標(biāo)題: Titlebook: Genotoxicity and DNA Repair; A Practical Approach L. María Sierra,Isabel Gaiv?o Book 2014 Springer Science+Business Media New York 2014 DNA [打印本頁(yè)] 作者: 皺紋 時(shí)間: 2025-3-21 20:00
書目名稱Genotoxicity and DNA Repair影響因子(影響力)
書目名稱Genotoxicity and DNA Repair影響因子(影響力)學(xué)科排名
書目名稱Genotoxicity and DNA Repair網(wǎng)絡(luò)公開度
書目名稱Genotoxicity and DNA Repair網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Genotoxicity and DNA Repair被引頻次
書目名稱Genotoxicity and DNA Repair被引頻次學(xué)科排名
書目名稱Genotoxicity and DNA Repair年度引用
書目名稱Genotoxicity and DNA Repair年度引用學(xué)科排名
書目名稱Genotoxicity and DNA Repair讀者反饋
書目名稱Genotoxicity and DNA Repair讀者反饋學(xué)科排名
作者: 哄騙 時(shí)間: 2025-3-21 21:54 作者: pulmonary-edema 時(shí)間: 2025-3-22 01:00
Das Beispiel ?Bürgergutachten Merler Keil“ative results, whereas the other in vitro genotoxicity assays were usually positive. Accordingly, the efficiency of the test for NP evaluation was questioned, as was the NP entrance in bacterial cells. Indeed, prokaryotes are unable to perform endocytosis and NPs are too large to be transported thro作者: 表否定 時(shí)間: 2025-3-22 04:33
https://doi.org/10.1007/978-3-662-29095-8media, or metabolic activation. These result in volatile, sorptive, and biotransformation losses of the test compound, and thus to poorly defined exposure. This has implications for the apparent sensitivity of the assay as well as for establishing a reliable relationship between concentration and re作者: CLAN 時(shí)間: 2025-3-22 10:45 作者: STENT 時(shí)間: 2025-3-22 16:04
Die Begriffsform im Mythischen Denken,purpose of the assay is to identify substances that cause clastogenicity (chromosome breakage) and aneugenicity (chromosome lagging due to spindle dysfunction), and bone marrow toxicity by estimating the ratio of polychromatic erythrocytes to normochromatic erythrocytes. This chapter describes the m作者: STENT 時(shí)間: 2025-3-22 19:51 作者: 吸引人的花招 時(shí)間: 2025-3-22 22:14 作者: 音的強(qiáng)弱 時(shí)間: 2025-3-23 04:24
Geschichte der Sauerstofftherapie,try using anti-CD3 and anti-CD4 monoclonal antibodies labeled with different fluorescent dyes. This is because incomplete TCR αβ/CD3 complexes are not transported to the surface membrane. TCR mutations are spontaneously generated at a frequency of about 2 × 10. in peripheral CD4. T-cells, and the mu作者: Sedative 時(shí)間: 2025-3-23 08:44
https://doi.org/10.1007/978-3-662-26343-3in key endogenous tumor suppressor genes and the genes for cell-cycle regulators drives the carcinogenesis process. Safety assessments, though, typically measure mutations in reporter genes that have easily identifiable phenotypes. Mutation in genes that contribute to the biosynthesis of the anchor 作者: 龍蝦 時(shí)間: 2025-3-23 10:02 作者: 凝視 時(shí)間: 2025-3-23 15:58 作者: Indigence 時(shí)間: 2025-3-23 19:53 作者: GULF 時(shí)間: 2025-3-24 00:58 作者: Myocyte 時(shí)間: 2025-3-24 05:54 作者: Innovative 時(shí)間: 2025-3-24 08:00
https://doi.org/10.1007/978-3-642-91799-8phila are in vivo short-term assays that assess genetic damage induction in somatic cells of adult flies after larval exposure. They are less onerous than other Drosophila tests (the germinal ones) and are very sensitive, specific, and accurate. All of them are based in obtaining heterozygous offspr作者: investigate 時(shí)間: 2025-3-24 12:35
https://doi.org/10.1007/978-3-662-29093-4in vitro approaches, neglecting the repair and metabolic properties of the whole organism, some doubts about the accuracy of the obtained results exist. To overcome this gap more in vivo approaches testing the potential genotoxic risk of nanomaterials are required. In this context we propose to use 作者: 痛苦一生 時(shí)間: 2025-3-24 15:52
https://doi.org/10.1007/978-3-662-29092-7cer. It is important to have methods available to test chemicals to which humans may be exposed for their mutagenic potential. In 2011 the Organization for Economic Cooperation and Development adopted a test guideline on the use of transgenic rodent (TGR) assays for investigating the mutagenic poten作者: PIZZA 時(shí)間: 2025-3-24 19:47 作者: 洞穴 時(shí)間: 2025-3-24 23:31
978-1-4939-4829-1Springer Science+Business Media New York 2014作者: lacrimal-gland 時(shí)間: 2025-3-25 05:37
Genotoxicity and DNA Repair978-1-4939-1068-7Series ISSN 1557-2153 Series E-ISSN 1940-6053 作者: Needlework 時(shí)間: 2025-3-25 08:47 作者: 甜瓜 時(shí)間: 2025-3-25 12:34 作者: 從容 時(shí)間: 2025-3-25 18:05 作者: 友好關(guān)系 時(shí)間: 2025-3-25 20:33
https://doi.org/10.1007/978-3-663-04272-3put as compared to the standard format. The liquid system allows for processing several replicates at once with the possibility of using pipetting robots and has an easy colorimetric readout. The Ames II/Ames MPF also uses less S9 and produces less hazardous waste due to the low-volume multiwell format.作者: Germinate 時(shí)間: 2025-3-26 03:54
Die Begriffsform im Mythischen Denken,echanism of micronucleus formation, presents practical guidelines for designing studies, and gives the step-by-step protocols of the in vivo micronucleus test in bone marrow and peripheral blood cells of rodents.作者: expansive 時(shí)間: 2025-3-26 08:06
https://doi.org/10.1007/978-3-642-92571-9terial. Here, we describe the standard alkaline version of the comet assay, both in vitro and in vivo, as well as the lesion-specific enzyme-modified comet assay (for detection of oxidized DNA lesions) to test nanoparticles. We also highlight critical points that need to be taken into consideration when assessing nanomaterial genotoxicity.作者: seduce 時(shí)間: 2025-3-26 09:43
https://doi.org/10.1007/978-3-662-42980-8ntal contaminants, and metals. The obtained results clearly confirm the usefulness of this combination (. and comet assay), and open its possibilities for a more widely use, selecting new cell targets and exposure scenarios..In this context, we present here detailed protocols to perform this assay using neuroblast and hemocyte cells.作者: CLAIM 時(shí)間: 2025-3-26 14:13 作者: 我要威脅 時(shí)間: 2025-3-26 20:19 作者: Affectation 時(shí)間: 2025-3-26 22:10 作者: 兵團(tuán) 時(shí)間: 2025-3-27 04:38 作者: Pedagogy 時(shí)間: 2025-3-27 08:36
https://doi.org/10.1007/978-3-642-91523-9preparation of mouse metaphase cells for whole chromosome FISH analysis. Also presented are basic recommendations on how to visualize the slides and how to organize the data for analysis and interpretation.作者: 只有 時(shí)間: 2025-3-27 12:54
https://doi.org/10.1007/978-3-662-39472-4 action (MOA) of the test substance. This chapter provides up-to-date methodology for carrying out the assay in different cell lines in the presence and absence of metabolism with relevant technical information and emerging advances in statistical analysis of data generated from the HPRT gene mutation assay.作者: 外來(lái) 時(shí)間: 2025-3-27 15:18
https://doi.org/10.1007/978-3-662-05530-4limitations, both experimental and biological, is essential to improve both data quality and data relevance obtained and to guarantee that comet assay continues to provide enhanced reliability as a biomarker in human biomonitoring studies.作者: 偶像 時(shí)間: 2025-3-27 21:34
Chromosomal Aberration Test Utilities In Vitro and In Vivoons that can exercise their mutagenic potential, and their action mechanism. This chapter discusses the history of CA formation and some cytogenetic protocols that may be used to perform the chromosomal aberration test in in vivo and in vitro studies.作者: Intercept 時(shí)間: 2025-3-28 00:58 作者: 可憎 時(shí)間: 2025-3-28 03:08
The Applicable Use of the HPRT Gene Mutation Assay as a Practical Tool in Mutagenesis and DNA Repair action (MOA) of the test substance. This chapter provides up-to-date methodology for carrying out the assay in different cell lines in the presence and absence of metabolism with relevant technical information and emerging advances in statistical analysis of data generated from the HPRT gene mutation assay.作者: 允許 時(shí)間: 2025-3-28 07:07
The Comet Assay In Vivo in Humanslimitations, both experimental and biological, is essential to improve both data quality and data relevance obtained and to guarantee that comet assay continues to provide enhanced reliability as a biomarker in human biomonitoring studies.作者: aggressor 時(shí)間: 2025-3-28 12:07 作者: KEGEL 時(shí)間: 2025-3-28 18:21 作者: oxidant 時(shí)間: 2025-3-28 19:29 作者: acheon 時(shí)間: 2025-3-29 01:05
https://doi.org/10.1007/978-3-642-91799-8e will discuss the wing-spot assay (..) and the eye-spot .. (..) assay, provide a comprehensive overview, introduce the principles of the assays, and provide the details to properly conduct both of them.作者: MUMP 時(shí)間: 2025-3-29 05:42 作者: 松果 時(shí)間: 2025-3-29 09:53 作者: vitreous-humor 時(shí)間: 2025-3-29 14:20
T-Cell Receptor Mutation Assay for Monitoring Human Genotoxic Exposuren detection of chronic exposure in large-scale studies. Here, I will briefly review past studies reporting the applications, and describe methods for both preparation of the target cells and detection of the mutant cells.作者: 羅盤 時(shí)間: 2025-3-29 15:57 作者: 反感 時(shí)間: 2025-3-29 22:31 作者: Lipoma 時(shí)間: 2025-3-30 01:06
Ames Test (Bacterial Reverse Mutation Test): Why, When, and How to Useenic potential of compounds and mixtures. This assay uses histidine-dependent strains to detect mutations, e.g., substitutions, additions, or deletions of one or several DNA nucleotides reverting originally changed gene sequence of the tester strains. The addition of a mutagenic chemical agent to a 作者: 透明 時(shí)間: 2025-3-30 04:39 作者: 戰(zhàn)役 時(shí)間: 2025-3-30 11:13
Revised Procedure of the Bacterial Reverse Mutation Test for Genotoxic Evaluation of Nanoparticlesative results, whereas the other in vitro genotoxicity assays were usually positive. Accordingly, the efficiency of the test for NP evaluation was questioned, as was the NP entrance in bacterial cells. Indeed, prokaryotes are unable to perform endocytosis and NPs are too large to be transported thro作者: 立即 時(shí)間: 2025-3-30 16:11 作者: DUCE 時(shí)間: 2025-3-30 18:23 作者: aesthetic 時(shí)間: 2025-3-31 00:45
The In Vivo Rodent Micronucleus Testpurpose of the assay is to identify substances that cause clastogenicity (chromosome breakage) and aneugenicity (chromosome lagging due to spindle dysfunction), and bone marrow toxicity by estimating the ratio of polychromatic erythrocytes to normochromatic erythrocytes. This chapter describes the m作者: handle 時(shí)間: 2025-3-31 04:49
Chromosomal Aberration Test Utilities In Vitro and In Vivo the formation of chromosomal aberrations (CAs). CAs are recognized as an important biomarker of human exposure, being a very important tool for environmental biomonitoring. Although there are several types, little is known about the mechanisms involved in the processing of induced lesions in DNA an作者: nocturnal 時(shí)間: 2025-3-31 08:14 作者: Directed 時(shí)間: 2025-3-31 11:06 作者: 輕信 時(shí)間: 2025-3-31 15:46
The Human RBC , Gene Mutation Assayin key endogenous tumor suppressor genes and the genes for cell-cycle regulators drives the carcinogenesis process. Safety assessments, though, typically measure mutations in reporter genes that have easily identifiable phenotypes. Mutation in genes that contribute to the biosynthesis of the anchor 作者: Heresy 時(shí)間: 2025-3-31 19:57
The Applicable Use of the HPRT Gene Mutation Assay as a Practical Tool in Mutagenesis and DNA Repair types. As with the thymidine kinase (TK) mouse lymphoma assay (MLA), the HPRT gene mutation assay is considered a significant tool as set out in the guidelines for mammalian gene mutation tests [OECD Guideline for the Testing of Chemicals. . Mammalian Cell Gene Mutation Test: 476]. Since its refine作者: Living-Will 時(shí)間: 2025-3-31 22:51 作者: Flustered 時(shí)間: 2025-4-1 05:22 作者: 名次后綴 時(shí)間: 2025-4-1 07:12
Analysis of Nanoparticle-Induced DNA Damage by the Comet Assayh and the environment. In this context, it is essential to assess the ability of nanoparticles to cause DNA damage. Single cell gel electrophoresis assay (comet assay) is widely used for evaluating nanoparticle-induced DNA damage in cells and is the most used assay for genotoxicity testing of nanoma作者: 顯而易見 時(shí)間: 2025-4-1 12:39 作者: 公豬 時(shí)間: 2025-4-1 17:59 作者: Liberate 時(shí)間: 2025-4-1 20:23
Testing the Genotoxic Potential of Nanomaterials Using Drosophilain vitro approaches, neglecting the repair and metabolic properties of the whole organism, some doubts about the accuracy of the obtained results exist. To overcome this gap more in vivo approaches testing the potential genotoxic risk of nanomaterials are required. In this context we propose to use
