標題: Titlebook: G Protein-Coupled Receptor Kinases; Vsevolod V. Gurevich,Eugenia V. Gurevich,John J.G. Book 2016 Springer Science+Business Media New York [打印本頁] 作者: T-cell 時間: 2025-3-21 17:11
書目名稱G Protein-Coupled Receptor Kinases影響因子(影響力)
作者: 昆蟲 時間: 2025-3-21 22:17 作者: 熟練 時間: 2025-3-22 00:30
Rainer-Peter Meyer,Fabrizio Moro,Fritz Heftihis chapter summarizes the current state of knowledge, discusses the relationship between GRK1 and GRK7 in the context of . disease, and pinpoints fruitful future directions for advancement of the vision research field.作者: 材料等 時間: 2025-3-22 05:40 作者: debunk 時間: 2025-3-22 11:14 作者: 軌道 時間: 2025-3-22 15:03
https://doi.org/10.1007/3-540-33316-9 cAMP signaling to Epac/PKCε/ERK- mediated pathway. Via mechanisms that remain to be elucidated, low monocyte GRK2 leads to IL-10 deficiency and prolonged inflammatory pain. The clinical relevance of these findings is discussed in the light of the observed decrease of GRK2 in nociceptors, glia and l作者: 軌道 時間: 2025-3-22 18:55 作者: Herd-Immunity 時間: 2025-3-23 00:53 作者: mosque 時間: 2025-3-23 05:20
100 Keywords Wirtschaftsprüfung, contractility, and blood pressure, in response to catecholamines and other neurohormones. For these reasons, GPCRs are dynamically regulated to prevent overstimulation that could lead to cardiac diseases like heart failure (HF). This dampening process, known as desensitization, is initiated throug作者: 多產(chǎn)子 時間: 2025-3-23 07:27 作者: BABY 時間: 2025-3-23 12:11
1557-2153 upled Receptor Kinases. features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies..978-1-4939-8142-7978-1-4939-3798-1Series ISSN 1557-2153 Series E-ISSN 1940-6053 作者: 大量 時間: 2025-3-23 17:34 作者: acrophobia 時間: 2025-3-23 18:02 作者: Canary 時間: 2025-3-23 23:10
Differential Regulation of IGF-1 and Insulin Signaling by GRKsents of the GPCR system have been described for the insulin receptor (IR) and the insulin-like growth factor type 1 receptor (IGF-1R) and hence the rationale behind the development of a functional RTK/GPCR hybrid model. Given the IGF-1R’s important role in the development and maintenance of a malign作者: 性學院 時間: 2025-3-24 02:37 作者: abnegate 時間: 2025-3-24 07:09
Critical Role of GRK2 in the Prevention of Chronic Pain cAMP signaling to Epac/PKCε/ERK- mediated pathway. Via mechanisms that remain to be elucidated, low monocyte GRK2 leads to IL-10 deficiency and prolonged inflammatory pain. The clinical relevance of these findings is discussed in the light of the observed decrease of GRK2 in nociceptors, glia and l作者: 敬禮 時間: 2025-3-24 12:16 作者: forthy 時間: 2025-3-24 17:54 作者: Mechanics 時間: 2025-3-24 19:35
G-Protein-Coupled Receptors and Their Kinases in Cardiac Regulation, contractility, and blood pressure, in response to catecholamines and other neurohormones. For these reasons, GPCRs are dynamically regulated to prevent overstimulation that could lead to cardiac diseases like heart failure (HF). This dampening process, known as desensitization, is initiated throug作者: BALK 時間: 2025-3-25 02:58
Evolutionarily Conserved Role of G-Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathwaein kinase A, a key regulator of the Cubitus interruptus/GLI family transcription factors that mediate Hh transcriptional responses. This indirect role hints at a broader interconnectivity between GRKs, GPCR signaling, and Hh pathway function, an idea supported by the recent identification of severa作者: Tremor 時間: 2025-3-25 03:46
https://doi.org/10.1007/978-3-642-17267-0ed in numerous aspects of chemosensation, from regulation of specialized sensory structures to circadian control over chemosensory sensitivity. In this chapter, we discuss the functions of both in detail and, to avoid confusion with the mammalian gene names, we refer to the . genes as . and ., respectively.作者: 有罪 時間: 2025-3-25 10:50
GRK Roles in ,ed in numerous aspects of chemosensation, from regulation of specialized sensory structures to circadian control over chemosensory sensitivity. In this chapter, we discuss the functions of both in detail and, to avoid confusion with the mammalian gene names, we refer to the . genes as . and ., respectively.作者: conservative 時間: 2025-3-25 15:17
1557-2153 range of studies from invertebrates to humans.Provides pracThis collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide作者: 贊成你 時間: 2025-3-25 17:25
,Leistungen der Unterstützungskasse,hese enzymes interact with membranes and how they might be regulated. This review highlights these advances and discusses why GRK4 subfamily members may be more predisposed than other GRKs to phosphorylate both active and inactive forms of GPCRs.作者: 收到 時間: 2025-3-25 20:50
Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Rechese enzymes interact with membranes and how they might be regulated. This review highlights these advances and discusses why GRK4 subfamily members may be more predisposed than other GRKs to phosphorylate both active and inactive forms of GPCRs.作者: MOT 時間: 2025-3-26 01:10
Book 2016-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pat作者: 思想 時間: 2025-3-26 08:03 作者: 失誤 時間: 2025-3-26 10:12
https://doi.org/10.1007/978-3-322-83060-9phorylation (the “barcode”) result in distinct consequences in receptor function and signaling. Here, we review these recent findings and discuss the ramifications of this phenomenon in biology and medicine.作者: 流動才波動 時間: 2025-3-26 12:44 作者: ingestion 時間: 2025-3-26 20:10
Structure and Function of G-Protein-Coupled Receptor Kinases 1 and 7olecular basis of GRK activation and interactions with GPCR substrates, as well as the GRK interactions with cellular membranes and inhibitors. Here, we focused on retinal GRKs, or photopigment kinases, rhodopsin kinase (GRK1), and GRK7, in the context of major general advances in the GRK field.作者: 英寸 時間: 2025-3-27 00:47
“Barcode” and Differential Effects of GPCR Phosphorylation by Different GRKsphorylation (the “barcode”) result in distinct consequences in receptor function and signaling. Here, we review these recent findings and discuss the ramifications of this phenomenon in biology and medicine.作者: Myofibrils 時間: 2025-3-27 01:41 作者: Anguish 時間: 2025-3-27 07:21 作者: Physiatrist 時間: 2025-3-27 13:23 作者: Musket 時間: 2025-3-27 14:38 作者: 僵硬 時間: 2025-3-27 19:58
Rainer-Peter Meyer,Fabrizio Moro,Fritz Hefti receptor kinase 1 (GRK1), and a close homolog GRK7, are indispensable for timely phototransduction recovery and dark adaptation of retinal rod and cone photoreceptors. By phosphorylating activated visual pigments, these GRKs enable the binding of visual arrestins to photoexcited pigments to stop ph作者: 發(fā)微光 時間: 2025-3-28 01:51 作者: 放逐某人 時間: 2025-3-28 02:52 作者: 津貼 時間: 2025-3-28 06:21 作者: Chauvinistic 時間: 2025-3-28 11:25 作者: 分離 時間: 2025-3-28 15:43
100 Jahre Dermatologische Klinik Zürich control GPCRs activation of effectors that depend on the G protein βγ subunits (Gβγ), independent of their catalytic activity. GPCR-coupled potassium channels (GIRK) are found in excitable tissues such as neurons, heart, and endocrine organs, where they are known to decrease cells’ excitability fol作者: Bureaucracy 時間: 2025-3-28 20:45 作者: FLAX 時間: 2025-3-29 01:31
https://doi.org/10.1007/978-3-0348-6714-6eptor desensitization, a procedure initiated by a group of kinases, including GPCR kinases (GRKs). GRK2 upregulation and GRK5 deficiency were reported to occur in Alzheimer’s disease. GRK2 accumulation was proposed to participate in cerebral vascular pathology, whereas GRK5 deficiency is believed to作者: 逢迎春日 時間: 2025-3-29 03:50
100 Jahre Schiffbautechnische Gesellschaftin-coupled receptors (GPCRs). Agonist-activated GPCRs are selectively phosphorylated by GRKs, whereupon arrestin proteins bind active phosphoreceptors, blocking further G protein activation, facilitating GPCR internalization via coated pits, and initiating G protein-independent round of signaling. G作者: FLAG 時間: 2025-3-29 07:31
100 Keywords Wirtschaftsprüfungroteins that transduce cell signals via heterotrimeric G proteins from neurohormones, ions, and sensory stimuli to regulate virtually every aspect of mammalian physiology. In the normal and diseased heart, it is apparent that major players include the β-adrenergic receptors (βARs) and the angiotensi作者: Limited 時間: 2025-3-29 14:22
https://doi.org/10.1007/978-3-642-17267-0gnaling. Proteins of the arrestin family then bind to the phosphorylated receptor, blocking both receptor and G-protein reactivation. Thus, GRKs are critical regulators of GPCR signaling that function to protect cells against receptor overstimulation, maintain sensitivity to changing environmental s作者: ablate 時間: 2025-3-29 19:30 作者: 并入 時間: 2025-3-29 23:01 作者: 喃喃訴苦 時間: 2025-3-30 02:56 作者: 磨碎 時間: 2025-3-30 08:07 作者: Fibrillation 時間: 2025-3-30 11:06
G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and DiscoveryPCR field. The existence of GRKs and arrestins revealed the primary mechanism for termination of GPCR signaling. GRKs appeared in evolution long before animals, and it remains to be elucidated whether their first substrates were GPCRs or other proteins. It is also unclear whether and how GRKs are ac作者: Deduct 時間: 2025-3-30 14:59 作者: botany 時間: 2025-3-30 17:52 作者: Dysplasia 時間: 2025-3-30 21:57
Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Recignals during stress. The seven human GRKs belong to three subfamilies with distinct structural features and membrane targeting mechanisms. Although crystal structures representing each subfamily have now been reported, a recent series of GRK4 subfamily structures provide new information about how t作者: MANIA 時間: 2025-3-31 02:58
“Barcode” and Differential Effects of GPCR Phosphorylation by Different GRKster of modern medicine. Multiple site phosphorylation of GPCRs by G protein-coupled receptor kinases (GRKs) plays an essential role in the regulation of various functions and signaling cascades of a receptor. Research in recent years has elucidated a common mechanism by which different ligand-bound 作者: 得意人 時間: 2025-3-31 07:58
Cell-Type Specific GRK2 Interactomes: Pathophysiological Implicationsreceptors, GRK2 can phosphorylate and/or functionally interact with a complex network of cellular proteins in a cell-type and physiological context-dependent way. A combination of such canonical and noncanonical interactions underlies the participation of this kinase in the control of cell migration
