標(biāo)題: Titlebook: Genome Editing; The Next Step in Gen Toni Cathomen,Matthew Hirsch,Matthew Porteus Book 2016 The Editor(s) (if applicable) and The Author(s) [打印本頁] 作者: amateur 時間: 2025-3-21 17:39
書目名稱Genome Editing影響因子(影響力)
書目名稱Genome Editing影響因子(影響力)學(xué)科排名
書目名稱Genome Editing網(wǎng)絡(luò)公開度
書目名稱Genome Editing網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Genome Editing被引頻次
書目名稱Genome Editing被引頻次學(xué)科排名
書目名稱Genome Editing年度引用
書目名稱Genome Editing年度引用學(xué)科排名
書目名稱Genome Editing讀者反饋
書目名稱Genome Editing讀者反饋學(xué)科排名
作者: evince 時間: 2025-3-21 21:40
Personal Journal, February 2013,SPR/Cas9— to introduce DSBs at specific sites in the genome for the purposes of modification is revolutionizing the biological and biomedical sciences. This chapter provides an overview of the research that led to these advances in gene editing and also summarizes DSB repair mechanisms in mammalian cells.作者: A簡潔的 時間: 2025-3-22 04:20
Christoph Lange,J?rg Langkau,Sebastian Baderhe parameters and approaches for nuclease-stimulated genome manipulation. Although much of the territory has been ceded in the last few years to the more easily designed TALENs and CRISPR/Cas nucleases, successful ZFNs are still in wide use in a number of applications, including current clinical trials.作者: Preserve 時間: 2025-3-22 06:38
Designing Digital Products for Kidste specifically via homologous recombination (HR) or targeted mutagenesis based mechanisms. In this chapter we will discuss the advances made in triplex technology involving triplex forming oligonucleotides (TFOs) and peptide nucleic acids (PNAs) for site specific genome editing.作者: 漂亮 時間: 2025-3-22 10:41 作者: epinephrine 時間: 2025-3-22 14:14
Gene Editing 20 Years Later,SPR/Cas9— to introduce DSBs at specific sites in the genome for the purposes of modification is revolutionizing the biological and biomedical sciences. This chapter provides an overview of the research that led to these advances in gene editing and also summarizes DSB repair mechanisms in mammalian cells.作者: epinephrine 時間: 2025-3-22 17:50 作者: progestogen 時間: 2025-3-22 22:03 作者: Vertebra 時間: 2025-3-23 02:49 作者: 使害怕 時間: 2025-3-23 06:44 作者: Iniquitous 時間: 2025-3-23 12:19 作者: 配置 時間: 2025-3-23 15:04 作者: 可行 時間: 2025-3-23 20:15 作者: ectropion 時間: 2025-3-24 01:57
Stimulation of AAV Gene Editing via DSB Repair,atus of AAV vectors for gene editing via site specific DNA double strand break repair. In addition, the remaining obstacles towards the combination of AAV vectorology and site-specific endonucleases for genetic engineering are discussed.作者: 發(fā)炎 時間: 2025-3-24 05:34 作者: OFF 時間: 2025-3-24 07:13
Book 2016ereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integras作者: 使迷醉 時間: 2025-3-24 11:53
https://doi.org/10.1007/978-1-4939-3509-3DNA Repair Mechanisms; gene therapy; Germline; Nuclease; Mutagenesis作者: generic 時間: 2025-3-24 16:55
978-1-4939-8061-1The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: Mitigate 時間: 2025-3-24 22:02
Genome Editing978-1-4939-3509-3Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: 游行 時間: 2025-3-25 01:33 作者: headlong 時間: 2025-3-25 05:38 作者: 假 時間: 2025-3-25 10:18
Christoph Lange,J?rg Langkau,Sebastian Baderbly effective, enhancing the frequency of gene targeting several orders of magnitude. The modularity of DNA recognition by zinc fingers has made it possible to design ZFNs for a wide range of genomic targets in a remarkable assortment of organisms and cell types. Use of this platform helped define t作者: 熱烈的歡迎 時間: 2025-3-25 12:05 作者: Isometric 時間: 2025-3-25 19:33
https://doi.org/10.1057/9780230504905euromuscular diseases are the result of a broad spectrum of genetic mutations, including point mutations, insertions and deletions, chromosomal rearrangements, epigenetic aberrations, and repeat expansions or contractions. Targeted genome editing is a promising method to correct the inherited mutati作者: 全面 時間: 2025-3-25 22:46 作者: sparse 時間: 2025-3-26 03:43
Designing Digital Products for Kidsdification of genomic DNA sequences at specific sites has been employed to manipulate the function and expression of various genes, which are implicated in various genetic disorders. On this front, triplex technology has been used to alter the expression of different genes by correcting mutations si作者: fringe 時間: 2025-3-26 05:42 作者: 北極人 時間: 2025-3-26 10:27 作者: 遠(yuǎn)足 時間: 2025-3-26 15:54 作者: curettage 時間: 2025-3-26 17:45 作者: Expostulate 時間: 2025-3-26 21:08 作者: Incommensurate 時間: 2025-3-27 04:23
Electromechanical Control Using the Arduinoar pluripotency, and the ability to precisely manipulate the genome with engineered nucleases. Together, these two advances have significant potential in the development of the next generation of cell and gene therapies. This review will discuss human and animal models of stem cells and the applicat作者: 品嘗你的人 時間: 2025-3-27 07:36 作者: 不合 時間: 2025-3-27 10:31
The Development and Use of Zinc-Finger Nucleases,bly effective, enhancing the frequency of gene targeting several orders of magnitude. The modularity of DNA recognition by zinc fingers has made it possible to design ZFNs for a wide range of genomic targets in a remarkable assortment of organisms and cell types. Use of this platform helped define t作者: 翻布尋找 時間: 2025-3-27 14:09 作者: 耕種 時間: 2025-3-27 21:33 作者: crucial 時間: 2025-3-28 01:23 作者: MAPLE 時間: 2025-3-28 02:37 作者: 刺耳的聲音 時間: 2025-3-28 07:29
Genome Editing by Aptamer-Guided Gene Targeting (AGT), only recently been applied to gene correction. The effectiveness of using aptamers for gene targeting comes from their versatility, as aptamers can be used in conjunction with currently existing genome modification systems. Here we describe how DNA aptamers can be exploited to increase donor DNA av作者: 老巫婆 時間: 2025-3-28 14:20
Stimulation of AAV Gene Editing via DSB Repair,relevant for disease therapy. In fact, zinc-finger nucleases (ZFNs) that induce deletions in the HIV CCR5 receptor in patient T cells ex vivo have demonstrated promise upon treated cell infusion in the clinic. In these applications, adenoviral delivery vectors were employed however; there is growing作者: 不確定 時間: 2025-3-28 18:36
Engineered Nucleases and Trinucleotide Repeat Diseases,late gene function and heritable traits in a number of species including human. Mutations at a subset of repeats, most of which are trinucleotide repeats, trigger devastating human neurological and skeletal disorders. In particular, at least a dozen neurological disorders share a common etiology—the作者: Harness 時間: 2025-3-28 19:31
Using Engineered Nucleases to Create HIV-Resistant Cells, treatments, which require life-long adherence to antiretroviral drug regimens. Engineered nucleases have the capability to either disrupt a specific gene, or to promote precise gene edits or additions at the targeted gene. As one application for the gene disruption capabilities of the nucleases, HI作者: thalamus 時間: 2025-3-29 00:08
Strategies to Determine Off-Target Effects of Engineered Nucleases,e-induced DNA breaks by either non-homologous end joining (NHEJ) or homology-directed repair (HDR) allows genome editing in a wide range of organisms and cell lines. However, if a nuclease cleaves at genomic locations other than the intended target, known as “off-target sites”, it can lead to mutati作者: 果仁 時間: 2025-3-29 03:04 作者: 尊重 時間: 2025-3-29 09:06
https://doi.org/10.1057/9780230504905thies or neuropathies are discussed. The genome editing tools available to create targeted genetic modifications are reviewed. Promising cell- and gene-based therapies are introduced in the context of the treatment of neuromuscular disorders in combination with genome editing therapies. Finally, spe作者: beta-cells 時間: 2025-3-29 12:40
https://doi.org/10.1007/978-3-031-46297-9rized here, from creation of transgenic organisms and in vivo gene therapy, to cellular reprogramming and precise genome editing by cassette exchange. The latest system, dual integrase cassette exchange (DICE), uses target phiC31 and Bxb1 . sequences precisely placed in genomes by homologous recombi
