標題: Titlebook: GABAB Receptor; Giancarlo Colombo Book 20161st edition Springer International Publishing Switzerland 2016 GABA B receptor.Gastroesophageal [打印本頁] 作者: Assert 時間: 2025-3-21 19:56
書目名稱GABAB Receptor影響因子(影響力)
書目名稱GABAB Receptor影響因子(影響力)學科排名
書目名稱GABAB Receptor網(wǎng)絡公開度
書目名稱GABAB Receptor網(wǎng)絡公開度學科排名
書目名稱GABAB Receptor被引頻次
書目名稱GABAB Receptor被引頻次學科排名
書目名稱GABAB Receptor年度引用
書目名稱GABAB Receptor年度引用學科排名
書目名稱GABAB Receptor讀者反饋
書目名稱GABAB Receptor讀者反饋學科排名
作者: Permanent 時間: 2025-3-22 00:17 作者: 過濾 時間: 2025-3-22 04:11
https://doi.org/10.1007/978-3-476-02825-9 of mesolimbic circuits. Beyond a physiological role GABA. receptors may also affect disease, such as addiction. GABA. receptors may therefore constitute an interesting target for pharmacological interventions to treat this condition.作者: 勉強 時間: 2025-3-22 08:03
https://doi.org/10.1007/978-3-476-04308-5t GABA. receptor agonists and positive allosteric modulators may have efficacy in the treatment of SUD, with GABA. receptor positive allosteric modulators having a better pharmacological profile than orthosteric agonists. There is the need for additional clinical studies to ascertain whether preclinical data translate to the human.作者: DEAWL 時間: 2025-3-22 11:18 作者: osculate 時間: 2025-3-22 13:01
The Allosteric Modulation of the GABAB Receptor: A Medicinal Chemistry Perspectivetural classes of GABA. allosteric modulators are described with an emphasis on structure–activity relationships (SAR) and synthesis of the main representatives of each class. Medicinal chemistry strategies to overcome issues related to allosteric modulators development are also discussed.作者: osculate 時間: 2025-3-22 18:43
GABAB Receptor Functions in the Mesolimbic Dopamine System of mesolimbic circuits. Beyond a physiological role GABA. receptors may also affect disease, such as addiction. GABA. receptors may therefore constitute an interesting target for pharmacological interventions to treat this condition.作者: 的闡明 時間: 2025-3-23 00:08
Targeting the GABAB Receptor for the Treatment of Substance Use Disordert GABA. receptor agonists and positive allosteric modulators may have efficacy in the treatment of SUD, with GABA. receptor positive allosteric modulators having a better pharmacological profile than orthosteric agonists. There is the need for additional clinical studies to ascertain whether preclinical data translate to the human.作者: FELON 時間: 2025-3-23 01:49
Targeting the GABAB Receptor for the Treatment of Alcohol Use DisorderA more recent avenue of research is represented by generalization of baclofen effects to the positive allosteric modulators of the GABA. receptor: preclinical data collected to date suggest that these compounds reproduce, with a much higher therapeutic index, several suppressing effects of baclofen on alcohol-motivated behaviors.作者: Grievance 時間: 2025-3-23 07:09
1048-6909 nt perspectives from various fields of study including medic.An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders inclu作者: Retrieval 時間: 2025-3-23 11:33 作者: 不合 時間: 2025-3-23 15:28 作者: 外表讀作 時間: 2025-3-23 21:21 作者: Proponent 時間: 2025-3-24 02:13
Activation Mechanism and Allosteric Properties of the GABAB Receptorfor G protein activation. Here, we will summarize our actual knowledge on the structure, stoichiometry, allosteric properties, and activation mechanism. These reveal some similarities and major differences with the other class C GPCRs and highlight novel possibilities to develop approaches to regulate its activity.作者: 評論者 時間: 2025-3-24 02:35 作者: defray 時間: 2025-3-24 08:45 作者: nerve-sparing 時間: 2025-3-24 11:37
https://doi.org/10.1007/978-3-319-46044-4GABA B receptor; Gastroesophageal reflux disease; Epilepsy; Alcohol and Substance Use Disorder; Anxiety; 作者: 笨拙的我 時間: 2025-3-24 17:37
Deutschland: Hofoper und Stadttheater,he presence of chloride-dependent GABA receptors on ganglion cell bodies had been established in the early 1970s and this prompted us to consider the possibility that the receptors were also on the efferent nerve fibres of these cells and on the nerve terminal membranes. To pursue this, we examined 作者: 支形吊燈 時間: 2025-3-24 19:00 作者: 巨大沒有 時間: 2025-3-24 23:52
https://doi.org/10.1007/978-3-476-03668-1l conditions such as spasticity, pain, drug addiction, epilepsy, anxiety, mood disorders. Baclofen, the only GABA. receptor agonist currently approved for the treatment of muscle rigidity and spasm associated with multiple sclerosis or spinal cord injury, suffers from a number of side effects which 作者: 榮幸 時間: 2025-3-25 03:48
https://doi.org/10.1007/978-3-476-03322-2essed in the vast majority of neurons and primarily regulate neuronal excitability via several distinct effector systems. There is evidence that GABA. receptors are organized in large macromolecular complexes composed of accessory and effector proteins to ensure efficient signaling. Communication th作者: BLOT 時間: 2025-3-25 09:26
https://doi.org/10.1007/978-3-476-99625-1subunits have been identified: GB1, GB2, and GB3. The GB1 and GB2 subunits need to be coexpressed in Xenopus oocytes or in mammalian cell lines to produce functional GABAB.s. A subfamily of potassium channel tetramerization domain-containing (KCTD8, 12, 12b, and 16) proteins that are constituents of作者: 打包 時間: 2025-3-25 14:49 作者: 松軟無力 時間: 2025-3-25 18:27 作者: synovitis 時間: 2025-3-25 22:07 作者: 妨礙議事 時間: 2025-3-26 02:05
Die Ewige Wiederkehr des Gleichen, qualities have enabled investigators to classify and differentiate closely related compounds and gather important information concerning their mechanism(s) of action in vivo. Although drugs from various pharmacological classes have been used to establish discriminative stimulus control, the focus o作者: 虛情假意 時間: 2025-3-26 07:33
,?In Meinen T?nen Spreche Ich?,he pathogenesis of seizures depends upon neural networks involved, which determine the seizure type. Generalized seizures involve diffuse, bi-hemispheric neuronal networks, while focal seizures involve regional brain networks. GABA. receptor agonists have been shown to diminish seizure activity in m作者: 演繹 時間: 2025-3-26 09:06
Rezeption, Funktion und Aussagewert,linical studies demonstrating that selective activation of GABAergic transmission yields a nociceptive response. This is particularly true for agents that stimulate GABA. receptors. While these findings are in accord with the neuroanatomical localization of GABA. receptors on nociceptive pathways, s作者: Hot-Flash 時間: 2025-3-26 13:27 作者: meretricious 時間: 2025-3-26 16:58
Das Weib ?voll bet?ubender Lust am Wehtun?c research necessary to define the molecular pathophysiology. Understanding the disease biology was an essential step in identifying potential targeted treatments that are disease modifying. In FXS, the regulation of protein synthesis at the neuronal synapse is now thought to be a central pathway fo作者: Overstate 時間: 2025-3-26 22:13 作者: fixed-joint 時間: 2025-3-27 04:12 作者: 高興去去 時間: 2025-3-27 08:12
Klassisch-romantische Mysterien,factor in gastroesophageal reflux disease (GERD). TLESR is a reflex dependent on the vagus and as such, it shares many similarities with the cough reflex. Moreover, GER is a known cause of chronic cough in some patients, and agents inhibiting both TLESR and cough may be useful antitussives. There is作者: 火光在搖曳 時間: 2025-3-27 11:48
Giancarlo ColomboFocuses on recent therapeutic applications and future potential for drug discovery.Bench-to-bedside" translational approach.Explores different perspectives from various fields of study including medic作者: Constituent 時間: 2025-3-27 16:56 作者: debris 時間: 2025-3-27 21:05
GABAB Receptor978-3-319-46044-4Series ISSN 1048-6909 Series E-ISSN 2524-6488 作者: 側面左右 時間: 2025-3-28 00:51 作者: MENT 時間: 2025-3-28 02:08
Molecular Organization, Trafficking, and Degradation of the GABAB Receptor of major importance since it is increasingly recognized that aberrant regulation of GABA. receptor cell surface expression contributes to disease states including addiction, cerebral ischemia, and chronic pain. Here we briefly review our current understanding of the macromolecular structural organi作者: 繁殖 時間: 2025-3-28 09:12
Distribution and Localization of the GABAB Receptormatergic terminals and is necessary for hetero-receptor function. Both isoforms 1a and 1b are detected in dendrites, but only GABA. in spine heads. Electron microscopy studies show that, in the central nervous system (CNS), GABA. and GABA. are both pre- and postsynaptic, but mostly localize to posts作者: 繁榮地區(qū) 時間: 2025-3-28 11:20 作者: gastritis 時間: 2025-3-28 18:19 作者: 收藏品 時間: 2025-3-28 18:57
Targeting the GABAB Receptor for the Treatment of Epilepsy) and hippocampal-thalamocortical circuitry is involved in AASs. In addition, high doses of GABA. receptor agonists active at the GABA. receptor/G-protein coupled inwardly rectifying potassium 2 (GIRK2) channel recently have been shown to induce the phenotype of a specific catastrophic epilepsy synd作者: UNT 時間: 2025-3-29 02:28 作者: 發(fā)電機 時間: 2025-3-29 04:02 作者: tendinitis 時間: 2025-3-29 10:08
Targeting the GABAB Receptor in Fragile X Syndrome and Autism Spectrum Disorderse abnormally elevated protein synthesis. The existing safety data on baclofen facilitated clinical development, and arbaclofen was tested in autistic and FXS patients in multiple large, controlled clinical trials. The results of these studies failed to show clinical benefit in the chosen outcome mea作者: 束縛 時間: 2025-3-29 14:22
Targeting the GABAB Receptors for the Treatment of Gastroesophageal Reflux Disease and Chronic Coughs and discusses the findings of GABA. receptor agonists on TLESR, GER, GERD, and cough in both the preclinical setting, healthy individuals and patients. Special attention is devoted to the role of the vagus in mediating these pharmacological effects.作者: Kinetic 時間: 2025-3-29 16:15
Deutschland: Hofoper und Stadttheater,aclofen). Further studies on the release of radiolabelled noradrenaline from rat brain cortex slices revealed a similar effect. Subsequently, in 1981, we were able to demonstrate the presence of a baclofen-sensitive .H-GABA binding site on rat cortical membranes. It was at this stage we were able to作者: gentle 時間: 2025-3-29 21:21
https://doi.org/10.1007/978-3-476-03322-2 of major importance since it is increasingly recognized that aberrant regulation of GABA. receptor cell surface expression contributes to disease states including addiction, cerebral ischemia, and chronic pain. Here we briefly review our current understanding of the macromolecular structural organi作者: 饒舌的人 時間: 2025-3-30 03:24
https://doi.org/10.1007/978-3-476-99625-1matergic terminals and is necessary for hetero-receptor function. Both isoforms 1a and 1b are detected in dendrites, but only GABA. in spine heads. Electron microscopy studies show that, in the central nervous system (CNS), GABA. and GABA. are both pre- and postsynaptic, but mostly localize to posts作者: 避開 時間: 2025-3-30 07:30
,Gedichte und Kritische Aufs?tze,d excitatory neurotransmission. This chapter will describe the understanding of the molecular mechanisms underlying GABA. receptor regulation of glutamate and GABA. receptors and how they modulate excitatory and inhibitory neurotransmission.作者: 鍍金 時間: 2025-3-30 11:38
Die Ewige Wiederkehr des Gleichen,ate (GHB)]. A number of studies have provided evidence that the behavioral effects of baclofen and GHB are mediated predominantly by GABA. receptors; however, there is growing evidence that the mechanisms mediating the effects of these two drugs are not identical. The differences between baclofen an作者: FRAX-tool 時間: 2025-3-30 14:04 作者: ICLE 時間: 2025-3-30 19:58
Rezeption, Funktion und Aussagewert,ns why GABAergic compounds, especially orthosteric receptor agonists, display limited clinical efficacy as analgesics. Among these are the variations in GABA receptor expression and function that occur with the persistent receptor activation associated with a painful stimulus and the chronic adminis作者: 預測 時間: 2025-3-30 21:49 作者: –吃 時間: 2025-3-31 04:19 作者: 寬度 時間: 2025-3-31 07:10 作者: 極大痛苦 時間: 2025-3-31 11:36 作者: 支柱 時間: 2025-3-31 15:59
Chemistry of GABAB Receptor Ligands: Focus on Agonists and Antagoniststo develop GABAB receptor ligands for therapeutic application in a variety of diseases associated with dysfunctions of the gabaergic system. Although baclofen (Lioresal) is still the only approved GABA. receptor agonist, this sustained research effort has produced many new compounds which are able t
