標(biāo)題: Titlebook: Gene Transfer and Therapy in the Nervous System; Fred H. Gage,Yves Christen Conference proceedings 1992 Springer-Verlag Berlin Heidelberg [打印本頁] 作者: ACID 時(shí)間: 2025-3-21 16:33
書目名稱Gene Transfer and Therapy in the Nervous System影響因子(影響力)
書目名稱Gene Transfer and Therapy in the Nervous System影響因子(影響力)學(xué)科排名
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書目名稱Gene Transfer and Therapy in the Nervous System網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Gene Transfer and Therapy in the Nervous System被引頻次
書目名稱Gene Transfer and Therapy in the Nervous System被引頻次學(xué)科排名
書目名稱Gene Transfer and Therapy in the Nervous System年度引用
書目名稱Gene Transfer and Therapy in the Nervous System年度引用學(xué)科排名
書目名稱Gene Transfer and Therapy in the Nervous System讀者反饋
書目名稱Gene Transfer and Therapy in the Nervous System讀者反饋學(xué)科排名
作者: 運(yùn)動吧 時(shí)間: 2025-3-21 23:27 作者: 漸變 時(shí)間: 2025-3-22 04:24
Conference proceedings 20035th editionll types in the Drosophila retina (Van Vactor et al. 1991; Simon et al. 1991). Transplants of neuroepithelial cells also show that local extracellular signals also regulate the fate of the multipotential neuronal precursors in mammals. A crucial signalling step that commits the multipotential precur作者: 向宇宙 時(shí)間: 2025-3-22 05:28
Manfred Wick,Wulf Pinggera,Paul Lehmannte the degenerative process. In fact, it is quite possible that the grafted cells themselves could succumb to the basic disease process. In neurological disorders such as Alzheimer’s disease (AD; Fig. 1a), a variety of neural pathways are selectively vulnerable and not all of the neurotransmitter de作者: 勉強(qiáng) 時(shí)間: 2025-3-22 12:18 作者: Immunotherapy 時(shí)間: 2025-3-22 14:06 作者: Immunotherapy 時(shí)間: 2025-3-22 19:25
https://doi.org/10.1007/978-1-4615-7237-4, a modified vector based on the muscle creatine kinase promoter with the El and E2 enhancers was developed to drive the dystrophin cDNA. Microinjection of this construct into a mouse ovum resulted in a transgenic mouse with a single copy integration of the dystrophin cDNA. Dystrophin expression in 作者: 躲債 時(shí)間: 2025-3-23 00:26
Clinical Aspects of Inner Ear Deafnessal tissue. In the grafted striatum, both fibroblast and endocrine cells restored normal levels of extracellular fluid DA. Release of dopamine from fibroblasts was notably unaffected by high concentrations of potassium, in agreement with the . properties of the grafted cells. The intrastriatal grafts作者: GRILL 時(shí)間: 2025-3-23 02:18 作者: MELD 時(shí)間: 2025-3-23 06:55 作者: 情感 時(shí)間: 2025-3-23 10:54
The Sympathoadrenal Progenitor of the Neural Crest: Basic Biology and Therapeutic Potential,rs into chromaffin cells, whereas fibroblast growth factor (FGF) and nerve growth factor (NGF) promote their development into sympathetic neurons. FGF and NGF appear to act sequentially; the former factor promotes neurite outgrowth and proliferation while the latter factor supports the survival of p作者: PATHY 時(shí)間: 2025-3-23 15:49
Immortal Mammalian Neuronal Stem Cells Differentiate after Implantation into the Developing Brain,ll types in the Drosophila retina (Van Vactor et al. 1991; Simon et al. 1991). Transplants of neuroepithelial cells also show that local extracellular signals also regulate the fate of the multipotential neuronal precursors in mammals. A crucial signalling step that commits the multipotential precur作者: NUL 時(shí)間: 2025-3-23 19:19
Establishment of Clonal Cell Lines for the Study of Neural Function and Dysfunction,te the degenerative process. In fact, it is quite possible that the grafted cells themselves could succumb to the basic disease process. In neurological disorders such as Alzheimer’s disease (AD; Fig. 1a), a variety of neural pathways are selectively vulnerable and not all of the neurotransmitter de作者: JOT 時(shí)間: 2025-3-23 23:21 作者: 絕種 時(shí)間: 2025-3-24 03:59
Gene Transfer into the Nervous System using Recombinant Herpes Virus Vectors, short- and long-term expression of foreign genes on neurons in the peripheral and central nervous systems. Examples will be given here for gene delivery to the adult rat nervous system using vectors which lack viral thymidine kinase activity and cannot replicate in neurons, focusing on the use of t作者: zonules 時(shí)間: 2025-3-24 09:49
Gene Transfer of a Murine Dystrophin Minigene Construct,, a modified vector based on the muscle creatine kinase promoter with the El and E2 enhancers was developed to drive the dystrophin cDNA. Microinjection of this construct into a mouse ovum resulted in a transgenic mouse with a single copy integration of the dystrophin cDNA. Dystrophin expression in 作者: 轉(zhuǎn)向 時(shí)間: 2025-3-24 13:52
Gene Therapy in Animal Models of Neurological Disorders,al tissue. In the grafted striatum, both fibroblast and endocrine cells restored normal levels of extracellular fluid DA. Release of dopamine from fibroblasts was notably unaffected by high concentrations of potassium, in agreement with the . properties of the grafted cells. The intrastriatal grafts作者: atopic-rhinitis 時(shí)間: 2025-3-24 16:04
Neurotrophins and their Receptors,els of NGF, BDNF and NT-3 mRNAs are found within the hippocampus, where they are expressed in a unique set of neurons. Both BDNF and NT-3 mRNAs are transiently expressed in some brain regions during postnatal brain development, suggesting that trophic interactions during brain development are a dyna作者: Brochure 時(shí)間: 2025-3-24 19:57
Viral Hepatitis in the Compromised Host,Somatic cell gene therapy for the correction of many human genetic diseases is now technically possible. We review several methods and cell types that can be used successfully in gene transfer studies in animals, and discuss their potential promise and limitations in the treatment of human genetic diseases.作者: peptic-ulcer 時(shí)間: 2025-3-25 03:07 作者: exceptional 時(shí)間: 2025-3-25 07:03
https://doi.org/10.1007/978-3-642-84842-1Alzheimer‘s disease; Alzheimer′s disease; Gehirn; Gentherapie; Parkinson; brain; cancer; clinical applicati作者: d-limonene 時(shí)間: 2025-3-25 11:28 作者: sed-rate 時(shí)間: 2025-3-25 12:07 作者: innovation 時(shí)間: 2025-3-25 17:39
0945-6082 Overview: 978-3-642-84844-5978-3-642-84842-1Series ISSN 0945-6082 Series E-ISSN 2196-3096 作者: 講個(gè)故事逗他 時(shí)間: 2025-3-25 21:48 作者: CRUC 時(shí)間: 2025-3-26 02:45
Antonio Oliva,Vincenzo L. Pascalicell cycle and with cell replication. Some of the normal cellular genes engaged in such regulatory functions have been shown to lead to, or be associated with, aberrant growth of cells and to the development of the neoplastic changes in the cells. There are at least two kinds of genes associated wit作者: 哪有黃油 時(shí)間: 2025-3-26 08:16 作者: NIP 時(shí)間: 2025-3-26 12:04
Allison Leonard,James Mautner,Andrew Bennie neural progenitor cells. The sympathoadrenal (SA) progenitor of the peripheral nervous system is among the best-characterized of such progenitors, in vertebrates. This cell, which derives from the neural crest, has a restricted developmental program that allows it to develop into a chromaffin cell 作者: AER 時(shí)間: 2025-3-26 14:25
Stephanie Bender,Katherine Oakdenker gene, ., were employed as tracers to analyze the lineage and migration of tectal cells. These studies demonstrated that a multipotential progenitor gives rise to neurons, astrocytes, and radial glial cells, and revealed a striking relationship between the migratory path that a cell follows and t作者: 幻影 時(shí)間: 2025-3-26 19:24 作者: 補(bǔ)助 時(shí)間: 2025-3-26 21:13
Manfred Wick,Wulf Pinggera,Paul Lehmannders are a result of defective gene expression and can be corrected by application of modern molecular approaches. The ultimate success of this strategy requires a detailed understanding of normal gene expression in the nervous system. In the case of Parkinson’s disease (Fig. 1b), the primary therap作者: ciliary-body 時(shí)間: 2025-3-27 04:44
Preparation and control of serum albumin, of one or more human CuZnSOD transgenes into the mouse genome. Although physically normal, these transgenic mice exhibit several differences from control mice when exposed to known or presumed forms of oxidative stress. After a 30-second cold injury to the cerebral cortex, transgenic mice with appr作者: Somber 時(shí)間: 2025-3-27 09:00
Sickle-cell Disease and Vascular Occlusionstranded DNA virus has a large genome (150 kb) which may carry up to 50 kb of foreign DNA at replaceable sites. This virus has a number of advantages for delivery of genes to neurons. It can be taken up by nerve terminals and transported by rapid retrograde transport to the cell nucleus; it can be p作者: Exclaim 時(shí)間: 2025-3-27 10:53
Signal-averaged surface electrocardiography,ons, the virus replicates primarily in skin or mucosal epithelial cells prior to entering regional axon terminals and retrograde transport of the virus capsid to sensory ganglia, where it may either replicate or establish latency (Roizman and Sears 1990; Fig. 1). Latent virus can be reactivated by a作者: 舊式步槍 時(shí)間: 2025-3-27 14:05
Clinical Aspects of Electroporationoximately two thirds of DMD patients carry detectable deletions in the gene encoding dystrophin (Walker et al. 1989; Koenig et al. 1987), which is a muscle cytoskeletal protein (Koenig et al. 1988). Dystrophin protein (Hoffmann et al. 1988) and transcript (Oronzi Scott et al. 1988) are either absent作者: aggravate 時(shí)間: 2025-3-27 19:23
https://doi.org/10.1007/978-1-4615-7237-4rstanding of the conditions required for efficient gene transfer and subsequent stable expression. A 14 kilobase mouse dystrophin cDNA was cloned by splicing together two overlapping partial cDNA constructs at a unique . I restriction site. The clone was full-length, as determined by selective seque作者: 圖表證明 時(shí)間: 2025-3-28 01:33
Clinical Aspects of Inner Ear Deafnesst, been established. In the present study, we grafted cell lines expressing form I of human tyrosine hydroxylase after infection with a recombinant retrovirus and selection in tyrosine-free-medium to dopamine (DA) denervated striatum. Our goal was to analyse the extent to which extracellular DA leve作者: strain 時(shí)間: 2025-3-28 03:21 作者: Ornament 時(shí)間: 2025-3-28 07:14
Clinical Aspects of Neutron Capture Therapygenes. Both human NF-L and NF-H genes are expressed in a tissue-specific fashion in transgenic mice. For the NF-L gene, various constructs have been tested in transgenic mice to define regulatory regions contributing to neuronal expression. Unexpectedly, this analysis demonstrated the presence of in作者: reperfusion 時(shí)間: 2025-3-28 11:29
Lowell S. Young,Robert H. Rubin As importantly, nerve growth factor is needed to induce and promote the regeneration of lesioned axons. Regardless of the cellular or extracellular substrates used by these regrowing axons, the availability of nerve growth factor is a minimum requirement for successful regeneration of adult perturbed axons.作者: MINT 時(shí)間: 2025-3-28 15:38
Delivery of Nerve Growth Factor Within the Rat Brain Using Genetically Modified Cells, As importantly, nerve growth factor is needed to induce and promote the regeneration of lesioned axons. Regardless of the cellular or extracellular substrates used by these regrowing axons, the availability of nerve growth factor is a minimum requirement for successful regeneration of adult perturbed axons.作者: Prostatism 時(shí)間: 2025-3-28 22:22
Clinical Aspects of Electroporationuscle cytoskeletal protein (Koenig et al. 1988). Dystrophin protein (Hoffmann et al. 1988) and transcript (Oronzi Scott et al. 1988) are either absent or severely deficient in DMD patients (Koenig et al. 1988).作者: AXIS 時(shí)間: 2025-3-29 01:04 作者: Adj異類的 時(shí)間: 2025-3-29 04:41 作者: thrombus 時(shí)間: 2025-3-29 07:14
Clinical Aspects of Neutron Capture Therapyation of transgenic mice bearing a high-copy number of the NF-L gene revealed the existence of a translational control impeding overexpression of NF-L in CNS neurons. Unlike the NF-L gene, overexpression of the human NF-H gene in transgenic mice was not impeded by the existence of such posttranscriptional controls.作者: Barter 時(shí)間: 2025-3-29 14:04
Phenotypic Plasticity and Neural Grafting,host environment to provide the instructive cues necessary to promote the differentiation of phenotypes suitable for the host circuitry. If the latter paradigm proves efficacious, such grafts could serve as bioassays for instructive factors ..作者: 疲勞 時(shí)間: 2025-3-29 19:15
Lineage, Migration, and Phenotype in Avian Optic Tectum: Analysis with Recombinant Retroviral Vectoand a potentially bioactive gene, or its antisense copy, in clones of cells. In initial studies, overexpression of an oncogene (v-src) and antisense suppression of an adhesion molecule (integrin β1) have perturbed the behavior of lacZ-positive cells in ways that provide insights into the functions of these genes.作者: V洗浴 時(shí)間: 2025-3-29 21:33 作者: sparse 時(shí)間: 2025-3-30 01:07
Signal-averaged surface electrocardiography, olfactory bulb after intranasal inoculation (Dobson et al. 1989). Focal infection of specific brain regions can be achieved by stereotactic injection of small volumes of virus into defined brain regions (McFarland et al. 1986; Bak et al. 1977).作者: 一夫一妻制 時(shí)間: 2025-3-30 05:23
Development of Herpes Simplex Virus as a Gene Transfer Vector for the Central Nervous System, olfactory bulb after intranasal inoculation (Dobson et al. 1989). Focal infection of specific brain regions can be achieved by stereotactic injection of small volumes of virus into defined brain regions (McFarland et al. 1986; Bak et al. 1977).作者: 憤怒事實(shí) 時(shí)間: 2025-3-30 12:11 作者: Spirometry 時(shí)間: 2025-3-30 15:44
Delivery of Nerve Growth Factor Within the Rat Brain Using Genetically Modified Cells, system. Intracerebral grafts of nerve growth factor-producing fibroblasts have been used to assess the regenerative capacities of select neuronal populations within the damaged adult rat brain. Our data reveal that this trophic factor is a necessary requirement to sustain neurons following axotomy.作者: Thyroid-Gland 時(shí)間: 2025-3-30 17:57 作者: 使顯得不重要 時(shí)間: 2025-3-31 00:33
Phenotypic Plasticity and Neural Grafting, to replace in the host. For this purpose, fetal neurons of the same type or suitable neuronal cell lines are often used. Two other possibilities are discussed here. First, adrenal chromaffin cells are a source of multipotential progenitor cells capable of generating a variety of neuronal phenotypes作者: hyperuricemia 時(shí)間: 2025-3-31 02:46
The Sympathoadrenal Progenitor of the Neural Crest: Basic Biology and Therapeutic Potential, neural progenitor cells. The sympathoadrenal (SA) progenitor of the peripheral nervous system is among the best-characterized of such progenitors, in vertebrates. This cell, which derives from the neural crest, has a restricted developmental program that allows it to develop into a chromaffin cell 作者: 鬼魂 時(shí)間: 2025-3-31 06:27 作者: Synthesize 時(shí)間: 2025-3-31 10:53 作者: 無孔 時(shí)間: 2025-3-31 17:11 作者: folliculitis 時(shí)間: 2025-3-31 20:01 作者: MAOIS 時(shí)間: 2025-4-1 00:06
Gene Transfer into the Nervous System using Recombinant Herpes Virus Vectors,stranded DNA virus has a large genome (150 kb) which may carry up to 50 kb of foreign DNA at replaceable sites. This virus has a number of advantages for delivery of genes to neurons. It can be taken up by nerve terminals and transported by rapid retrograde transport to the cell nucleus; it can be p
