標題: Titlebook: G Protein-Coupled Receptors - Modeling and Simulation; Marta Filizola Book 2014 The Editor(s) (if applicable) and The Author(s), under exc [打印本頁] 作者: CLIP 時間: 2025-3-21 17:02
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作者: Ceramic 時間: 2025-3-21 20:51 作者: 陰郁 時間: 2025-3-22 01:04 作者: 解決 時間: 2025-3-22 06:11
How the Dynamic Properties and Functional Mechanisms of GPCRs Are Modulated by Their Coupling to theated new quantitative studies of the coupling between the proteins and the membrane. It is important to develop such a quantitative understanding at the molecular level because the effects of the coupling are seen to be physiologically and clinically significant. Here we review findings that offer i作者: resuscitation 時間: 2025-3-22 10:13 作者: Credence 時間: 2025-3-22 14:20
Beyond Standard Molecular Dynamics: Investigating the Molecular Mechanisms of G Protein-Coupled Recestandard molecular dynamics (MD) approaches, notwithstanding the current availability of specialized parallel computer architectures, and efficient simulation algorithms. Enhanced MD-based methods have started to assume an important role in the study of the rugged energy landscape of GPCRs by provid作者: Credence 時間: 2025-3-22 20:31
From Three-Dimensional GPCR Structure to Rational Ligand Discoverys individual elements will be introduced, covering amongst others the use of experimental data to steer the virtual screening process, ligand binding mode prediction, virtual screening for novel ligands, and rational structure-based virtual screening hit optimization. An overview of recent successfu作者: 疼死我了 時間: 2025-3-22 21:54 作者: Relinquish 時間: 2025-3-23 01:45
GPCR & Company: Databases and Servers for GPCRs and Interacting Partnerstheir tasks, GPCRs interact with a variety of partners, including small molecules, lipids and proteins. They are accompanied by different proteins during all phases of their life cycle. Therefore, GPCR interactions with their partners are of great interest in basic cell-signaling research and in dru作者: considerable 時間: 2025-3-23 07:31 作者: Debate 時間: 2025-3-23 12:08
Erratum to: B. Seeh?fen und Seekan?le with their ligands, and to assess their applicability the rational discovery of GPCR modulators. Given the current state of the art and the pace of the field, the future of GPCR structural studies is likely to be characterized by a landscape populated by an increasingly higher number of experimental and theoretical structures.作者: 左右連貫 時間: 2025-3-23 14:41
The GPCR Crystallography Boom: Providing an Invaluable Source of Structural Information and Expandin with their ligands, and to assess their applicability the rational discovery of GPCR modulators. Given the current state of the art and the pace of the field, the future of GPCR structural studies is likely to be characterized by a landscape populated by an increasingly higher number of experimental and theoretical structures.作者: 領(lǐng)袖氣質(zhì) 時間: 2025-3-23 20:40
,Berichte der Arbeitsausschüsse,he use of homology modeling techniques for building three-dimensional models of homologous G protein–coupled receptors, higher order oligomers, and their complexes with ligands and signaling proteins.作者: insurgent 時間: 2025-3-23 22:30 作者: Enzyme 時間: 2025-3-24 06:15
Modeling of G Protein-Coupled Receptors Using Crystal Structures: From Monomers to Signaling Complexhe use of homology modeling techniques for building three-dimensional models of homologous G protein–coupled receptors, higher order oligomers, and their complexes with ligands and signaling proteins.作者: 現(xiàn)任者 時間: 2025-3-24 09:07
Beyond Standard Molecular Dynamics: Investigating the Molecular Mechanisms of G Protein-Coupled Receing mechanistic details of complex receptor processes such as ligand recognition, activation, and oligomerization. We provide here an overview of these methods in their most recent application to the field.作者: 古董 時間: 2025-3-24 14:14 作者: Hormones 時間: 2025-3-24 15:02 作者: Metastasis 時間: 2025-3-24 19:36 作者: 貪婪的人 時間: 2025-3-24 23:28
Structure and Dynamics of G-Protein Coupled Receptors kink angle on the transmembrane helix6. The activation mechanism of the β.-adrenergic receptor has been studied using multiscale computational methods. The results of these studies showed that the receptor without any ligand bound, samples conformations that resemble some of the structural characte作者: peritonitis 時間: 2025-3-25 04:42
How the Dynamic Properties and Functional Mechanisms of GPCRs Are Modulated by Their Coupling to thee membrane-facing surface of GPCRs in their interaction with the surrounding membrane. As the radial asymmetry creates adjacencies of hydrophobic and polar residues at specific sites of the GPCR, the ability of membrane remodeling to achieve complete hydrophobic matching is limited, and the residual作者: 徹底檢查 時間: 2025-3-25 08:32
Coarse-Grained Molecular Dynamics Provides Insight into the Interactions of Lipids and Cholesterol wmicking those found naturally. Our results agree with those found experimentally and in previous simulations, but with far better statistical certainty. The results demonstrate the value of combining all-atom and coarse-grained models with experiment to provide a well-rounded view of lipid-protein i作者: 大范圍流行 時間: 2025-3-25 13:53 作者: CALL 時間: 2025-3-25 19:21
Mathematical Modeling of G Protein-Coupled Receptor Function: What Can We Learn from Empirical and Mn be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.作者: 陶瓷 時間: 2025-3-25 23:42 作者: INTER 時間: 2025-3-26 01:17
Bioinformatics Tools for Predicting GPCR Gene Functions is performed according to their protein-protein interaction type: binding G-protein type, oligomerized partner type, etc. Those methods have achieved predictive accuracies of around 90 %. Finally, I described the future subject of research of the bioinformatics technique about functional prediction作者: 他去就結(jié)束 時間: 2025-3-26 04:55
Book 2014ook, which provides, for the first time, state-of-the-art views on modeling and simulation of GPCRs, is divided into 4 parts. In the first part, the impact of currently available GPCR crystal structures on structural modeling is discussed extensively as are critical insights from simulations in the 作者: 逢迎春日 時間: 2025-3-26 08:27
https://doi.org/10.1007/978-1-4899-5235-6 kink angle on the transmembrane helix6. The activation mechanism of the β.-adrenergic receptor has been studied using multiscale computational methods. The results of these studies showed that the receptor without any ligand bound, samples conformations that resemble some of the structural characte作者: 熱情的我 時間: 2025-3-26 16:31 作者: Acupressure 時間: 2025-3-26 17:44 作者: 過濾 時間: 2025-3-27 00:45 作者: cocoon 時間: 2025-3-27 03:48 作者: 輕而薄 時間: 2025-3-27 06:02 作者: Budget 時間: 2025-3-27 12:00 作者: Debark 時間: 2025-3-27 15:15
0065-2598 of GPCRs, is divided into 4 parts. In the first part, the impact of currently available GPCR crystal structures on structural modeling is discussed extensively as are critical insights from simulations in the 978-94-024-0258-2978-94-007-7423-0Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: Glaci冰 時間: 2025-3-27 19:32
https://doi.org/10.1007/978-94-007-7423-0Bioinformatics; Computational Methods; G Protein-Coupled Receptors; GPCR Dynamics; GPCR Structure; Protei作者: Debility 時間: 2025-3-28 00:11
Erratum to: B. Seeh?fen und Seekan?leeen particularly elusive, and rhodopsin has been for many years the only member of the superfamily with experimentally elucidated structures. However, a number of recent technical and scientific advancements made the determination of GPCR structures more feasible, thus leading to the solution of the作者: LAP 時間: 2025-3-28 06:10 作者: CALL 時間: 2025-3-28 10:02
https://doi.org/10.1007/978-1-4899-5235-6family of drug targets. Hence detailed studies of the three dimensional structure and dynamics are critical to understanding the functional role of GPCRs in signal transduction pathways, and for drug design. In this chapter we compare the features of the crystal structures of various biogenic amine 作者: slow-wave-sleep 時間: 2025-3-28 12:04
https://doi.org/10.1007/978-1-4899-5280-6ated new quantitative studies of the coupling between the proteins and the membrane. It is important to develop such a quantitative understanding at the molecular level because the effects of the coupling are seen to be physiologically and clinically significant. Here we review findings that offer i作者: airborne 時間: 2025-3-28 15:16
Ritualkritik und Rituale des Protestshis is particularly true in the case of membrane proteins, such as the visual receptor rhodopsin. It has been well documented that lipid headgroups, polyunsaturated tails, and the concentration of cholesterol in membranes all play a role in the function of rhodopsin. Recently, we used all-atom simul作者: Benzodiazepines 時間: 2025-3-28 22:18
Everyone Longs for a Master: Lacan and 1968standard molecular dynamics (MD) approaches, notwithstanding the current availability of specialized parallel computer architectures, and efficient simulation algorithms. Enhanced MD-based methods have started to assume an important role in the study of the rugged energy landscape of GPCRs by provid作者: attenuate 時間: 2025-3-29 01:16 作者: Aviary 時間: 2025-3-29 04:14
Tom Winnifrith,William V. Whiteheadysical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulat作者: GLUT 時間: 2025-3-29 08:56 作者: 芳香一點 時間: 2025-3-29 15:20
Kentaro Takami,Luciano Rezzolla,Luca Baiottition is important for the development of novel drugs. Since GPCR proteome is classified hierarchically, general ways for GPCR function prediction are based on hierarchical classification. Various computational tools have been developed to predict GPCR functions; those tools use not simple sequence s作者: nuclear-tests 時間: 2025-3-29 17:22
978-94-024-0258-2The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature B.V. 201作者: hermitage 時間: 2025-3-29 20:44
G Protein-Coupled Receptors - Modeling and Simulation978-94-007-7423-0Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: 贊成你 時間: 2025-3-30 00:18
