標(biāo)題: Titlebook: Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy; Divya Vohora Book 2021 Springer Science+Bu [打印本頁(yè)] 作者: Coarse 時(shí)間: 2025-3-21 17:56
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書(shū)目名稱Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy讀者反饋
書(shū)目名稱Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy讀者反饋學(xué)科排名
作者: 改進(jìn) 時(shí)間: 2025-3-21 20:41
Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy978-1-0716-1254-5Series ISSN 0893-2336 Series E-ISSN 1940-6045 作者: minion 時(shí)間: 2025-3-22 04:13
Andreas Kornelakis,Horen VoskeritsianSince the discovery of phenytoin in the 1930s, almost all antiseizure drugs (ASDs) have been identified by their effects in animal models, and millions of patients have profited from the successful translation of animal data into the clinic. However, several unmet clinical needs remain, including re作者: Amendment 時(shí)間: 2025-3-22 06:53
Zoltan J. Acs,László Szerb,Erkko Autiod 30% of patients become resistant. Better understanding of epileptogenesis, the process in which the injury-induced cellular and subcellular modifications transform a healthy neuronal network to a malfunctioned state, has the potential to generate novel, more effective treatments. Creating a model 作者: voluble 時(shí)間: 2025-3-22 11:56
Zoltan J. Acs,László Szerb,Erkko Autioal pathophysiological pattern. These models are being used for the screening of new antiseizure drugs as well as for the evaluation of associated cell-signaling events. Considering these applications, in this chapter, we describe a novel method for the screening of antiseizure molecules using an in 作者: 易于出錯(cuò) 時(shí)間: 2025-3-22 15:24 作者: 易于出錯(cuò) 時(shí)間: 2025-3-22 20:55
Methodology and Data Description,ventional MES test, seizures are induced by applying an electrical stimulus of high intensity and high frequency for a short duration, which evokes tonic seizures that are manifested by a rigid extension of the hindlimbs. The subcutaneous (s.c.) PTZ test is in turn employed to produce clonic seizure作者: floodgate 時(shí)間: 2025-3-23 00:34 作者: Admire 時(shí)間: 2025-3-23 02:12 作者: 改正 時(shí)間: 2025-3-23 07:37
Global Environmental Changes in South Asiastanding the process of epileptogenesis, determining the natural history of the disease, and discovering new therapies. Central to these questions is seeing the seizures behaviorally and physiologically. Because the seizures occur spontaneously and unpredictably, continuous EEG and video monitoring 作者: 集聚成團(tuán) 時(shí)間: 2025-3-23 13:06
Issues of Global Environmental Economics,ify the drugs or molecules acting via different mechanisms, unlike the traditional models. Seizure is induced by corneal stimulation (6?Hz, 0.2?ms for 3?s duration) using electroconvulsometer. The characteristic features seen in rodents are stun position and minimal clonic phase, followed by stereot作者: malapropism 時(shí)間: 2025-3-23 15:46 作者: 擴(kuò)大 時(shí)間: 2025-3-23 18:16
https://doi.org/10.1057/9780230601222natal seizures are the most common neurological emergency in newborns, occurring in 1–3.5 per 1000 newborns. The majority of neonatal seizures, chiefly those associated with hypoxic ischemic encephalopathy (HIE), are refractory to first-line anti-seizure medications (ASMs). The global first-line ASM作者: forthy 時(shí)間: 2025-3-23 22:55
https://doi.org/10.1007/978-1-349-25211-4motor and cognition dysfunction. In contrast, epilepsy is characterized by a chronic tendency to spawn these epileptic seizures. One way of studying epilepsy or seizures is to induce either acute seizures or epilepsy in animals via chemoconvulsants such as pentylenetetrazol (acute seizures) or kaini作者: STALE 時(shí)間: 2025-3-24 05:04
J. John Sepkoski Jr.,Carl F. Kochne third of people with epilepsy do not respond to currently available treatments, and so new AEDs are surely?needed. However, traditional rodent models are expensive, pose ethical problems, and are poorly suited to high-throughput drug discovery. As a result, methods for front-line screening of com作者: Mendicant 時(shí)間: 2025-3-24 10:18 作者: STAT 時(shí)間: 2025-3-24 11:53 作者: Myocarditis 時(shí)間: 2025-3-24 15:22 作者: 語(yǔ)言學(xué) 時(shí)間: 2025-3-24 19:54
Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy作者: 大火 時(shí)間: 2025-3-25 01:06 作者: Blanch 時(shí)間: 2025-3-25 04:44 作者: 不法行為 時(shí)間: 2025-3-25 07:36 作者: 致命 時(shí)間: 2025-3-25 12:17
https://doi.org/10.1007/978-1-349-21816-5ng, and interpretation of neurodegenerative changes along with the troubleshooting associated with the procedure are described. Our aim is to provide guidance for the readers to induce recurrent seizures in rodents that resemble the continuous spontaneous seizures associated with TLE.作者: Intruder 時(shí)間: 2025-3-25 17:32
https://doi.org/10.1007/978-3-319-98110-9d recording electrodes and the large size of rats that prohibits the early evaluation of investigational compound libraries. Furthermore, despite the more than 20 ASMs on the market today, nearly 30% of patients with epilepsy remain resistant to these currently available medications. To address this作者: 社團(tuán) 時(shí)間: 2025-3-25 21:21 作者: surrogate 時(shí)間: 2025-3-26 03:24 作者: 火花 時(shí)間: 2025-3-26 06:31
0893-2336 and Epilepsy. is a valuable resource for researchers, in both industry and academia, interested in learning about this important and developing field..978-1-0716-1256-9978-1-0716-1254-5Series ISSN 0893-2336 Series E-ISSN 1940-6045 作者: 儀式 時(shí)間: 2025-3-26 09:47 作者: bioavailability 時(shí)間: 2025-3-26 12:58
Acute Seizure Tests Used in Epilepsy Research: Step-by-Step Protocol of the Maximal Electroshock Sei PTZ test in detail. In addition, we describe the method used for the assessment of seizure thresholds in the maximal electroshock seizure threshold (MEST) test, s.c. PTZ test, and the timed intravenous PTZ test in mice. All the protocols include the materials used, step-by-step instructions, and so作者: 避開(kāi) 時(shí)間: 2025-3-26 17:51
Procedures for Electrical and Chemical Kindling Models in Rats and Micehophysiological role of a protein of interest based on kindling in genetically modified animals. Comparison of preclinical and clinical findings confirmed a high predictive validity for the testing of drug candidates in fully kindled animals. Thus, kindling models remain a mainstay of antiseizure dr作者: 盡責(zé) 時(shí)間: 2025-3-26 22:36 作者: MINT 時(shí)間: 2025-3-27 03:14
A Method to Induce Lamotrigine-Resistant Corneal Kindled Miced recording electrodes and the large size of rats that prohibits the early evaluation of investigational compound libraries. Furthermore, despite the more than 20 ASMs on the market today, nearly 30% of patients with epilepsy remain resistant to these currently available medications. To address this作者: 無(wú)聊點(diǎn)好 時(shí)間: 2025-3-27 08:21 作者: TAP 時(shí)間: 2025-3-27 10:19 作者: TRACE 時(shí)間: 2025-3-27 16:31
Book 2021for ex vivo and in vitro experimental models and widely-used in vivo (acute and chronic seizure) models in epilepsy research. Chapters also cover techniques to screen the effective leads for the treatment of refractory seizures of pharmacoresistant epilepsy and invertebrate, non-mammalian models. In作者: Supplement 時(shí)間: 2025-3-27 21:38 作者: 慷慨不好 時(shí)間: 2025-3-27 22:00 作者: 過(guò)份好問(wèn) 時(shí)間: 2025-3-28 04:24 作者: 假裝是我 時(shí)間: 2025-3-28 09:43
Models of Seizures and Epilepsy: Important Tools in the Discovery and Evaluation of Novel Epilepsy Tprevent development of epilepsy in patients at risk following brain injury. This minireview, which serves as an introduction to the Neuromethods volume ., briefly introduces the challenges and opportunities for in vivo and in vitro models of seizures and epilepsy and how such models may help to develop the next generation of drug therapies.作者: 恭維 時(shí)間: 2025-3-28 14:13 作者: 痛苦一下 時(shí)間: 2025-3-28 18:33
Book 2021oratory.?.Cutting-edge and practical, .Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy. is a valuable resource for researchers, in both industry and academia, interested in learning about this important and developing field..作者: 射手座 時(shí)間: 2025-3-28 21:13 作者: 戲服 時(shí)間: 2025-3-29 01:07
Zoltan Acs,László Szerb,Erkko Autiotients with hippocampal sclerosis, the most common DRE pathology using patch clamp electrophysiology. Our aim is to provide a guideline on how to apply the cellular electrophysiological methods to study altered synaptic transmission associated with DRE and its application to identify drug-resistant epileptogenic network.作者: 舊石器 時(shí)間: 2025-3-29 04:31
Global Environmental Changes in South Asiaing as well as provide an outline of the key components of the recording system, including housing, that are needed to perform the studies. In addition, we offer suggestions what precautions are necessary and the potential technical and interpretive pitfalls.作者: Parley 時(shí)間: 2025-3-29 08:51
J. John Sepkoski Jr.,Carl F. Kochns of both assay and the?animal model. In addition, we give examples of how the assay can be used to determine pathogenicity in epilepsy-associated genetic variants, to screen for anticonvulsants, and to identify AED mechanisms of action.作者: 破譯 時(shí)間: 2025-3-29 12:23
Protocol for Rodent Organotypic Hippocampal Slice Culture Model for Ex Vivo Monitoring of Epileptogeses different aspects of the epileptogenesis process in a compressed time scale such that within 7?days, cultures become spontaneously epileptic. Here, in this chapter, we seek to elucidate and describe several methodologies that can be utilized to study epileptogenesis in vitro.作者: essential-fats 時(shí)間: 2025-3-29 16:41
Cellular Electrophysiological Methods to Decipher the Altered Synaptic Transmission Associated with tients with hippocampal sclerosis, the most common DRE pathology using patch clamp electrophysiology. Our aim is to provide a guideline on how to apply the cellular electrophysiological methods to study altered synaptic transmission associated with DRE and its application to identify drug-resistant epileptogenic network.作者: 性別 時(shí)間: 2025-3-29 20:29 作者: persistence 時(shí)間: 2025-3-30 00:22 作者: PET-scan 時(shí)間: 2025-3-30 06:32
Models of Seizures and Epilepsy: Important Tools in the Discovery and Evaluation of Novel Epilepsy TSince the discovery of phenytoin in the 1930s, almost all antiseizure drugs (ASDs) have been identified by their effects in animal models, and millions of patients have profited from the successful translation of animal data into the clinic. However, several unmet clinical needs remain, including re作者: 異教徒 時(shí)間: 2025-3-30 10:21
