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標(biāo)題: Titlebook: Experimental Cholestasis Research; Mathieu Vinken Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Drug-induce [打印本頁(yè)]

作者: 傳家寶    時(shí)間: 2025-3-21 17:08
書目名稱Experimental Cholestasis Research影響因子(影響力)




書目名稱Experimental Cholestasis Research影響因子(影響力)學(xué)科排名




書目名稱Experimental Cholestasis Research網(wǎng)絡(luò)公開度




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書目名稱Experimental Cholestasis Research被引頻次




書目名稱Experimental Cholestasis Research被引頻次學(xué)科排名




書目名稱Experimental Cholestasis Research年度引用




書目名稱Experimental Cholestasis Research年度引用學(xué)科排名




書目名稱Experimental Cholestasis Research讀者反饋




書目名稱Experimental Cholestasis Research讀者反饋學(xué)科排名





作者: 終點(diǎn)    時(shí)間: 2025-3-21 23:03
Vesicle- and Hepatocyte-Based Assays for Identification of Drug Candidates Inhibiting BSEP Functionsubstrate signal can be determined in the cells and bile or the cells alone, respectively. Performing this assay in the presence and absence of potentially interfering compounds of interest enables exploration of the relative effect of these compounds on biliary excretion of the probe substrate.
作者: placebo-effect    時(shí)間: 2025-3-22 00:47

作者: 多產(chǎn)魚    時(shí)間: 2025-3-22 06:35
In Vivo Measurement of Hepatic Drug Transporter Inhibition with Radiolabeled Bile Acids,sporters in mice, using the nuclear imaging techniques positron emission tomography and single photon emission computed tomography. The protocol includes detailed information on preparation of the animal, scan acquisition, processing, and (statistical) analysis.
作者: Cleave    時(shí)間: 2025-3-22 09:09

作者: frozen-shoulder    時(shí)間: 2025-3-22 13:11

作者: frozen-shoulder    時(shí)間: 2025-3-22 18:23
Transcriptomic Analysis of Cholestatic Compounds In Vitro,r repeat exposure-related toxicities, as well as for the study of adaptive responses. This primary human hepatocyte culture system combined with transcriptomics carries the future promise to identify individual gene expression profiles predictive of increased drug-induced cholestasis risk..This chap
作者: Digest    時(shí)間: 2025-3-22 23:18
System Microscopy of Stress Response Pathways in Cholestasis Research,having cholestasis liability and affected genes during cholestatic injury on cellular adaptive stress pathway activation. The approach involves high-throughput live-cell visualization of GFP-tagged key proteins of the oxidative stress response/Nrf2 pathway and inflammatory cytokine signaling. Quanti
作者: RADE    時(shí)間: 2025-3-23 04:04
1064-3745 .Experimental Cholestasis Research. serves as an ideal guide for basic andapplied researchers pursuing this vital area of research in pharmacology and toxicology..978-1-4939-9422-9978-1-4939-9420-5Series ISSN 1064-3745 Series E-ISSN 1940-6029
作者: 無法破譯    時(shí)間: 2025-3-23 06:06

作者: cogent    時(shí)間: 2025-3-23 11:08
The Large Scale Structure of the Universecture and the appearance of lumina in thin slices may be explained by the appearance of novel ducts or by ramification or convolution of existing ducts in 3D. In many such aspects, traditional 2D histology on thin slices limits our understanding of the response of the biliary tree. A comprehensive u
作者: nonsensical    時(shí)間: 2025-3-23 15:30

作者: FUME    時(shí)間: 2025-3-23 18:58
https://doi.org/10.1007/978-3-322-95972-0DILI? assay integrates the effects of bile salt export pump inhibition, farnesoid X receptor antagonism, and basolateral efflux inhibition of bile acids to more accurately predict a drug’s potential to cause cholestatic hepatotoxicity and drug-induced liver injury.
作者: gout109    時(shí)間: 2025-3-24 01:31
Hartmut Esser,Jürgen Friedrichssporters in mice, using the nuclear imaging techniques positron emission tomography and single photon emission computed tomography. The protocol includes detailed information on preparation of the animal, scan acquisition, processing, and (statistical) analysis.
作者: 有危險(xiǎn)    時(shí)間: 2025-3-24 04:14

作者: Inoperable    時(shí)間: 2025-3-24 09:41
Generation, Milieu und Geschlechtinflammatory gene activation in rodent hepatocytes and a necro-inflammatory injury in vivo. On the other hand, human hepatocytes are more resistant to glycine-conjugated bile acids and die by necrosis when exposed to high biliary levels of these bile acids. In this chapter, we describe multiple assa
作者: antecedence    時(shí)間: 2025-3-24 14:28
Net Taxes of Living Generations,r repeat exposure-related toxicities, as well as for the study of adaptive responses. This primary human hepatocyte culture system combined with transcriptomics carries the future promise to identify individual gene expression profiles predictive of increased drug-induced cholestasis risk..This chap
作者: inflame    時(shí)間: 2025-3-24 18:12

作者: 庇護(hù)    時(shí)間: 2025-3-24 19:03
Preparations for a Third OPA Stage,culation. A variety of factors may evoke cholestasis, including genetic disorders, metabolic pathologies, infectious diseases, immunogenic stimuli, and drugs. Drug-induced cholestasis is a mechanistically complex process. At least three triggering factors of drug-induced cholestasis have been descri
作者: Salivary-Gland    時(shí)間: 2025-3-25 03:08

作者: 領(lǐng)帶    時(shí)間: 2025-3-25 05:18

作者: 絆住    時(shí)間: 2025-3-25 09:25

作者: essential-fats    時(shí)間: 2025-3-25 12:04

作者: Proponent    時(shí)間: 2025-3-25 16:34
Hartmut Esser,Jürgen Friedrichsdrug candidates in preclinical drug development. Drug-induced cholestasis can be triggered by drugs that are inhibitors of the hepatic bile acid transporters. Therefore, it is of considerable interest in preclinical drug development to detect whether new candidate drugs can cause interference with t
作者: 口味    時(shí)間: 2025-3-25 21:52
Aritra Acharyya,Arindam Biswas,Palash Daspatocyte and biliary injury. As amphipathic molecules, bile acids can intercalate in lipid membranes, and pathophysiologic concentrations of bile acids have the potential to induce marked changes in the biophysical properties of biomembranes, including membrane ordering. These effects, particularly
作者: DOTE    時(shí)間: 2025-3-26 03:50

作者: collagenase    時(shí)間: 2025-3-26 07:12
Generation, Milieu und Geschlechttasis, i.e., apoptosis or necrosis, has been controversial. There are fundamental reasons for the controversies, both of which are discussed here, namely the design of experiments and the use of parameters with limited specificity for a certain mode of cell death. Based on the assumption that choles
作者: 埋伏    時(shí)間: 2025-3-26 10:52

作者: 冒煙    時(shí)間: 2025-3-26 15:33
https://doi.org/10.1007/978-3-658-38736-5ated destruction of the small and medium-sized intrahepatic bile ducts. However, the pathophysiology of primary biliary cholangitis has not yet been completely elucidated. In recent years, proteomics has been comprehensively applied in many research fields, including the pathogenesis, prognosis, and
作者: 歡樂東方    時(shí)間: 2025-3-26 17:54

作者: 身體萌芽    時(shí)間: 2025-3-27 00:48
is. Cellular counter measures against those stressors are called adaptive stress response pathways. While in early stages of the disease adaptive stress pathways protect the hepatocytes, in later stages during prolonged stressed conditions they fail. The quantitative imaging-based assessment of cell
作者: 袖章    時(shí)間: 2025-3-27 04:33
,Umsetzung der Agilit?t in Unternehmen,the biliary system can be studied in mouse models. A particular focus is placed on mouse models for Alagille syndrome, a cholangiopathy with a strong genetic link to dysfunctional Notch signaling. Recently, a number of different genetic mouse models based on various manipulations of the Notch signal
作者: 逢迎春日    時(shí)間: 2025-3-27 07:02
Generationen aus Sicht der Soziologieincluding choledocholithiasis, surgical trauma, and autoimmune disorders. Cholestatic liver disease can be mild but generally progresses to more severe conditions with increased hepatobiliary injury, cholangitis, and ultimately liver fibrosis and cirrhosis. An extensively used experimental model to
作者: 和平    時(shí)間: 2025-3-27 13:02
,Verschiedene Alter gut (zusammen)führen,tis represent relevant causes of chronic liver disease, associated to significant morbidity and mortality. To better understand and to address therapeutic strategies to cholangiopathies is essential to develop an in vivo model which recapitulates the pathological features of the disease. Chronic fee
作者: 江湖郎中    時(shí)間: 2025-3-27 16:07
https://doi.org/10.1007/978-3-658-23712-7ver disease by 2 years of age. Despite re-establishment of biliary drainage following a Kasai portoenterostomy (surgical procedure), many infants develop fibrosis requiring liver transplant. In the murine model of biliary atresia, rhesus rotavirus infection of newborn pups results in a cholangiopath
作者: forager    時(shí)間: 2025-3-27 20:16
Fakten und Tendenzen im Wohnungswesen, due to pruritus, malnutrition, and complications from portal hypertension secondary to biliary cirrhosis. The zebrafish (.) has emerged as a valuable model organism for studying cholestasis that complements with the in vitro systems and rodent models. Its main advantages include conserved mechanism
作者: Morsel    時(shí)間: 2025-3-28 00:45
Heike Bruch,Florian Kunze,Stephan B?hmnt an appropriate surrogate to primary human hepatocytes for investigations on drug-induced cholestasis mechanisms. In this chapter, culture conditions for obtaining HepaRG hepatocytes and the main methods used to detect cholestatic potential of drugs are described. Assays for evaluation of bile can
作者: Expressly    時(shí)間: 2025-3-28 03:05

作者: 元音    時(shí)間: 2025-3-28 06:19

作者: coalition    時(shí)間: 2025-3-28 14:16
Methods in Molecular Biologyhttp://image.papertrans.cn/e/image/318815.jpg
作者: ATOPY    時(shí)間: 2025-3-28 16:52

作者: Lethargic    時(shí)間: 2025-3-28 19:33

作者: 用樹皮    時(shí)間: 2025-3-29 00:28

作者: 無思維能力    時(shí)間: 2025-3-29 07:00
LC-MS/MS Analysis of Bile Acids in In Vitro Samples,BA) and their conjugates in different matrices, such as plasma, blood, urine, and cell lysates. Numerous reports have indeed been published describing methods for quantitative determination of bile acids in plasma samples obtained during in vivo studies. However, information on bioanalytical methods
作者: 額外的事    時(shí)間: 2025-3-29 08:57

作者: 殺菌劑    時(shí)間: 2025-3-29 14:39

作者: condemn    時(shí)間: 2025-3-29 17:34
,The C-DILI? Assay: An Integrated In Vitro Approach to Predict Cholestatic Hepatotoxicity, mechanism of cholestatic hepatotoxicity. Bile acids are synthesized in the hepatocyte, and excreted into the bile primarily by the bile salt export pump. Therefore, inhibition of the bile salt export pump by drugs has been postulated as a risk factor in the development of cholestatic hepatotoxicity
作者: 高歌    時(shí)間: 2025-3-29 21:47
In Vivo Measurement of Hepatic Drug Transporter Inhibition with Radiolabeled Bile Acids,drug candidates in preclinical drug development. Drug-induced cholestasis can be triggered by drugs that are inhibitors of the hepatic bile acid transporters. Therefore, it is of considerable interest in preclinical drug development to detect whether new candidate drugs can cause interference with t
作者: Cougar    時(shí)間: 2025-3-30 00:08
Measuring the Impact of Bile Acids on the Membrane Order of Primary Hepatocytes and Isolated Mitochpatocyte and biliary injury. As amphipathic molecules, bile acids can intercalate in lipid membranes, and pathophysiologic concentrations of bile acids have the potential to induce marked changes in the biophysical properties of biomembranes, including membrane ordering. These effects, particularly
作者: critique    時(shí)間: 2025-3-30 08:04
The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis,s, such as bile acids, during cholestasis, not only impairs liver function, but also affects other organs, including the kidneys. Although the precise mechanisms of cytotoxicity and organ injury in cholestasis are far from clear, oxidative stress and its subsequent events seem to play a central role
作者: Oafishness    時(shí)間: 2025-3-30 11:34
Measuring Apoptosis and Necrosis in Cholestatic Liver Injury,tasis, i.e., apoptosis or necrosis, has been controversial. There are fundamental reasons for the controversies, both of which are discussed here, namely the design of experiments and the use of parameters with limited specificity for a certain mode of cell death. Based on the assumption that choles
作者: 極少    時(shí)間: 2025-3-30 15:00

作者: expository    時(shí)間: 2025-3-30 18:20
Proteomics in Primary Biliary Cholangitis,ated destruction of the small and medium-sized intrahepatic bile ducts. However, the pathophysiology of primary biliary cholangitis has not yet been completely elucidated. In recent years, proteomics has been comprehensively applied in many research fields, including the pathogenesis, prognosis, and
作者: ELUC    時(shí)間: 2025-3-31 00:32
Transcriptomic Analysis of Cholestatic Compounds In Vitro,lation of endogenous metabolites normally excreted in the bile such as bile salts, cholesterol, bilirubin, or drug metabolites. The possibility to determine early in the drug development process whether a compound presents a risk of inducing drug-induced cholestasis is key information. Since preclin
作者: INCH    時(shí)間: 2025-3-31 04:52
System Microscopy of Stress Response Pathways in Cholestasis Research,is. Cellular counter measures against those stressors are called adaptive stress response pathways. While in early stages of the disease adaptive stress pathways protect the hepatocytes, in later stages during prolonged stressed conditions they fail. The quantitative imaging-based assessment of cell
作者: 多產(chǎn)魚    時(shí)間: 2025-3-31 06:52
Mouse Models for Diseases in the Cholangiocyte Lineage,the biliary system can be studied in mouse models. A particular focus is placed on mouse models for Alagille syndrome, a cholangiopathy with a strong genetic link to dysfunctional Notch signaling. Recently, a number of different genetic mouse models based on various manipulations of the Notch signal
作者: 暖昧關(guān)系    時(shí)間: 2025-3-31 12:27

作者: 桉樹    時(shí)間: 2025-3-31 16:45
3,5-Diethoxycarbonyl-1,4-Dihydrocollidine Diet: A Rodent Model in Cholestasis Research,tis represent relevant causes of chronic liver disease, associated to significant morbidity and mortality. To better understand and to address therapeutic strategies to cholangiopathies is essential to develop an in vivo model which recapitulates the pathological features of the disease. Chronic fee
作者: multiply    時(shí)間: 2025-3-31 17:34

作者: 留戀    時(shí)間: 2025-4-1 00:18





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