標(biāo)題: Titlebook: Excitotoxins; Proceedings of an In Kjell Fuxe,Peter Roberts,Robert Schwarcz Conference proceedings 1983 Springer Science+Business Media New [打印本頁] 作者: 可憐 時間: 2025-3-21 16:49
書目名稱Excitotoxins影響因子(影響力)
書目名稱Excitotoxins影響因子(影響力)學(xué)科排名
書目名稱Excitotoxins網(wǎng)絡(luò)公開度
書目名稱Excitotoxins網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Excitotoxins被引頻次
書目名稱Excitotoxins被引頻次學(xué)科排名
書目名稱Excitotoxins年度引用
書目名稱Excitotoxins年度引用學(xué)科排名
書目名稱Excitotoxins讀者反饋
書目名稱Excitotoxins讀者反饋學(xué)科排名
作者: BOLT 時間: 2025-3-21 22:13 作者: ovation 時間: 2025-3-22 02:04
The Role of Seizures in Kainic Acid Induced Brain Damageental conditions the distant damage is largely due to the spread of paroxysmal discharge and not to a direct action of the toxin (by diffusion). The usefulness of KA to study the relationship between epilepsy and brain pathology is reviewed and the possible causes of the particular vulnerability of the ammon’s horn to epilepsy is discussed.作者: Ordnance 時間: 2025-3-22 06:23 作者: 指數(shù) 時間: 2025-3-22 10:27
Mechanisms of Excitotoxins Examined in Organotypic Cultures of Rat Central Nervous Systemle et al, 1977; Fibiger, 1978). Our studies (Whetsell et al, 1979; Whetsell, 1979; Whetsell and Nicklas, 1980) in organotypic cultures of rat striatum (CA), striatum-plus-frontal cortex (CA-CX) and frontal cortex alone (CX), have demonstrated that the neurotoxic effects of KA can be observed only in CA-CX and CX cultures.作者: initiate 時間: 2025-3-22 16:36
https://doi.org/10.1007/978-3-663-07712-1 tasks in the brain. It is involved in energy metabolism and fatty acid synthesis, incorporated into proteins and peptides and is even a precursor for the inhibitory neurotransmitter GABA. In addition its action as a neuroexcitant has been regarded as universal and non-specific.作者: initiate 時間: 2025-3-22 17:07
, and Forward Lease ,—Case Study,o alterations in glial cells secondary to massive depolarization of neurons. These results and those of others are discussed in terms of their implication for the mechanism of neurotoxicity of excitatory substances.作者: 侵略者 時間: 2025-3-22 23:35 作者: Asymptomatic 時間: 2025-3-23 05:01
https://doi.org/10.1007/978-3-030-33380-5t which depresses agonist-induced responses in the order kainate > quisqualate > N-methyl-D- aspartate > L-glutamate. Other sulphonic peptides have similar, though weaker actions. The actions of excitatory amino acid antagonists in depressing polysynaptic and monosynaptic excitation in the spinal cord are described.作者: Cholecystokinin 時間: 2025-3-23 06:22
Recent Advances in the Pharmacology of Excitatory Amino Acids in the Mammalian Central Nervous Systet which depresses agonist-induced responses in the order kainate > quisqualate > N-methyl-D- aspartate > L-glutamate. Other sulphonic peptides have similar, though weaker actions. The actions of excitatory amino acid antagonists in depressing polysynaptic and monosynaptic excitation in the spinal cord are described.作者: STANT 時間: 2025-3-23 11:52
Electrophysiological Actions of Kainate and Other Excitatory Amino Acids, and the Structure of Theirace. It should however be noted that more recent evidence has been obtained indicating that the reaction of more than one molecule of an amino acid is required for functional activation to occur (McLennan and Wheal, 1976a). It was further noted that the “receptor” was not stereoselective, although f作者: POLYP 時間: 2025-3-23 17:20
Two Types of Excitatory Amino Acid Responses in the Cat Caudate Nucleused the same effects. Aspartic acid showed mixed effects but type 1 always seemed to predominate..At low doses, the antagonist D-alpha-aminoadipic acid inhibited only type 2 effects, whereas higher doses also reduced type 1 responses. On the same cells, however, antagonism of type 2 effects was alway作者: quiet-sleep 時間: 2025-3-23 21:15
Excitotoxins: An Overviewnus for which we must indeed be grateful. But there are many gaps in our understanding of these agents, gaps which can only be filled by years of methodical research, but gaps which must be filled if we are to decipher the roles of ET in the physiology and pathology of the CNS and realize their full作者: 不發(fā)音 時間: 2025-3-24 01:22 作者: 舊病復(fù)發(fā) 時間: 2025-3-24 04:13
The Neurodegenerative Properties of Intracerebral Quinolinic Acid and its Structural Analog Cis-2,3-e merely yielded equivocal results (Perry et al., 1975; Gray et al., 1980; Perry and Hansen, 1981; Mangano and Schwarcz, 1981, 1982). Their dysfunction in neuro-psychiatric disorders has as yet not been established.作者: averse 時間: 2025-3-24 08:05
Studies on Excitatory Amino Acid Receptors and Their Interactions and Regulation of Pre- and Postsynd, at least in the striatum where the present experiments indicate that activation of glutamate receptors increases the number of .H-kainic acid binding sites, so that they may reach a certain critical number required for neurotoxicity. Furthermore, kainic acid by increasing the affinity of the .H-g作者: Buttress 時間: 2025-3-24 11:50 作者: semiskilled 時間: 2025-3-24 18:21
Springer Series in Optical Sciencesace. It should however be noted that more recent evidence has been obtained indicating that the reaction of more than one molecule of an amino acid is required for functional activation to occur (McLennan and Wheal, 1976a). It was further noted that the “receptor” was not stereoselective, although f作者: Amenable 時間: 2025-3-24 20:24 作者: 后退 時間: 2025-3-25 01:53 作者: Acumen 時間: 2025-3-25 05:43 作者: accrete 時間: 2025-3-25 09:05
https://doi.org/10.1007/978-3-031-56790-2e merely yielded equivocal results (Perry et al., 1975; Gray et al., 1980; Perry and Hansen, 1981; Mangano and Schwarcz, 1981, 1982). Their dysfunction in neuro-psychiatric disorders has as yet not been established.作者: Ige326 時間: 2025-3-25 14:25
José Luis Prado,María Teresa Alberdid, at least in the striatum where the present experiments indicate that activation of glutamate receptors increases the number of .H-kainic acid binding sites, so that they may reach a certain critical number required for neurotoxicity. Furthermore, kainic acid by increasing the affinity of the .H-g作者: DRAFT 時間: 2025-3-25 19:15 作者: reflection 時間: 2025-3-25 22:14 作者: 有雜色 時間: 2025-3-26 02:47 作者: 性滿足 時間: 2025-3-26 08:03
Jorge Tirira,Yves Serruys,Patrick Trocellier“Excitotoxins” represent a very special group of neurotoxic substances, in that they act upon specific somatic and dendritic receptors such that if the excitation produced is of sufficient magnitude, the neurones die.作者: incision 時間: 2025-3-26 10:38
Fragments Within Pseudotachylyte Veins,It is now well established that systemic and intracerebral injections of . (KA), a potent excitatory analogue of the endogenous amino acid glutamic acid (21), cause degeneration of neuronal cell bodies while leaving axons and nerveterminals in the lesion area intact. (3,20,21,23,25,26,27,30)作者: 毗鄰 時間: 2025-3-26 15:57
Microbial Spheres from Microbial Mats,This review presents evidence which favors a special role of aspartate in the climbing fibers of the rat cerebellum and of glutamate and aspartate in some fibers of the pigeon optic nerve. The localisation and properties of kainic acid binding sites in the cerebellum are also discussed.作者: Thyroxine 時間: 2025-3-26 19:26 作者: 隱藏 時間: 2025-3-27 00:12 作者: Exploit 時間: 2025-3-27 02:28 作者: chance 時間: 2025-3-27 05:16
https://doi.org/10.1007/978-3-663-07712-1 difficult to confirm its role as a neurotransmitter in the mammalian CNS. Unlike other putative neurotransmitters, glutamate fullfills a multitude of tasks in the brain. It is involved in energy metabolism and fatty acid synthesis, incorporated into proteins and peptides and is even a precursor for作者: endarterectomy 時間: 2025-3-27 11:37
Springer Series in Optical Scienceslarize and excite neurones of the mammalian spinal cord (Curtis, .., 1959; 1960), and that similar excitatory effects could be elicited by a variety of other compounds chemically related to the natural substances (Curtis and Watkins, 1960; 1963). Curtis and Watkins (1960) set forth the criteria whic作者: 托人看管 時間: 2025-3-27 16:14 作者: Ophthalmoscope 時間: 2025-3-27 19:37 作者: alliance 時間: 2025-3-28 01:42
, and Forward Lease ,—Case Study,amate and aspartate from the tissue and decreased the synthesis of glutamine from a variety of radioactive precursors. These effects were attributed to alterations in glial cells secondary to massive depolarization of neurons. These results and those of others are discussed in terms of their implica作者: Radiation 時間: 2025-3-28 03:10 作者: CHANT 時間: 2025-3-28 09:55 作者: 怕失去錢 時間: 2025-3-28 11:12 作者: Adj異類的 時間: 2025-3-28 15:26
José Luis Prado,María Teresa Alberdi membranes. Kainic acid (10. M) . rapidly reduces the number (11%) and increases the affinity (12%) in the striatal .H-glutamate binding sites, while glutamate (10. M) . increases the number of striatal .H-kainic acid binding sites (18%) and reduces their affinity (46%). The specificity of this inte作者: 粗鄙的人 時間: 2025-3-28 22:34
British Triassic fossil reptile sites,me sensitivity of CA. pyramidal hippocampal neurons to the neurotoxic action of ka?nic acid (KA), these neurons were found to be exquisitely sensitive to the excitatory action of KA applied microiontophoretically. The excitatory action of KA on CA. but not on CA. neurons was selectively antagonized 作者: 減少 時間: 2025-3-29 00:35 作者: 爭議的蘋果 時間: 2025-3-29 03:13 作者: 上腭 時間: 2025-3-29 09:45 作者: 豐富 時間: 2025-3-29 11:33
https://doi.org/10.1007/978-1-4757-0384-9biochemistry; brain; dementia; epilepsy; experiment; nervous system; neurobiology; neurons; neuroscience; phy作者: left-ventricle 時間: 2025-3-29 18:01
Wenner-Gren Center International Symposium Serieshttp://image.papertrans.cn/e/image/318417.jpg作者: 聯(lián)合 時間: 2025-3-29 22:24
978-1-4757-0386-3Springer Science+Business Media New York 1983作者: 不知疲倦 時間: 2025-3-30 02:02 作者: 寵愛 時間: 2025-3-30 04:38 作者: 稱贊 時間: 2025-3-30 11:39
Electrophysiological Actions of Kainate and Other Excitatory Amino Acids, and the Structure of Theirlarize and excite neurones of the mammalian spinal cord (Curtis, .., 1959; 1960), and that similar excitatory effects could be elicited by a variety of other compounds chemically related to the natural substances (Curtis and Watkins, 1960; 1963). Curtis and Watkins (1960) set forth the criteria whic作者: interference 時間: 2025-3-30 14:57 作者: 先行 時間: 2025-3-30 16:57
Recent Advances in the Pharmacology of Excitatory Amino Acids in the Mammalian Central Nervous Systeagonists and antagonists for NMA receptors and non-NMA receptors are summarized. New NMA receptor antagonists include a range of D-aspartyl- and D-glutamyl dipeptides where the second amino acid contains a phosphonic acid moiety. None of these dipeptides is more potent or specific than 2-amino-5-pho作者: 古董 時間: 2025-3-31 00:27
Alteration by Kainate of Energy Stores and Neuronal-Glial Metabolism of Glutamate ,amate and aspartate from the tissue and decreased the synthesis of glutamine from a variety of radioactive precursors. These effects were attributed to alterations in glial cells secondary to massive depolarization of neurons. These results and those of others are discussed in terms of their implica作者: DEBT 時間: 2025-3-31 02:16
Excitotoxins: An Overviewfor the effort spent in pursuing these challenges. If we are right in suspecting that endogenous excitotoxins--glutamate (Glu), aspartate (Asp) and perhaps others--are the neurotransmitters released at the majority of excitatory synapses in the mammalian CNS, this is reason enough for our intrigue w作者: amenity 時間: 2025-3-31 07:34
Kainic Acid: Insights into Its Receptor-Mediated Neurotoxic Mechanismsrmationally restricted analogue of L-glutamate, it was a potent agonist at glutamate receptors (Olney .., 1974; Coyle and Schwarcz, 1976). Since the first reports of the perikaryal-specific neurotoxic action of intracerebrally injected KA, it has become increasingly apparent that the mechanism of it作者: 并排上下 時間: 2025-3-31 11:15
The Neurodegenerative Properties of Intracerebral Quinolinic Acid and its Structural Analog Cis-2,3- have led to the hypothesis that human neurodegenerative diseases, e.g. Huntington’s disease (HD) and temporal lobe epilepsy, may be related to a pathological overproduction of endogenous neuroexcitatory amino acids (Coyle et al., 1977; Divac, 1977; Olney and de Gubareff, 1978; French et al., 1982).
