metabolic effectors [2], and by metabolite controlled chemical interconversion of the enzyme [3,4].作者: 支形吊燈 時(shí)間: 2025-3-31 08:04
Liver Glutaminasemonstrated that the major part of the glutaminase activity was dependent on added phosphate and was located in the particulate fraction of the liver. Definitive evidence that glutaminase is a mitochondrial enzyme was first obtained by Guha [3]. Liver extracts also contain a phosphate-independent glu作者: 使入迷 時(shí)間: 2025-3-31 09:40 作者: 后來(lái) 時(shí)間: 2025-3-31 16:11
Renal Glutamine Metabolism and Hydrogen Ion Homeostasisand accelerates cellular autophagy. Most animals, including man, are faced with a surfeit of acid. The daily metabolic CO. production obligates the formation of some 15 mol of carbonic acid; normally expiration matches cellular CO. production so the H. homeostais is not threatened by this volatile a作者: 嚴(yán)重傷害 時(shí)間: 2025-3-31 18:31
Effects of 2-Oxoglutarate and Glutamate on Glutamine Metabolism by Rat Kidney Mitochondriaacidosis. A perplexing problem has been the observation that despite an increase in renal ammoniagenesis from glutamine known to occur in acidosis in vivo, glutamine metabolism in vitro was depressed by acid pH [1–3], probably by inhibition of phosphate-dependent glutaminase [4]. Although glutamine
