標(biāo)題: Titlebook: Epigenetic Methods in Neuroscience Research; Nina Karpova Book 2016 Springer Science+Business Media New York 2016 ChIP.DNA.chromatin immun [打印本頁(yè)] 作者: 會(huì)議記錄 時(shí)間: 2025-3-21 17:21
書(shū)目名稱(chēng)Epigenetic Methods in Neuroscience Research影響因子(影響力)
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書(shū)目名稱(chēng)Epigenetic Methods in Neuroscience Research被引頻次
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書(shū)目名稱(chēng)Epigenetic Methods in Neuroscience Research讀者反饋
書(shū)目名稱(chēng)Epigenetic Methods in Neuroscience Research讀者反饋學(xué)科排名
作者: 陶器 時(shí)間: 2025-3-21 22:07
Nina KarpovaIncludes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts作者: 完整 時(shí)間: 2025-3-22 02:07 作者: defuse 時(shí)間: 2025-3-22 08:03 作者: 輕打 時(shí)間: 2025-3-22 12:17
Epigenetic Methods in Neuroscience Research978-1-4939-2754-8Series ISSN 0893-2336 Series E-ISSN 1940-6045 作者: 入會(huì) 時(shí)間: 2025-3-22 15:22
Alternative Views of the State,ce. Epigenetic mechanisms are fundamental for normal development and maintenance of tissue-specific gene expression. Abnormalities in epigenetic processes can lead to abnormal gene function and the development of diseases. Recent evidences suggest that several diseases and behavioral disorders resul作者: 入會(huì) 時(shí)間: 2025-3-22 17:36 作者: 親密 時(shí)間: 2025-3-22 22:26 作者: 保守黨 時(shí)間: 2025-3-23 02:16
,Possible Ways of Roundabouts’ Development,and promoter methylation state can also be often observed. To elucidate the functional significance of DNA methylation for gene transcriptional activity, the simultaneous analysis of RNA expression and DNA methylation levels should be performed. In this chapter we introduce a protocol for extracting作者: PANEL 時(shí)間: 2025-3-23 08:50
Discussion Panel 4: Alternative Land Usen of the central nervous system. Observations of experience-dependent fluctuations in the patterns of 5mC at neuronal gene enhancers, promoters and intragenic regions have prompted great interest in the role of DNA methylation mechanisms in the brain. In addition, the recent discovery of 5-hydroxyme作者: Celiac-Plexus 時(shí)間: 2025-3-23 13:12 作者: 門(mén)窗的側(cè)柱 時(shí)間: 2025-3-23 14:23 作者: stressors 時(shí)間: 2025-3-23 22:04 作者: 即席演說(shuō) 時(shí)間: 2025-3-24 01:59
An Introduction to Theoretical Issues,c development, cellular differentiation, and maintenance of cellular function. Histone modifications, together with DNA methylation, represent the major epigenetic events. Here, we describe a chromatin immunoprecipitation (ChIP) method for the analysis of histone modifications, taking a study of ore作者: 哥哥噴涌而出 時(shí)間: 2025-3-24 03:07 作者: 打谷工具 時(shí)間: 2025-3-24 09:19 作者: lactic 時(shí)間: 2025-3-24 10:57
https://doi.org/10.1007/978-3-662-44420-7ting synapses in response to stimulation. Indeed, highly specific activity-dependent neuronal responses are critical for modulating synapses in order to facilitate learning and memory. Brain-derived neurotrophic factor (BDNF) is a small, secreted protein that has been shown to play critical roles in作者: Hyperlipidemia 時(shí)間: 2025-3-24 18:53 作者: 玉米棒子 時(shí)間: 2025-3-24 20:43
Determinanten des Strukturwandels,les modulate gene expression by either repressing translation or inducing mRNA degradation, and collectively may regulate as much as two-thirds of the transcriptome. By affecting gene regulation, miRNAs are likely to be involved in most biological processes, with small variations in miRNA expression作者: APNEA 時(shí)間: 2025-3-25 00:59
Interdisciplinary Systems Researchne secretion. Alignment of drug dosing time to body time can maximize the pharmacological effect and minimize untoward effects. Therefore, a simple and robust method for estimating body time is important for drug efficacy or “chronotherapy”. We previously reported that a metabolite timetable could e作者: 旁觀者 時(shí)間: 2025-3-25 06:14 作者: flavonoids 時(shí)間: 2025-3-25 10:38
Site-Specific Delivery of Epigenetic Modulating Drugs into the Rat Brainnique enables the pharmacological manipulation of targeted molecules, such as DNMT and HDAC, in specific brain areas, in conscious animals. This chapter presents a step-by-step description of cannula implantation in targeted brain structures and microinjection using neurostereotaxic surgery.作者: 臥虎藏龍 時(shí)間: 2025-3-25 13:44
Book 2016n the popular?.Neuromethods.?series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory..Concise and easy-to-use,?.Epigenetic Methods in Neuroscience Research.?provides multidisciplinary epigenetic approach to study g作者: oxidant 時(shí)間: 2025-3-25 19:51
Epigenetics: From Basic Biology to Chromatin-Modifying Drugs and New Potential Clinical Applicationsrs are focusing on finding new epigenetic targets for the development of new molecules for the treatment of different CNS disorders such as autism and schizophrenia targeting specific enzymes that play an important role in gene expression and function.作者: intention 時(shí)間: 2025-3-25 21:32
Simultaneous Quantification of Global 5mC and 5hmC Levels in the Nervous System Using an HPLC/MS Metonitoring (HPLC-ESI-MS/MS-MRM) for the simultaneous detection and quantification of global 5mC and 5hmC levels present in genomic DNA from nervous-system derived samples. HPLC-ESI-MS/MS-MRM analysis offers the highest levels of sensitivity, selectivity, and precision available for the determination 作者: 皺痕 時(shí)間: 2025-3-26 04:10
Immunohistochemical Detection of Oxidized Forms of 5-Methylcytosine in Embryonic and Adult Brain Tisd secondary antibodies and tyramide signal amplification. This technique can be instrumental in determining the relative enrichments of oxidized forms of 5mC in different brain cell types, effectively complementing other established approaches to investigate the functions of these marks in embryonic作者: Apogee 時(shí)間: 2025-3-26 04:35
Protocol for High-Throughput miRNA Profiling of the Rat Brains such as the rat provide an affordable and reliable means to investigate the role of miRNA in relation to structure, function, and behavior. Here we present a systematic approach to examining genome-wide expression of miRNA in the rat brain. This method involves the isolation and quantification of 作者: Itinerant 時(shí)間: 2025-3-26 10:52
Alternative Views of the State,rs are focusing on finding new epigenetic targets for the development of new molecules for the treatment of different CNS disorders such as autism and schizophrenia targeting specific enzymes that play an important role in gene expression and function.作者: 吞下 時(shí)間: 2025-3-26 14:44 作者: 使成整體 時(shí)間: 2025-3-26 18:05
Elmar Altvater,Kurt Hübner,Michael Stangerd secondary antibodies and tyramide signal amplification. This technique can be instrumental in determining the relative enrichments of oxidized forms of 5mC in different brain cell types, effectively complementing other established approaches to investigate the functions of these marks in embryonic作者: 一大群 時(shí)間: 2025-3-26 21:14
Determinanten des Strukturwandels,s such as the rat provide an affordable and reliable means to investigate the role of miRNA in relation to structure, function, and behavior. Here we present a systematic approach to examining genome-wide expression of miRNA in the rat brain. This method involves the isolation and quantification of 作者: 表示向下 時(shí)間: 2025-3-27 02:15
0893-2336 to get successful results in your own laboratory..Concise and easy-to-use,?.Epigenetic Methods in Neuroscience Research.?provides multidisciplinary epigenetic approach to study g978-1-4939-4941-0978-1-4939-2754-8Series ISSN 0893-2336 Series E-ISSN 1940-6045 作者: limber 時(shí)間: 2025-3-27 07:32
Analysis of Brain Epigenome: A Guide to Epigenetic Methodsis of DNA methylation (Sect. 2), histone modifications (Sect. 3) and noncoding RNAs (Sect. 4). Each section briefly introduces the main steps and output, advantages, considerations, and limitations of the methods, as well as some alternative approaches further developed from the original method.作者: moratorium 時(shí)間: 2025-3-27 11:59 作者: Leaven 時(shí)間: 2025-3-27 15:21
,Possible Ways of Roundabouts’ Development,an then be used for expression microarray, transcriptome or small RNA analyses by next-generation sequencing (NGS), while the bisulfite PCR products can be analyzed using capillary sequencing, pyrosequencing, or NGS.作者: Obedient 時(shí)間: 2025-3-27 19:50 作者: orthodox 時(shí)間: 2025-3-28 01:18
Colin D. Buxton,Patrick A. Garratt and animal models of diseases from cancer to neurodegeneration. These findings have stimulated further interest in transposon biology and created the need for further dissemination of the methods for analysis of TE expression, which is the goal of this chapter.作者: Palter 時(shí)間: 2025-3-28 04:35
A Protocol for the Simultaneous Analysis of Gene DNA Methylation and mRNA Expression Levels in the Ran then be used for expression microarray, transcriptome or small RNA analyses by next-generation sequencing (NGS), while the bisulfite PCR products can be analyzed using capillary sequencing, pyrosequencing, or NGS.作者: 生意行為 時(shí)間: 2025-3-28 06:30 作者: 乏味 時(shí)間: 2025-3-28 12:31 作者: 放大 時(shí)間: 2025-3-28 16:20 作者: 尖酸一點(diǎn) 時(shí)間: 2025-3-28 21:38
https://doi.org/10.1007/978-3-662-44420-7itro studies have demonstrated that dendritically synthesized BDNF, derived from long 3′ UTR . mRNA, is required for spine maturation and spine pruning. In this chapter, we describe methodology used to understand the molecular mechanisms through which dendritically synthesized proteins (i.e., BDNF) modulate synaptic plasticity.作者: Temporal-Lobe 時(shí)間: 2025-3-28 23:43
https://doi.org/10.1007/978-3-531-93301-6NA) probes and the tyramide signal amplification (TSA) system for detection of microRNAs in frozen brain tissue sections. Combining this miRNA-FISH method with immunofluorescence using neuron-specific antibodies allows cell type-specific localization of miRNAs in the brain.作者: 使更活躍 時(shí)間: 2025-3-29 06:36 作者: Diastole 時(shí)間: 2025-3-29 07:38 作者: 合唱隊(duì) 時(shí)間: 2025-3-29 15:09 作者: Tractable 時(shí)間: 2025-3-29 18:32 作者: heart-murmur 時(shí)間: 2025-3-29 20:30 作者: 功多汁水 時(shí)間: 2025-3-30 02:20 作者: Offstage 時(shí)間: 2025-3-30 05:00 作者: 流行 時(shí)間: 2025-3-30 10:58
Interdisciplinary Systems Researchstimate body time with good accuracy. A metabolite timetable was constructed by profiling metabolites in human and mouse with capillary electrophoresis-mass spectrometry (CE-MS) and liquid chromatography–mass spectrometry (LC-MS). In this chapter, we describe practical methods to profile and identify oscillating metabolites.作者: Supplement 時(shí)間: 2025-3-30 12:34
0893-2336 ation advice from the experts.This volume presents state-of-the-art methods for reliable detection of epigenetic changes in the nervous system.?.Epigenetic Methods in Neuroscience Research.? guides readers through methods for the analyses of chromatin remodeling, transposable elements, non-coding RN作者: 呼吸 時(shí)間: 2025-3-30 20:03 作者: 工作 時(shí)間: 2025-3-30 21:39
An Introduction to Theoretical Issues,or epigenetic events. Here, we describe a chromatin immunoprecipitation (ChIP) method for the analysis of histone modifications, taking a study of orexin neurons as an example. This method can be used in basic and applied neurobiology.作者: 手段 時(shí)間: 2025-3-31 01:06 作者: unstable-angina 時(shí)間: 2025-3-31 06:59
Analysis of Brain Epigenome: A Guide to Epigenetic Methodsity is controlled by the epigenetic mechanisms. This chapter describes the key epigenetic events at gene promoters, gene bodies, and 3′-untranslated regions that are critical for control of gene expression especially in the brain. Sections 2–4 of the chapter overview different methods for the analys作者: 大范圍流行 時(shí)間: 2025-3-31 10:10
Analysis of DNA Methylation by Bisulfite Reaction in Neural Cells as an Example of Orexin Neurons involved in various biological phenomena through gene silencing, stabilizing chromosomal structure and suppressing the mobility of retrotransposons. Here, we describe the methods of analyzing DNA methylation by bisulfite-DNA reactions and combined bisulfite restriction analysis (COBRA), as an examp作者: 玉米棒子 時(shí)間: 2025-3-31 15:02
A Protocol for the Simultaneous Analysis of Gene DNA Methylation and mRNA Expression Levels in the Rand promoter methylation state can also be often observed. To elucidate the functional significance of DNA methylation for gene transcriptional activity, the simultaneous analysis of RNA expression and DNA methylation levels should be performed. In this chapter we introduce a protocol for extracting
