作者: 觀察 時(shí)間: 2025-3-21 23:35
Glutamate in Neurodegenerative Disorders: Phenotype Resulting from Decreased Expression of AMPA Rechin this locus is controlled by posttranscriptional RNA editing (Sommer et al. 1991). Transgenic mice engineered to synthesize unedited GluR-B subunits express Ca.permeable AMPA receptors. These mice develop progressive neurodegeneration and spontaneous seizures (Brusa et al. 1995).作者: 接合 時(shí)間: 2025-3-22 01:21 作者: Recess 時(shí)間: 2025-3-22 06:19 作者: 逢迎春日 時(shí)間: 2025-3-22 10:47
Conference proceedings 1998 Since glutamate antagonists are still the major hope for the therapy of neurodegenerative disorders in humans, research activities dedicated towards the development of such novel drugs are the focus of public attention. The book comments on the most recent discoveries in the field of neuroprotectio作者: hemoglobin 時(shí)間: 2025-3-22 15:23
0947-6075 discussed. Since glutamate antagonists are still the major hope for the therapy of neurodegenerative disorders in humans, research activities dedicated towards the development of such novel drugs are the focus of public attention. The book comments on the most recent discoveries in the field of neur作者: hemoglobin 時(shí)間: 2025-3-22 18:30 作者: graphy 時(shí)間: 2025-3-22 22:27 作者: mortuary 時(shí)間: 2025-3-23 03:41 作者: 誤傳 時(shí)間: 2025-3-23 09:28
Quantitative Estimation of NMDA Receptor-Mediated Ca2+ Entry in Central Neurons,forms of synaptic plasticity (Bliss and Collingridge 1993; Malenka and Nicoll 1993), as well as excitatotoxicity (Lipton 1993; Mody and MacDonald 1995) and programmed cell death (Bonfoco et al. 1995; Qin et al. 1996). Ca. entry through activated NMDA receptors has been suggested to be involved in the triggering of all of these processes.作者: 鋼筆記下懲罰 時(shí)間: 2025-3-23 10:47
Localisation and Surface Expression of the AMPA Receptor Subunit GluR1 Using Green Fluorescent Protrum 1994; Fletcher and Lodge 1996). In general, glutamate receptors can be characterised into two broad groups: (1) The ionotropic glutamate receptors (GluRs) which contain an integral ion channel, and (2) the metabotropic glutamate receptors (mGluRs) which are G-protein coupled.作者: 針葉類的樹 時(shí)間: 2025-3-23 14:20
https://doi.org/10.1007/978-3-662-03596-2Glutamat; Molekulargenetik in der Neurologie; Neurobiologie; Neurodegenerative Krankheiten; RNA; antibody作者: Defense 時(shí)間: 2025-3-23 20:12
Von Computern, Netzen und fetten FischenIonotropic glutamate receptor (GluR) channels are assembled from structurally homologous subunits that can be grouped into three families according to sequence identity and agonist binding characteristics.作者: 搖曳的微光 時(shí)間: 2025-3-23 23:05
Calcium Permeability of Glutamate-Gated Channels in the CNS: Functional Role of the Ca2+-Permeable Ionotropic glutamate receptor (GluR) channels are assembled from structurally homologous subunits that can be grouped into three families according to sequence identity and agonist binding characteristics.作者: 決定性 時(shí)間: 2025-3-24 05:52
https://doi.org/10.1007/978-3-642-90766-1ate and NMDA receptor families (Collingridge and Lester 1989; Mayer and Westbrook 1987; Watkins et al. 1990). The AMPA receptors mediate the fast component of excitatory postsynaptic currents, whereas the slow component is contributed by NMDA receptors (e.g., Stern et al. 1992). The latter can be vi作者: Epithelium 時(shí)間: 2025-3-24 08:03
Formeln und Tabellen der W?rmetechniks such as synaptogenesis, formation of neuronal circuitry, and synaptic plasticity, including long-term potentiation and long-term depression. However, excessive activation of GluRs contributes to neurodegeneration following a wide range of neurological insults including ischemia, trauma, hypoglycem作者: Geyser 時(shí)間: 2025-3-24 11:34 作者: Orgasm 時(shí)間: 2025-3-24 18:23
Formen ambulanter Gruppentherapiely selective for upper motor neurones, a proportion of which are represented by Betz cells (Fig. lA) in the fifth layer of the motor cortex, and for lower motor neurones in the ventral horn of the spinal cord (Fig. 1B) and brainstem. The selective vulnerability of motor neurones in ALS is relative a作者: 喚起 時(shí)間: 2025-3-24 21:25 作者: 純樸 時(shí)間: 2025-3-25 02:13
,Kritische Würdigung der Arbeit,5-methyl-4-isoxazolepropionate (AMPA) and kainate (KA) receptor stimulation triggers Na+ influx into neurons, while N-methyl-D-aspartate (NMDA) receptor stimulation additionally leads to considerable Ca. influx (Hollmann and Heinemann 1994). Relative impermeability of the AMPA receptor channel to Ca作者: LAIR 時(shí)間: 2025-3-25 04:42
Friedens- und Konfliktforschung and their high Ca. permeability, are utilized in a variety of complex physiological mechanisms. So far, NMDA receptor channels have been implicated in the regulation of activity-dependent neuronal development (Constantine-Paton 1990; McDonald and Johnston 1990), in triggering the formation of some 作者: 凹處 時(shí)間: 2025-3-25 11:06
Hanns Ch. Heinrich,Ingo Langoschnt in processes as varied as the control of motor, cardiovascular and visual functions; synapse formation, stabilisation and elimination; learning and memory; and epilepsy, neuronal degenerative disorders and the mediation neuronal cell death (for recent reviews see Bliss and Collingridge 1993; Meld作者: 修改 時(shí)間: 2025-3-25 13:43 作者: 郊外 時(shí)間: 2025-3-25 17:23
Conference proceedings 1998 Since glutamate antagonists are still the major hope for the therapy of neurodegenerative disorders in humans, research activities dedicated towards the development of such novel drugs are the focus of public attention. The book comments on the most recent discoveries in the field of neuroprotection and neurodegeneration.作者: narcissism 時(shí)間: 2025-3-26 00:00 作者: 灰姑娘 時(shí)間: 2025-3-26 01:44
Excitatory Amino Acids978-3-662-03596-2Series ISSN 0947-6075 作者: AVERT 時(shí)間: 2025-3-26 07:02 作者: Slit-Lamp 時(shí)間: 2025-3-26 09:28 作者: negligence 時(shí)間: 2025-3-26 16:10
Regulation of Glutamate Receptor Gene Expression in Global Ischemia,s such as synaptogenesis, formation of neuronal circuitry, and synaptic plasticity, including long-term potentiation and long-term depression. However, excessive activation of GluRs contributes to neurodegeneration following a wide range of neurological insults including ischemia, trauma, hypoglycem作者: 自作多情 時(shí)間: 2025-3-26 17:02
Factors Regulating Excitotoxic Neurodegeneration: The Role of Calcium and the Mitochondria,ion, we know that glutamate-mediated neurotransmission is mediated by a very large number of glutamate receptors (GluRs) which include families of both ionotropic (iGluRs) and metabotropic (mGluRs) receptors. Activation of these receptors can trigger several important phenomena. These include fast s作者: CHANT 時(shí)間: 2025-3-26 22:26
Excitotoxicity, Genetics and Neurodegeneration in Amyotrophic Lateral Sclerosis,ly selective for upper motor neurones, a proportion of which are represented by Betz cells (Fig. lA) in the fifth layer of the motor cortex, and for lower motor neurones in the ventral horn of the spinal cord (Fig. 1B) and brainstem. The selective vulnerability of motor neurones in ALS is relative a作者: SEED 時(shí)間: 2025-3-27 03:35
NO-NMDA Receptor Interactions: A Neuromolecular Approach to Novel Therapeutics, as an important mechanism for many cell types. For our purposes, we will confine our review of redox modulation to covalent modification of sulfhydryl (thiol) groups on protein cysteine residues. If they possess a sufficient redox potential, oxidizing agents can react to form adducts on single sulf作者: 含沙射影 時(shí)間: 2025-3-27 07:49 作者: 分發(fā) 時(shí)間: 2025-3-27 11:02
Quantitative Estimation of NMDA Receptor-Mediated Ca2+ Entry in Central Neurons, and their high Ca. permeability, are utilized in a variety of complex physiological mechanisms. So far, NMDA receptor channels have been implicated in the regulation of activity-dependent neuronal development (Constantine-Paton 1990; McDonald and Johnston 1990), in triggering the formation of some 作者: dyspareunia 時(shí)間: 2025-3-27 13:48 作者: artifice 時(shí)間: 2025-3-27 18:01 作者: 從容 時(shí)間: 2025-3-28 00:56
https://doi.org/10.1007/978-3-642-90766-1eptors are designed for high Ca. permeability, and Ca. influx through the NMDA receptor channel is thought to be essential for activity-dependent synaptic modulation (reviewed in Bliss and Collingridge 1993). Furthermore, excessively high Ca. influx through NMDA receptors has pathophysiological cons作者: Coronary-Spasm 時(shí)間: 2025-3-28 04:46 作者: 多嘴多舌 時(shí)間: 2025-3-28 10:07
Formen ambulanter Gruppentherapie usually dies from respiratory failure within 3–5 years from the onset of symptoms. One of the interesting clinical features in ALS is that certain groups of motor neurones tend to be selectively spared from injury, including those brainstem nuclei innervating extraocular muscles responsible for eye作者: 熱心助人 時(shí)間: 2025-3-28 14:06 作者: 冷峻 時(shí)間: 2025-3-28 17:33
,Ethnopoetik: Traum oder M?glichkeit?,-type] have been identified and classified according to their agonist selectivity, physiological properties and amino acid sequence homology between subunits constituting subtypes of these GluRs (reviewed by Seeburg 1993; Hollmann and Heinemann 1994). Several subunits have been discovered within eac作者: Misnomer 時(shí)間: 2025-3-28 22:35
Glutamate Receptor Channels, RNA Editing, and Epilepsy,eptors are designed for high Ca. permeability, and Ca. influx through the NMDA receptor channel is thought to be essential for activity-dependent synaptic modulation (reviewed in Bliss and Collingridge 1993). Furthermore, excessively high Ca. influx through NMDA receptors has pathophysiological cons作者: 草本植物 時(shí)間: 2025-3-29 01:39
Factors Regulating Excitotoxic Neurodegeneration: The Role of Calcium and the Mitochondria,ite 1990). Research from a number of laboratories has shown that the Ca permeability of ionotropic GluRs is subject to a number of control mechanisms which include the subunit composition of the receptor, editing of subunit specific mRNA, etc. Although the precise significance of all of these factor作者: 可卡 時(shí)間: 2025-3-29 06:18
Excitotoxicity, Genetics and Neurodegeneration in Amyotrophic Lateral Sclerosis, usually dies from respiratory failure within 3–5 years from the onset of symptoms. One of the interesting clinical features in ALS is that certain groups of motor neurones tend to be selectively spared from injury, including those brainstem nuclei innervating extraocular muscles responsible for eye作者: 效果 時(shí)間: 2025-3-29 07:39 作者: cocoon 時(shí)間: 2025-3-29 12:56 作者: aplomb 時(shí)間: 2025-3-29 18:01
