標題: Titlebook: Epigenetic Alterations in Oncogenesis; Adam R. Karpf Book 2013 The Editor(s) (if applicable) and The Author(s), under exclusive license to [打印本頁] 作者: BOUT 時間: 2025-3-21 17:37
書目名稱Epigenetic Alterations in Oncogenesis影響因子(影響力)
書目名稱Epigenetic Alterations in Oncogenesis影響因子(影響力)學科排名
書目名稱Epigenetic Alterations in Oncogenesis網(wǎng)絡公開度
書目名稱Epigenetic Alterations in Oncogenesis網(wǎng)絡公開度學科排名
書目名稱Epigenetic Alterations in Oncogenesis被引頻次
書目名稱Epigenetic Alterations in Oncogenesis被引頻次學科排名
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書目名稱Epigenetic Alterations in Oncogenesis年度引用學科排名
書目名稱Epigenetic Alterations in Oncogenesis讀者反饋
書目名稱Epigenetic Alterations in Oncogenesis讀者反饋學科排名
作者: LAVA 時間: 2025-3-21 23:02 作者: Aspiration 時間: 2025-3-22 01:57
Ten Eleven Translocation Enzymes and 5-Hydroxymethylation in Mammalian Development and Cancerlthough 5hmC was discovered several decades ago, it was only after its recent identification in murine brain and stem cell DNA that it has become a major focus of epigenomic research. Part of the reason for this delay is due to the difficulty in detecting both global and locus-specific 5hmC levels. 作者: Wordlist 時間: 2025-3-22 07:01
Altered Histone Modifications in Cancerin coding genes. These actions are central to human health and are evidently aberrant in cancer. Central components of regulated gene expression are a variety of epigenetic mechanisms that include histone modifications. The post-translational modifications of histones are widespread and diverse, and作者: 砍伐 時間: 2025-3-22 08:58
Nucleosome Occupancy and Gene Regulation During Tumorigenesiscert with other epigenetic mechanisms (such as DNA methylation, histone modifications, changes in histone variants, as well as small noncoding regulatory RNAs) play essential roles in the control of gene expression. Here, we discuss the mechanisms and factors that regulate nucleosome position and ge作者: 確定方向 時間: 2025-3-22 12:54
Epigenetic Regulation of miRNAs in Cancerme regulatory epigenetic processes of protein coding genes. In turn, a specific subgroup of miRNAs, called epi-miRNAs, is able to directly target key enzymatic effectors of the epigenetic machinery (such as DNA methyltransferases, histone deacetylases, and polycomb genes), therefore indirectly affec作者: 確定方向 時間: 2025-3-22 18:04
DNA Hypomethylation and Activation of Germline-Specific Genes in Cancers become profoundly altered in cancer cells: both gains (hypermethylation) and losses (hypomethylation) of methylated sites are observed. Although DNA hypomethylation is detected in a vast majority of human tumors and affects many genomic regions, its role in tumor biology remains elusive. Surprisin作者: Leisureliness 時間: 2025-3-22 22:40 作者: glans-penis 時間: 2025-3-23 02:30
Epigenetic Changes During Cell Transformationmental inputs participate in driving the epigenetic changes that occur during human carcinogenesis. The pathologic changes seen in DNA methylation and histone posttranslational modifications are complex, deeply intertwined, and act in concert to produce malignant transformation. To better understand作者: Custodian 時間: 2025-3-23 07:02 作者: anagen 時間: 2025-3-23 13:10 作者: Firefly 時間: 2025-3-23 14:41 作者: 馬具 時間: 2025-3-23 21:06
Epigenetic Therapies in MDS and AMLsignificant impact. In the past, therapies for these diseases were limited and patients who elected to receive treatment were subject to highly toxic, inpatient chemotherapeutics, which were often ineffective. In the era of hypomethylating agents (azacitidine and decitabine), a patient with high gra作者: 茁壯成長 時間: 2025-3-23 22:29 作者: dragon 時間: 2025-3-24 05:10
Methods for Cancer Epigenome Analysisn cancer are functionally important and clinically relevant, but even this well-studied area is continually re-evaluated in light of unanticipated results, such as the strong association between aberrant DNA methylation in adult tumors and polycomb group profiles in embryonic stem cells, cancer-asso作者: 充氣球 時間: 2025-3-24 09:11 作者: 虛構的東西 時間: 2025-3-24 13:12 作者: 橡子 時間: 2025-3-24 17:42 作者: malapropism 時間: 2025-3-24 21:47
Schlussbetrachtung und Ausblick,in coding genes. These actions are central to human health and are evidently aberrant in cancer. Central components of regulated gene expression are a variety of epigenetic mechanisms that include histone modifications. The post-translational modifications of histones are widespread and diverse, and作者: 雇傭兵 時間: 2025-3-25 00:16
Angela Nikelski,Annette Nauerthcert with other epigenetic mechanisms (such as DNA methylation, histone modifications, changes in histone variants, as well as small noncoding regulatory RNAs) play essential roles in the control of gene expression. Here, we discuss the mechanisms and factors that regulate nucleosome position and ge作者: 使?jié)M足 時間: 2025-3-25 07:19 作者: Consequence 時間: 2025-3-25 11:18
Lebensweltorientierte Soziale (Alten-)Arbeits become profoundly altered in cancer cells: both gains (hypermethylation) and losses (hypomethylation) of methylated sites are observed. Although DNA hypomethylation is detected in a vast majority of human tumors and affects many genomic regions, its role in tumor biology remains elusive. Surprisin作者: chiropractor 時間: 2025-3-25 14:36 作者: 親密 時間: 2025-3-25 17:56 作者: commodity 時間: 2025-3-25 20:55
Sterben und Tod intra und extra murosl types. Although MSCs possess immune privilege and are more easily obtained than embryonic stem cells, their propensity to tumorigenesis has not been fully explored. Epigenomic changes in DNA methylation and chromatin structure have been hypothesized to be critical in the determination of lineage-s作者: IRK 時間: 2025-3-26 00:31
https://doi.org/10.1007/978-1-4613-1657-2lation of multiple cancer-specific heritable phenotypes triggered by the mutational and/or non-mutational (i.e., epigenetic) events. Accumulating evidence suggests that environmental and occupational exposures to natural substances, as well as man-made chemical and physical agents, play a causative 作者: myalgia 時間: 2025-3-26 08:11
Body Temperature and Drug Effects,the development of a tumor. Particularly, alteration of gene-specific and genomic DNA methylation has been extensively characterized in tumors, and has become an attractive biomarker of risk due to its specificity and stability in human samples. It also is clear that tumors do not develop as isolate作者: Diaphragm 時間: 2025-3-26 11:56 作者: 我吃花盤旋 時間: 2025-3-26 14:53 作者: Mundane 時間: 2025-3-26 18:19
,Constructing a Reputation, 1866–1879,n cancer are functionally important and clinically relevant, but even this well-studied area is continually re-evaluated in light of unanticipated results, such as the strong association between aberrant DNA methylation in adult tumors and polycomb group profiles in embryonic stem cells, cancer-asso作者: 彩色的蠟筆 時間: 2025-3-27 00:42 作者: 刺激 時間: 2025-3-27 01:06 作者: 自愛 時間: 2025-3-27 07:06
Angela Nikelski,Annette Nauerthcert with other epigenetic mechanisms (such as DNA methylation, histone modifications, changes in histone variants, as well as small noncoding regulatory RNAs) play essential roles in the control of gene expression. Here, we discuss the mechanisms and factors that regulate nucleosome position and gene expression in normal and cancer cells.作者: 舊石器時代 時間: 2025-3-27 11:35
Nucleosome Occupancy and Gene Regulation During Tumorigenesiscert with other epigenetic mechanisms (such as DNA methylation, histone modifications, changes in histone variants, as well as small noncoding regulatory RNAs) play essential roles in the control of gene expression. Here, we discuss the mechanisms and factors that regulate nucleosome position and gene expression in normal and cancer cells.作者: 大喘氣 時間: 2025-3-27 17:02
978-1-4899-8558-3The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: municipality 時間: 2025-3-27 18:36
DNA Methyltransferases, DNA Damage Repair, and Cancergenes, an array of DNA repair genes frequently sustain promoter hypermethylation in a variety of tumors. In addition, DNMT1, but not the DNMT3s, appear to function coordinately with DNA damage repair pathways to protect cells from sustaining mutagenic events, which is very likely through a DNA methy作者: 我沒有命令 時間: 2025-3-28 00:48
DNA Hypomethylation and Hemimethylation in Cancer alter transcription rates. In -addition, cancer-associated intragenic DNA hypomethylation might modulate -alternative promoter usage, -production of intragenic noncoding RNA transcripts, cotranscriptional splicing, and transcription initiation or elongation. Initial studies of hemimethylation of DN作者: Gourmet 時間: 2025-3-28 03:09
Ten Eleven Translocation Enzymes and 5-Hydroxymethylation in Mammalian Development and Cancerpes of cancer, affecting their activity and likely altering genomic 5hmC and 5mC patterns. Furthermore, oxidation of 5mC appears to be a step in several active DNA demethylation pathways, which may be important for normal processes, as well as global hypomethylation during cancer development and pro作者: motivate 時間: 2025-3-28 09:48
Altered Histone Modifications in Cancerterns also appear to reflect a correlation with altered histone modifications at both the candidate loci and genome-wide level. Clarity is emerging in resolving these relationships between histone modification status and gene expression -patterns. For example, altered transcription factor interactio作者: CRASS 時間: 2025-3-28 11:07
DNA Hypomethylation and Activation of Germline-Specific Genes in Cancer in tumors. Moreover, as CG genes encode tumor-specific antigens, their activation in cancer highlights a direct link between epigenetic alterations and tumor immunity. As a result, clinical trials combining epigenetic drugs with anti-CG antigen vaccines are being considered.作者: Resistance 時間: 2025-3-28 14:51
Epigenetic Changes During Cell Transformatione cell’s transition through well-defined cell proliferation barriers of stasis and telomere dysfunction. Following cell immortalization, stressors, such as environmental toxicants, can induce malignant transformation in a process in which the epigenetic changes occur in a smoother progressive fashio作者: jaundiced 時間: 2025-3-28 19:34
Blood-Derived DNA Methylation Markers of Cancer Riskis. Research to date has generally focused on how environmental exposures alter genomic DNA methylation content in peripheral blood. More recent work has begun to translate these findings to clinically useful endpoints, by defining the relationship between DNA methylation alterations and cancer risk作者: 法律的瑕疵 時間: 2025-3-28 23:54
Epigenetic Therapies in MDS and AMLs regarding patient selection, optimal dosing strategy, latency to best response and optimal duration of therapy following disease progression remain, but there is no question that for some patients these agents offer, for a time, an almost miraculous clinical benefit. Ongoing clinical trials in com作者: 樹膠 時間: 2025-3-29 05:28
Methods for Cancer Epigenome Analysispecific alterations in histone modifications in tumor etiology, drug response, and tumor progression. Meanwhile, the discovery of new epigenetic marks continues, and there are many useful methods for epigenome analysis applicable to primary tumor samples, in addition to cancer cell lines. For DNA me作者: 注意 時間: 2025-3-29 09:01
Dorothee Elm,Thorsten Fitzon,Kathrin Liessgenes, an array of DNA repair genes frequently sustain promoter hypermethylation in a variety of tumors. In addition, DNMT1, but not the DNMT3s, appear to function coordinately with DNA damage repair pathways to protect cells from sustaining mutagenic events, which is very likely through a DNA methy作者: 健壯 時間: 2025-3-29 14:31
Alle aktivattraktiv und keiner arm alter transcription rates. In -addition, cancer-associated intragenic DNA hypomethylation might modulate -alternative promoter usage, -production of intragenic noncoding RNA transcripts, cotranscriptional splicing, and transcription initiation or elongation. Initial studies of hemimethylation of DN作者: 整頓 時間: 2025-3-29 17:45 作者: 彎曲道理 時間: 2025-3-29 21:13 作者: Encumber 時間: 2025-3-30 00:39 作者: Conscientious 時間: 2025-3-30 05:16 作者: NOT 時間: 2025-3-30 11:19
Body Temperature and Drug Effects,is. Research to date has generally focused on how environmental exposures alter genomic DNA methylation content in peripheral blood. More recent work has begun to translate these findings to clinically useful endpoints, by defining the relationship between DNA methylation alterations and cancer risk作者: Original 時間: 2025-3-30 14:39
Malnutrition and Brain Development,s regarding patient selection, optimal dosing strategy, latency to best response and optimal duration of therapy following disease progression remain, but there is no question that for some patients these agents offer, for a time, an almost miraculous clinical benefit. Ongoing clinical trials in com作者: 擔心 時間: 2025-3-30 19:47
,Constructing a Reputation, 1866–1879,pecific alterations in histone modifications in tumor etiology, drug response, and tumor progression. Meanwhile, the discovery of new epigenetic marks continues, and there are many useful methods for epigenome analysis applicable to primary tumor samples, in addition to cancer cell lines. For DNA me作者: Ventricle 時間: 2025-3-30 21:26
ion of miRNAs in cancer.Includes supplementary material: The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not 作者: Conflagration 時間: 2025-3-31 03:00
,Alter(n) non-verbal verk?rpern,xpression of the DNA demethylase system leads to the hypomethylation of specific loci, including intestinal cell fating genes, and stabilizes intestinal cells in an undifferentiated state. Further, misregulation of this system may influence the acquisition of subsequent genetic mutations that drive tumorigenesis.作者: 創(chuàng)新 時間: 2025-3-31 07:45 作者: Adrenaline 時間: 2025-3-31 11:15
https://doi.org/10.1007/978-3-030-04774-0 will routinely include epigenetic therapies, possibly in conjunction with inhibitors of “stemness” signal pathways, to effectively reduce the devastating occurrence of cancer chemotherapy resistance.作者: 粗糙 時間: 2025-3-31 16:36
APC and DNA Demethylation in Cell Fate Specification and Intestinal Cancerxpression of the DNA demethylase system leads to the hypomethylation of specific loci, including intestinal cell fating genes, and stabilizes intestinal cells in an undifferentiated state. Further, misregulation of this system may influence the acquisition of subsequent genetic mutations that drive tumorigenesis.
