標(biāo)題: Titlebook: Evolutionary Dynamics of Malignancy; The Genetic and Envi Robert C. Jackson Book 2023 The Editor(s) (if applicable) and The Author(s), unde [打印本頁] 作者: CYNIC 時間: 2025-3-21 16:24
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作者: MANIA 時間: 2025-3-21 22:23
Genetic and Chromosomal Instability,etic damage. Tumours are genetically unstable, such that the number of mutations and chromosomal abnormalities increases with time. Genetic and/or chromosomal instability is now regarded as the defining characteristic of cancer..Cancer genome projects, based upon whole genome sequencing, have identi作者: Mhc-Molecule 時間: 2025-3-22 04:01
Cancer as a Disease of Defective Cell Cycle Checkpoint Function,factors. The normal cell division cycle contains checkpoints that prevent a cell from progressing to the next phase if abnormalities (e.g. DNA damage) are present; the cell will not progress until the problem is corrected. If the damage cannot be corrected in a few hours, the damaged cell will under作者: guardianship 時間: 2025-3-22 05:09
The DNA Damage Checkpoint,DNA damage that can trigger the checkpoint include single-strand breaks, double-strand breaks, stalled replication forks, and premature chain termination. Many tumours have mutations or deletions of one or more components of the DDR. For this reason, tumours are often repair-deficient, so that DNA-d作者: 熱情的我 時間: 2025-3-22 10:30
Dynamics of the Spindle Assembly Checkpoint,ergoing cytokinesis and completing cell division. In normal cells, prolonged cell cycle arrest by the SAC results in apoptosis. Most cancer cells have mutations or expression changes in components of the SAC that allow cells with abnormal chromosomes to escape the checkpoint, and because of over-rid作者: 柔聲地說 時間: 2025-3-22 16:43 作者: 柔聲地說 時間: 2025-3-22 19:17 作者: 散布 時間: 2025-3-23 00:00
Chronic Myelomonocytic Leukaemia: A Three-Hit Malignancy,ined. Those epigenetic changes may in turn be a result of genetic or chromosomal instability. Malignant progression caused by epigenetic silencing of function of tumour suppressor genes will often require inactivation of both alleles, though in some cases loss of a single allele may result in alleli作者: 偏離 時間: 2025-3-23 03:40 作者: CLAP 時間: 2025-3-23 09:16
Evading the Antitumour Immune Response,r immune response. As tumour progression proceeds, genetic instability results in the developing tumour becoming increasingly immunogenic. Immune surveillance may result in early-stage tumours being eliminated without developing into clinically evident disease. Less immunogenic tumours may be held i作者: 制定法律 時間: 2025-3-23 09:41
Implications of Evolutionary Dynamics for Cancer Treatment and Prevention,tially prevented by minimising exposure to radiation and chemical carcinogens, but there is a baseline amount of spontaneous chromosomal damage and genetic mutation, meaning that cancer can never be completely prevented. Although it may never be possible to prevent cancer initiation, many of the dea作者: FRONT 時間: 2025-3-23 14:56 作者: 懶洋洋 時間: 2025-3-23 18:32 作者: 玉米 時間: 2025-3-23 22:48
http://image.papertrans.cn/e/image/317934.jpg作者: lattice 時間: 2025-3-24 05:01 作者: Offstage 時間: 2025-3-24 08:48
https://doi.org/10.1007/978-3-031-32573-1cancer evolution; evolutionary dynamics; mathematical modeling of cancer; computational models; cancer t作者: Diastole 時間: 2025-3-24 13:56
Gerard A. J. M. Jagers op Akkerhuistes. The cellular environment exerts selective pressure on the cellular variants in the tumour population. Tumours have multiple biochemical abnormalities, but the most consistent changes relate to increased cell division. Decreased spontaneous cell death is also often seen. Loss of differentiated t作者: 關(guān)心 時間: 2025-3-24 15:46
Lecture Notes in Biomathematicsetic damage. Tumours are genetically unstable, such that the number of mutations and chromosomal abnormalities increases with time. Genetic and/or chromosomal instability is now regarded as the defining characteristic of cancer..Cancer genome projects, based upon whole genome sequencing, have identi作者: dialect 時間: 2025-3-24 22:24
Hot Issues of the Yangtze River,factors. The normal cell division cycle contains checkpoints that prevent a cell from progressing to the next phase if abnormalities (e.g. DNA damage) are present; the cell will not progress until the problem is corrected. If the damage cannot be corrected in a few hours, the damaged cell will under作者: originality 時間: 2025-3-25 02:27 作者: ANNUL 時間: 2025-3-25 04:53 作者: 卜聞 時間: 2025-3-25 10:22 作者: 粉筆 時間: 2025-3-25 12:54 作者: 內(nèi)行 時間: 2025-3-25 16:55
Hans-Erhard Lessing,Tony Hadlandined. Those epigenetic changes may in turn be a result of genetic or chromosomal instability. Malignant progression caused by epigenetic silencing of function of tumour suppressor genes will often require inactivation of both alleles, though in some cases loss of a single allele may result in alleli作者: GEN 時間: 2025-3-25 22:44 作者: 發(fā)牢騷 時間: 2025-3-26 00:53
A Thermodynamic View of Successionr immune response. As tumour progression proceeds, genetic instability results in the developing tumour becoming increasingly immunogenic. Immune surveillance may result in early-stage tumours being eliminated without developing into clinically evident disease. Less immunogenic tumours may be held i作者: Dictation 時間: 2025-3-26 06:39 作者: 船員 時間: 2025-3-26 11:46 作者: 胎兒 時間: 2025-3-26 13:55
Cancer as a Disease of Cell Proliferation,athways, that have mutated in malignant cells to become independent of their normal regulation. Tumour suppressor genes are recessive genes, often involved in signal transduction and apoptosis pathways, that carry loss-of-function mutations in tumour cells..Many anticancer drugs target the biochemic作者: demote 時間: 2025-3-26 20:30
Genetic and Chromosomal Instability,inations of mutations. The process of tumour progression results from Darwinian natural selection, with cells that have a competitive advantage eventually dominating the population..An important class of anticancer drugs, the alkylating agents, acts by causing DNA damage; their antitumour selectivit作者: stress-response 時間: 2025-3-26 23:34 作者: nonradioactive 時間: 2025-3-27 02:00 作者: 協(xié)迫 時間: 2025-3-27 09:11 作者: 小卷發(fā) 時間: 2025-3-27 09:40
Dynamics of Drug Resistance,reduce the probability of multi-drug-resistant tumour cells. Resistance of normal tissues, such as bone marrow, is not seen because the number of sensitive stem cells is too small, and because their mutation rates are lower. Evolutionary dynamics calculations can predict the probability of developme作者: 收藏品 時間: 2025-3-27 17:36
Chronic Myeloid Leukaemia: A One-Hit Malignancy, the switch-off does not occur, and high levels of ROS are responsible for much of the morbidity of CML. Among the damaging effects of ROS is oxidation of DNA guanine bases to 8-oxo-guanine. This is mutagenic because 8-oxo-G miscodes, resulting in genetic instability. Inhibitors of Abl kinase activi作者: 偏離 時間: 2025-3-27 18:24
Chronic Myelomonocytic Leukaemia: A Three-Hit Malignancy,iology. About 20% of CMML patients progress to a form of AML, but progression is slow, and most CMML patients succumb to other effects of the disease before it progresses to the acute stage. Hypomethylating agents such as decitabine are frequently effective treatment for CMML. Histone deacetylase in作者: Brittle 時間: 2025-3-28 01:32
The Cancer Stem Cell and Tumour Progression,presence of antitumour drugs. Evolutionary dynamics calculations suggest that the Warburg effect (aerobic glycolysis) confers a selective advantage on metastatic cells by downregulation of the intrinsic pathway of apoptosis. At least three mutations are required for a tumour stem cell to progress to作者: 令人作嘔 時間: 2025-3-28 04:24
Evading the Antitumour Immune Response,ng growth factor receptors and immune checkpoints. Monoclonal antibodies are limited to extracellular targets. Cancer vaccines that target neo-epitopes found on tumour cells are under evaluation against multiple tumour types. To prevent the rapid emergence of resistance, vaccines usually target mult作者: 偏狂癥 時間: 2025-3-28 09:04 作者: 無辜 時間: 2025-3-28 12:38 作者: tariff 時間: 2025-3-28 14:35 作者: critic 時間: 2025-3-28 18:50
Gerard A. J. M. Jagers op Akkerhuisathways, that have mutated in malignant cells to become independent of their normal regulation. Tumour suppressor genes are recessive genes, often involved in signal transduction and apoptosis pathways, that carry loss-of-function mutations in tumour cells..Many anticancer drugs target the biochemic作者: 符合規(guī)定 時間: 2025-3-29 00:45 作者: Climate 時間: 2025-3-29 05:03 作者: Pepsin 時間: 2025-3-29 10:11 作者: STENT 時間: 2025-3-29 14:53 作者: neuron 時間: 2025-3-29 15:44
Christine Mitter,Thomas Wohlschlagerreduce the probability of multi-drug-resistant tumour cells. Resistance of normal tissues, such as bone marrow, is not seen because the number of sensitive stem cells is too small, and because their mutation rates are lower. Evolutionary dynamics calculations can predict the probability of developme作者: IST 時間: 2025-3-29 22:35
Evolution der Sprache und Vernunft the switch-off does not occur, and high levels of ROS are responsible for much of the morbidity of CML. Among the damaging effects of ROS is oxidation of DNA guanine bases to 8-oxo-guanine. This is mutagenic because 8-oxo-G miscodes, resulting in genetic instability. Inhibitors of Abl kinase activi
