標(biāo)題: Titlebook: Enzymology and Molecular Biology of Carbonyl Metabolism 3; Henry Weiner,Bendicht Wermuth,David W. Crabb Book 1991 The Editor(s) (if applic [打印本頁(yè)] 作者: patch-test 時(shí)間: 2025-3-21 16:47
書目名稱Enzymology and Molecular Biology of Carbonyl Metabolism 3影響因子(影響力)
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書目名稱Enzymology and Molecular Biology of Carbonyl Metabolism 3年度引用學(xué)科排名
書目名稱Enzymology and Molecular Biology of Carbonyl Metabolism 3讀者反饋
書目名稱Enzymology and Molecular Biology of Carbonyl Metabolism 3讀者反饋學(xué)科排名
作者: happiness 時(shí)間: 2025-3-21 22:59 作者: MONY 時(shí)間: 2025-3-22 01:12 作者: 膽小鬼 時(shí)間: 2025-3-22 06:33
Localization of Cysteine 302 at the Active Site of Aldehyde Dehydrogenaseart of 35 residue tryptic peptide (Hempel, 1981; Hempel and Pietruszko, 1981; Hempel et al., 1982) by employing iodoacetamide. When the primary structures of the El and E2 isozymes were established (Hempel et al., 1984, 1985; Hsu et al., 1985), this cysteine was found to occupy position 302 in a 500作者: 含鐵 時(shí)間: 2025-3-22 11:15
PH Effects on Cytoplasmic Aldehyde Dehydrogenase from Sheep Livergive a complete picture of the mechanism of the aldehyde dehydrogenase catalyzed oxidation of propionaldehyde over an extended pH range. The enzyme catalyzed oxidation reaction at pH 7.0 and 7.6 is generally agreed to occur by the following ordered mechanism:.Scheme IAt least at low propionaldehyde 作者: 范例 時(shí)間: 2025-3-22 13:15
Biochemical, Immunological, and Molecular Characterization of a “High KM” Aldehyde Dehydrogenaseportant role in the toxic consequences of a deranged acetaldehyde metabolism in alcohol-related disorders (Agarwal and Goedde, 1989, 1990; Goedde and Agarwal, 1989). Two broadly defined groups of ALDHs have been recognized based upon their Michaelis constants (“l(fā)ow Km” and “high Km” isozymes). The m作者: 范例 時(shí)間: 2025-3-22 18:32
Purification and Properties of Baboon Corneal Aldehyde Dehydrogenase: Proposed UVR Protective Roleal cells and the lens, by the absorption of UVR in the 290–320 nm wavelength range (UV-B) (Boettner and Wolters, 1962; Zigman, 1983). The mechanisms of corneal photoreception of UV-B light have not been determined, as yet, although studies examining the action spectra for the cornea in the induction作者: 注射器 時(shí)間: 2025-3-23 00:52 作者: 未成熟 時(shí)間: 2025-3-23 02:18 作者: TOXIN 時(shí)間: 2025-3-23 07:13
Metabolism of 4-Hydroxynonenal in Hepatoma Cell Linesidation is well regulated and, as noted in a recent review (Esterbauer. et al. , 1990), is always associated with the formation of numerous and chemically diverse aldehydic products. Malondialdehyde (MDA) and trans-4-hydroxy-2-nonenal (HNE) are classified as major products of lipid peroxidation sinc作者: 無(wú)價(jià)值 時(shí)間: 2025-3-24 03:27 作者: 不舒服 時(shí)間: 2025-3-24 07:59 作者: 泥瓦匠 時(shí)間: 2025-3-24 13:40
Purification of Aldose and Aldehyde Reductases from Dog Kidneylude the enzymes aldose reductase (EC 1.1.1.21), aldehyde reductase (EC 1.1.1.2) and carbonyl reductase (EC 1.1.1.184). Aldose reductase and aldehyde reductase, discovered by Hers (1960) in the late 1950’s, were named for their ability to reduce aldonic sugars versus aliphatic and aromatic aldehydes作者: 增強(qiáng) 時(shí)間: 2025-3-24 15:52 作者: NATAL 時(shí)間: 2025-3-24 20:01
Book 1991esents the fifth time that I had the privilege of organizing the scientific program. It was the first time that I actually hosted the meeting. I wish to salute my four previous co-organizers and the thousands of scientists who have hosted other meetings. It is much easier to arrange the scientific p作者: finite 時(shí)間: 2025-3-25 01:07
0065-2598 This represents the fifth time that I had the privilege of organizing the scientific program. It was the first time that I actually hosted the meeting. I wish to salute my four previous co-organizers and the thousands of scientists who have hosted other meetings. It is much easier to arrange the sc作者: gain631 時(shí)間: 2025-3-25 03:28 作者: 表示向前 時(shí)間: 2025-3-25 10:32
Charles R. Filburn,Edward G. Lakattatalyzed oxidation reaction at pH 7.0 and 7.6 is generally agreed to occur by the following ordered mechanism:.Scheme IAt least at low propionaldehyde concentrations, the rate of the reaction is controlled by the slow conformational change which occurs during the release of NADH from the enzyme (Blackwell et al., 1987; Dickinson, 1985).作者: 偽造 時(shí)間: 2025-3-25 15:02 作者: 代理人 時(shí)間: 2025-3-25 17:05
Biochemical, Immunological, and Molecular Characterization of a “High KM” Aldehyde Dehydrogenaseammalian liver ALDHs differ in their electrophoretic mobility, isoelectric point, molecular size, kinetic properties, inhibition with disulfiram, subunit structure, as well as in their cellular and tissue distribution, and chromosomal assignment.作者: 舉止粗野的人 時(shí)間: 2025-3-25 23:09
A Polymorphism in the Rat Liver Mitochondrial , Gene is Associated with Alcohol Drinking Behaviorich deters alcohol-drinking and thus reduces the risk of becoming an alcoholic. Japanese alcoholics have a low incidence of the ALDH2-deficient phenotype (2.3%) compared with the general Japanese population (41%) suggesting that polymorphism of . could play a role in an individual’s susceptibility to alcoholism (Harada et al., 1982).作者: 有效 時(shí)間: 2025-3-26 03:29
Aldehydic Products of Lipid Peroxidation: Substrates or Inhibitors of Hepatic Aldehyde Dehydrogenaseey are present in the greatest quantities during peroxidation of cellular membrane lipids while .-2-hexenal, acrolein and crotonaldehdye are representative of minor products of lipid peroxidation thought to be formed in significantly smaller quantities.作者: lacrimal-gland 時(shí)間: 2025-3-26 06:12 作者: Ancillary 時(shí)間: 2025-3-26 10:48
Sleep, Biological Rhythms and Aging,ormed with either amino acid; a thiohemiacetal in the former, a hemiacetal in the latter. The intermediate would then be oxidized in the presence of NAD to produce a thioacyl or an acyl intermediate respectively, as illustrated in Fig. 1.作者: placebo-effect 時(shí)間: 2025-3-26 16:17 作者: uncertain 時(shí)間: 2025-3-26 19:51
Michael W. Rich MD,William J. Nienaber MDAlthough the latter two have important roles in health and disease, for the enzymologist HDH offers the advantage of a long and interesting genetic history, and is particularly well suited to molecular approaches.作者: 過(guò)分自信 時(shí)間: 2025-3-27 00:34 作者: 極少 時(shí)間: 2025-3-27 02:38
Neurohumoral Mechanisms of Cellular Aging,s a cascade of biochemical alterations that slowly progress to cell dysfunction and structural damage. While the role of AR in the pathogenesis of diabetic complications is well documented, its physiologic role, if any, under normal glycemic conditions is still unknown.作者: Osteoporosis 時(shí)間: 2025-3-27 07:24
Farhan Siddiqui,Carolyn D’Ambrosiots ability to utilize NADP. to oxidize aldonic acids such as L-gulonate to D-glucuronate (Mano et al., 1961). Carbonyl reductase was first described in the 1970’s as “aromatic aldehyde and ketone reductase” by Culp and McMahon (1968). More recently, it has been referred to as carbonyl reductase (Wermuth, 1981) .作者: GREG 時(shí)間: 2025-3-27 10:42
Probing the Active Site of Aldehyde Dehydrogenase by Site Directed Mutagenesisormed with either amino acid; a thiohemiacetal in the former, a hemiacetal in the latter. The intermediate would then be oxidized in the presence of NAD to produce a thioacyl or an acyl intermediate respectively, as illustrated in Fig. 1.作者: 施舍 時(shí)間: 2025-3-27 13:53 作者: insurrection 時(shí)間: 2025-3-27 18:16
A Paradigm for Aldehyde Oxidation: Histidinol DehydrogenaseAlthough the latter two have important roles in health and disease, for the enzymologist HDH offers the advantage of a long and interesting genetic history, and is particularly well suited to molecular approaches.作者: 愛國(guó)者 時(shí)間: 2025-3-27 23:39
, Expression of Human Placental Aldose Reductase in ,989; Kador, et al., 1988; Fukushi, Merola and Kinoshita, 1983; Yue, et al., 1982). Aldose reductase inhibitors have also shown promise in clinical studies (Sakamoto, et al., 1986; Judzewitsch, et al., 1983).作者: SPURN 時(shí)間: 2025-3-28 03:29 作者: 彎腰 時(shí)間: 2025-3-28 07:16 作者: 雄辯 時(shí)間: 2025-3-28 11:12
Rat Class 3 Aldehyde Dehydrogenase: Crystals and Preliminary Analysisredictions suggest that the subunit tertiary structures of all three A1DH classes are largely similar (Lindahl and Evces, 1984; Hempel et al., 1989). Although functional residues have been identified from chemical modification and sequence comparisons, no tertiary structure of an A1DH has yet been determined.作者: 指令 時(shí)間: 2025-3-28 16:42 作者: 時(shí)代 時(shí)間: 2025-3-28 22:19 作者: Estrogen 時(shí)間: 2025-3-28 23:17 作者: 輕信 時(shí)間: 2025-3-29 03:45 作者: CLASP 時(shí)間: 2025-3-29 11:07
Memory Functioning in Late Adulthood,ey are present in the greatest quantities during peroxidation of cellular membrane lipids while .-2-hexenal, acrolein and crotonaldehdye are representative of minor products of lipid peroxidation thought to be formed in significantly smaller quantities.作者: TRUST 時(shí)間: 2025-3-29 11:27 作者: 柱廊 時(shí)間: 2025-3-29 18:52 作者: 不愛防注射 時(shí)間: 2025-3-29 22:26 作者: 燈絲 時(shí)間: 2025-3-30 00:26
0065-2598 also was apparent that not all biochemical problems could be solved by using these techniques. Many of the presentations showed how important advances still could be made using more traditional biochemical approaches.978-1-4684-5903-6978-1-4684-5901-2Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: brachial-plexus 時(shí)間: 2025-3-30 04:10
Aldehyde Dehydrogenases: What can be Learned from a Baker’s Dozen Sequences?derived from membrane lipid peroxidation and perhaps some aldehydes generated from neurotransmitter metabolism are potential physiological substrates for one or more ALDH forms (Tank et al., 1981; Esterbauer, 1982; Weiner, 1982; Mitchell and Petersen, 1989). While all aldehyde dehydrogenases likely 作者: 癡呆 時(shí)間: 2025-3-30 09:42
Localization of Cysteine 302 at the Active Site of Aldehyde Dehydrogenase and Weiner, 1988 a,b) and dimethylaminocinnamaldehyde identified serine 74 (Loomes et al., 1990). Our laboratory developed a substrate-based affinity reagent, bromo-acetophenone (MacKerell et al., 1986), which identified glutamate 268 (Abriola et al., 1987).作者: 自作多情 時(shí)間: 2025-3-30 13:23 作者: Overstate 時(shí)間: 2025-3-30 18:07 作者: Libido 時(shí)間: 2025-3-30 22:16
https://doi.org/10.1007/978-3-642-82101-1 and Weiner, 1988 a,b) and dimethylaminocinnamaldehyde identified serine 74 (Loomes et al., 1990). Our laboratory developed a substrate-based affinity reagent, bromo-acetophenone (MacKerell et al., 1986), which identified glutamate 268 (Abriola et al., 1987).作者: 乳汁 時(shí)間: 2025-3-31 02:31 作者: Alopecia-Areata 時(shí)間: 2025-3-31 08:21 作者: ureter 時(shí)間: 2025-3-31 12:14
cDNA Cloning and Expression of Human Aldose ReductaseAldose reductase (ALR2; EC 1.1.1.21), a member of the monomeric NADPH-dependent aldoketoreductase family, has been strongly suggested to play a key role in the development of various diabetic complications (Gabbay et al., 1966; Engerman and Kern, 1984; Nishimura et al., 1987; Kinoshita and Nishimura, 1988).作者: mucous-membrane 時(shí)間: 2025-3-31 17:00
https://doi.org/10.1007/978-1-4684-5901-2biology; carbon; enzymes; enzymology; metabolism; molecular biology; research作者: TAP 時(shí)間: 2025-3-31 17:38 作者: JOT 時(shí)間: 2025-4-1 01:06 作者: Flu表流動(dòng) 時(shí)間: 2025-4-1 02:38
Role of Aldehyde Dehydrogenase (ALDH) in the Detoxication of Cyclophosphamide (CP) in Rat Embryostion has been quantified in rat liver homogenates, microsomes and whole parenchymal cells under various conditions of enhanced lipid peroxidation (Benedetti, et al., 1980; Esterbauer, et al., 1982; Poli, et al., 1985,1986).作者: pantomime 時(shí)間: 2025-4-1 09:55 作者: abracadabra 時(shí)間: 2025-4-1 12:48
G. Riccioni,V. Sblendorio,N. D’Orazioner, 1979). Aldehyde dehydrogenase has been identified in virtually every organism and tissue examined. Distinct ALDHs have been identified in the mitochondrial, microsomal and cytosolic compartments of the cell (Tottmar et al., 1973; Greenfield and Pietruszko, 1977; Lindahl and Evces, 1984). Some f作者: 口訣 時(shí)間: 2025-4-1 15:03 作者: CLASP 時(shí)間: 2025-4-1 22:25 作者: A精確的 時(shí)間: 2025-4-1 23:27
https://doi.org/10.1007/978-3-642-82101-1art of 35 residue tryptic peptide (Hempel, 1981; Hempel and Pietruszko, 1981; Hempel et al., 1982) by employing iodoacetamide. When the primary structures of the El and E2 isozymes were established (Hempel et al., 1984, 1985; Hsu et al., 1985), this cysteine was found to occupy position 302 in a 500作者: ULCER 時(shí)間: 2025-4-2 05:43
Charles R. Filburn,Edward G. Lakattagive a complete picture of the mechanism of the aldehyde dehydrogenase catalyzed oxidation of propionaldehyde over an extended pH range. The enzyme catalyzed oxidation reaction at pH 7.0 and 7.6 is generally agreed to occur by the following ordered mechanism:.Scheme IAt least at low propionaldehyde 作者: 較早 時(shí)間: 2025-4-2 09:39
Dean O. Smith,Julie L. Rosenheimerportant role in the toxic consequences of a deranged acetaldehyde metabolism in alcohol-related disorders (Agarwal and Goedde, 1989, 1990; Goedde and Agarwal, 1989). Two broadly defined groups of ALDHs have been recognized based upon their Michaelis constants (“l(fā)ow Km” and “high Km” isozymes). The m作者: Accord 時(shí)間: 2025-4-2 14:50
Warren Kline Bolton,Benjamin C. Sturgillal cells and the lens, by the absorption of UVR in the 290–320 nm wavelength range (UV-B) (Boettner and Wolters, 1962; Zigman, 1983). The mechanisms of corneal photoreception of UV-B light have not been determined, as yet, although studies examining the action spectra for the cornea in the induction作者: Rejuvenate 時(shí)間: 2025-4-2 19:04
Cognitive Changes in Older Adults,consumption. In humans, a single base pair mutation produces a catalytically inactive enzyme (Yoshida et al., 1984). Approximately 50% of Asians have this defective . allele; upon ingestion of ethanol, these individuals experience classic symptoms of acetaldehyde accumulation (Mizoi et al., 1979) wh
