標(biāo)題: Titlebook: Gene Therapeutics; Methods and Applicat Jon A. Wolff Book 1994 Birkh?user Boston 1994 DNA.Promoter.Translation.gene expression.gene therapy [打印本頁] 作者: oxidation 時(shí)間: 2025-3-21 17:12
書目名稱Gene Therapeutics影響因子(影響力)
書目名稱Gene Therapeutics影響因子(影響力)學(xué)科排名
書目名稱Gene Therapeutics網(wǎng)絡(luò)公開度
書目名稱Gene Therapeutics網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Gene Therapeutics被引頻次
書目名稱Gene Therapeutics被引頻次學(xué)科排名
書目名稱Gene Therapeutics年度引用
書目名稱Gene Therapeutics年度引用學(xué)科排名
書目名稱Gene Therapeutics讀者反饋
書目名稱Gene Therapeutics讀者反饋學(xué)科排名
作者: FLIRT 時(shí)間: 2025-3-21 23:55
Producing Mouse Genetic Models for Human Diseasesluable to the basic research support of fields as wide-ranging as immunology, reproduction, oncology, nutrition, infectious diseases, transplantation, cardiology, and anesthesiology (Report of the Council on Scientific Affairs, 1989). Due to recent advances in the techniques required for somatic gen作者: 噴出 時(shí)間: 2025-3-22 03:50
Post-Transcriptional Considerations of Gene Expression: Translation, MRNA Stability, and Poly(A) Proich the mRNA is synthesized, but also upon the rates at which the mRNA is processed, trans-ported and translated along with the rates at which the mRNA and protein are degraded. Therefore, each of these post-transcriptional processes is linked to “gene expression,” and it is important to know how ea作者: MEAN 時(shí)間: 2025-3-22 04:54
Promoters, Enhancers, and Inducible Elements for Gene Therapyll in gestation. The midwives to the birth of this area are those molecular biologists who are actively involved in the study of the control of gene expression. In particular, the tremendous surge of the last several years in understanding of the promoter elements and the protein factors involved in作者: PURG 時(shí)間: 2025-3-22 11:01 作者: EXUDE 時(shí)間: 2025-3-22 15:27 作者: EXUDE 時(shí)間: 2025-3-22 19:38 作者: 前面 時(shí)間: 2025-3-22 23:08
In Vivo Gene Therapy via Receptor-Mediated DNA Deliverys in recombinant DNA methodologies have fostered molecular studies in such fields as regulation of gene expression, human genetics and disease states, and gene transfer techniques. The confluence of these fields has led to the emergence of gene therapy as a reality, albeit limited at present to a sm作者: inflate 時(shí)間: 2025-3-23 03:33
Calcium Phosphate-Mediated DNA Transfectione transcriptional and translational activities of exogenous DNA but also the regulation of gene expression by other genetic elements. Furthermore, the approach to somatic gene therapy is entirely based on introducing genes either to correct a prior genetic defect or to augment the genetic repertoire作者: 卵石 時(shí)間: 2025-3-23 06:59
Cellular Internalization of Oligodeoxynucleotidesngs have been in contrast to the prevailing view that cells are impermeable to negatively charged large molecules. With this in mind, several groups have attempted to modify oligos in order to circumvent the problem of negative charge. Thus, methylphosphonates are ionically neutral, and poly-L-lysin作者: ADAGE 時(shí)間: 2025-3-23 11:52
Gene Transfer via Particle Bombardment: Applications of the Accell Gene GunAdvances in recombinant DNA and PCR technologies have significantly facilitated the identification of functional genes which cause, promote, control, or correct a variety of diseases. Gene transfer techniques must now be developed which can efficiently deliver candidate therapeutic genes into target作者: Cursory 時(shí)間: 2025-3-23 17:49
Electrically-Induced DNA Transfer into Cells. Electrotransfection in Vivoof exogenous DNA into cells of virtually any origin (Potter et al., 1984, Fromm et al., 1985, Dower et al., 1988, Potter, 1988). In many cases, electroporation is the only method that works. Ultimately, it is because electrotransfection is to a great extent a physical rather than biological techniqu作者: GRIN 時(shí)間: 2025-3-23 20:31 作者: Alcove 時(shí)間: 2025-3-24 01:11 作者: 有權(quán) 時(shí)間: 2025-3-24 02:35 作者: 昏迷狀態(tài) 時(shí)間: 2025-3-24 07:31
Development of Herpes Simplex Virus Vectors for Gene Transfer to the Central Nervous Systemcertain heritable diseases of the central nervous system (CNS) as well as many of those encoding neurotransmitters, receptors, and growth factors which influence brain function. For example, the genes responsible for the neurodegenerative diseases amyotrophic lateral sclerosis (Rosen et al., 1993) a作者: APNEA 時(shí)間: 2025-3-24 12:44 作者: Spinous-Process 時(shí)間: 2025-3-24 16:37
,Cyclones and other gas—solids separators, several decades. Many of the pioneers of modern genetics realized that their discoveries eventually could lead to medical applications. Some even proposed gene transfer approaches decades ago that are still being explored today.作者: spondylosis 時(shí)間: 2025-3-24 21:04 作者: ethereal 時(shí)間: 2025-3-25 03:11
A History of Gene Transfer and Therapy several decades. Many of the pioneers of modern genetics realized that their discoveries eventually could lead to medical applications. Some even proposed gene transfer approaches decades ago that are still being explored today.作者: FIS 時(shí)間: 2025-3-25 05:49
Gene Therapy for Adenosine Deaminase Deficiency and Malignant Solid Tumors the defective gene instead of merely treating symptoms is very appealing. Significant progress in the development of clinical applications of gene therapy has occurred. More than 40 human gene transfer and therapy experiments have been initiated since the introduction of this approach in 1989 (Anderson, 1992; Miller, 1992).作者: CYN 時(shí)間: 2025-3-25 07:51 作者: osteoclasts 時(shí)間: 2025-3-25 12:17
Y. K. Tong,R.W.K. Chiu,Y.M.D. Loluable to the basic research support of fields as wide-ranging as immunology, reproduction, oncology, nutrition, infectious diseases, transplantation, cardiology, and anesthesiology (Report of the Council on Scientific Affairs, 1989). Due to recent advances in the techniques required for somatic gen作者: finale 時(shí)間: 2025-3-25 19:31
https://doi.org/10.1007/978-1-349-19435-3ich the mRNA is synthesized, but also upon the rates at which the mRNA is processed, trans-ported and translated along with the rates at which the mRNA and protein are degraded. Therefore, each of these post-transcriptional processes is linked to “gene expression,” and it is important to know how ea作者: 主動(dòng) 時(shí)間: 2025-3-25 21:09 作者: 平項(xiàng)山 時(shí)間: 2025-3-26 02:01 作者: progestogen 時(shí)間: 2025-3-26 07:00
Advantages of the Circumareolar Approache transfer has been accomplished via the receptor-mediated endocytosis pathway employing molecular conjugate vectors (Wu and Wu, 1987; Wu et al., 1989; Wagner et al., 1990; Wagner et al., 1991b; Cotten et al., 1990; Curiel et al., 1992a; Huckett et al., 1990; Rosenkranz et al., 1992). The molecular 作者: HPA533 時(shí)間: 2025-3-26 10:17 作者: 拱形面包 時(shí)間: 2025-3-26 14:02
V. A. Hughes,R. J. Cohen,S. Garringtons in recombinant DNA methodologies have fostered molecular studies in such fields as regulation of gene expression, human genetics and disease states, and gene transfer techniques. The confluence of these fields has led to the emergence of gene therapy as a reality, albeit limited at present to a sm作者: ostensible 時(shí)間: 2025-3-26 16:55
Naturally Occurring , and Poly, Carotenoidse transcriptional and translational activities of exogenous DNA but also the regulation of gene expression by other genetic elements. Furthermore, the approach to somatic gene therapy is entirely based on introducing genes either to correct a prior genetic defect or to augment the genetic repertoire作者: Locale 時(shí)間: 2025-3-26 21:58 作者: 為現(xiàn)場 時(shí)間: 2025-3-27 02:36 作者: 某人 時(shí)間: 2025-3-27 05:52
Chris Carthern,William Wilson,Noel Riveraof exogenous DNA into cells of virtually any origin (Potter et al., 1984, Fromm et al., 1985, Dower et al., 1988, Potter, 1988). In many cases, electroporation is the only method that works. Ultimately, it is because electrotransfection is to a great extent a physical rather than biological techniqu作者: AGATE 時(shí)間: 2025-3-27 12:01
Cisco Routers for the Small Businessoint in time with the expectation that these genes will associate permanently with the target cell, producing therapeutic amounts of the gene product indefinitely. This requires the use of vectors which integrate their genetic material into the chromosomes of the host cell or persist in an episomal 作者: 裝飾 時(shí)間: 2025-3-27 16:17
Cisgenics and Crop Improvement, United States. This tumor has proven to be extremely refractory to currently available therapeutic modalities. A combination of aggressive surgical excision, radiation therapy, and chemotherapy has increased the life expectancy of patients suffering from this illness by only a few months (Schoenber作者: Accolade 時(shí)間: 2025-3-27 18:50
Quantitative and Qualitative Evaluation, the defective gene instead of merely treating symptoms is very appealing. Significant progress in the development of clinical applications of gene therapy has occurred. More than 40 human gene transfer and therapy experiments have been initiated since the introduction of this approach in 1989 (Ande作者: Macronutrients 時(shí)間: 2025-3-28 01:17 作者: Measured 時(shí)間: 2025-3-28 05:22 作者: perjury 時(shí)間: 2025-3-28 06:43
https://doi.org/10.1007/978-1-349-19435-3cts of RNA splicing, 3′ end formation/polyadenylation, RNA localization, translation and stability of the cytoplasmic mRNA and protein all influence the production of a protein. In keeping with the purpose of this review, specific examples of each type of control will be described. Obviously, the ex作者: Analogy 時(shí)間: 2025-3-28 14:01
Maria Spatz,B. B. Mr?ulja,W. D. Lustbiological membranes are, at this time, mostly speculative and require more research to fully define the processes involved in polynucleotide transport. This chapter will discuss what is known about the uptake of naked foreign DNA by muscle cells after intramuscular injection or implantation as well作者: 江湖郎中 時(shí)間: 2025-3-28 18:33 作者: Overdose 時(shí)間: 2025-3-28 19:17 作者: 提煉 時(shí)間: 2025-3-29 01:36
Xiaoying Dong,Yan Yu,Jiali Zhouome equally apparent that backbone or pendant oligonucleotide modifications can alter olionucleotide uptake characteristics, although not always in the way intended. In this chapter, we will review the current state of knowledge concerning internalization pathways for modified and unmodified oligonu作者: flaggy 時(shí)間: 2025-3-29 05:45 作者: AMPLE 時(shí)間: 2025-3-29 11:16 作者: 保留 時(shí)間: 2025-3-29 15:15 作者: expdient 時(shí)間: 2025-3-29 19:36
Possible Mechanisms of DNA Uptake in Skeletal Musclebiological membranes are, at this time, mostly speculative and require more research to fully define the processes involved in polynucleotide transport. This chapter will discuss what is known about the uptake of naked foreign DNA by muscle cells after intramuscular injection or implantation as well作者: 諷刺 時(shí)間: 2025-3-29 20:56
Receptor-Mediated Gene Delivery Employing Adenovirus-Polylysine-DNA Complexesween the negatively charged DNA and the positively charged DNA-binding domain serves not only to bind the DNA, but also to condense it into a compact toroid structure (Wagner et al., 1991a). As the ligand is covalently linked to the polylysine DNA-binding domain, after binding of the DNA, at least a作者: Expand 時(shí)間: 2025-3-30 02:11
In Vivo Gene Therapy via Receptor-Mediated DNA Deliveryerapy strategy would be available, the current inability to achieve permanent transgene expression necessitates periodic retreatments, making these procedures highly cost-ineffective over the long term.作者: Working-Memory 時(shí)間: 2025-3-30 06:04
Cellular Internalization of Oligodeoxynucleotidesome equally apparent that backbone or pendant oligonucleotide modifications can alter olionucleotide uptake characteristics, although not always in the way intended. In this chapter, we will review the current state of knowledge concerning internalization pathways for modified and unmodified oligonu作者: Presbycusis 時(shí)間: 2025-3-30 11:28 作者: 思考而得 時(shí)間: 2025-3-30 13:38
Development of Herpes Simplex Virus Vectors for Gene Transfer to the Central Nervous Systeml disease in a considerable percentage of affected patients. For example, the administration of L-DOPA to Parkinson’s patients may even accelerate the decline in dopamine producing neurons. Other difficulties with traditional therapies are that the blood-brain barrier limits the delivery of systemic作者: commonsense 時(shí)間: 2025-3-30 16:34
Book 1994tter op- portunity. The fITSt reproducible in vivo gene therapy in a whole animal came in 1981. This was in Drosophila, with a transposable element as carrier. Flies were "cured" of a mutant eye color by incorporation of the normal allele, and the effect was transmissible, foreshadowing not only som作者: corporate 時(shí)間: 2025-3-30 21:14 作者: 群居男女 時(shí)間: 2025-3-31 02:54 作者: Ancestor 時(shí)間: 2025-3-31 06:37
ease by altering or replacing defective genes. H. J. Muller wrote of the great advantages of mutations, "nanoneedles" in his apt term, for delicately probing physiological and chemical processes. In the same spirit, genes could be used to provide treatments of needle point delicacy. Yet, during this作者: Insufficient 時(shí)間: 2025-3-31 13:05
Y. K. Tong,R.W.K. Chiu,Y.M.D. Lo cardiology, and anesthesiology (Report of the Council on Scientific Affairs, 1989). Due to recent advances in the techniques required for somatic gene transfer and in the ability to produce desired models for human heritable diseases, the stage is now set to extend the range of these areas of biomedical impact to include somatic gene therapy.作者: 洞察力 時(shí)間: 2025-3-31 14:12 作者: 廣大 時(shí)間: 2025-3-31 21:08
Naturally Occurring , and Poly, Carotenoids approach to somatic gene therapy is entirely based on introducing genes either to correct a prior genetic defect or to augment the genetic repertoire of the recipient cell. The technology of gene transfer is truly one of the cornerstones in molecular genetics.
