標(biāo)題: Titlebook: GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity; Denis J. Dupré,Terence E. Hébert,Ralf Jockers Book 2012 Spri [打印本頁] 作者: supplementary 時(shí)間: 2025-3-21 19:30
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書目名稱GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity影響因子(影響力)學(xué)科排名
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書目名稱GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity被引頻次
書目名稱GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity被引頻次學(xué)科排名
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書目名稱GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity年度引用學(xué)科排名
書目名稱GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity讀者反饋
書目名稱GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity讀者反饋學(xué)科排名
作者: 騙子 時(shí)間: 2025-3-21 21:28
Book 2012 defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.作者: Protein 時(shí)間: 2025-3-22 00:43
ER-Bound Steps in the Biosynthesis of G Protein-Coupled Receptors,ceptors (but not of receptor subtypes where ligand binding requires a stable fold of the N-tail) is unlikely to establish a stable fold. These segments can cause ER retention when mutated to inappropriately expose hydrophobic peptide patches; to prevent protein aggregation chaperone molecules attach作者: 顯赫的人 時(shí)間: 2025-3-22 08:34 作者: Harrowing 時(shí)間: 2025-3-22 10:19
Regulatory Processes Governing the Cell Surface Expression of LH and FSH Receptors,xpressed with a misfolded mutant, the misfolded receptor dimerizes with immature wild-type receptor in the ER, causing a dominant-negative effect on cell surface expression of the mature wild-type receptor. Notably, the propensity for homodimerization is not affected by the activation status of the 作者: Virtues 時(shí)間: 2025-3-22 14:49 作者: Virtues 時(shí)間: 2025-3-22 18:19
,Synthesis and Assembly of G Protein βγ Dimers: Comparison of , and , Studies,ular) studies provide different perspectives of these processes, and a comparison of them can provide insight into both our current level of understanding and directions to be taken in future investigations.作者: 橡子 時(shí)間: 2025-3-22 23:27
GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity作者: 付出 時(shí)間: 2025-3-23 02:25
I. N. Bronshtein,K. A. Semendyayevceptors (but not of receptor subtypes where ligand binding requires a stable fold of the N-tail) is unlikely to establish a stable fold. These segments can cause ER retention when mutated to inappropriately expose hydrophobic peptide patches; to prevent protein aggregation chaperone molecules attach作者: 惹人反感 時(shí)間: 2025-3-23 08:40
https://doi.org/10.1007/978-3-030-39908-5erent partners. In this chapter, we will cover some aspects of the current knowledge about how chaperones are involved in both the formation of GPCR oligomers and in the assembly of the receptors with their signaling complex components.作者: allude 時(shí)間: 2025-3-23 12:32
The Python Programming Language,xpressed with a misfolded mutant, the misfolded receptor dimerizes with immature wild-type receptor in the ER, causing a dominant-negative effect on cell surface expression of the mature wild-type receptor. Notably, the propensity for homodimerization is not affected by the activation status of the 作者: ineffectual 時(shí)間: 2025-3-23 16:45 作者: 莎草 時(shí)間: 2025-3-23 20:31
A Guide to Bone Marrow Transplantationular) studies provide different perspectives of these processes, and a comparison of them can provide insight into both our current level of understanding and directions to be taken in future investigations.作者: MIME 時(shí)間: 2025-3-23 22:29
https://doi.org/10.1007/978-94-007-4765-4Assembly; Chaperone; G protein coupled receptor; Signaling; Trafficking; Receptors作者: 富饒 時(shí)間: 2025-3-24 06:10 作者: Cocker 時(shí)間: 2025-3-24 09:33 作者: Generalize 時(shí)間: 2025-3-24 12:02 作者: Unsaturated-Fat 時(shí)間: 2025-3-24 15:28 作者: CT-angiography 時(shí)間: 2025-3-24 20:49
https://doi.org/10.1007/978-3-540-77044-2hat trafficking from the endoplasmic reticulum to the plasma membrane is strictly regulated and involves interactions with specific proteins, such as resident ER chaperones. These interactions help with GPCR folding, but more importantly, they ensure that only properly folded proteins proceed from t作者: 偽善 時(shí)間: 2025-3-25 01:52
Appointments, adjunct/part-time,r of studies have since weighed in on this notion. Are native, functional GPCRs monomers, dimers or as some would suggest even higher order structures? Here, we review some of the latest evidence regarding the organization of these receptors in both homo- and hetero-oligomeric formats, with a partic作者: photopsia 時(shí)間: 2025-3-25 06:21 作者: 易發(fā)怒 時(shí)間: 2025-3-25 08:16
A Guide to Addiction and Its Treatmentll biology and pharmacology. This phenomenon requires a complex network of interactions between GPCRs with either chaperones and escort proteins or gatekeepers, which are respectively involved in the progression of GPCRs along the biosynthetic pathway to the plasma membrane or in their retention in 作者: 具體 時(shí)間: 2025-3-25 13:31
The Python Programming Language,receptors each contain N-linked carbohydrates that are not directly involved in hormone binding, but contribute to the proper folding, and therefore, cell surface expression of the receptor. Loss-of-function mutations of an LHR or FSHR results in decreased target cell responsiveness. Most inactivati作者: 仇恨 時(shí)間: 2025-3-25 19:45 作者: glans-penis 時(shí)間: 2025-3-25 23:02
A Guide to Bone Marrow Transplantation(GPCRs) in the human genome to transduce extracellular signals across the plasma membrane. The synthesis of the constituent G protein subunits, and their assembly into Gβγ dimers and G protein heterotrimers, determines the signaling repertoire for G-protein/GPCR signaling in cells. These synthesis/a作者: JADED 時(shí)間: 2025-3-26 03:55 作者: 繁重 時(shí)間: 2025-3-26 05:14
https://doi.org/10.1007/978-1-349-07472-3tivated by an appropriate G protein-coupled receptor. Once activated, the GTP-bound Gα and the free Gβγ are able to regulate plasma membrane-localized effectors, such as adenylyl cyclase, phospholipase C-β, RhoGEFs and ion channels. Hydrolysis of GTP by the Gα subunit returns the G protein to the in作者: Fracture 時(shí)間: 2025-3-26 10:13
Eve Sprunt,Maria Angela Capelloprivileged entry points for extracellular signals that are transmitted through the plasma membrane into the cell. The adequate cellular response and signaling specificity is regulated by GPCR-associated protein modules. The composition of these modules is dynamic and might depend on receptor stimula作者: eardrum 時(shí)間: 2025-3-26 13:10
The Architecture of Chaucer’s Languageactivity and density at the plasma membrane must be specifically and efficiently coupled to these channels in order to control critical physiological functions such as action potential propagation. Although their regulation by G-protein receptor activation has been extensively explored, the assembly作者: 未成熟 時(shí)間: 2025-3-26 17:26
Clinical research in a developing country,sensory signals. In humans, more than 30 disorders are associated with mutations in GPCRs and these proteins are common drug development targets, with 30–50% of drugs targeting them. GPCR mutants are frequently misfolded, recognized as defective by the cellular quality control system, retained in th作者: happiness 時(shí)間: 2025-3-27 00:45
Denis J. Dupré,Terence E. Hébert,Ralf JockersThis is the first book addressing specifically the assembly of G protein coupled receptors signaling complexes.Several colors images.Compilations of manuscripts made from experts in the field作者: voluble 時(shí)間: 2025-3-27 04:26 作者: vasospasm 時(shí)間: 2025-3-27 05:38 作者: ELUC 時(shí)間: 2025-3-27 13:27
GPCR Oligomerization: Contribution to Receptor Biogenesis,hat trafficking from the endoplasmic reticulum to the plasma membrane is strictly regulated and involves interactions with specific proteins, such as resident ER chaperones. These interactions help with GPCR folding, but more importantly, they ensure that only properly folded proteins proceed from t作者: 監(jiān)禁 時(shí)間: 2025-3-27 16:48
,The Functional Size of GPCRs – Monomers, Dimers or Tetramers?,r of studies have since weighed in on this notion. Are native, functional GPCRs monomers, dimers or as some would suggest even higher order structures? Here, we review some of the latest evidence regarding the organization of these receptors in both homo- and hetero-oligomeric formats, with a partic作者: 創(chuàng)造性 時(shí)間: 2025-3-27 19:49 作者: 來就得意 時(shí)間: 2025-3-27 22:30
Regulated GPCR Trafficking to the Plasma Membrane: General Issues and the CCR5 Chemokine Receptor Ell biology and pharmacology. This phenomenon requires a complex network of interactions between GPCRs with either chaperones and escort proteins or gatekeepers, which are respectively involved in the progression of GPCRs along the biosynthetic pathway to the plasma membrane or in their retention in 作者: 疲憊的老馬 時(shí)間: 2025-3-28 02:07 作者: 紋章 時(shí)間: 2025-3-28 09:51 作者: Nausea 時(shí)間: 2025-3-28 13:20
,Synthesis and Assembly of G Protein βγ Dimers: Comparison of , and , Studies,(GPCRs) in the human genome to transduce extracellular signals across the plasma membrane. The synthesis of the constituent G protein subunits, and their assembly into Gβγ dimers and G protein heterotrimers, determines the signaling repertoire for G-protein/GPCR signaling in cells. These synthesis/a作者: 好色 時(shí)間: 2025-3-28 15:12
,Preferential Assembly of G-αβγ Complexes Directed by the γ Subunits,s of the G-αβγ combinations that actually exist in physiological setting are largely unknown. Moreover, there is uncertainty regarding whether the individual subunits associate by a random process, or combine by a regulated process to form quasi-stable G-αβγ complexes. In this chapter, we will focus作者: Preamble 時(shí)間: 2025-3-28 21:53
G Protein Trafficking,tivated by an appropriate G protein-coupled receptor. Once activated, the GTP-bound Gα and the free Gβγ are able to regulate plasma membrane-localized effectors, such as adenylyl cyclase, phospholipase C-β, RhoGEFs and ion channels. Hydrolysis of GTP by the Gα subunit returns the G protein to the in作者: Guileless 時(shí)間: 2025-3-29 00:20 作者: investigate 時(shí)間: 2025-3-29 06:05 作者: Presbyopia 時(shí)間: 2025-3-29 11:00 作者: BIPED 時(shí)間: 2025-3-29 15:06
0306-0225 tions of manuscripts made from experts in the fieldMain Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to und作者: 外形 時(shí)間: 2025-3-29 18:09 作者: Keshan-disease 時(shí)間: 2025-3-29 20:57
Introduction to the Original Guide,of the receptors remain poorly defined. In this chapter, I will discuss current advances in understanding post-Golgi transport of GPCRs by focusing on specific motifs or sequences that may function as sorting signals regulating export from the Golgi and subsequent transport to the plasma membrane of GPCRs.作者: 嘴唇可修剪 時(shí)間: 2025-3-30 00:49
A Guide to Addiction and Its Treatmentintracellular compartments. The regulated export of GPCRs is also controlled by external stimuli and might represent an adaptive mechanism to specific physiological constraints, such as the sustained activation of the CCR5 chemokine receptor in the context of chemotaxis.作者: MIRE 時(shí)間: 2025-3-30 05:32
GPCR Oligomerization: Contribution to Receptor Biogenesis,he ER to the trans-golgi network. The assembly of several GPCRs into a quaternary structure is started in the ER, before cell surface delivery, and helps in the correct expression of the GPCRs. This review will mainly focus on the role of GPCR oligomerization in receptor biogenesis.作者: Ccu106 時(shí)間: 2025-3-30 11:29 作者: 無意 時(shí)間: 2025-3-30 13:39
Regulated GPCR Trafficking to the Plasma Membrane: General Issues and the CCR5 Chemokine Receptor Eintracellular compartments. The regulated export of GPCRs is also controlled by external stimuli and might represent an adaptive mechanism to specific physiological constraints, such as the sustained activation of the CCR5 chemokine receptor in the context of chemotaxis.作者: installment 時(shí)間: 2025-3-30 19:04
