作者: 排名真古怪 時間: 2025-3-21 23:41 作者: 印第安人 時間: 2025-3-22 02:57
Pulmonary Co-delivery of DOX and siRNA,RNA complex nanoparticles were obviously smaller and fewer in numbers than mice treated with DOX or siRNA alone, which could be due to the synergistic antitumor effects of DOX and siRNA. Furthermore, most DOX and siRNA were found in the tumor of lungs after pulmonary administration, but rarely restr作者: Nostalgia 時間: 2025-3-22 06:05
,Fluorinated α-Helical Polypeptides Toward Pulmonary siRNA Delivery,in vivo anti-inflammatory results indicated that the P3F16/siTNF-α and P7F7/siTNF-α polyplexes can significantly reduce the expression of pro-inflammatory factors, such as TNF-α and IL-6. It thus renders promising potentials toward the treatment of pulmonary diseases via noninvasive, localized deliv作者: 整理 時間: 2025-3-22 11:15
Preparation and Evaluation of Polymeric Hybrid Micelles to Co-deliver Small Molecule Drug and siRNAn. In order to efficiently block the key inflammatory signaling NF-κB pathway in rheumatoid arthritis (RA), siRNA targeting p65 (a key subunit of NF-κB family) combined with small molecule drugs dexamethasone (Dex) using the hybrid micelle as a carrier has been developed for the treatment of RA. The作者: guzzle 時間: 2025-3-22 15:36
Preparation and Application of MPEG-PCL-g-PEI Cationic Micelles in Cancer Therapy,lation time, targeting to tumor tissue via enhanced permeability and retention effect. In this regard, this protocol focuses on the functional gene and chemotherapeutic drug co-delivery cationic micelles used in cancer therapy. Here, the preparation and characterization of gene and drug co-delivery 作者: guzzle 時間: 2025-3-22 20:53 作者: 擁護(hù) 時間: 2025-3-23 01:13 作者: Rodent 時間: 2025-3-23 03:19 作者: NIL 時間: 2025-3-23 06:04 作者: periodontitis 時間: 2025-3-23 09:59
Preparation of Chimeric Polymersomes for Gene Delivery,tion of trimethylene carbonate and dithiolane trimethylene carbonate using methoxy poly(ethylene glycol) as an initiator and diphenyl phosphate as a catalyst followed by activating the terminal hydroxyl group with N, N′-carbonyldiimidazole and conjugation with PEI or spermine. siRNA-loaded chimeric 作者: OVERT 時間: 2025-3-23 14:19 作者: 仲裁者 時間: 2025-3-23 19:18 作者: Eeg332 時間: 2025-3-24 01:24
2523-8809 to systematically understand the preparation and characterization of the existing non-viral gene delivery systems, as well as providing a technology platform for clinical gene therapy.978-981-16-5419-0Series ISSN 2523-8809 Series E-ISSN 2523-8817 作者: Detonate 時間: 2025-3-24 04:10 作者: 蟄伏 時間: 2025-3-24 10:02 作者: CANT 時間: 2025-3-24 12:12
https://doi.org/10.1007/978-3-319-39487-9RNA complex nanoparticles were obviously smaller and fewer in numbers than mice treated with DOX or siRNA alone, which could be due to the synergistic antitumor effects of DOX and siRNA. Furthermore, most DOX and siRNA were found in the tumor of lungs after pulmonary administration, but rarely restr作者: 簡略 時間: 2025-3-24 18:40 作者: 圖表證明 時間: 2025-3-24 22:09 作者: 流行 時間: 2025-3-25 01:54 作者: Flustered 時間: 2025-3-25 03:21
Yvonne Winfildah Takawira-Matwaya-PBA) via electrostatic interaction. The results demonstrated that PEGylated polymer shell significantly reduces nonspecific interaction at physiological condition. Furthermore, MDNP is capable of detaching polymer shell at tumor acidic microenvironment, facilitating the cellular internalization and作者: RLS898 時間: 2025-3-25 08:17 作者: Palpitation 時間: 2025-3-25 12:47
Fred M. Ssewamala,Ozge Sensoy Baharilic MPEG-PCL-PEI (PPP) tri-block cationic polymer have been designed to deliver Nur77/ΔDBD gene with high transfection efficiency, which consisted of methoxy-poly(ethylene glycol) (MPEG), polycaprolactone (PCL), and positively charged polyethyleneimine (PEI). In order to further maintain long-lasti作者: Project 時間: 2025-3-25 18:49
https://doi.org/10.1007/978-1-349-15827-0The miRNA- and SPIO-encapsulating micelle was named T-PBP@miRNA/SPIO which specifically delivered the miRNA-29b and miRNA-122 into the HSCs in an MRI-monitorable manner, leading to a synergistic anti-fibrosis outcome via the downregulation of pro-fibrotic protein such as collagen I (COL1A1), .-smoot作者: 平躺 時間: 2025-3-26 00:03 作者: lipoatrophy 時間: 2025-3-26 02:27
Jér?me Ballet,Benoit Lallau,Claudine Dumbi nanomicelle for co-delivery of drug/gene. The co-delivery system of chemotherapy drugs (docetaxel, DTX) and siRNA (siRNA-Bcl-2) obviously reduced the expression of antiapoptotic Bcl-2 gene and synergistically promoted antitumor activity of DTX. The present results demonstrate that the polypeptide c作者: VEN 時間: 2025-3-26 06:06 作者: Crayon 時間: 2025-3-26 09:53
Reference work 2022ementation of gene therapy. This book provides a platform for young scholars and students to systematically understand the preparation and characterization of the existing non-viral gene delivery systems, as well as providing a technology platform for clinical gene therapy.作者: 易達(dá)到 時間: 2025-3-26 13:14 作者: intimate 時間: 2025-3-26 17:08 作者: 消極詞匯 時間: 2025-3-26 22:12
Preparation of Ultrasmall Gold Nanoparticles for Nuclear-Based Gene Delivery,Here, we summarize the preparation method of ultrasmall Au NPs for direct nucleus targeting, the followed test method can be used to demonstrate the excellent stability and high efficiency of the nuclear-targeting ultrasmall Au NPs which provides a promising gene delivery vector for gene therapy.作者: OVERT 時間: 2025-3-27 01:55 作者: Prophylaxis 時間: 2025-3-27 05:41
https://doi.org/10.1007/978-94-015-0491-1tained results demonstrated that the fabricated nanovectors exhibited high gene transfection efficiency, specific turn-on fluorescence imaging in tumors, and fast drug release from the dendritic arginine peptide-prodrug conjugates.作者: 孤僻 時間: 2025-3-27 11:56 作者: 可憎 時間: 2025-3-27 15:32
Caroline Rey-Salmon,Catherine Adamsbaum gene delivery and monitor protein expression. In vitro and in vivo results demonstrated that the ARNHs exhibited high gene transfection efficiency, good biocompatibility, facile fabrication, and real-time bioimaging capabilities.作者: ordain 時間: 2025-3-27 18:37 作者: saturated-fat 時間: 2025-3-27 22:21
Carole R. Smith,Mary T. Lane,Terry Walsherizations of a class of bioreducible cationic nanomicelles endowed with high DNA-binding affinity, allowing for efficient DNA condensation and high transfection efficiency at a low nitrogen to phosphorus (N/P) ratio. These cationic nanomicelles hold promising potential as a high efficiency nonviral gene delivery vector for clinical use.作者: 形容詞詞尾 時間: 2025-3-28 03:31
Preparation and Evaluation of Lipopeptides with Arginine-Rich Periphery for Gene Delivery,tained results demonstrated that the fabricated nanovectors exhibited high gene transfection efficiency, specific turn-on fluorescence imaging in tumors, and fast drug release from the dendritic arginine peptide-prodrug conjugates.作者: Torrid 時間: 2025-3-28 08:06 作者: vitreous-humor 時間: 2025-3-28 14:26
Molecular and Supramolecular Construction of Arginine-Rich Nanohybrids for Visible Gene Delivery, gene delivery and monitor protein expression. In vitro and in vivo results demonstrated that the ARNHs exhibited high gene transfection efficiency, good biocompatibility, facile fabrication, and real-time bioimaging capabilities.作者: VOC 時間: 2025-3-28 16:51
Bioinspired Fabrication of Peptide-Based Capsid-Like Nanoparticles for Gene Delivery,noparticles have capsid-like nanostructures, ordered secondary structures and biofunctions for molecular delivery. CLNs are capable of serving as biocompatible, biosafety, and efficient gene vectors. The following section will describe the typical protocols for fabricating the peptide-based capsid-like nanoparticles for gene delivery.作者: 別炫耀 時間: 2025-3-28 22:11 作者: transient-pain 時間: 2025-3-28 23:51 作者: Dedication 時間: 2025-3-29 05:45 作者: 行為 時間: 2025-3-29 08:24 作者: 恃強凌弱 時間: 2025-3-29 12:18 作者: Blood-Vessels 時間: 2025-3-29 19:07
https://doi.org/10.1007/978-1-4842-1931-7te the mucus layer due to the adsorption of mucin glycoproteins that trap and destabilize the polyplexes. In this study, a series of fluorinated cationic polypeptides were constructed based on ring-opening polymerization and click chemistry, aiming to synchronize mucus permeation and cell penetratio作者: Glutinous 時間: 2025-3-29 20:51
https://doi.org/10.1007/978-1-4842-7866-6ecules to the cytoplasm of target cells still remains a huge challenge for the application in vivo. Here, this protocol describes a practical approach to prepare a highly flexible polymeric hybrid micelles for the in vivo delivery of siRNA. The micelles consist of cationic polycaprolactone-polyethyl作者: 不近人情 時間: 2025-3-30 02:43
,‘Walking in the middle of the road’,cy. In recent years, the development of nonviral gene carriers has received great interest worldwide. However, the limitations of safety and low therapeutic efficacy make few nonviral gene vectors be used in clinical therapy of cancer. Therefore, co-delivery of functional genes and chemotherapeutic 作者: urethritis 時間: 2025-3-30 06:18
https://doi.org/10.1007/978-94-015-0491-1ication. The present protocol focuses on synthesis, preparation, characterization of the gene carriers, including gene transfection efficiency evaluation as well as intracellular tracking. The synthesis of dendritic lipopeptides with bio-reducible disulfide linkage and dual aliphatic chains was firs作者: 含沙射影 時間: 2025-3-30 10:41 作者: 調(diào)整 時間: 2025-3-30 15:17 作者: 人造 時間: 2025-3-30 18:56 作者: ABOUT 時間: 2025-3-30 21:30 作者: overture 時間: 2025-3-31 04:46 作者: 腐蝕 時間: 2025-3-31 08:11
Fred M. Ssewamala,Ozge Sensoy Baharn most tumor cells is caused by overexpression of Bcl-2 protein. Orphan nuclear receptor Nur77/ΔDBD which lacks DNA-binding domain can combine in the middle of BH3 and BH4 domain of Bcl-2 protein to reverse Bcl-2 protein function from anti-apoptosis to promoting apoptosis. Therefore, cancer gene the作者: Debate 時間: 2025-3-31 10:19 作者: blight 時間: 2025-3-31 16:44 作者: 熱心 時間: 2025-3-31 18:55 作者: 保存 時間: 2025-4-1 00:46 作者: 漂亮 時間: 2025-4-1 05:15 作者: 興奮過度 時間: 2025-4-1 07:48
Cementing ‘Child First’ in Practiced and programmed manner inside cells. In this regard, a new concept of reduction-controlled hierarchical unpacking is proposed for developing a virus-mimicking gene delivery system. This protocol describes the fabrications of the reduction-controlled hierarchical unpacking terplexes based on the dis作者: 斗志 時間: 2025-4-1 12:23
https://doi.org/10.1007/978-981-16-5419-0Gene carriers; Gene therapy; Antitumor; Gene editing; Cationic polymers
