標(biāo)題: Titlebook: Genetics and Alzheimer’s Disease; Colloque Medecine et Pierre Marie Sinet,Yvon Lamour,Yves Christen Conference proceedings 1988 Springer-Ve [打印本頁] 作者: Nutraceutical 時間: 2025-3-21 16:16
書目名稱Genetics and Alzheimer’s Disease影響因子(影響力)
書目名稱Genetics and Alzheimer’s Disease影響因子(影響力)學(xué)科排名
書目名稱Genetics and Alzheimer’s Disease網(wǎng)絡(luò)公開度
書目名稱Genetics and Alzheimer’s Disease網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Genetics and Alzheimer’s Disease被引頻次
書目名稱Genetics and Alzheimer’s Disease被引頻次學(xué)科排名
書目名稱Genetics and Alzheimer’s Disease年度引用
書目名稱Genetics and Alzheimer’s Disease年度引用學(xué)科排名
書目名稱Genetics and Alzheimer’s Disease讀者反饋
書目名稱Genetics and Alzheimer’s Disease讀者反饋學(xué)科排名
作者: Immunoglobulin 時間: 2025-3-21 23:45
,Heterogeneity in Alzheimer’s Disease: an Exercise in the Resolution of a Phenotype,st heterogeneity in Alzheimer’s disease. Since some of these features run in Alzheimer’s disease families there could be genetic heterogeneity. Understanding the mechanisms which determine the age of onset and related features will be as important as the discovery of the genes, because delay of the 作者: 瘙癢 時間: 2025-3-22 04:10 作者: 確認(rèn) 時間: 2025-3-22 04:50
Familial Aggregation of Dementia of Alzheimer Type: Analysis from an Epidemiological Point of View,se latter studies is to examine whether an increased familial risk does exist. Case-control studies have yet to provide clear evidence for familial aggregation of DAT. The inconclusiveness of these results is due to the very small number of studies with positive results and to methodological problem作者: bonnet 時間: 2025-3-22 10:05 作者: 抱負(fù) 時間: 2025-3-22 15:59 作者: 抱負(fù) 時間: 2025-3-22 20:02 作者: 體貼 時間: 2025-3-22 23:36 作者: pacifist 時間: 2025-3-23 02:12 作者: 假裝是我 時間: 2025-3-23 05:56
,Molecular Genetic Strategies in Familial Alzheimer’s Disease: Theoretical and Practical Considerati Alzheimer’s disease (AD), at least in the four large pedigrees examined. Further studies have indicated that the β-amyloid gene and the superoxide dismutase-1 gene are not the site of the familial AD (FAD) mutation, and that duplication of large regions of chromosome 21 is not the pathogenetic mech作者: 審問 時間: 2025-3-23 11:07 作者: SLING 時間: 2025-3-23 16:05 作者: Myelin 時間: 2025-3-23 21:06 作者: 極深 時間: 2025-3-24 02:15
,Precursor of Alzheimer’s Disease (PAD) A4 Amyloid Protein,al dysfunction and depositions of. amyloid A4 protein (β-protein) in the form of intracellular neurofibrillary tangles, extracellular plaques and cerebrovascular amyloid. Amyloid A4 is a self-aggregating protein that consists of 42–43 residues. “Reverse genetics” based on the sequence of amyloid A4 作者: ALTER 時間: 2025-3-24 04:06 作者: Immobilize 時間: 2025-3-24 09:20 作者: 多嘴 時間: 2025-3-24 11:27
Paired Helical Filaments (PHF): Update 1988,eactive proteins in cerebrospinal fluid (CSF) from patients with Alzheimer’s disease (AD). This PHF reactivity is present in higher concentration in CSF from AD than from non-AD controls. The method employed for detection of this reactivity is enzyme-linked immunosorbent assay. By analyzing a greate作者: 顯而易見 時間: 2025-3-24 18:11 作者: 嚙齒動物 時間: 2025-3-24 20:53 作者: Jargon 時間: 2025-3-25 00:29
,Die Brücke zwischen Chemie und Physik,ia must be constructed for the purpose of identifying probands and secondary cases in linkage studies in order to reduce the number of false positives. To put it another way, we must increase the predictive value of case detection methods, particularly regarding early cases, in linkage studies.作者: COMA 時間: 2025-3-25 04:24 作者: 微塵 時間: 2025-3-25 08:03
Der Aufbau der Siedlungsstelle,ein precursor, the protooncogene ETS2 and various anonymous DNA sequences. Results indicate that duplication of two regions might be important in Down’s syndrome pathogeny: one containing the SOD gene, the other the protooncogene ETS2.作者: 悶熱 時間: 2025-3-25 15:40 作者: Excitotoxin 時間: 2025-3-25 16:33
Der Ursprung der Neuen Philosophiepredicted that there will be both some false positives and some false negatives. Data from a large group of cases are therefore necessary to define the specificity of the diagnostic test, which hopefully will be available in the near future.作者: Hallmark 時間: 2025-3-25 23:50 作者: 溫順 時間: 2025-3-26 02:07 作者: Accrue 時間: 2025-3-26 05:33 作者: theta-waves 時間: 2025-3-26 09:54 作者: 熟練 時間: 2025-3-26 13:37 作者: pacific 時間: 2025-3-26 19:48 作者: 沙發(fā) 時間: 2025-3-26 22:12
Der Aufbau des Selbst beim Kindir connections, which underwent integrated elaboration during recent hominid evolution, became vulnerable to Alzheimer pathology through the genomic processes that promoted their evolution. Some genes involved in integrated phylogeny of the association system, therefore, may contribute to the genetic liability for Alzheimer’s disease in man.作者: ALLEY 時間: 2025-3-27 04:47
,Informationen für das Management,ely related and may in fact be regarded as one locus in the linkage analysis of Alzheimer families. Linkage data indicate that the FAD gene is most likely located near D21S13/S16, closer to the centromere.作者: BRUNT 時間: 2025-3-27 07:51 作者: lethal 時間: 2025-3-27 12:09 作者: 琺瑯 時間: 2025-3-27 14:21 作者: Arteriography 時間: 2025-3-27 21:19
https://doi.org/10.1007/978-3-642-92361-6anism in either FAD or sporadic AD. Additional studies are currently under way to more precisely map the location of the FAD gene in order to expedite the ultimate goal of isolating and characterizing the actual FAD gene.作者: emission 時間: 2025-3-28 01:33
Bemessung der elektrischen Anla?einrichtungfailed to establish linkage and excluded linkage from a portion of the region where the EOAD gene was localized. These findings suggest that more than one etiology may exist for familial Alzheimer’s disease and indicate the need for continued screening of the genome in LOAD families.作者: MOTTO 時間: 2025-3-28 03:29
Technische Bemerkungen zur Untersuchung,ng pathogenesis of normal aging. Alzheimer’s disease, Down’s syndrome, and Guamanian ALS/PD. The same applies to isolating the gene for the normal host precursor protein for the much different amyloid of the scrapie-associated fibrils of unconventional viruses (scrapie-kuru-Creutzfeldt-Jakob disease) and the amyloid plaques of these diseases.作者: antecedence 時間: 2025-3-28 09:51
,Genetics of Alzheimer’s Disease: Current Status and Future Development of Research,c still, whether they would have developed the disease had they lived longer. The earliest onset cases make familiality easier to establish, and it seems that the age of onset may be one of the factors that is genetically determined, as the age of onset is fairly consistent and typical for each affected family (Folstein, this volume).作者: BALE 時間: 2025-3-28 11:52
,Molecular Genetic Strategies in Familial Alzheimer’s Disease: Theoretical and Practical Consideratianism in either FAD or sporadic AD. Additional studies are currently under way to more precisely map the location of the FAD gene in order to expedite the ultimate goal of isolating and characterizing the actual FAD gene.作者: 懶洋洋 時間: 2025-3-28 14:51
,Genetic Linkage Studies in Late-Onset Alzheimer’s Disease Families,failed to establish linkage and excluded linkage from a portion of the region where the EOAD gene was localized. These findings suggest that more than one etiology may exist for familial Alzheimer’s disease and indicate the need for continued screening of the genome in LOAD families.作者: 美學(xué) 時間: 2025-3-28 19:10 作者: 有組織 時間: 2025-3-29 00:13
Conference proceedings 1988echerche Therapeuti- que. This meeting was the second of the series of Colloques Medecine et Recherche devoted to Alzheimer‘s disease. The first one was held in Angers (France) on September 14, 1987; the proceedings of this meeting have already been published and are entitled Immunology and Alzheime作者: 征服 時間: 2025-3-29 06:37
https://doi.org/10.1007/978-3-662-39683-4narrow confidence limits from large bias-free pedigrees; these are the only ones for which Mendelian dominant autosomal transmission, to the exclusion of environmental effects, has been established. Large pedigrees have been decisive in recent progress in the molecular genetics of Alzheimer’s diseas作者: NICE 時間: 2025-3-29 11:10 作者: 愚蠢人 時間: 2025-3-29 13:46
,Druck- und Zugfestigkeit der Kalkm?rtel,alue of this index was also significantly more frequent in the SDAT group than in the two other groups (P < 0.02), as was an index of transversality higher than 31 on at least one hand (P < 0.01)..In contrast with other reports, we have not found significantly different frequencies of digital ulnar 作者: CHIDE 時間: 2025-3-29 19:15 作者: atopic-rhinitis 時間: 2025-3-29 21:25
https://doi.org/10.1007/978-3-322-97795-3We also suggest that if amyloid deposition occurs at clinical target sites, such as in neurons or between synapses, amyloid formation could be a crucial event for the clinical expression of dementia..The localization of the amyloid precursor in rat brain at or near the surface of neurons is in agree作者: Reservation 時間: 2025-3-30 02:16
Neuer Kulturkampf und Populismus,n cDNA libraries constructed from three patients with AD, we never observed the insertion of 168 bp between position 865 and 866 which has been recently reported in cultured cells. This suggests that even if different populations of BAPP mRNA are present in normal and AD brain, as a result of an alt作者: deactivate 時間: 2025-3-30 04:34
,Die Kultur der realen Virtualit?t, potentially interesting to study chromosome 21 gene expression in AD. RNA quantification experiments were run on fibroblast cultures from five AD patients, three age-matched controls and two DS patients: mRNA for CuZn superoxide dismutase was significantly increased in four AD patients and two DS p作者: bizarre 時間: 2025-3-30 11:50
Alfred Bellebaum,Robert Hettlagend neurofibrillary tangles. The sequence of several tau monoclonal antibody recognition sites has been identified and demonstrates that large portions of the tau molecule are included in the neurofibrillary tangle.作者: 微粒 時間: 2025-3-30 16:13
,Extended Kindreds as a Model for Research on Alzheimer’s Disease,narrow confidence limits from large bias-free pedigrees; these are the only ones for which Mendelian dominant autosomal transmission, to the exclusion of environmental effects, has been established. Large pedigrees have been decisive in recent progress in the molecular genetics of Alzheimer’s diseas作者: frivolous 時間: 2025-3-30 18:34 作者: grotto 時間: 2025-3-30 20:42
,Dermatoglyphic Patterns in Senile Dementia of Alzheimer’s Type,alue of this index was also significantly more frequent in the SDAT group than in the two other groups (P < 0.02), as was an index of transversality higher than 31 on at least one hand (P < 0.01)..In contrast with other reports, we have not found significantly different frequencies of digital ulnar 作者: cardiopulmonary 時間: 2025-3-31 01:55
,Trisomic and Transgenic Mice in the Study of the Pathogenesis of Alzheimer’s Disease and Down’s Synde direct injury to the nervous system as the result of increased activity of one or a few genes, as well as indirect effects brought about by abnormalities in the development of the trisomic nervous system or by increased susceptibility to injurious agents. Several model systems for studying these 作者: Solace 時間: 2025-3-31 05:03
,Precursor of Alzheimer’s Disease (PAD) A4 Amyloid Protein,We also suggest that if amyloid deposition occurs at clinical target sites, such as in neurons or between synapses, amyloid formation could be a crucial event for the clinical expression of dementia..The localization of the amyloid precursor in rat brain at or near the surface of neurons is in agree作者: BARGE 時間: 2025-3-31 09:22
,Cloning of the Beta Amyloid Peptide Gene in Alzheimer’s Disease,n cDNA libraries constructed from three patients with AD, we never observed the insertion of 168 bp between position 865 and 866 which has been recently reported in cultured cells. This suggests that even if different populations of BAPP mRNA are present in normal and AD brain, as a result of an alt作者: 剝削 時間: 2025-3-31 13:21
,Molecular Analysis of Patients with Alzheimer’s Disease, potentially interesting to study chromosome 21 gene expression in AD. RNA quantification experiments were run on fibroblast cultures from five AD patients, three age-matched controls and two DS patients: mRNA for CuZn superoxide dismutase was significantly increased in four AD patients and two DS p作者: corpus-callosum 時間: 2025-3-31 18:53 作者: Culmination 時間: 2025-4-1 01:22 作者: CURB 時間: 2025-4-1 02:48
0945-6066 Disease (AD) stands at the very forefront of research carried out in the last 2 years. It complements research using the formal approach, which has become possi978-3-642-73649-0978-3-642-73647-6Series ISSN 0945-6066 Series E-ISSN 2196-310X 作者: Dawdle 時間: 2025-4-1 09:59 作者: 男生如果明白 時間: 2025-4-1 12:47
,Die Brücke zwischen Chemie und Physik,st heterogeneity in Alzheimer’s disease. Since some of these features run in Alzheimer’s disease families there could be genetic heterogeneity. Understanding the mechanisms which determine the age of onset and related features will be as important as the discovery of the genes, because delay of the
