作者: 繁忙 時(shí)間: 2025-3-21 22:55 作者: 古董 時(shí)間: 2025-3-22 03:57 作者: Decimate 時(shí)間: 2025-3-22 06:58 作者: shrill 時(shí)間: 2025-3-22 09:55
DPOAEs for the Assessment of Noise- or Toxicant-Induced Cochlear Damage in the Raten stimulated simultaneously by two pure tone frequencies. DPOAEs are useful because they are reduced or absent when the OHCs are impaired by noise or ototoxic agents, and they offer an objective and noninvasive assessment of the OHC function, which is not mitigated by central plasticity. Here, we p作者: ORE 時(shí)間: 2025-3-22 15:35
Use of Visual Evoked Potentials to Assess Deficits in Contrast Sensitivity in Rats Following Neurotoats. When recorded over a range of visual pattern contrast values, the results can be used to derive estimates of visual contrast threshold, contrast sensitivity, and contrast gain. Visual contrast is defined as the difference between the bright and dark regions of a visual pattern, adjusted for the作者: ORE 時(shí)間: 2025-3-22 17:44 作者: A保存的 時(shí)間: 2025-3-23 00:46 作者: 招待 時(shí)間: 2025-3-23 01:49
Assessment of Olfactory Toxicity in Rodentsy neurons found within the olfactory epithelium that lines part of the dorsal or dorsoposterior nasal cavity. These neurons play a critical role in olfaction and current tests of the integrity or function of the olfactory system in rodents often begins with a histologic assessment of this epithelium作者: 座右銘 時(shí)間: 2025-3-23 07:52 作者: inscribe 時(shí)間: 2025-3-23 12:28
Assessing Neurotoxicant-Induced Inflammation in the Central Nervous System: Cytokine mRNA with Immunresult from injury and trauma. It serves as a balanced process of pro- and anti-inflammatory responses to maintain normal tissue. The increased role of inflammation in the manifestation of neurotoxicity, whether directly induced or the result of pathological changes, has led to assessments of inflam作者: habile 時(shí)間: 2025-3-23 16:52
Mitochondrial Stress Assay and Glycolytic Rate Assay in Microglia Using Agilent Seahorse Extracellulg cellular health and functional capabilities. The more recent evidence that indicates mitochondria as a critical central component of immunity and inflammatory responses has prompted research into mitochondrial functions in immune cells. Mitochondrial biogenesis, fusion, and fission have contributo作者: Obsequious 時(shí)間: 2025-3-23 20:11
Rhesa N. Ledbetter,Timothy S. Magnusonbstances that reduce silver ions against the natural reducing properties of the tissue, can also successfully reveal degenerative changes in the nervous system. It is not known how silver binds these degenerating elements. During degeneration, silver ions may form complexes with exposed amino acid c作者: 采納 時(shí)間: 2025-3-23 22:57
Eva Pakostova,Carmen Falagan,Ruiyong Zhang highly vulnerable because of their location in the cochlea. These cells are indeed subjected both to mechanical stress, through the vibration of the basilar membrane at the base of sound transduction, and to chemical exposure, through the imperfectly protective blood–labyrinth barrier of the .. Coc作者: 直覺(jué)沒(méi)有 時(shí)間: 2025-3-24 02:30
Jean-Paul Bravard,Pauline Gaydound the afferent terminals of the post-synaptic ganglion neurons have also been shown to be a target of ototoxic damage. In this chapter, we describe immunohistochemistry protocols adapted to the quantification of hair cells and synapses in the vestibular epithelia to assess ototoxic damage in rodent作者: opalescence 時(shí)間: 2025-3-24 09:12 作者: deforestation 時(shí)間: 2025-3-24 11:52
Jeff Warburton,Mark Macklin,David Prestonen stimulated simultaneously by two pure tone frequencies. DPOAEs are useful because they are reduced or absent when the OHCs are impaired by noise or ototoxic agents, and they offer an objective and noninvasive assessment of the OHC function, which is not mitigated by central plasticity. Here, we p作者: 粗鄙的人 時(shí)間: 2025-3-24 18:37 作者: 青石板 時(shí)間: 2025-3-24 19:36 作者: 指派 時(shí)間: 2025-3-24 23:17 作者: labile 時(shí)間: 2025-3-25 07:05 作者: CORD 時(shí)間: 2025-3-25 10:43
On the History of Tropical Geomorphology,in behavior. Behavior encompasses multiple domains, and numerous behavioral testing paradigms, ranging from simple to complex, are available for assessment within each such domain and described in the literature. Many laboratories adapt the simplest procedures, based on the assumption that these pro作者: 猛擊 時(shí)間: 2025-3-25 14:39 作者: 商議 時(shí)間: 2025-3-25 15:48
Ping An,Wooil M. Moon,Fotis Kalantzisg cellular health and functional capabilities. The more recent evidence that indicates mitochondria as a critical central component of immunity and inflammatory responses has prompted research into mitochondrial functions in immune cells. Mitochondrial biogenesis, fusion, and fission have contributo作者: Sedative 時(shí)間: 2025-3-25 21:02 作者: visceral-fat 時(shí)間: 2025-3-26 02:46
Neuromethodshttp://image.papertrans.cn/e/image/318888.jpg作者: 混合 時(shí)間: 2025-3-26 04:19 作者: 不合 時(shí)間: 2025-3-26 10:20
978-1-0716-1639-0Springer Science+Business Media, LLC, part of Springer Nature 2021作者: 摸索 時(shí)間: 2025-3-26 13:45 作者: Exploit 時(shí)間: 2025-3-26 18:04
Michael E. Meadows,Jiun-Chuan LinThe rat functional observational battery is the regulatory standard assay for the assessment of the central nervous system prior to the first dose administration in man. This chapter describes the utility and scientific foundation for the general adoption of this technique by both European and the United States drug regulatory agencies.作者: 混沌 時(shí)間: 2025-3-26 23:30
The Functional Observation Battery: Utility in Safety Assessment of New Molecular EntitiesThe rat functional observational battery is the regulatory standard assay for the assessment of the central nervous system prior to the first dose administration in man. This chapter describes the utility and scientific foundation for the general adoption of this technique by both European and the United States drug regulatory agencies.作者: spondylosis 時(shí)間: 2025-3-27 02:39 作者: 粉筆 時(shí)間: 2025-3-27 07:42
Book 2021ver a variety of available methods from the molecular level to the organism level, and both in vitro and in vivo approaches, including alternative model organisms. In the .Neuromethods. series style, chapters include the kind of detail and key advice from the specialists needed to get successful res作者: aphasia 時(shí)間: 2025-3-27 10:35 作者: 索賠 時(shí)間: 2025-3-27 15:11 作者: 上下連貫 時(shí)間: 2025-3-27 18:45
Jean-Paul Bravard,Pauline Gaydoubefore confocal microscopy imaging. The data thus obtained offer a thorough evaluation of the damage suffered by the vestibular sensory epithelia, including overt hair cell loss and subtle synaptic loss. Together, these pathological outcomes determine the loss vestibular input and the resulting behavioral alterations.作者: 饑荒 時(shí)間: 2025-3-27 23:16 作者: right-atrium 時(shí)間: 2025-3-28 03:34
Evaluation of Cellular and Molecular Pathology in the Rodent Vestibular Sensory Epithelia by Immunofbefore confocal microscopy imaging. The data thus obtained offer a thorough evaluation of the damage suffered by the vestibular sensory epithelia, including overt hair cell loss and subtle synaptic loss. Together, these pathological outcomes determine the loss vestibular input and the resulting behavioral alterations.作者: 詳細(xì)目錄 時(shí)間: 2025-3-28 08:39 作者: 譏笑 時(shí)間: 2025-3-28 12:14 作者: 廣大 時(shí)間: 2025-3-28 17:19
DPOAEs for the Assessment of Noise- or Toxicant-Induced Cochlear Damage in the Ratrovide a detailed method to measure DPOAEs in rats. We emphasize especially on the calibration of the sound stimulation and the analysis of the otoacoustic emissions, which?ensure the reliability of the method.作者: 語(yǔ)源學(xué) 時(shí)間: 2025-3-28 21:43 作者: 含糊其辭 時(shí)間: 2025-3-28 23:54 作者: AER 時(shí)間: 2025-3-29 04:02
Assessment of Auditory Hair Cell Loss by Cytocochleograms considered species provides a wealth of information, both quantitative and objective, on the type and severity of the exposure. This article describes a method to (1) harvest the cochlea, (2) stain and dissect the organ of Corti, (2) quantify the hair cell loss, and (3) construct a graphic represen作者: ordain 時(shí)間: 2025-3-29 10:12
Use of Visual Evoked Potentials to Assess Deficits in Contrast Sensitivity in Rats Following Neurotoual patterns. The resulting evoked potentials are signal averaged, subjected to spectral analysis and interpreted relative to the contrast of the eliciting visual patterns. The resulting parameters include measurements of response amplitude, contrast threshold, contrast sensitivity, and contrast gai作者: 極端的正確性 時(shí)間: 2025-3-29 12:33 作者: 過(guò)分 時(shí)間: 2025-3-29 15:50
Assessment of Olfactory Toxicity in Rodentssts evaluating olfactory discrimination or olfactory thresholds in exposed animals. These more complicated tests often require specialized equipment and extensive training of the animal to display an odor-mediated behavior. This chapter provides an update of our current understanding of chemically i作者: 肉體 時(shí)間: 2025-3-29 23:15
Assessment of Neurotoxicant-Induced Changes in Behavior : Issues Related to Interpretation of Outcomnge in behavior, particularly for cognitive/executive functions, such as learning. Additionally, this chapter addresses issues related to the use and misuse of test batteries and the influence of the behavioral history resulting from use of a test battery that may interact with the toxicant treatmen
