標(biāo)題: Titlebook: G Protein-Coupled Receptor Genetics; Research and Methods Craig W. Stevens Book 2014 Springer Science+Business Media New York 2014 G Protei [打印本頁(yè)] 作者: 休耕地 時(shí)間: 2025-3-21 16:56
書目名稱G Protein-Coupled Receptor Genetics影響因子(影響力)
作者: fulcrum 時(shí)間: 2025-3-21 23:24 作者: Cerebrovascular 時(shí)間: 2025-3-22 00:31
G Protein-Coupled Receptor Genetics978-1-62703-779-2Series ISSN 1557-2153 Series E-ISSN 1940-6053 作者: BLINK 時(shí)間: 2025-3-22 07:51
Katheter-assoziierte Infektionenategorize those genes, and follow their evolutionary history. Being present in fungi, plants, and unicellular eukaryotes, GPCR must have evolved before the plant-fungi-animal split about 1.5 billion years ago. Phylogenetic analyses revealed several kinds of evolutionary patterns that occurred during作者: PLUMP 時(shí)間: 2025-3-22 11:50 作者: 不可比擬 時(shí)間: 2025-3-22 15:22 作者: 不可比擬 時(shí)間: 2025-3-22 19:32
https://doi.org/10.1007/978-3-662-05545-8 different vertebrate species. There is evidence for the existence of opioid receptors from very early in evolution, and here we discuss a possible evolutionary path for their development. The physiological characteristics of the endogenous opioid system as well as the biochemical and pharmacologica作者: 獨(dú)裁政府 時(shí)間: 2025-3-22 22:21
1x1 der chirurgischen Instrumentecting proteins, or modulate downstream signaling molecules. Where appropriate agents are unobtainable, alternative molecular methods have been developed to determine the specific roles that individual proteins play in GPCR regulation and signaling. One such method utilizes RNA interference (RNAi) to作者: 時(shí)代 時(shí)間: 2025-3-23 01:24 作者: 針葉 時(shí)間: 2025-3-23 07:54
https://doi.org/10.1007/978-3-642-50767-0trol of neuronal signaling and could allow for the study of receptor pathways that occur faster than the rate of diffusion. Furthermore, with the aid of implantable light devices, light-activated receptors have the potential for use in live animals and later in humans to control and cure G protein-c作者: Outshine 時(shí)間: 2025-3-23 13:30
https://doi.org/10.1007/978-3-642-73191-4pled receptors (GPCRs) or other proteins of interest. Adenoviruses are non-enveloped viruses containing a linear double-stranded DNA genome. Their life cycle does not normally involve integration into the host genome, rather they replicate as episomal elements in the nucleus of the host cell, and co作者: Nutrient 時(shí)間: 2025-3-23 17:26
https://doi.org/10.1007/978-1-349-09984-9no acid residues that contribute to ligand binding, G protein coupling, and receptor folding. Mutagenesis is commonly used to change or mutate a DNA sequence so that one or more amino acid residues in a given G protein-coupled receptor are changed to different residues. These techniques can also be 作者: Prostatism 時(shí)間: 2025-3-23 21:56 作者: addition 時(shí)間: 2025-3-23 22:53
Daniel G. Bachrach,Eric J. Rzeszuteveral GPCRs and a new era of conformational dynamic studies of GPCRs is in fast progress. Traditional pharmacological studies in tissues and native cells yielded structure-function relationships through the manipulation of the drugs, resulting in a rich array of tools for research as well as use in作者: initiate 時(shí)間: 2025-3-24 04:06
Die ersten Wochen im neuen Job,nd neurotransmitters and hence are central players in communication between the cells of multicellular organisms and their environment. Characterization of these receptors at the molecular level has shown that GPCRs form dimers or oligomers (for simplicity, herein called dimers), yet their function 作者: Asymptomatic 時(shí)間: 2025-3-24 08:14
Zentrale Akteure und Strukturen,ing also underlies certain acquired pathological conditions. The coupling of most GPCRs to their cognate G proteins is stopped by the natural desensitization mechanism, which includes receptor phosphorylation by GRKs followed by arrestin binding to active phosphoreceptor. Elucidation of the molecula作者: 審問(wèn) 時(shí)間: 2025-3-24 14:24
https://doi.org/10.1007/978-3-031-53108-8ular regulatory activities. By virtue of widespread distribution and important roles in cell physiology and biochemistry, GPCRs play multiple important roles in clinical medicine. The understanding of how GPCRs interact with G proteins, effectors, as well as other regulatory proteins has enormous im作者: 和藹 時(shí)間: 2025-3-24 15:44
The molecular biology of disease resistance,individual’s lifestyle. Essential hypertension is a major public health challenge because it affects one in every three adult Americans and about one billion people worldwide, yet its current treatment is empirical and is focused on the remediation of a physical sign (i.e., high blood pressure [BP])作者: 貧窮地活 時(shí)間: 2025-3-24 19:29
Eddi E. lernt zu differenzieren,G protein-coupled receptors (GPCRs) are the number one class of receptor targets for the pharmacotherapy of many pathological and disease states. This chapter presents an overview of the chapter topics presented in this new volume on the genetics of GPCRs.作者: 我怕被刺穿 時(shí)間: 2025-3-25 02:18
G Protein-Coupled Receptors: Research and Methods in the Post-Genomic EraG protein-coupled receptors (GPCRs) are the number one class of receptor targets for the pharmacotherapy of many pathological and disease states. This chapter presents an overview of the chapter topics presented in this new volume on the genetics of GPCRs.作者: 尖叫 時(shí)間: 2025-3-25 03:45
https://doi.org/10.1007/978-1-62703-779-2G Protein-Coupled Receptors; GPCRs; Genetic Mechanisms; Membrane Protein; Receptor Discovery; Proteomics作者: 嬉耍 時(shí)間: 2025-3-25 09:00
1557-2153 are lab-proven and ready to use.Includes expert opinions on.G Protein.‐.Coupled Receptor Genetics: Research and Methods in the Post.‐.Genomic Era. features practical techniques inspired by the fast moving GPCR field.?From powerful bioinformatic tools tracing the evolution of GPCRs, to methods for t作者: 馬籠頭 時(shí)間: 2025-3-25 15:34
https://doi.org/10.1007/978-3-642-50767-0of implantable light devices, light-activated receptors have the potential for use in live animals and later in humans to control and cure G protein-coupled receptor (GPCR) pathways involved in diseases. We will summarize here the latest developments for controlling intracellular signaling pathways by light-activated GPCRs and enzymes.作者: Thyroiditis 時(shí)間: 2025-3-25 19:27
Use of Optogenetic Approaches to Control Intracellular Signaling of G Protein-Coupled Receptorsof implantable light devices, light-activated receptors have the potential for use in live animals and later in humans to control and cure G protein-coupled receptor (GPCR) pathways involved in diseases. We will summarize here the latest developments for controlling intracellular signaling pathways by light-activated GPCRs and enzymes.作者: 辯論 時(shí)間: 2025-3-25 22:51 作者: rods366 時(shí)間: 2025-3-26 01:35
The molecular biology of disease resistance,sion and target organ susceptibility, as well as predict therapeutic efficacy. An increasing number of studies have shown that certain variants of genes that regulate blood pressure, including G protein-coupled receptors (GPCRs), also affect the response to antihypertensive treatment.作者: 墊子 時(shí)間: 2025-3-26 06:44 作者: 挫敗 時(shí)間: 2025-3-26 09:19
Examining the Dynamic Evolution of G Protein-Coupled Receptorsategorize those genes, and follow their evolutionary history. Being present in fungi, plants, and unicellular eukaryotes, GPCR must have evolved before the plant-fungi-animal split about 1.5 billion years ago. Phylogenetic analyses revealed several kinds of evolutionary patterns that occurred during作者: 胰臟 時(shí)間: 2025-3-26 13:16
Functional Properties of Virus-Encoded and Virus-Regulated G Protein-Coupled Receptorsprotein-coupled receptors (GPCRs). These include virus-encoded GPCRs and ligands and viral regulation of endogenous GPCRs. Many functional properties have been ascribed to virus-exploited GPCRs, and although the list of putative functions is steadily growing, the presence and/or function of virus-as作者: forthy 時(shí)間: 2025-3-26 19:40 作者: puzzle 時(shí)間: 2025-3-26 21:18 作者: vascular 時(shí)間: 2025-3-27 03:36
Investigation of G Protein-Coupled Receptor Function and Regulation Using Antisensecting proteins, or modulate downstream signaling molecules. Where appropriate agents are unobtainable, alternative molecular methods have been developed to determine the specific roles that individual proteins play in GPCR regulation and signaling. One such method utilizes RNA interference (RNAi) to作者: Calibrate 時(shí)間: 2025-3-27 09:07 作者: agitate 時(shí)間: 2025-3-27 10:02 作者: 壓迫 時(shí)間: 2025-3-27 15:37
Viral Infection for G Protein-Coupled Receptor Expression in Eukaryotic Cellspled receptors (GPCRs) or other proteins of interest. Adenoviruses are non-enveloped viruses containing a linear double-stranded DNA genome. Their life cycle does not normally involve integration into the host genome, rather they replicate as episomal elements in the nucleus of the host cell, and co作者: Anthrp 時(shí)間: 2025-3-27 19:37 作者: 使腐爛 時(shí)間: 2025-3-28 00:21 作者: Itinerant 時(shí)間: 2025-3-28 03:01 作者: browbeat 時(shí)間: 2025-3-28 09:43 作者: 掙扎 時(shí)間: 2025-3-28 12:29
Design of Super-arrestins for Gene Therapy of Diseases Associated with Excessive Signaling of G Proting also underlies certain acquired pathological conditions. The coupling of most GPCRs to their cognate G proteins is stopped by the natural desensitization mechanism, which includes receptor phosphorylation by GRKs followed by arrestin binding to active phosphoreceptor. Elucidation of the molecula作者: 宏偉 時(shí)間: 2025-3-28 16:10
Importance of G Protein-Coupled Receptor Genetics in Clinical Medicineular regulatory activities. By virtue of widespread distribution and important roles in cell physiology and biochemistry, GPCRs play multiple important roles in clinical medicine. The understanding of how GPCRs interact with G proteins, effectors, as well as other regulatory proteins has enormous im作者: Devastate 時(shí)間: 2025-3-28 21:37 作者: –吃 時(shí)間: 2025-3-28 23:26 作者: 認(rèn)識(shí) 時(shí)間: 2025-3-29 05:42 作者: gout109 時(shí)間: 2025-3-29 11:18 作者: SPER 時(shí)間: 2025-3-29 15:15
Discovery and Function of the Very Large G Protein-Coupled Receptormpairment. VLGR1 is one of the few adhesion GPCR family members in which mutations have been shown to be responsible for a human malady. Mutations in VLGR1 in humans result in one form (2C) of Usher syndrome, the most common genetic cause of combined blindness and deafness. Consistent with this phen作者: 凹槽 時(shí)間: 2025-3-29 16:11 作者: 一再煩擾 時(shí)間: 2025-3-29 23:04 作者: 按時(shí)間順序 時(shí)間: 2025-3-30 03:55 作者: Institution 時(shí)間: 2025-3-30 05:14 作者: mortuary 時(shí)間: 2025-3-30 10:43
Using , Mutagenesis to Characterize Structure-Function Relationships in G Protein-Coupled Receptorsm mutagenesis, scanning mutagenesis, deletion mutagenesis, and the construction of receptor chimeras. Important considerations for conducting and interpreting mutagenesis studies are also highlighted.作者: Working-Memory 時(shí)間: 2025-3-30 14:19 作者: 延期 時(shí)間: 2025-3-30 17:32
Inducing Conformational Changes in G Protein-Coupled Receptors by Domain Coupling control transmembrane signal transduction and intracellular processes in mediating diverse physiological and pathophysiological pathways. This chapter focuses on one such operational principle – induction of conformational changes through domain coupling – by which GPCRs operate.作者: PALMY 時(shí)間: 2025-3-30 21:16
Rescue of Defective G Protein-Coupled Receptor Function by Intermolecular Cooperationsuch as the glycoprotein hormone receptors. Before explaining the phenomenon of intermolecular cooperation between domains of GPCR dimers, this chapter first discusses the molecular interactions between GPCR dimers, which leads to .-activation, and then explains various experimental strategies emplo作者: 殘廢的火焰 時(shí)間: 2025-3-31 02:33 作者: Epidural-Space 時(shí)間: 2025-3-31 08:53
Importance of G Protein-Coupled Receptor Genetics in Clinical Medicine the most relevant research topics about the implication of heterotrimeric G proteins in the etiology of genetics and neurobiology of mood will provide a broad perspective of this potential therapeutic target field. In this chapter, an attempt is made to show how far GPCR research advanced with rega作者: 刪除 時(shí)間: 2025-3-31 10:32
