標(biāo)題: Titlebook: Excipient Applications in Formulation Design and Drug Delivery; Ajit S Narang,Sai H S. Boddu Book 2015 Springer International Publishing S [打印本頁] 作者: Lincoln 時(shí)間: 2025-3-21 16:53
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作者: Adrenaline 時(shí)間: 2025-3-21 22:39 作者: gustation 時(shí)間: 2025-3-22 00:41 作者: 媽媽不開心 時(shí)間: 2025-3-22 08:32
Reactive Impurities in Excipientsessing, and their potential reactions with drug candidates are discussed. Specific examples of drug–excipient impurity interaction are presented as illustrative case studies. Mitigation strategies and corrective measures are also discussed.作者: cardiac-arrest 時(shí)間: 2025-3-22 11:20 作者: Maximize 時(shí)間: 2025-3-22 16:53 作者: Maximize 時(shí)間: 2025-3-22 17:51
Protein—Surfactant Interactions at the Air-Water Interfaceeater than that of Mouse IgG. Degrees of displacement by Triton X-100 were comparable in case of studied proteins. Surface tension characterization suggests that the interfacial interactions between proteins and surfactants are driven not only by their surface activity but also by the network format作者: Vldl379 時(shí)間: 2025-3-22 21:26 作者: Hla461 時(shí)間: 2025-3-23 05:21 作者: 分解 時(shí)間: 2025-3-23 09:03
Excipient Selection in Oral Solid Dosage Formulations Containing Moisture Sensitive Drugsa barrier coating to reduce rate and extent of moisture ingress into the core of the solid dosage form during the storage (in original packaging or while in-use), are some of the many simple options that have been considered and described.作者: Aspirin 時(shí)間: 2025-3-23 12:40 作者: 柔聲地說 時(shí)間: 2025-3-23 13:53 作者: Perigee 時(shí)間: 2025-3-23 18:04 作者: 現(xiàn)代 時(shí)間: 2025-3-24 00:23 作者: Transfusion 時(shí)間: 2025-3-24 02:48
Gerald Kapp,David Butler Manning Recent developments in the understanding of degradation pathways further impact methodologies used in the pharmaceutical industry for prospective stability assessment. This paper discusses these emerging aspects in terms of limitations of drug-excipient compatibility studies, emerging paradigms in 作者: exercise 時(shí)間: 2025-3-24 07:02 作者: GROG 時(shí)間: 2025-3-24 12:13
Advances in Global Change Research degradation at the site of absorption plays a role in determining its bioavailability. Nonetheless, a mechanistic understanding of drug-excipient interactions and their impact on drug release and absorption can help develop formulations that exhibit optimum drug bioavailability.作者: 解凍 時(shí)間: 2025-3-24 15:37
https://doi.org/10.1007/978-3-642-75211-7r physicochemical characteristics, and increasing their stability. In this chapter, we focus primarily on the factors determining and influencing bioavailability as well as the selection of excipients for formulating new dosage forms with enhanced therapeutic efficacy, based on the physicochemical p作者: Ingenuity 時(shí)間: 2025-3-24 20:28
https://doi.org/10.1007/978-3-322-95714-6a barrier coating to reduce rate and extent of moisture ingress into the core of the solid dosage form during the storage (in original packaging or while in-use), are some of the many simple options that have been considered and described.作者: granite 時(shí)間: 2025-3-24 23:25
https://doi.org/10.1007/978-1-4302-4051-8ducts. Similarly, in topical drug delivery applications, silicone based novel excipients have demonstrated their capability in improving drug delivery efficiency. Recent silicone technologies like swollen crosslinked silicone elastomer blend networks, sugar siloxanes, amphiphilic resin linear polyme作者: 使厭惡 時(shí)間: 2025-3-25 05:25
Methoden der Diskontierung und Kalkulation,sessment by practitioners to avoid potential toxicity issues. Regulatory agencies in the United States of America and Europe are working together to create and maintain a database of Safety and Toxicity of Excipients for Pediatrics (STEP). The purpose of this book chapter is to review the role of ex作者: Mumble 時(shí)間: 2025-3-25 09:53
Excipient Applications in Formulation Design and Drug Delivery,materials provide opportunities to design optimal drug delivery systems. Emerging trends in the design and development of drug products indicate ever greater need for characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents an integra作者: 平項(xiàng)山 時(shí)間: 2025-3-25 13:27 作者: Airtight 時(shí)間: 2025-3-25 19:12
Reactive Impurities in Excipientsr formation of potentially toxic degradants. The levels of reactive impurities in excipients may vary between lots and vendors. Screening of excipients for these impurities and a thorough understanding of their potential interaction with drug candidates during early formulation development can ensur作者: Ankylo- 時(shí)間: 2025-3-25 21:19 作者: albuminuria 時(shí)間: 2025-3-26 04:11
Impact of Excipient Interactions on Solid Dosage Form Stabilitylowdown, or chemically by causing drug degradation. Recent research has allowed the distinction in chemical instability resulting from direct drug-excipient interactions and from drug interactions with excipient impurities. A review of chemical instability in solid dosage forms highlights common mec作者: HATCH 時(shí)間: 2025-3-26 08:08
Protein—Surfactant Interactions at the Air-Water Interfaceurface characterization methods. A . ring geometry was utilized to quantify the elastic (G?) and viscous (G?) shear moduli of protein interfacial networks and to probe the effect of several nonionic surfactants at various concentrations. Time sweep protocols of buffered protein solutions yielded G? 作者: 陳舊 時(shí)間: 2025-3-26 11:18 作者: 金桌活畫面 時(shí)間: 2025-3-26 15:36
Tailoring the Release of Drugs Using Excipientsent compliance. Polymeric excipients play a critical role in determining the mechanism and rate of drug release from the solid oral dosage forms. Regardless of the physicochemical properties of drug molecules and physiological conditions of the body, it is now possible to achieve site-specific deliv作者: ULCER 時(shí)間: 2025-3-26 18:26 作者: 幾何學(xué)家 時(shí)間: 2025-3-26 21:42
Impact of Excipient Interactions on Drug Bioavailability from Solid Dosage Formson to affect the bioavailability of a drug product. A general mechanistic understanding of the basis of these interactions is essential to design robust drug products. This chapter focuses on drug-excipient interactions in solid dosage forms that impact drug bioavailability, the drug substance and d作者: Harness 時(shí)間: 2025-3-27 03:22 作者: occurrence 時(shí)間: 2025-3-27 07:01
Selection of Excipients Based on the Biopharmaceutics Classification System of Drugsance of the inactive ingredients has been realized during the last three decades. With the development and manufacturing of more intelligent and multifunction excipients, new ways became available for formulation technologists to increase the beneficial effects of drugs on human body. Many modern ac作者: synovium 時(shí)間: 2025-3-27 12:42 作者: 敬禮 時(shí)間: 2025-3-27 17:18
Silicone Excipients in Pharmaceutical Drug Delivery Applications many oral antiflatulent remedies and topically applied skin protectant creams, and ointments. The plethora of physical forms and the physio-chemical properties that silicones can display has led to their adoption in a diverse array of healthcare applications in different physical forms including as作者: 小步走路 時(shí)間: 2025-3-27 17:55
Excipients That Facilitate Amorphous Drug Stabilizationtherefore the apparent high solubility of the amorphous phase are some of the advantages for promoting the amorphous phase, as compared to its crystalline counterpart. It is well known that the amorphous phase is thermodynamically unstable. This might result in the conversion of the metastable form 作者: remission 時(shí)間: 2025-3-27 22:06 作者: 琺瑯 時(shí)間: 2025-3-28 03:23 作者: 織物 時(shí)間: 2025-3-28 07:46
State of Research and Structure of the Book,d for biopharmaceutical applications are exemplified by pH, ionic strength, temperature, light,and magnetic or electric field. This chapter will highlight most popular smart polymers used in drug delivery.作者: 帶來墨水 時(shí)間: 2025-3-28 12:10 作者: Anticoagulants 時(shí)間: 2025-3-28 16:23 作者: Extemporize 時(shí)間: 2025-3-28 21:07
Brian C. Murray,Jeffrey P. Prestemonrdless of the physicochemical properties of drug molecules and physiological conditions of the body, it is now possible to achieve site-specific delivery of drugs in a sustained manner. This chapter highlights the polymeric excipients that are widely used in modulating the release and enhancing the oral absorption of drugs.作者: 善變 時(shí)間: 2025-3-29 02:02 作者: 剝皮 時(shí)間: 2025-3-29 04:34 作者: 蚊帳 時(shí)間: 2025-3-29 07:18 作者: 思想靈活 時(shí)間: 2025-3-29 14:58 作者: 純樸 時(shí)間: 2025-3-29 17:41
Excipient Applications in Formulation Design and Drug Delivery,and drug delivery with focus on stability implications of drug-excipient interactions, impact of excipients on drug release and bioavailability, the factors that weigh into excipient selection and formulation design, including excipient functionality.作者: gene-therapy 時(shí)間: 2025-3-29 22:47 作者: 大洪水 時(shí)間: 2025-3-30 03:40 作者: 持續(xù) 時(shí)間: 2025-3-30 06:37 作者: Neutropenia 時(shí)間: 2025-3-30 10:51 作者: HALL 時(shí)間: 2025-3-30 12:52
Heiko Schmolke,Anabel Ternès,Ian Towersfficacy of the amorphous material. This book chapter intends to highlight the delivery issues pertaining to amorphous drugs with a special emphasis on the most commonly used excipients in stabilizing amorphous drug substances in formulations.作者: flaunt 時(shí)間: 2025-3-30 17:03 作者: 窩轉(zhuǎn)脊椎動(dòng)物 時(shí)間: 2025-3-30 23:58
Excipients That Facilitate Amorphous Drug Stabilizationfficacy of the amorphous material. This book chapter intends to highlight the delivery issues pertaining to amorphous drugs with a special emphasis on the most commonly used excipients in stabilizing amorphous drug substances in formulations.作者: perimenopause 時(shí)間: 2025-3-31 01:08
978-3-319-37107-8Springer International Publishing Switzerland 2015作者: LIKEN 時(shí)間: 2025-3-31 06:22
J. J. C. Picot,D. D. Kristmansonmaterials provide opportunities to design optimal drug delivery systems. Emerging trends in the design and development of drug products indicate ever greater need for characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents an integra
