標(biāo)題: Titlebook: Genomic Instability and Immortality in Cancer; Enrico Mihich,Leland Hartwell Book 1997 Springer Science+Business Media New York 1997 DNA.M [打印本頁(yè)] 作者: 不友善 時(shí)間: 2025-3-21 17:17
書目名稱Genomic Instability and Immortality in Cancer影響因子(影響力)
書目名稱Genomic Instability and Immortality in Cancer影響因子(影響力)學(xué)科排名
書目名稱Genomic Instability and Immortality in Cancer網(wǎng)絡(luò)公開(kāi)度
書目名稱Genomic Instability and Immortality in Cancer網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書目名稱Genomic Instability and Immortality in Cancer被引頻次
書目名稱Genomic Instability and Immortality in Cancer被引頻次學(xué)科排名
書目名稱Genomic Instability and Immortality in Cancer年度引用
書目名稱Genomic Instability and Immortality in Cancer年度引用學(xué)科排名
書目名稱Genomic Instability and Immortality in Cancer讀者反饋
書目名稱Genomic Instability and Immortality in Cancer讀者反饋學(xué)科排名
作者: STALE 時(shí)間: 2025-3-21 21:43 作者: sleep-spindles 時(shí)間: 2025-3-22 02:43
Aneuploidy and Heterogeneity Mechanisms in Human Colorectal Tumor Progression,ics and, more recently, by chromosome painting and interphase cytogenetics using fluorescence in situ hybridization (12,13), appears simply too difficult to be set in a cause-effect relationship. An initial preneoplastic genetic event predisposing to more generalized disruption of the genome has bee作者: CLEAR 時(shí)間: 2025-3-22 06:18
p53-Dependent Signaling in Response to DNA Damage or Arrest of DNA Synthesis and its Role in Cell Cls arrest late in G1 when p53 is active. In addition to G1 arrest, regulation by p53 of the other major cell cycle checkpoint, G2/M, has recently been reported in two different systems (Stewart ., 1995; Agarwal .., 1995).作者: NIL 時(shí)間: 2025-3-22 10:19 作者: Cardioplegia 時(shí)間: 2025-3-22 16:05 作者: Cardioplegia 時(shí)間: 2025-3-22 20:35
Regulation of Telomere Length in Mammalian Cells,ons would lead to a progressive loss of DNA. Mammalian telomerase activity was first identified in HeLa cell extracts which can add over sixty T.AG. repeats onto a T.AG. oligonucleotide . [5]. Mouse cell extracts were shown to add at most one or two T.AG. repeats onto a T.AG. oligonucleotide . sugge作者: TERRA 時(shí)間: 2025-3-22 22:23 作者: 名義上 時(shí)間: 2025-3-23 03:30
,Neoplastic Progression in Barrett’s Esophagus,d carcinomas in surgical specimens. Although the study of advanced cancers is useful for identifying genetic abnormalities that have accumulated in the cancer, the ability of this approach to determine the order in which genetic and other abnormalities develop during earlier stages of neoplastic pro作者: 偏狂癥 時(shí)間: 2025-3-23 07:33 作者: 不安 時(shí)間: 2025-3-23 11:02 作者: Obliterate 時(shí)間: 2025-3-23 14:34
Praktische Hilfen zur Lebensgestaltung,ticipated both the importance of genetic instability in the initiation and progression of cancer and the existence of negative regulators of cell growth, whose loss would result from inappropriate chromosome segregation.作者: STYX 時(shí)間: 2025-3-23 18:06 作者: induct 時(shí)間: 2025-3-24 00:26
Zusammenfassung, Diskussion und Ausblick,ls arrest late in G1 when p53 is active. In addition to G1 arrest, regulation by p53 of the other major cell cycle checkpoint, G2/M, has recently been reported in two different systems (Stewart ., 1995; Agarwal .., 1995).作者: Frequency 時(shí)間: 2025-3-24 04:20 作者: aplomb 時(shí)間: 2025-3-24 06:42
Hinweise zum Gebrauch des Glossars, 8–12 bases of unreplicated DNA at the terminus. Cells avoid this loss by utilizing a specialized telomeric DNA replication enzyme called telomerase that specifically recognizes telomeric DNA as a substrate. Telomerase is a unique reverse transcriptase that utilizes an RNA template to create a singl作者: excrete 時(shí)間: 2025-3-24 11:45 作者: 高度 時(shí)間: 2025-3-24 15:02 作者: Hemodialysis 時(shí)間: 2025-3-24 21:43
https://doi.org/10.1057/978-1-137-57889-1d carcinomas in surgical specimens. Although the study of advanced cancers is useful for identifying genetic abnormalities that have accumulated in the cancer, the ability of this approach to determine the order in which genetic and other abnormalities develop during earlier stages of neoplastic pro作者: occult 時(shí)間: 2025-3-25 00:26 作者: overrule 時(shí)間: 2025-3-25 04:59
https://doi.org/10.1007/978-1-4939-1607-8a tumor suppressor gene,. pRb, binds to some members of the E2F family, including E2F-1, and transforms them into transcriptional repressors.. In this manner, pRb performs at least part its growth suppressive function.作者: Fantasy 時(shí)間: 2025-3-25 10:00 作者: Embolic-Stroke 時(shí)間: 2025-3-25 15:15 作者: Kindle 時(shí)間: 2025-3-25 16:49
https://doi.org/10.1007/978-3-662-62692-4, evolutionary conserved proteins (Biessman and Mason, 1992). For example, both . and yeast telomeres have heterochromatic properties and share the ability of modulating the expression of adjacent genes, a phenomenon called telomere position effect (Levis et al., 1985; Shore, 1995).作者: DOTE 時(shí)間: 2025-3-25 22:59
https://doi.org/10.1007/978-3-642-96136-6o maintain genomic integrity. By studying how the yeast cell controls the fidelity of the genome we hope to further our understanding of those cellular functions that work coordinately to ensure genomic integrity.作者: laparoscopy 時(shí)間: 2025-3-26 01:11
Telomeres and Cell Division in ,,, evolutionary conserved proteins (Biessman and Mason, 1992). For example, both . and yeast telomeres have heterochromatic properties and share the ability of modulating the expression of adjacent genes, a phenomenon called telomere position effect (Levis et al., 1985; Shore, 1995).作者: CREST 時(shí)間: 2025-3-26 08:16 作者: superfluous 時(shí)間: 2025-3-26 09:25 作者: happiness 時(shí)間: 2025-3-26 14:42
W. Mombour,G. Kockott,R. Degkwitz In a variety of organisms, these telomeric repeat arrays are known to be maintained by telomerase, a ribonucleoprotein reverse transcriptase that synthesizes single strand copies of the unit telomeric repeat onto the 3’ end of the chromosomal terminus by using part of its RNA subunit as a template (Blackburn, 1994; Zakian, 1995).作者: Mere僅僅 時(shí)間: 2025-3-26 19:42 作者: Repetitions 時(shí)間: 2025-3-27 01:02
Documentation: What You Say Mattersin D1 is different from that (Ser/Thr-Pro-X-Arg/Lys) for phosphorylation by Cdk2-cyclin E/A, and that at least one site among 13–14 potential phosphorylation sites of pRB is specifically phosphorylated by Cdk4-cyclin D1 during the cell cycle..作者: Minuet 時(shí)間: 2025-3-27 01:41
Consequences of Mutations that Alter Telomeres in the Yeast ,, In a variety of organisms, these telomeric repeat arrays are known to be maintained by telomerase, a ribonucleoprotein reverse transcriptase that synthesizes single strand copies of the unit telomeric repeat onto the 3’ end of the chromosomal terminus by using part of its RNA subunit as a template (Blackburn, 1994; Zakian, 1995).作者: Ascendancy 時(shí)間: 2025-3-27 09:18
Antitumor Drugs and Yeast Cell Cycle Checkpoints,correspond to inhibitory effects on two fundamentally different processes involved in DNA replication-initiation of DNA replication at origins of replication, and subsequent elongation of nascent chains at replication forks.作者: 地殼 時(shí)間: 2025-3-27 10:08 作者: LINES 時(shí)間: 2025-3-27 16:31 作者: Salivary-Gland 時(shí)間: 2025-3-27 18:52 作者: 有害 時(shí)間: 2025-3-28 00:29
Praktische Hilfen zur Lebensgestaltung,, T., 1914). It is remarkable that it came as an extrapolation of his observations on the developmental consequences of multipolar mitoses created by polyspermic fertilization. He noted that the resulting blastomeres exhibited the atypical growth and morphologic features that he had observed in tumo作者: aesthetic 時(shí)間: 2025-3-28 02:34 作者: NAG 時(shí)間: 2025-3-28 09:18
Zusammenfassung, Diskussion und Ausblick,. p53 function is lost during the evolution of a diverse group of human malignancies (Hollstein .., 1991; Greenblatt .., 1994). Homozygous inactivation of p53 predisposes mice to neoplasia and hemizygous inactivation of p53 in humans is the basis of the hereditary cancer syndrome first described by 作者: 諄諄教誨 時(shí)間: 2025-3-28 12:48 作者: 怪物 時(shí)間: 2025-3-28 16:04 作者: gout109 時(shí)間: 2025-3-28 19:42 作者: inflame 時(shí)間: 2025-3-28 23:13
https://doi.org/10.1007/978-3-642-67529-4ntion of end to end fusion and prot7ection from exonucleolytic degradation [3]. A ribonucleoprotein complex called telomerase, which was first isolated in . and shown to be a specialised reverse transcriptase, facilitates . synthesis of terminal repeats to compensate for sequence loss caused by inco作者: installment 時(shí)間: 2025-3-29 06:38 作者: Cabg318 時(shí)間: 2025-3-29 09:30 作者: 淡紫色花 時(shí)間: 2025-3-29 14:01
The FDA and the Drug Development Processant mixture of surgery and radio- and chemo-therapy, all of which can carry severe side effects and are of limited efficacy. Cancer is therefore both a very common disease and a frequent cause of death. Tumours are, however, clonal in origin: they arise from single mutant cells that progressively ev作者: 投票 時(shí)間: 2025-3-29 15:41 作者: 純樸 時(shí)間: 2025-3-29 19:57
https://doi.org/10.1057/978-1-137-57889-1clones of cells with accumulated genetic errors (Nowell, 1976). Some clones gain selective proliferative advantages, and eventually a subclone evolves that has acquired the capacity for invasion, becoming an early carcinoma. There is now substantial evidence that human cancers develop in association作者: BRAVE 時(shí)間: 2025-3-30 03:33
https://doi.org/10.1007/978-1-4939-1607-8s form heterodimers and transactivate genes, some of which are required for cell cycle progression or DNA synthesis.. The product of the retinoblastoma tumor suppressor gene,. pRb, binds to some members of the E2F family, including E2F-1, and transforms them into transcriptional repressors.. In this作者: explicit 時(shí)間: 2025-3-30 06:50 作者: 混沌 時(shí)間: 2025-3-30 11:40 作者: Lime石灰 時(shí)間: 2025-3-30 13:37 作者: pacific 時(shí)間: 2025-3-30 20:25
Overview: 978-1-4613-7448-0978-1-4615-5365-6作者: 火海 時(shí)間: 2025-3-30 21:35 作者: 甜瓜 時(shí)間: 2025-3-31 04:45
Telomeres and Cell Division in ,,. In most organisms telomeres contain arrays of tandem G-rich repeats that are added to the chromosomal termini by a specialized polymerase, called telomerase, which contains an integral RNA template (reviewed by Zakian, 1989). In . telomeric DNA is comprised of two LINE-like retrotransposable eleme作者: GROG 時(shí)間: 2025-3-31 06:56 作者: NEEDY 時(shí)間: 2025-3-31 12:25
Cell Cycle Control of Genetic Stability,, T., 1914). It is remarkable that it came as an extrapolation of his observations on the developmental consequences of multipolar mitoses created by polyspermic fertilization. He noted that the resulting blastomeres exhibited the atypical growth and morphologic features that he had observed in tumo
