標(biāo)題: Titlebook: Gene Vaccines; Josef Thalhamer,Richard Weiss,Sandra Scheiblhofer Book 2012 Springer-Verlag/Wien 2012 RNA and DNA vaccines.antigen-specific [打印本頁(yè)] 作者: KEN 時(shí)間: 2025-3-21 17:45
書(shū)目名稱(chēng)Gene Vaccines影響因子(影響力)
作者: infantile 時(shí)間: 2025-3-21 23:20 作者: 正常 時(shí)間: 2025-3-22 01:05 作者: APO 時(shí)間: 2025-3-22 06:48
Cytokine Genes as Molecular Adjuvants for DNA Vaccines,s, parasites, cancers, and autoimmune diseases. However the relatively low efficacy of DNA vaccinations in large animal species and humans has hindered their practical use as therapeutics. Therefore, there is an urgent need to improve protective responses generated by DNA vaccines. Among various imp作者: 受人支配 時(shí)間: 2025-3-22 10:42
Pharmaceutical Non-Viral Formulations for Gene Vaccines,ffort has been spared in order to make genetic vaccination feasible. Unfortunately, most approaches failed to convert the promising results from rodents to larger animals and human beings. To make such systems available for a global community, simple, safe and highly effective delivery systems are h作者: EXALT 時(shí)間: 2025-3-22 14:57 作者: EXALT 時(shí)間: 2025-3-22 19:07 作者: Aprope 時(shí)間: 2025-3-22 21:20 作者: constitute 時(shí)間: 2025-3-23 02:54
Prime Boost Regimens for Enhancing Immunity: Magnitude, Quality of Mucosal and Systemic Gene Vaccins to mimic infection and induce immunological memory that has the potential to confer protection. The use of live attenuated viruses, “killed” viruses and recombinant viral proteins for vaccination are classical vaccine approaches that have successfully induced protective antibody and cell mediated 作者: grandiose 時(shí)間: 2025-3-23 08:43 作者: inflame 時(shí)間: 2025-3-23 10:59
Messenger RNA Vaccines,r RNA (mRNA) vaccines have found entry into clinical development. Through improved vector design, formulation, and delivery, mRNA, initially perceived as unstable and difficult to manipulate, has been developed into a convenient, efficacious, and flexible vaccine platform. Importantly, the same prod作者: 新奇 時(shí)間: 2025-3-23 14:05 作者: 提名 時(shí)間: 2025-3-23 21:16 作者: 寒冷 時(shí)間: 2025-3-24 01:25 作者: Condescending 時(shí)間: 2025-3-24 02:48 作者: Guileless 時(shí)間: 2025-3-24 07:03 作者: 殺子女者 時(shí)間: 2025-3-24 14:29
Book 2012 After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hur作者: 暗語(yǔ) 時(shí)間: 2025-3-24 15:38
cal use objective comparison of different methods and protocThe induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies di作者: olfction 時(shí)間: 2025-3-24 19:50
John C. Parker,Lee R. Berkowitz as unstable and difficult to manipulate, has been developed into a convenient, efficacious, and flexible vaccine platform. Importantly, the same production process can be used to produce a variety of different vaccines, independent of the specifics of particular constructs, which ultimately decreases costs and development time.作者: 煩擾 時(shí)間: 2025-3-25 00:25
https://doi.org/10.1007/978-1-84882-521-5re conventional vaccines, killed or modified live vaccines. Until now, the only animal infection eradicated by vaccination is rinderpest, and for numerous pathogens no effective and safe vaccine is available. There is an undisputed urgent need to develop novel vaccination strategies with improved efficacy.作者: relieve 時(shí)間: 2025-3-25 04:11
Mucus Extravasation and Retention Phenomenaar, in directing T-cell polarization. This chapter reviews recent progress in the co-application of cytokine-encoding genes used for enhancement and direction of immunogenicity, as well as discusses their therapeutic potential for future applications.作者: 安慰 時(shí)間: 2025-3-25 08:58
Phillip Dawson,Colin R. McHenryis and chromatographic purification still often represent engineering challenges in view of high product scales. This article summarizes the state of the art in industrial plasmid manufacturing and discusses bottlenecks and pitfalls to be avoided in order to obtain pDNA products of high and reproducible quantity and quality.作者: 有花 時(shí)間: 2025-3-25 13:12
Cytokine Genes as Molecular Adjuvants for DNA Vaccines,ar, in directing T-cell polarization. This chapter reviews recent progress in the co-application of cytokine-encoding genes used for enhancement and direction of immunogenicity, as well as discusses their therapeutic potential for future applications.作者: 抒情短詩(shī) 時(shí)間: 2025-3-25 16:57
Industrial Manufacturing of Plasmid-DNA Products for Gene Vaccination and Therapy,is and chromatographic purification still often represent engineering challenges in view of high product scales. This article summarizes the state of the art in industrial plasmid manufacturing and discusses bottlenecks and pitfalls to be avoided in order to obtain pDNA products of high and reproducible quantity and quality.作者: rectum 時(shí)間: 2025-3-25 22:13 作者: 針葉類(lèi)的樹(shù) 時(shí)間: 2025-3-26 01:47 作者: 先行 時(shí)間: 2025-3-26 06:14 作者: 制度 時(shí)間: 2025-3-26 08:29 作者: 使迷醉 時(shí)間: 2025-3-26 13:47
Book 2012to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.作者: 接觸 時(shí)間: 2025-3-26 20:07
Ton J. Cleophas,Aeilko H. Zwindermanis emerging. This introductory chapter will give a broad overview on the current status of gene vaccine design, their delivery and fate after introduction into the body, their immunostimulatory capacities, and finally, the processing and presentation of vaccine-encoded antigen to the immune system.作者: Prophylaxis 時(shí)間: 2025-3-27 01:01 作者: –LOUS 時(shí)間: 2025-3-27 01:34
Anal Conditions: Fistula-in-Anohe incorporation of gene sequences for the alphaviral replicase complex into a naked DNA plasmid. The original objective was to significantly increased antigen production with the help of a viral enzyme which replicates (vaccine encoded-) mRNA in transfected cells. Although this mechanism continues 作者: 分解 時(shí)間: 2025-3-27 07:55 作者: 合并 時(shí)間: 2025-3-27 09:47
Adam Blechman M.D.,Anar Mikailov M.D.cently electroporation (EP) in particular, in combination with other technological developments such as species-specific codon optimization, improved RNA structural design, incorporation of novel leader sequences, novel formulations and adjuvant strategies have had a significant effect on immune out作者: flimsy 時(shí)間: 2025-3-27 14:33
https://doi.org/10.1007/978-3-319-17094-7ite, rate, and timing of agent administration relative to the application of EP. This design ensures co-localization of the electrical fields with the site of genetic vaccine distribution and facilitates consistent procedure application independent of operator skill or experience. Device configurati作者: myriad 時(shí)間: 2025-3-27 20:21 作者: 民間傳說(shuō) 時(shí)間: 2025-3-27 22:40
Diagnostic Applications of the Hand Testy other infectious agents, the discussion and comparison of these different routes usually focuses on patient convenience, reduction of pain and distress for children, cost and on the possibility for mass vaccination. In this review, however, we would like to focus on how the route of administration作者: 心胸狹窄 時(shí)間: 2025-3-28 04:25
Treatment Strategies for Memory Disorders,nteracts the induction of allergic immune responses. Such prophylactic vaccines may very well resemble naturally acquired protection from allergy as it is observed in individuals exposed to microbial compounds during early childhood (hygiene hypothesis). In this chapter, we will discuss different ty作者: canonical 時(shí)間: 2025-3-28 09:08
https://doi.org/10.1007/978-1-4471-3785-6view of the regulatory status and requirements for DNA vaccines intended for human use. We first introduce the regulatory process in Europe and in the USA and then highlight the most relevant aspects of the already existing guidance documents for DNA vaccines.作者: Derogate 時(shí)間: 2025-3-28 12:22 作者: 樹(shù)木中 時(shí)間: 2025-3-28 15:12
General Mechanisms of Gene Vaccines,is emerging. This introductory chapter will give a broad overview on the current status of gene vaccine design, their delivery and fate after introduction into the body, their immunostimulatory capacities, and finally, the processing and presentation of vaccine-encoded antigen to the immune system.作者: 文藝 時(shí)間: 2025-3-28 22:45
Strategies to Improve DNA Vaccine Potency: HPV-Associated Cervical Cancer as a Model System,tegies that modify the function of DCs. In this review, we use human papillomavirus (HPV)-associated cervical cancer as a model system to illustrate the various strategies that improve DNA vaccine potency. Specifically, we will discuss the various strategies to improve targeting of DNA to DCs, antig作者: 平息 時(shí)間: 2025-3-28 23:11
Immune-Activating Mechanisms of Replicase-Based DNA and RNA Vaccines and Their Role in Immune-Apopthe incorporation of gene sequences for the alphaviral replicase complex into a naked DNA plasmid. The original objective was to significantly increased antigen production with the help of a viral enzyme which replicates (vaccine encoded-) mRNA in transfected cells. Although this mechanism continues 作者: MURAL 時(shí)間: 2025-3-29 03:52 作者: Corroborate 時(shí)間: 2025-3-29 08:52
Improvement of DNA Vaccines by Electroporation,cently electroporation (EP) in particular, in combination with other technological developments such as species-specific codon optimization, improved RNA structural design, incorporation of novel leader sequences, novel formulations and adjuvant strategies have had a significant effect on immune out作者: Locale 時(shí)間: 2025-3-29 14:08
,Electroporation Based TriGrid? Delivery System (TDS) for DNA Vaccine Administration,ite, rate, and timing of agent administration relative to the application of EP. This design ensures co-localization of the electrical fields with the site of genetic vaccine distribution and facilitates consistent procedure application independent of operator skill or experience. Device configurati作者: HIKE 時(shí)間: 2025-3-29 18:25 作者: adequate-intake 時(shí)間: 2025-3-29 21:08
Intralymphatic Vaccination,y other infectious agents, the discussion and comparison of these different routes usually focuses on patient convenience, reduction of pain and distress for children, cost and on the possibility for mass vaccination. In this review, however, we would like to focus on how the route of administration作者: Meager 時(shí)間: 2025-3-30 01:48 作者: 商店街 時(shí)間: 2025-3-30 06:56
Current Status of Regulations for DNA Vaccines,view of the regulatory status and requirements for DNA vaccines intended for human use. We first introduce the regulatory process in Europe and in the USA and then highlight the most relevant aspects of the already existing guidance documents for DNA vaccines.作者: encyclopedia 時(shí)間: 2025-3-30 11:26
Minicircle-DNA,short introduction in problems and drawbacks associated with these elements and focuses on the production of plasmid derived DNA agents devoid of bacterial backbone sequences by site-specific recombination and subsequent purification by DNA interaction affinity chromatography (minicircle-DNA).作者: 短程旅游 時(shí)間: 2025-3-30 12:29
erties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.978-3-7091-1929-7978-3-7091-0439-2作者: Filibuster 時(shí)間: 2025-3-30 16:50 作者: 小鹿 時(shí)間: 2025-3-31 00:02
Ton J. Cleophas,Aeilko H. Zwindermanm, similar to live attenuated vaccines, but at a higher safety profile and with superior efficacy in production and costs. After impressive performance in small animal models, gene vaccines were quickly transferred into the clinics without detailed knowledge of the underlying molecular and immunolog作者: 亞當(dāng)心理陰影 時(shí)間: 2025-3-31 03:30 作者: ALE 時(shí)間: 2025-3-31 06:37
Anal Conditions: Fistula-in-Anoon-adjuvanted DNA vaccines have proven their ability to prevent or treat a very broad range of diseases in animal models, their immunogenicity – not only in certain animal models but also when used in non-human primates or humans in general – has been unsatisfactory. Numerous strategies have been de作者: peritonitis 時(shí)間: 2025-3-31 11:01 作者: 有發(fā)明天才 時(shí)間: 2025-3-31 15:41
