標(biāo)題: Titlebook: Enzyme Kinetics in Drug Metabolism; Fundamentals and App Swati Nagar,Upendra A. Argikar,Donald J. Tweedie Book 2014 Springer Science+Busine [打印本頁(yè)] 作者: ISSUE 時(shí)間: 2025-3-21 18:28
書目名稱Enzyme Kinetics in Drug Metabolism影響因子(影響力)
書目名稱Enzyme Kinetics in Drug Metabolism影響因子(影響力)學(xué)科排名
書目名稱Enzyme Kinetics in Drug Metabolism網(wǎng)絡(luò)公開度
書目名稱Enzyme Kinetics in Drug Metabolism網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Enzyme Kinetics in Drug Metabolism被引頻次
書目名稱Enzyme Kinetics in Drug Metabolism被引頻次學(xué)科排名
書目名稱Enzyme Kinetics in Drug Metabolism年度引用
書目名稱Enzyme Kinetics in Drug Metabolism年度引用學(xué)科排名
書目名稱Enzyme Kinetics in Drug Metabolism讀者反饋
書目名稱Enzyme Kinetics in Drug Metabolism讀者反饋學(xué)科排名
作者: falsehood 時(shí)間: 2025-3-21 23:39
https://doi.org/10.1007/978-1-349-20065-8metabolism, kinetics of depletion of substrates (endogenous or exogenous) and formation of metabolites deals with the rate of metabolism. The current textbook specifically focuses on kinetics of drug-metabolizing enzymes, detailing specific enzyme classes, and discusses kinetics as they apply to dru作者: 善于 時(shí)間: 2025-3-22 02:11 作者: Flagging 時(shí)間: 2025-3-22 06:34
Impacts of Climate Change in Africa,ombinant enzyme systems utilized in drug metabolism, each of these has different components that can influence the free drug concentration. The physicochemical properties of the test compound are also paramount in determining the influential factors in any deviation between true and apparent kinetic作者: echnic 時(shí)間: 2025-3-22 11:05 作者: inquisitive 時(shí)間: 2025-3-22 16:10
Leon Mwamba Tshimpaka,Samuel Ojo Oloruntobage of substrate concentrations, the rate of product formation initially increases as substrate concentration increases, then decreases at high substrate concentrations, i.e., they exhibit substrate inhibition or partial substrate inhibition. This chapter gives an introduction to sulfotransferases, i作者: inquisitive 時(shí)間: 2025-3-22 17:33 作者: Adrenaline 時(shí)間: 2025-3-23 00:34 作者: 形容詞 時(shí)間: 2025-3-23 04:47 作者: Fierce 時(shí)間: 2025-3-23 06:48
African Air Transport Managementof multiple initial drug concentrations and multiple time points at each concentration, until steady state is reached between P-gp-mediated efflux into the apical chamber and passive permeability from apical chamber back into the cytosol. Although this model optimally requires a larger than usual da作者: 河流 時(shí)間: 2025-3-23 12:48
Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications,metabolism, kinetics of depletion of substrates (endogenous or exogenous) and formation of metabolites deals with the rate of metabolism. The current textbook specifically focuses on kinetics of drug-metabolizing enzymes, detailing specific enzyme classes, and discusses kinetics as they apply to dru作者: 皮薩 時(shí)間: 2025-3-23 16:58
Multienzyme Kinetics and Sequential Metabolismt. The second is sequential metabolism, in other words, the formation of multiple products from one CYP enzyme. Given the degree of CYP enzyme promiscuity, it is hardly surprising that there is also a high degree of complex kinetic profiles generated during the catalytic cycle.作者: Dorsal 時(shí)間: 2025-3-23 18:51
Consideration of the Unbound Drug Concentration in Enzyme Kineticsombinant enzyme systems utilized in drug metabolism, each of these has different components that can influence the free drug concentration. The physicochemical properties of the test compound are also paramount in determining the influential factors in any deviation between true and apparent kinetic作者: 有特色 時(shí)間: 2025-3-24 00:51 作者: 易受騙 時(shí)間: 2025-3-24 03:57 作者: misanthrope 時(shí)間: 2025-3-24 10:02
Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)es” provides the prospect for more reliable reaction phenotyping and assessment of DDI potential. Although extrapolation of the in vitro intrinsic clearance of a glucuronidated drug often under-predicts in vivo clearance, careful selection of in vitro experimental conditions and inclusion of extrahe作者: minaret 時(shí)間: 2025-3-24 10:58 作者: RAGE 時(shí)間: 2025-3-24 16:42 作者: 可轉(zhuǎn)變 時(shí)間: 2025-3-24 20:12 作者: cortisol 時(shí)間: 2025-3-25 02:06 作者: carotenoids 時(shí)間: 2025-3-25 05:59
1064-3745 levant and current topics including Drug Metabolizing Enzyme.Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. .Enzyme Kine作者: 干旱 時(shí)間: 2025-3-25 10:35 作者: Dignant 時(shí)間: 2025-3-25 13:24 作者: 信任 時(shí)間: 2025-3-25 16:18
Book 2014arly in characterizing and modeling the disposition and elimination of drugs. .Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications. focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, top作者: STEER 時(shí)間: 2025-3-25 21:41 作者: DEMN 時(shí)間: 2025-3-26 01:14 作者: Ossification 時(shí)間: 2025-3-26 06:01 作者: 吸引人的花招 時(shí)間: 2025-3-26 11:32 作者: 擔(dān)心 時(shí)間: 2025-3-26 13:39 作者: 不透明性 時(shí)間: 2025-3-26 17:33 作者: 表示問 時(shí)間: 2025-3-26 23:27 作者: CONE 時(shí)間: 2025-3-27 01:57
Irreversible Enzyme Inhibition Kinetics and Drug–Drug InteractionsThis chapter describes the types of irreversible inhibition of drug-metabolizing enzymes and the methods commonly employed to quantify the irreversible inhibition and subsequently predict the extent and time course of clinically important drug–drug interactions.作者: 浮夸 時(shí)間: 2025-3-27 07:21 作者: 沉默 時(shí)間: 2025-3-27 10:39
https://doi.org/10.1007/978-3-031-51000-7to understanding enzyme kinetics is having a clear grasp of the meanings of “enzyme” and “catalysis.” Catalysts are reagents that can increase the rate of a chemical reaction without being consumed in the reaction. Enzymes are proteins that form a subset of catalysts. These concepts are further explored below.作者: 鼓掌 時(shí)間: 2025-3-27 15:13
Fundamentals of Enzyme Kineticsto understanding enzyme kinetics is having a clear grasp of the meanings of “enzyme” and “catalysis.” Catalysts are reagents that can increase the rate of a chemical reaction without being consumed in the reaction. Enzymes are proteins that form a subset of catalysts. These concepts are further explored below.作者: 躲債 時(shí)間: 2025-3-27 20:57
Swati Nagar,Upendra A. Argikar,Donald J. TweedieIncludes clear explanations of fundamentals for correct application.Contains key notes, experiences and implementation advice from.Covers relevant and current topics including Drug Metabolizing Enzyme作者: JOG 時(shí)間: 2025-3-27 21:57
Methods in Molecular Biologyhttp://image.papertrans.cn/e/image/313091.jpg作者: inspiration 時(shí)間: 2025-3-28 03:25
978-1-4939-6046-0Springer Science+Business Media, LLC 2014作者: Anhydrous 時(shí)間: 2025-3-28 09:13
Enzyme Kinetics in Drug Metabolism978-1-62703-758-7Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: 骯臟 時(shí)間: 2025-3-28 12:07 作者: Affection 時(shí)間: 2025-3-28 17:03
https://doi.org/10.1007/978-3-031-51000-7to understanding enzyme kinetics is having a clear grasp of the meanings of “enzyme” and “catalysis.” Catalysts are reagents that can increase the rate of a chemical reaction without being consumed in the reaction. Enzymes are proteins that form a subset of catalysts. These concepts are further expl作者: 氣候 時(shí)間: 2025-3-28 21:50 作者: PATHY 時(shí)間: 2025-3-28 23:48
Malte Steinbrink,Hannah Niedenführ major cause of clinically significant drug–drug interactions. This chapter defines the four reversible mechanisms of inhibition exhibited by drugs: competitive, noncompetitive, uncompetitive, and mixed competitive/noncompetitive. An in vitro procedure to determine the potential of a drug to be a re作者: Tonometry 時(shí)間: 2025-3-29 04:23 作者: 巨碩 時(shí)間: 2025-3-29 09:42
Impacts of Climate Change in Africa,e. In all but the very simplest in vitro system, these drug concentrations can be influenced by a variety of nonspecific binding reservoirs that can reduce the available concentration to the enzyme system under investigation. As a consequence, the apparent kinetic parameters that are derived, such a作者: 小教堂 時(shí)間: 2025-3-29 12:15 作者: Matrimony 時(shí)間: 2025-3-29 17:55
Kwesi Dzapong Lwazi Sarkodee Prahd in the clinic because the clearance or toxicity is underestimated by preclinical species. Human AO is much more active than rodent AO, and dogs do not have functional AO. While AOs normally make non-reactive metabolites such as lactams, the metabolic products often have much lower solubility that 作者: MEET 時(shí)間: 2025-3-29 23:09
Leon Mwamba Tshimpaka,Samuel Ojo Oloruntobazing 3′-phosphoadenosyl-5′-phosphosulfate (PAPS) as the donor of the sulfonic group. The rate of product formation depends on the concentrations of PAPS and substrate as well as the sulfotransferase enzyme; thus, if PAPS is held constant while varying substrate concentration (or vice versa), the kin作者: 磨坊 時(shí)間: 2025-3-30 03:58 作者: ADAGE 時(shí)間: 2025-3-30 06:19 作者: agenda 時(shí)間: 2025-3-30 08:35 作者: 得體 時(shí)間: 2025-3-30 12:31 作者: Outmoded 時(shí)間: 2025-3-30 20:15 作者: 新手 時(shí)間: 2025-3-30 21:02 作者: 假裝是我 時(shí)間: 2025-3-31 02:44
Fundamentals of Enzyme Kineticsto understanding enzyme kinetics is having a clear grasp of the meanings of “enzyme” and “catalysis.” Catalysts are reagents that can increase the rate of a chemical reaction without being consumed in the reaction. Enzymes are proteins that form a subset of catalysts. These concepts are further expl作者: 腐爛 時(shí)間: 2025-3-31 07:12 作者: Psychogenic 時(shí)間: 2025-3-31 13:15
Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical Significance major cause of clinically significant drug–drug interactions. This chapter defines the four reversible mechanisms of inhibition exhibited by drugs: competitive, noncompetitive, uncompetitive, and mixed competitive/noncompetitive. An in vitro procedure to determine the potential of a drug to be a re作者: Coronary-Spasm 時(shí)間: 2025-3-31 14:37 作者: recession 時(shí)間: 2025-3-31 18:53
Consideration of the Unbound Drug Concentration in Enzyme Kineticse. In all but the very simplest in vitro system, these drug concentrations can be influenced by a variety of nonspecific binding reservoirs that can reduce the available concentration to the enzyme system under investigation. As a consequence, the apparent kinetic parameters that are derived, such a作者: STYX 時(shí)間: 2025-3-31 23:27 作者: bromide 時(shí)間: 2025-4-1 02:28
Enzyme Kinetics, Inhibition, and Regioselectivity of Aldehyde Oxidased in the clinic because the clearance or toxicity is underestimated by preclinical species. Human AO is much more active than rodent AO, and dogs do not have functional AO. While AOs normally make non-reactive metabolites such as lactams, the metabolic products often have much lower solubility that
