標(biāo)題: Titlebook: Epigenetics and Disease; Pharmaceutical Oppor Susan M. Gasser,En Li Book 2011 Springer Basel AG 2011 DNA methylation.cancer.neuronal disord [打印本頁] 作者: 遮陽傘 時間: 2025-3-21 18:08
書目名稱Epigenetics and Disease影響因子(影響力)
書目名稱Epigenetics and Disease影響因子(影響力)學(xué)科排名
書目名稱Epigenetics and Disease網(wǎng)絡(luò)公開度
書目名稱Epigenetics and Disease網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Epigenetics and Disease被引頻次
書目名稱Epigenetics and Disease被引頻次學(xué)科排名
書目名稱Epigenetics and Disease年度引用
書目名稱Epigenetics and Disease年度引用學(xué)科排名
書目名稱Epigenetics and Disease讀者反饋
書目名稱Epigenetics and Disease讀者反饋學(xué)科排名
作者: 使迷醉 時間: 2025-3-21 22:17
America, Pakistan, and the India Factorysine demethylases (erasers). Importantly, epigenetic modifications impact chromatin structure directly or can be read by effector regulatory modules. Here, we summarize current knowledge on structural and functional properties of various histone lysine methyltransfereases and demethylases, with emphasis on their importance as druggable targets.作者: Middle-Ear 時間: 2025-3-22 03:53
https://doi.org/10.1007/978-94-6209-878-7ed in important human diseases, including cancer and hepatitis C. We discuss antisense strategies targeting miR-122 as a potential therapeutic approach to treat hepatitis C and possibly other diseases.作者: Host142 時間: 2025-3-22 07:44 作者: 廣口瓶 時間: 2025-3-22 10:25 作者: 遵循的規(guī)范 時間: 2025-3-22 15:49
The Liver-Specific MicroRNA miR-122: Biology and Therapeutic Potential,ed in important human diseases, including cancer and hepatitis C. We discuss antisense strategies targeting miR-122 as a potential therapeutic approach to treat hepatitis C and possibly other diseases.作者: 遵循的規(guī)范 時間: 2025-3-22 19:40
Small Molecules in Cellular Reprogramming and Differentiation,tions, but also such small molecules could be further developed as conventional therapeutics to target patient’s own cells residing in different tissues/organs for treating degenerative diseases, injuries, and cancer. Here, we will review recent studies of small molecules in controlling cell fate.作者: collagen 時間: 2025-3-22 21:43 作者: palpitate 時間: 2025-3-23 01:48
https://doi.org/10.1057/9781137432841 of epigenetic regulators, highlighting a potentially new avenue for therapeutic intervention. In this review, we discuss recent studies on epigenetic regulation in MR and explore the concept of epigenetic therapy for MR.作者: 最有利 時間: 2025-3-23 05:58 作者: Gleason-score 時間: 2025-3-23 12:00 作者: Conspiracy 時間: 2025-3-23 15:10
Book 2011rsible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders.Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations 作者: 遠(yuǎn)地點(diǎn) 時間: 2025-3-23 21:42 作者: 移植 時間: 2025-3-23 23:03
Book 2011fic background for clinical applications of epigenetically active drugs.Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.作者: BAN 時間: 2025-3-24 02:52
Myth 6: Exceptional Living Standardsethylation of CpG islands, reducing epigenetic plasticity of critical developmental and tumor suppressor genes, rendering them unresponsive to normal stimuli. Here, we will discuss the importance of both established and novel molecular concepts that may underlie the role of DNA methylation in cancer作者: Intentional 時間: 2025-3-24 07:44
Multi-level Assessment on EPSCoR,cing a revolution in the strategies used to measure epigenetic alterations, which includes the incorporation of next generation sequencing tools. We also will review strategies that utilize epigenetic information for translational purposes, with a special emphasis on the potential use of DNA methyla作者: 美麗的寫 時間: 2025-3-24 13:20
https://doi.org/10.1007/978-3-030-44699-4thylation across their genomes, reflecting an underlying epigenetic instability that may have contributed to carcinogenesis. The phenotype of unstable methylation in cancer illustrates the importance of quality control in the DNA methylation system and implies the existence of proof-reading mechanis作者: Arrhythmia 時間: 2025-3-24 15:45 作者: spinal-stenosis 時間: 2025-3-24 21:00
China’s Approach to Economic Diplomacylterations in global levels of specific histone modifications, generating an additional layer of epigenetic heterogeneity at the cellular level in tumor tissues. Unlike locus-specific changes, the cellular epigenetic heterogeneity can be used to define previously unrecognized subsets of cancer patie作者: Tailor 時間: 2025-3-25 01:26 作者: 躺下殘殺 時間: 2025-3-25 06:26 作者: 分離 時間: 2025-3-25 09:21 作者: installment 時間: 2025-3-25 12:45 作者: Oversee 時間: 2025-3-25 17:36
Genome-Wide Epigenetic Modifications in Cancer,cing a revolution in the strategies used to measure epigenetic alterations, which includes the incorporation of next generation sequencing tools. We also will review strategies that utilize epigenetic information for translational purposes, with a special emphasis on the potential use of DNA methyla作者: Mere僅僅 時間: 2025-3-25 19:58
DNA Repair and the Control of DNA Methylation,thylation across their genomes, reflecting an underlying epigenetic instability that may have contributed to carcinogenesis. The phenotype of unstable methylation in cancer illustrates the importance of quality control in the DNA methylation system and implies the existence of proof-reading mechanis作者: MIME 時間: 2025-3-26 00:40
Errors in Erasure: Links Between Histone Lysine Methylation Removal and Disease,emoved from the chromatin template. We describe how these “erasure” mechanisms are linked to pathways that are known to be misregulated in diseases, such as cancer. We further describe how errors in the removal of histone methylation can and do lead to human pathologies, both directly and indirectly作者: HAUNT 時間: 2025-3-26 07:02 作者: observatory 時間: 2025-3-26 09:32 作者: Apoptosis 時間: 2025-3-26 13:27 作者: 越自我 時間: 2025-3-26 18:33
Transcriptional Regulatory Networks in Embryonic Stem Cells,lso beginning to unravel the transcriptional regulatory networks that govern the ESC identity. Loss-of-function RNAi screens also identified novel regulatory molecules involved in the stable propagation of the ESC state. This argues for an ESC transcriptional regulation program in which interconnect作者: 租約 時間: 2025-3-26 22:19
DNA Methylation and Cancer,. Aberrant DNA methylation patterns are acquired during carcinogenic transformation; such events are often accompanied by alterations in chromatin structure at gene regulatory regions. The expression pattern of any given gene is achieved by interacting epigenetic mechanisms. First, the insertion of 作者: foppish 時間: 2025-3-27 03:46 作者: Bombast 時間: 2025-3-27 08:50
DNA Repair and the Control of DNA Methylation,provided by epigenetic mechanisms that facilitate a selective readout of the genome. Operating at the level of chromatin, they establish defined gene expression programs during cell differentiation. Among the epigenetic modifications in mammalian chromatin, the 5′-methylation of cytosine in CpG dinu作者: 跟隨 時間: 2025-3-27 12:00 作者: 克制 時間: 2025-3-27 16:01
Histone Modifications in Cancer Biology and Prognosis,t various DNA-based processes, such as gene regulation. Histones are proteins around which the DNA wraps itself to form chromatin – the physiologically relevant form of the human genome. Histones are modified extensively by posttranslational modifications that alter chromatin structure and serve to 作者: BOOM 時間: 2025-3-27 18:12
Dynamics of Histone Lysine Methylation: Structures of Methyl Writers and Erasers,esses acting on DNA. ATP-dependent chromatin remodeling machines and histone-modifying complexes can overcome this barrier (or strengthen it in silencing processes). Both components of chromatin (DNA and histones) are subject to postsynthetic covalent modifications, including methylation of lysines 作者: 人類 時間: 2025-3-27 22:05
Epigenetic Mechanisms of Mental Retardation,me incorporates a highly diverse group of mental disorders characterized by the combination of cognitive impairment and defective adaptive behavior. The genetic basis of the disease is strongly supported by identification of the genetic lesions associated with impaired cognition, learning, and socia作者: mydriatic 時間: 2025-3-28 05:03 作者: CRAB 時間: 2025-3-28 10:10 作者: 舊病復(fù)發(fā) 時間: 2025-3-28 14:07 作者: BILK 時間: 2025-3-28 18:22 作者: lavish 時間: 2025-3-28 20:00 作者: 放肆的我 時間: 2025-3-28 23:55
Small Molecules in Cellular Reprogramming and Differentiation, derive functional tissue-specific cells for biomedical research and future therapies. Chemical compounds targeting enzymes or signaling proteins are powerful tools to regulate and reveal complex cellular processes and have been identified and applied to controlling cell fate and function, including作者: CHART 時間: 2025-3-29 06:13 作者: Endoscope 時間: 2025-3-29 08:53
Myth 6: Exceptional Living Standards. Aberrant DNA methylation patterns are acquired during carcinogenic transformation; such events are often accompanied by alterations in chromatin structure at gene regulatory regions. The expression pattern of any given gene is achieved by interacting epigenetic mechanisms. First, the insertion of 作者: archetype 時間: 2025-3-29 12:31
Multi-level Assessment on EPSCoR,t gene expression patterns. Due to recent technological advantages, the scientific community is now obtaining a better picture of the genome-wide epigenetic changes that occur in a cancer genome. These epigenetic alterations are associated with chromosomal instability and changes in transcriptional 作者: languid 時間: 2025-3-29 16:23
https://doi.org/10.1007/978-3-030-44699-4provided by epigenetic mechanisms that facilitate a selective readout of the genome. Operating at the level of chromatin, they establish defined gene expression programs during cell differentiation. Among the epigenetic modifications in mammalian chromatin, the 5′-methylation of cytosine in CpG dinu作者: glamor 時間: 2025-3-29 19:50 作者: Pepsin 時間: 2025-3-30 02:02 作者: 無能力 時間: 2025-3-30 05:19
America, Pakistan, and the India Factoresses acting on DNA. ATP-dependent chromatin remodeling machines and histone-modifying complexes can overcome this barrier (or strengthen it in silencing processes). Both components of chromatin (DNA and histones) are subject to postsynthetic covalent modifications, including methylation of lysines 作者: 空洞 時間: 2025-3-30 08:26 作者: cunning 時間: 2025-3-30 16:19
https://doi.org/10.1057/9781137432841ognitive impairment, which is diagnosed by a low intelligence quotient (IQ) (<70). Over the years, human genetic studies identified a plethora of candidate genes causing MR, but mechanisms by which these candidates regulate cognitive function remain poorly understood. While the functions of MR genes
