標(biāo)題: Titlebook: Genome Editing in Neurosciences; Rudolf Jaenisch,Feng Zhang,Fred Gage Book‘‘‘‘‘‘‘‘ 2017 The Editor(s) (if applicable) and The Author(s) 20 [打印本頁] 作者: HAND 時(shí)間: 2025-3-21 16:05
書目名稱Genome Editing in Neurosciences影響因子(影響力)
書目名稱Genome Editing in Neurosciences影響因子(影響力)學(xué)科排名
書目名稱Genome Editing in Neurosciences網(wǎng)絡(luò)公開度
書目名稱Genome Editing in Neurosciences網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Genome Editing in Neurosciences被引頻次
書目名稱Genome Editing in Neurosciences被引頻次學(xué)科排名
書目名稱Genome Editing in Neurosciences年度引用
書目名稱Genome Editing in Neurosciences年度引用學(xué)科排名
書目名稱Genome Editing in Neurosciences讀者反饋
書目名稱Genome Editing in Neurosciences讀者反饋學(xué)科排名
作者: aristocracy 時(shí)間: 2025-3-21 22:57
Aquatic Model Organisms in Neurosciences: The Genome-Editing Revolution,Cas9 in laboratories. Because of the simplicity and broad applicability of this later system, knock-out is now efficiently performed at medium scale. Forward genetics in zebrafish can now be performed by CRISPR-based F0 screening using high speed and high content phenotyping for example by confocal 作者: 關(guān)心 時(shí)間: 2025-3-22 00:41
Genome-Wide Genetic Screening in the Mammalian CNS,go, but neither a full molecular explanation for the cell loss seen in human patients nor a curative therapy has yet been achieved for any of these diseases. In most model organisms, when new hypotheses are needed to explain a cellular process, genetic screens are the tool of choice. For example, ‘s作者: 聰明 時(shí)間: 2025-3-22 05:41
CRISPR/Cas9-Mediated Knockin and Knockout in Zebrafish,ely small size, rapid external development and translucency. These features allow the easy application of in vivo microscopy analysis and optical perturbation of neuronal function. So far, genetic manipulation in zebrafish has been limited to the generation of constitutive loss-of-function alleles a作者: 陳舊 時(shí)間: 2025-3-22 11:09
Dissecting the Role of Synaptic Proteins with CRISPR,ion of the role of single proteins or, more significantly, their subunits and sub-domains has increased enormously the basic knowledge of synaptic function. CRISPR/Cas9 is a recently developed genome-editing tool that can be used to inactivate or modify genes of interest. Its ease of implementation 作者: 舊式步槍 時(shí)間: 2025-3-22 14:13
Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Functio is required for development of the immune and nervous system. We hypothesize that proper repair of neural DSBs via C-NHEJ or other end-joining pathways is critical for neural functionality and homeostasis over time and that improper DSB repair could contribute to complex psychiatric and neurodegene作者: 舊式步槍 時(shí)間: 2025-3-22 19:45
Neuroscience Research Using Non-human Primate Models and Genome Editing,omedical researchers and neuroscientists for its ease of handling and colony maintenance, unique behavioral characteristics, and several human-like traits, such as enriched social vocal communication and strong relationships between parents and offspring. Its high reproductive efficiency makes it pa作者: 多嘴多舌 時(shí)間: 2025-3-22 23:34 作者: Goblet-Cells 時(shí)間: 2025-3-23 04:56
,Using Genome Engineering to Understand Huntington’s Disease,o an expanded polyglutamine (polyQ) region in the encoded protein HTT. We have used homologous recombination (HR) to genetically correct HD patient-derived induced pluripotent stem cells (iPSCs) and found that this reversed HD disease phenotypes. We have utilized exploited genome editing tools inclu作者: 認(rèn)識(shí) 時(shí)間: 2025-3-23 06:12
Therapeutic Gene Editing in Muscles and Muscle Stem Cells,n the . gene that prevent expression of its encoded protein, Dystrophin (Burghes et al. Nature 328:434–437, 1987). Interestingly, patients with . mutations that delete certain segments of the Dystrophin coding region, but maintain protein reading frame, have a much milder form of the disease, known 作者: 過剩 時(shí)間: 2025-3-23 11:32 作者: RECUR 時(shí)間: 2025-3-23 15:09
Calculus for Cramér-Hida ProcessesCas9 in laboratories. Because of the simplicity and broad applicability of this later system, knock-out is now efficiently performed at medium scale. Forward genetics in zebrafish can now be performed by CRISPR-based F0 screening using high speed and high content phenotyping for example by confocal 作者: invade 時(shí)間: 2025-3-23 21:38 作者: 恫嚇 時(shí)間: 2025-3-24 01:21 作者: BANAL 時(shí)間: 2025-3-24 04:27
https://doi.org/10.1007/978-3-031-55284-7ion of the role of single proteins or, more significantly, their subunits and sub-domains has increased enormously the basic knowledge of synaptic function. CRISPR/Cas9 is a recently developed genome-editing tool that can be used to inactivate or modify genes of interest. Its ease of implementation 作者: 替代品 時(shí)間: 2025-3-24 09:23 作者: 驚呼 時(shí)間: 2025-3-24 10:50 作者: 發(fā)芽 時(shí)間: 2025-3-24 17:17 作者: 水汽 時(shí)間: 2025-3-24 21:53
https://doi.org/10.1007/978-3-8349-6807-4o an expanded polyglutamine (polyQ) region in the encoded protein HTT. We have used homologous recombination (HR) to genetically correct HD patient-derived induced pluripotent stem cells (iPSCs) and found that this reversed HD disease phenotypes. We have utilized exploited genome editing tools inclu作者: Herd-Immunity 時(shí)間: 2025-3-25 02:32 作者: transdermal 時(shí)間: 2025-3-25 05:02
https://doi.org/10.1007/978-3-319-60192-2CRISPR-Cas9; genetic engineering; recombinant-DNA methods; double-strand breaks; Ciona intestinalis; isog作者: legislate 時(shí)間: 2025-3-25 08:17 作者: ALOFT 時(shí)間: 2025-3-25 12:05 作者: Locale 時(shí)間: 2025-3-25 17:36 作者: 未成熟 時(shí)間: 2025-3-25 22:41
Entwicklung des Untersuchungsmodells,etic studies. Here, I discuss recent work from our group combining top-down approaches like genome-wide loss-of-function screens and bottom-up approaches like disease variant modeling in human stem cells and stem cell-derived cortical neurons.作者: 吹氣 時(shí)間: 2025-3-26 03:06
Multiscale Genome Engineering: Genome-Wide Screens and Targeted Approaches,etic studies. Here, I discuss recent work from our group combining top-down approaches like genome-wide loss-of-function screens and bottom-up approaches like disease variant modeling in human stem cells and stem cell-derived cortical neurons.作者: fleeting 時(shí)間: 2025-3-26 07:21 作者: Bph773 時(shí)間: 2025-3-26 11:06 作者: granite 時(shí)間: 2025-3-26 15:32 作者: 鬼魂 時(shí)間: 2025-3-26 20:51
: An Important Rhizospheric Inhabitant,ystem. We outline in this short monograph the steps needed to implement a methodology that allows for genome-wide genetic screening in the central nervous system of mice to study both normal and degenerative disease gene function.作者: Spinal-Fusion 時(shí)間: 2025-3-27 00:07
https://doi.org/10.1007/978-1-349-20987-3 gene function via tissue- or cell-specific mutagenesis remains challenging in zebrafish when the study of the function of certain loci might require tight spatiotemporal control of gene inactivation, which is particularly true in studying the function of a particular gene in post mitotic neurons, w作者: 終端 時(shí)間: 2025-3-27 01:51
https://doi.org/10.1007/978-3-8349-6807-4ogenic iPSC lines were created. We found that the disease phenotypes only manifested in the differentiated neural stem cell (NSC) stage, not in iPSCs. Transcriptomic analysis of HD iPSCs and HD NSCs compared to isogenic controls was utilized to understand the molecular basis for the CAG repeat expan作者: 或者發(fā)神韻 時(shí)間: 2025-3-27 08:05 作者: Synovial-Fluid 時(shí)間: 2025-3-27 09:57 作者: 男生戴手銬 時(shí)間: 2025-3-27 13:45
Determinanten der Bildungsungleichheitrated transgenic marmosets with germ line transmission, opening new avenues in primate research..In this chapter, we describe recent advances in neuroscience and disease research using common marmosets, and we outline potential uses of genome editing in non-human primates toward the development of knock-in/knock-out marmosets.作者: 劇本 時(shí)間: 2025-3-27 18:15
,Grundzüge der Kapitalstrukturtheorie,g or mutation-adjacent . exons are intentionally removed in order to restore protein reading frame, and thereby Dystrophin expression, in DMD patients (Beroud et al. Hum Mutat 28:196–202, 2007; Yokota et al. Expert Opin Biol Ther 7:831–842, 2007).作者: Insensate 時(shí)間: 2025-3-28 01:36
Dissecting the Role of Synaptic Proteins with CRISPR,chnique in addition to previous genetic approaches vastly simplifies and accelerates the study of specific synaptic proteins. Here we illustrate different ways that CRISPR/Cas9 can be used in the study of synaptic properties.作者: harmony 時(shí)間: 2025-3-28 05:55 作者: APEX 時(shí)間: 2025-3-28 08:15
Therapeutic Gene Editing in Muscles and Muscle Stem Cells,g or mutation-adjacent . exons are intentionally removed in order to restore protein reading frame, and thereby Dystrophin expression, in DMD patients (Beroud et al. Hum Mutat 28:196–202, 2007; Yokota et al. Expert Opin Biol Ther 7:831–842, 2007).作者: 追蹤 時(shí)間: 2025-3-28 12:35 作者: 表被動(dòng) 時(shí)間: 2025-3-28 18:36 作者: ADORN 時(shí)間: 2025-3-28 21:11
0945-6082 erstanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy..978-3-319-86801-1978-3-319-60192-2Series ISSN 0945-6082 Series E-ISSN 2196-3096 作者: 虛情假意 時(shí)間: 2025-3-29 01:09 作者: 令人心醉 時(shí)間: 2025-3-29 03:54
