作者: 打谷工具 時(shí)間: 2025-3-21 22:49
Models to Study Glioma Cell Invasion the invading glioma cells. Such research is ideally conducted with reliable and relevant models. We describe some of the most commonly used models in glioma invasion research. Each model has its benefits and drawbacks and the nature of the experiments being conducted will help choose the type of model most suitable.作者: 小臼 時(shí)間: 2025-3-22 02:23
ment.Presents experimental research models for glioma researGliomas are fatal diseases, but also represent good models for tumor research with the aim to eventually discover new and appropriate therapeutics against this disease. Glioma experimental research models are of help to investigate tumorige作者: 善辯 時(shí)間: 2025-3-22 05:06 作者: Thymus 時(shí)間: 2025-3-22 09:37 作者: 兇猛 時(shí)間: 2025-3-22 14:42
Book 2014inst this disease. Glioma experimental research models are of help to investigate tumorigenesis (tumor stem cell theory versus "classical" opinions), tumor angiogenesis (since they are highly vascularized) and tumor invasion (since they grow without limits). In addition, they have a very special mic作者: 兇猛 時(shí)間: 2025-3-22 20:14
Book 2014 various tumor stages, describes the interaction with the tumor microenvironment and furthermore depicts experimental models for Glioma research and future therapeutic concepts. The book is composed and written for Scientists and Medical Doctors in Oncology, Neurosciences and Molecular Biology.??作者: covert 時(shí)間: 2025-3-22 23:55 作者: 六邊形 時(shí)間: 2025-3-23 02:24
Immune Response: Glioma-Associated Immunosuppressioned T-cell function coupled with increased circulating immunosuppressive regulatory T cells and myeloid-derived suppressor cells. The relationships between these various immunosuppressive cell populations, their impact on T cells, and their implications for immunotherapies are reviewed in this chapter.作者: finale 時(shí)間: 2025-3-23 07:31 作者: 格子架 時(shí)間: 2025-3-23 10:50
https://doi.org/10.1007/978-3-7091-1431-5Brain; Glioblastoma; Glioma; Tumor; Tumor Angiogenesis; Tumorigenesis作者: 移動(dòng) 時(shí)間: 2025-3-23 14:21
978-3-7091-4841-9Springer-Verlag Wien 2014作者: indigenous 時(shí)間: 2025-3-23 20:13
Cancer Stem Cells and Glioblastoma to achieve “cure” and was based on the idea that the vast majority of cells have tumorigenic potential. One reason for the lack of clinical advances is the lack of understanding of the GBM biology in general and the cellular origin of this disease in particular. The cancer stem cell hypothesis post作者: FRAUD 時(shí)間: 2025-3-23 23:09 作者: RAGE 時(shí)間: 2025-3-24 04:01 作者: 節(jié)約 時(shí)間: 2025-3-24 06:34 作者: 使迷惑 時(shí)間: 2025-3-24 12:34
Para- and Autocrine Mediators in the Glioma Microenvironmentprogression. Growth factor receptors on glioma cells are partly overexpressed or constitutively activated through mutations, and therefore appear prominent targets for anti-glioma therapies. Several cytokines are heavily produced by glioma cells and exhibit not only immune-modulatory functions, but 作者: 承認(rèn) 時(shí)間: 2025-3-24 14:54 作者: oxidant 時(shí)間: 2025-3-24 22:04
Microglia in Gliomas: Friend or Foe?ir phenotype, and contribution to glioma pathology. Recent attempts to determine a profile of cytokine/chemokine production and gene expression profiling in CD11b. cells isolated from patients or rodent gliomas revealed their similarity to alternatively activated, the M2-type macrophages observed in作者: 規(guī)范要多 時(shí)間: 2025-3-25 02:50 作者: Axillary 時(shí)間: 2025-3-25 06:13 作者: 媒介 時(shí)間: 2025-3-25 09:09 作者: projectile 時(shí)間: 2025-3-25 13:55 作者: gnarled 時(shí)間: 2025-3-25 19:33
https://doi.org/10.1007/978-3-8350-9274-7 to achieve “cure” and was based on the idea that the vast majority of cells have tumorigenic potential. One reason for the lack of clinical advances is the lack of understanding of the GBM biology in general and the cellular origin of this disease in particular. The cancer stem cell hypothesis post作者: fibroblast 時(shí)間: 2025-3-25 20:03 作者: Genistein 時(shí)間: 2025-3-26 00:57
Horizontale Transportlogistik-Kooperationenes involved in gliomagenesis and glioma stem cell maintenance. Signaling pathway analysis has resulted in novel GBM subclassifications that could integrate with conventional histopathological features providing information regarding the molecular mechanism of pathogenicity. The identification of abe作者: 記成螞蟻 時(shí)間: 2025-3-26 06:55
Feuerfeste Werkstoffe in der Gasturbineget. Malignant gliomas are common primary tumors of the central nervous system, characterized by aggressive cell proliferation, diffuse infiltration, and resistance to cell death. New therapies against this devastating and invariably fatal disease are needed. This chapter aims at summarizing the rec作者: 勛章 時(shí)間: 2025-3-26 10:29
Hormesis: What it is and Why it Matters,progression. Growth factor receptors on glioma cells are partly overexpressed or constitutively activated through mutations, and therefore appear prominent targets for anti-glioma therapies. Several cytokines are heavily produced by glioma cells and exhibit not only immune-modulatory functions, but 作者: penance 時(shí)間: 2025-3-26 15:43
https://doi.org/10.1007/978-3-662-12026-2nd ECM proteins playing important roles. In this review we will highlight molecular pathways that link cerebral blood vessels and GBM cells during tumor growth, progression, and invasion. We will also discuss mechanisms underlying GBM-induced angiogenesis, with a particular focus placed on roles for作者: Bereavement 時(shí)間: 2025-3-26 17:58 作者: vasospasm 時(shí)間: 2025-3-26 23:47
Breast Susceptibility to Carcinogenesiscan vary largely in their composition. This mutual glioma–host–ECM interaction, which also involves the microvasculature of the brain, contributes to the devastating nature of glioma tumors, because it enables the malignant cells to pave their way into the parenchyma. The complex nature of normal as作者: GLIB 時(shí)間: 2025-3-27 02:42
Prostate Cancer, Androgens, and Estrogenss depend on the cellular membrane plasticity expressed by biophysical forces of interaction. In parallel to the properties of normal astrocytes, a growing astrocytoma develops new malignant behavior and interactions with parenchyma that differ from those of normal astrocytes. In this chapter, we ana作者: 小說 時(shí)間: 2025-3-27 07:07
Cristina Magi-Galluzzi,Angelo M. De Marzoitate tumor neovascularization. The role of proteases in glioma progression is therefore multifaceted and complex. Glioma-associated proteases represent attractive therapeutic targets and several approaches were proposed including the inhibition of the extracellular proteases involved in glioma inva作者: 疲憊的老馬 時(shí)間: 2025-3-27 11:55 作者: Negligible 時(shí)間: 2025-3-27 17:15
ermore depicts experimental models for Glioma research and future therapeutic concepts. The book is composed and written for Scientists and Medical Doctors in Oncology, Neurosciences and Molecular Biology.??978-3-7091-4841-9978-3-7091-1431-5作者: 翻布尋找 時(shí)間: 2025-3-27 20:42
https://doi.org/10.1007/978-3-8350-9274-7ending malignancy. . (GBM, WHO grade IV) is among the most lethal of human cancers with conventional therapy offering only palliation. GBM accounts for the most frequent type of primary brain tumors in Europe and the USA, comprising more than a half of all gliomas, with a 5-year survival of patients作者: galley 時(shí)間: 2025-3-27 23:37 作者: parasite 時(shí)間: 2025-3-28 04:30
Horizontale Transportlogistik-Kooperationenrieties of common genetic lesions in genes encoding signaling proteins. These DNA damages lead to either activating mutations (Ras, PI3K, and Akt) or loss of function of tumor suppressor proteins (TP53, Rb, and PTEN). The signaling pathways induced by the altered signaling proteins play a role in th作者: anarchist 時(shí)間: 2025-3-28 08:19 作者: delta-waves 時(shí)間: 2025-3-28 11:16 作者: 性別 時(shí)間: 2025-3-28 16:27
Hormesis: What it is and Why it Matters,tumor-promoting processes are several auto- and paracrine factors, mostly bioactive peptides. Among them, distinct neuropeptides, chemokines, growth factors, and cytokines play a prominent role. Since receptors for neuropeptides are often overexpressed on glioma cells, derivatives are increasingly u作者: 引起 時(shí)間: 2025-3-28 21:10
https://doi.org/10.1007/978-3-662-12026-2ctors. For example, GBM stem cells (GSCs) home to perivascular niches and invasive tumor cells commonly disperse through the brain microenvironment via extracellular matrix (ECM)-rich vascular basement membranes. Anti-vascular agents that target angiogenesis, and particularly those involving vascula作者: gonioscopy 時(shí)間: 2025-3-28 23:37
Analgesic Activity of Endorphins,n large part to the expression of multiple factors by tumor cells that inhibit T-cell responses. In addition, glioblastomas are heavily infiltrated with monocytic cells. These cells appear to have become immunosuppressive under the influence of the tumor and share characteristics with myeloid-derive作者: 發(fā)怨言 時(shí)間: 2025-3-29 03:22
https://doi.org/10.1007/978-1-4613-9208-8neuropathological disorders. Clinical and experimental data show that microglia constitute the dominant immune infiltrate in malignant gliomas. The clinical significance of the mononuclear infiltrate in gliomas remains the subject of controversy. Despite accumulation of these immune cells in both lo作者: macular-edema 時(shí)間: 2025-3-29 10:34
Breast Susceptibility to Carcinogenesisxtracellular matrix (ECM). The brain ECM is a complex structure composed of proteoglycans and glycoproteins of glial and neuronal origin, which is largely based on hyaluronic acid (HA) as central organizing glycosaminoglycan. It is particularly rich in different carbohydrate epitopes and undergoes a作者: Ledger 時(shí)間: 2025-3-29 14:29
Prostate Cancer, Androgens, and Estrogenstube, differently from other glial cells of the astrocyte-like, enteric glia, which originate from the neural crest. Cerebral astrocytes interact with other brain cells such as neurons, mediated by cellular contact involving extracellular matrix (ECM) elements and the integrin of astrocytes. Interac作者: enchant 時(shí)間: 2025-3-29 16:45
Cristina Magi-Galluzzi,Angelo M. De Marzo During gliomagenesis, the complex regulation of proteases in transformed and stromal cells is impaired as a result of several factors, and proteases critically contribute to the hallmarks of gliomas. Proteins regulated by proteases include components of the extracellular matrix, local mediators, ce作者: 向宇宙 時(shí)間: 2025-3-29 22:32
