標(biāo)題: Titlebook: GPCRs: From Deorphanization to Lead Structure Identification; H. Bourne,R. Horuk,H. Michel Conference proceedings 2007 Springer-Verlag Ber [打印本頁] 作者: HEIR 時(shí)間: 2025-3-21 18:28
書目名稱GPCRs: From Deorphanization to Lead Structure Identification影響因子(影響力)
書目名稱GPCRs: From Deorphanization to Lead Structure Identification影響因子(影響力)學(xué)科排名
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書目名稱GPCRs: From Deorphanization to Lead Structure Identification網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱GPCRs: From Deorphanization to Lead Structure Identification被引頻次
書目名稱GPCRs: From Deorphanization to Lead Structure Identification被引頻次學(xué)科排名
書目名稱GPCRs: From Deorphanization to Lead Structure Identification年度引用
書目名稱GPCRs: From Deorphanization to Lead Structure Identification年度引用學(xué)科排名
書目名稱GPCRs: From Deorphanization to Lead Structure Identification讀者反饋
書目名稱GPCRs: From Deorphanization to Lead Structure Identification讀者反饋學(xué)科排名
作者: Ambiguous 時(shí)間: 2025-3-21 22:10
QSAR Modeling of GPCR Ligands: Methodologies and Examples of Applications,oaches to GPCR ligands. We conclude with the comments on exciting developments in the QSAR modeling of GPCR ligands that focus on the study of emerging data sets of compounds with dual or even multiple activities against two or more of GPCRs.作者: Obverse 時(shí)間: 2025-3-22 03:53 作者: 音樂等 時(shí)間: 2025-3-22 05:05
High-Throughput Lead Finding and Optimisation for GPCR Targets,wledges the importance of parameters beyond potency and embraces the gain in knowledge of the last decade. This manuscripts attempts to summarise some of the changes and progress made across the pharmaceutical industry to design an efficient and effective strategy for finding and optimising small molecules modulating the activity of GPCRs.作者: 多嘴多舌 時(shí)間: 2025-3-22 08:49
Conference proceedings 2007dress GPCRs and depict how mature this target class-oriented research has become in the last decade. The book reflects the actual trends in the fast-emerging field of GPCR research in academia and industry..作者: MOAN 時(shí)間: 2025-3-22 15:00 作者: MOAN 時(shí)間: 2025-3-22 20:09 作者: 使害羞 時(shí)間: 2025-3-23 01:10 作者: 輕快帶來危險(xiǎn) 時(shí)間: 2025-3-23 02:41 作者: 佛刊 時(shí)間: 2025-3-23 08:25
A Short History of Modern Moneywards the discovery of small molecule antagonist, that so far have been mainly focused on the HCMV-encoded GPCR US28. This virus-encoded receptor might be involved in cardiovascular diseases and cancer and seems an interesting target for drug intervention.作者: Chronological 時(shí)間: 2025-3-23 10:43 作者: gangrene 時(shí)間: 2025-3-23 17:57 作者: Lipoma 時(shí)間: 2025-3-23 20:19 作者: 廣大 時(shí)間: 2025-3-24 00:55 作者: 包庇 時(shí)間: 2025-3-24 02:35 作者: 設(shè)想 時(shí)間: 2025-3-24 08:05
Drugs Used in Tropical Medicine,ch stories, formidable obstacles, confusion, and mistakes make eventual triumphs even more exciting. Because these pivotally important signaling molecules were discovered before the recombinant DNA revolution, today‘s well-trained molecular biologist may find it amazing that we learned anything at a作者: conduct 時(shí)間: 2025-3-24 13:51
Multiple Linear Regression Methods,ase of the structure of bovine rhodopsin in August 2000 enabled us to analyze models built before that period to learn things for the models we build today. We conclude that the GPCR modeling field is riddled with “common knowledge”. Several characteristics of the bovine rhodopsin structure came as 作者: 抑制 時(shí)間: 2025-3-24 15:50
https://doi.org/10.1007/978-981-10-0843-6se 3D structures of GPCRs as determined by experimental techniques are still unavailable, ligand-based drug discovery methods remain the major computational molecular modeling approaches to the analysis of growing data sets of tested GPCR ligands. This paper presents an overview of modern Quantitati作者: 滑動(dòng) 時(shí)間: 2025-3-24 19:15 作者: 類似思想 時(shí)間: 2025-3-25 00:54 作者: 得意人 時(shí)間: 2025-3-25 06:47 作者: Diuretic 時(shí)間: 2025-3-25 08:30 作者: Incorruptible 時(shí)間: 2025-3-25 11:47
Albert J. Bredenoord,André Smout,Jan Tackwn, are an attractive set of future targets for presently unmet medical needs. Screening strategies have been developed over the years in order to identify the natural ligands of these receptors. Natural or chimeric G-proteins that can redirect the natural coupling of receptors toward intracellular 作者: GENUS 時(shí)間: 2025-3-25 19:31
A Short History of Modern Moneynce of constitutive GPCR activity. These viral proteins are expressed on the cell surface of infected cells and often constitutively activate a?variety of G-proteins. For some virus-encoded GPCRs, the constitutive activity has been shown to occur in vivo, i.e., in infected cells. In this paper, we w作者: 同來核對 時(shí)間: 2025-3-25 22:37 作者: 完成才會(huì)征服 時(shí)間: 2025-3-26 03:41
Advanced Techniques for Graph Colouring,r action, pain and more. Consequently, they are considered as the most successful group of therapeutic targets on the pharmaceutical market, and the search for compounds that interfere with GPCR function in a?specific and selective way is a?major focus of the pharmaceutical industry. High Content Sc作者: 詞匯 時(shí)間: 2025-3-26 08:20
Rashmi Shetty,Meera Govindarajunent place in the portfolios of many pharmaceutical companies. To successfully address this target class, scientists need not only a?good understanding of the specific receptor under investigation, but also the right tools from assay technology, reagent production to a?hit-to-lead process that ackno作者: 過去分詞 時(shí)間: 2025-3-26 11:52
Drugs Used in Tropical Medicine,ch stories, formidable obstacles, confusion, and mistakes make eventual triumphs even more exciting. Because these pivotally important signaling molecules were discovered before the recombinant DNA revolution, today‘s well-trained molecular biologist may find it amazing that we learned anything at all.作者: SIT 時(shí)間: 2025-3-26 15:14
Guide to the Financial Institutionsors and the herewith linked dominant place in the discovery portfolios. In the present symposium chapter, we outline GPCR compound library design strategies recently followed by our group and discuss them in a?more general context.作者: 工作 時(shí)間: 2025-3-26 19:17 作者: 輕而薄 時(shí)間: 2025-3-26 21:32 作者: surmount 時(shí)間: 2025-3-27 01:24
A Guide to the Financial Institutionsto interact, one can predispose these substructures to favour either one state or the other; thus privileged structures can be used to create either agonists or antagonists. In terms of the mechanism of recognition, the region that the privileged structures bind to are rich in aromatic residues, whi作者: Exuberance 時(shí)間: 2025-3-27 05:48 作者: 清澈 時(shí)間: 2025-3-27 13:19 作者: Inordinate 時(shí)間: 2025-3-27 13:56
Albert J. Bredenoord,André Smout,Jan Tackrs have also been purified from complex biological sources. A?few old and recent examples, including nociceptin, chemerin, and the F2L peptide are illustrated. Future challenges for the functional characterization of the remaining orphan receptors include the potential requirement of specific protei作者: obsolete 時(shí)間: 2025-3-27 19:46 作者: CHYME 時(shí)間: 2025-3-28 01:33 作者: 江湖騙子 時(shí)間: 2025-3-28 04:35 作者: surmount 時(shí)間: 2025-3-28 09:45 作者: Kidney-Failure 時(shí)間: 2025-3-28 12:22
Orphan Seven Transmembrane Receptor Screening,nate receptor experimentally by screening of small molecule and peptide ligands, reverse pharmacology and the use of bioinformatics to predict candidate ligands. In this manuscript, we review the methodologies developed for the identification of ligands at orphan 7TMRs and exemplify these with case 作者: characteristic 時(shí)間: 2025-3-28 17:50 作者: 遵循的規(guī)范 時(shí)間: 2025-3-28 22:34 作者: carotid-bruit 時(shí)間: 2025-3-28 23:09
Modulation of GPCR Conformationsby Ligands, G-Proteins, and Arrestins,f GPCRs, G-proteins, arrestins, and ligands in solubilized systems, where the concentration of each component can be defined. Here we summarize results of these studies as they pertain to the regulation of GPCR conformations and affinities for interacting species.作者: inscribe 時(shí)間: 2025-3-29 03:12
High Content Screening to Monitor G Protein-Coupled Receptor Internalisation,n, resulting in the termination of receptor signalling and the seclusion of the GPCR from further extracellular stimulation. Complementary to other functional GPCR drug discovery assays, GPCR internalisation assays enable a?desensitisation-focussed pharmacological analysis of test compounds.作者: 膽小懦夫 時(shí)間: 2025-3-29 08:14 作者: 反抗者 時(shí)間: 2025-3-29 14:21
Modeling GPCRs,ase of the structure of bovine rhodopsin in August 2000 enabled us to analyze models built before that period to learn things for the models we build today. We conclude that the GPCR modeling field is riddled with “common knowledge”. Several characteristics of the bovine rhodopsin structure came as 作者: outset 時(shí)間: 2025-3-29 18:39
QSAR Modeling of GPCR Ligands: Methodologies and Examples of Applications,se 3D structures of GPCRs as determined by experimental techniques are still unavailable, ligand-based drug discovery methods remain the major computational molecular modeling approaches to the analysis of growing data sets of tested GPCR ligands. This paper presents an overview of modern Quantitati作者: 盲信者 時(shí)間: 2025-3-29 22:14
Privileged Structures in GPCRs, structures. In seeking an explanation for this phenomenon, it is observed that the privileged structure represents a?generic substructure that matches commonly recurring conserved structural motifs in the target proteins, which may otherwise be quite diverse in sequence and function. Using sequence作者: 現(xiàn)實(shí) 時(shí)間: 2025-3-30 00:27
Designing Compound Libraries Targeting GPCRs,ors and the herewith linked dominant place in the discovery portfolios. In the present symposium chapter, we outline GPCR compound library design strategies recently followed by our group and discuss them in a?more general context.作者: 微不足道 時(shí)間: 2025-3-30 07:01
Orphan Seven Transmembrane Receptor Screening,g them. However, it is clear that there remains an undefined potential within this protein family for successful drugs of the future. The human genome sequencing project identified approximately 720 genes that belong to the 7TMR superfamily. Around half of these genes encode sensory receptors, while作者: Mucosa 時(shí)間: 2025-3-30 10:53
The Role of GPCR Dimerisation/Oligomerisation in Receptor Signalling,hed that homo-dimerisation is common, recent studies have sought to explore the physical basis of these interactions and the role of dimerisation in signal transduction. Growing evidence hints at the existence of higher-order organisation of individual GPCRs and the potential for hetero-dimerisation作者: Uncultured 時(shí)間: 2025-3-30 12:25
Deorphanization of G-Protein-Coupled Receptors,wn, are an attractive set of future targets for presently unmet medical needs. Screening strategies have been developed over the years in order to identify the natural ligands of these receptors. Natural or chimeric G-proteins that can redirect the natural coupling of receptors toward intracellular 作者: arthrodesis 時(shí)間: 2025-3-30 16:44
Virus-Encoded G-Protein-Coupled Receptors: Constitutively Active (Dys)Regulators of Cell Function ance of constitutive GPCR activity. These viral proteins are expressed on the cell surface of infected cells and often constitutively activate a?variety of G-proteins. For some virus-encoded GPCRs, the constitutive activity has been shown to occur in vivo, i.e., in infected cells. In this paper, we w
