標(biāo)題: Titlebook: Enzyme Kinetics in Drug Metabolism; Fundamentals and App Swati Nagar,Upendra A. Argikar,Donald Tweedie Book 2021Latest edition Springer Sci [打印本頁] 作者: Croching 時間: 2025-3-21 19:23
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書目名稱Enzyme Kinetics in Drug Metabolism影響因子(影響力)學(xué)科排名
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書目名稱Enzyme Kinetics in Drug Metabolism網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Enzyme Kinetics in Drug Metabolism被引頻次
書目名稱Enzyme Kinetics in Drug Metabolism被引頻次學(xué)科排名
書目名稱Enzyme Kinetics in Drug Metabolism年度引用
書目名稱Enzyme Kinetics in Drug Metabolism年度引用學(xué)科排名
書目名稱Enzyme Kinetics in Drug Metabolism讀者反饋
書目名稱Enzyme Kinetics in Drug Metabolism讀者反饋學(xué)科排名
作者: 偽證 時間: 2025-3-21 21:19
Methods in Molecular Biologyhttp://image.papertrans.cn/e/image/313090.jpg作者: 確保 時間: 2025-3-22 02:44
https://doi.org/10.1007/978-1-0716-1554-6Kinetic models; Drug-drug interactions; Drug metabolizing enzymes; Regulatory guidelines; Drug transport作者: 牲畜欄 時間: 2025-3-22 08:12 作者: 輕而薄 時間: 2025-3-22 09:29
Africa-EU Partnership on Energy major cause of clinically significant drug–drug interactions. This chapter defines the four reversible mechanisms of inhibition exhibited by drugs: competitive, noncompetitive, uncompetitive, and mixed competitive/noncompetitive. An in vitro procedure to determine the potential of a drug to be a re作者: 遺留之物 時間: 2025-3-22 16:36
A. M. Vasiliev,D. A. Degterev,T. M. Shawt a million compared to the rate of the same reaction in the absence of the enzyme. In contrast to traditional catalytic enzymes, the family of cytochrome P450 (CYPs) enzymes are catalytically promiscuous and thus they possess remarkable versatility in substrates. The great diversity of reactions ca作者: 遺留之物 時間: 2025-3-22 19:58
Célestine L. D. Mangue,Jean Gonondoe. In all but the very simplest in vitro system, these drug concentrations can be influenced by a variety of nonspecific binding reservoirs that can reduce the available concentration to the enzyme system(s) under investigation. As a consequence, the apparent kinetic parameters, such as . or ., that作者: strdulate 時間: 2025-3-23 00:31 作者: 真 時間: 2025-3-23 02:06
Imperialism and U.S.-Africa Relationsf their crystallographic protein structures. Fortunately, despite low sequence similarity between different families of drug-metabolizing CYPs, there exists a high degree of structural homology within the superfamily. This similarity in the protein fold allows for a direct comparison of the structur作者: Wordlist 時間: 2025-3-23 08:32
https://doi.org/10.1007/978-1-349-06218-8hey translocate drugs, as well as endogenous molecules and toxins, across membranes using ATP hydrolysis, or ion/concentration gradients. In general, drug transporters are expressed ubiquitously, but they function in drug disposition by being concentrated in tissues such as the intestine, the kidney作者: DOTE 時間: 2025-3-23 09:48
Innocent I. Okwuosa,Sharif S. Khalidotics). The versatility of these enzymes results in some unusual kinetic properties, stemming from the simultaneous interaction of multiple substrates with the CYP active site. Often, the CYPs display kinetics that deviate from standard hyperbolic saturation or inhibition kinetics. Non-Michaelis-Men作者: Gerontology 時間: 2025-3-23 16:03
Brazil-Africa Relations: From Boom to Bust?he clearance or toxicity was underestimated by preclinical species. Human AO is much more active than rodent AO, and dogs do not have functional AO. Metabolic products from AO-catalyzed oxidation are generally nonreactive and often they have much lower solubility. AO metabolism is not limited to oxi作者: 野蠻 時間: 2025-3-23 18:07
Bakut tswah Bakut,Sagarika Dutthe –SO. group from 3′-phospho-adenosyl-5′-phosphosulfate (PAPS) to a nucleophilic hydroxyl or amine group in a drug substrate. SULTs are stable as dimers, with a highly conserved dimerization domain near the C-terminus of the protein. Crystal structures have revealed flexible loop regions in the nat作者: MUMP 時間: 2025-3-24 00:30 作者: 禮節(jié) 時間: 2025-3-24 02:45
Genevieve Dewar,Brian A. Stewart and exogenous compounds. Altered transporter function, whether due to genetic polymorphism, DDIs, disease, or environmental factors such as dietary constituents, can result in changes in drug efficacy and/or toxicity due to changes in circulating or tissue levels of either drugs or endogenous subst作者: 惡心 時間: 2025-3-24 07:30 作者: 千篇一律 時間: 2025-3-24 10:56
Increasing Agricultural Productivity,ent on a number of other cellular factors that can ultimately lead to unexpected behavior. In this review, we discuss the confounding processes and coupled reactions within bioactivation networks that require a systems-level perspective in order to fully understand the time-varying behavior. When co作者: Choreography 時間: 2025-3-24 18:01 作者: TOXIN 時間: 2025-3-24 22:02 作者: 的闡明 時間: 2025-3-25 02:22
https://doi.org/10.1007/978-1-349-18827-7This chapter describes the types of irreversible inhibition of drug-metabolizing enzymes and the methods commonly employed to quantify the irreversible inhibition and subsequently predict the extent and time course of clinically important drug–drug interactions.作者: Handedness 時間: 2025-3-25 06:46
Irreversible Enzyme Inhibition Kinetics and Drug–Drug InteractionsThis chapter describes the types of irreversible inhibition of drug-metabolizing enzymes and the methods commonly employed to quantify the irreversible inhibition and subsequently predict the extent and time course of clinically important drug–drug interactions.作者: 得意牛 時間: 2025-3-25 10:30
Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical Significanceompetitive, noncompetitive, uncompetitive, and mixed competitive/noncompetitive. An in vitro procedure to determine the potential of a drug to be a reversible inhibitor is also provided. Finally, a number of examples of clinically significant drug–drug interactions resulting from reversible inhibition are described.作者: CANON 時間: 2025-3-25 15:06 作者: 使殘廢 時間: 2025-3-25 19:28
1064-3745 ation advice from the experts.This second edition further develops the principles of applying kinetic principles to drug metabolizing enzymes and transporters. Chapters are divided into six sections detailing fundamental principles of enzyme kinetics, enzyme and transporter structures, highlighting 作者: Decibel 時間: 2025-3-25 20:40
Africa-EU Partnership on Energyompetitive, noncompetitive, uncompetitive, and mixed competitive/noncompetitive. An in vitro procedure to determine the potential of a drug to be a reversible inhibitor is also provided. Finally, a number of examples of clinically significant drug–drug interactions resulting from reversible inhibition are described.作者: Chandelier 時間: 2025-3-26 03:30
Book 2021Latest editiond into six sections detailing fundamental principles of enzyme kinetics, enzyme and transporter structures, highlighting specific oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for drug metabolizing enzymes and transporters, understanding of variabilit作者: oblique 時間: 2025-3-26 06:02
Imperialism and U.S.-Africa Relationsg metabolism. In this chapter, we first provide an overview of the nomenclature and the role of structural features that are common in all CYPs. We then apply these definitions to understand the different substrate specificities and functions in the CYP3A, CYP2C, and CYP2D families of enzymes.作者: 初次登臺 時間: 2025-3-26 12:07
Innocent I. Okwuosa,Sharif S. Khalidclude competitive inhibition, noncompetitive inhibition, mixed inhibition, partial inhibition, activation, and activation followed by inhibition (. Chapters . and .). Models and equations that can result in these kinetic profiles will be presented and discussed.作者: 野蠻 時間: 2025-3-26 16:18
Crystal Structures of Drug-Metabolizing CYPsg metabolism. In this chapter, we first provide an overview of the nomenclature and the role of structural features that are common in all CYPs. We then apply these definitions to understand the different substrate specificities and functions in the CYP3A, CYP2C, and CYP2D families of enzymes.作者: extinct 時間: 2025-3-26 17:53 作者: 放逐 時間: 2025-3-27 00:43 作者: aquatic 時間: 2025-3-27 04:43
Increasing Agricultural Productivity, during chemotherapy treatment serves as a basis to discuss an example of sensitivity analysis. Second, an example of doxorubicin bioactivation is used for discussing points of consideration when constructing and analyzing network models of drug metabolism.作者: Encephalitis 時間: 2025-3-27 06:06
Fundamentals of Enzyme Kinetics: Michaelis-Menten and Non-Michaelis–Type (Atypical) Enzyme KineticsDrug Metab Rev 36:231–242, 2004). Several cytochromes P450 (CYPs) have large active sites that enable binding of multiple molecules (Yano et al., J Biol Chem 279:38091–38094, 2004; Wester et al., J Biol Chem 279:35630–35637, 2004). Thus, atypical kinetics are not uncommon in in vitro drug metabolism studies.作者: forecast 時間: 2025-3-27 12:21 作者: 邊緣 時間: 2025-3-27 15:21
Numerical Methods for Modeling Enzyme Kineticsequations in the analysis of metabolism kinetics, reversible inhibition kinetics, and inactivation kinetics. The chapter describes the advantages of using numerical methods when Michaelis–Menten assumptions do not hold.作者: Outspoken 時間: 2025-3-27 20:53 作者: Pillory 時間: 2025-3-28 01:49 作者: 新陳代謝 時間: 2025-3-28 04:11 作者: caldron 時間: 2025-3-28 09:54 作者: 令人苦惱 時間: 2025-3-28 11:17
Numerical Methods for Modeling Enzyme Kineticsed to solve differential equations. This chapter describes the use of numerical methods in solving differential equations and its applications in characterizing the complexities observed in enzyme kinetics. A discussion is included on the use of numerical methods to overcome limitations of explicit 作者: Synchronism 時間: 2025-3-28 17:44
Crystal Structures of Drug-Metabolizing CYPsf their crystallographic protein structures. Fortunately, despite low sequence similarity between different families of drug-metabolizing CYPs, there exists a high degree of structural homology within the superfamily. This similarity in the protein fold allows for a direct comparison of the structur作者: Hyperalgesia 時間: 2025-3-28 22:12
The Structure and Mechanism of Drug Transportershey translocate drugs, as well as endogenous molecules and toxins, across membranes using ATP hydrolysis, or ion/concentration gradients. In general, drug transporters are expressed ubiquitously, but they function in drug disposition by being concentrated in tissues such as the intestine, the kidney作者: tinnitus 時間: 2025-3-28 23:37
Enzyme Kinetics of Oxidative Metabolism—Cytochromes P450otics). The versatility of these enzymes results in some unusual kinetic properties, stemming from the simultaneous interaction of multiple substrates with the CYP active site. Often, the CYPs display kinetics that deviate from standard hyperbolic saturation or inhibition kinetics. Non-Michaelis-Men作者: 嬉耍 時間: 2025-3-29 04:19 作者: 灌輸 時間: 2025-3-29 08:36 作者: 阻擋 時間: 2025-3-29 12:16 作者: 同來核對 時間: 2025-3-29 18:39 作者: Organization 時間: 2025-3-29 20:06 作者: GLUE 時間: 2025-3-30 03:42 作者: BRUNT 時間: 2025-3-30 08:00 作者: moratorium 時間: 2025-3-30 12:15
Célestine L. D. Mangue,Jean Gonondoombinant enzyme systems utilized in drug metabolism, each of these has different components which can influence the free drug concentration. The physicochemical properties of the test compound are also paramount in determining the influential factors in any deviation between true and apparent kineti作者: Lumbar-Spine 時間: 2025-3-30 12:41
https://doi.org/10.1007/978-1-349-06218-8t into the structural basis of transport. This chapter will provide particular focus on the promiscuous drug transporters because of their effect on drug disposition and the challenges associated with them.作者: 不安 時間: 2025-3-30 19:31
Brazil-Africa Relations: From Boom to Bust?e transformations may cause toxicity due to the formation of reactive metabolites. Moreover, the inhibition kinetics are complex, and multiple probe substrates should be used when assessing the potential for DDIs. Finally, AO appears to be amenable to computational predictions of both regioselectivi作者: Foolproof 時間: 2025-3-30 23:40 作者: dysphagia 時間: 2025-3-31 02:08
Africa: What does the Future Hold?ubstrate and inhibitor “probes” provides the prospect for more reliable reaction phenotyping and assessment of drug–drug interaction potential. Although extrapolation of the in vitro intrinsic clearance of a glucuronidated drug often underpredicts in vivo clearance, careful selection of in vitro exp作者: Rct393 時間: 2025-3-31 08:55 作者: 怒目而視 時間: 2025-3-31 11:10 作者: eardrum 時間: 2025-3-31 13:29
Book 2021Latest editionreferencing to assist in learning.? ..?..Authoritativeand fully updated,?.Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications, Second Edition.?serves as a practical teaching tool for novice and advanced scientists interested in the fundamental concepts..作者: 聽覺 時間: 2025-3-31 18:01
Multienzyme Kinetics and Sequential Metabolism. The second is sequential metabolism, in other words, the formation of multiple products from one CYP enzyme. Given the degree of CYP?enzyme promiscuity, it is hardly surprising that there is also a high degree of complex kinetic profiles generated during the catalytic cycle.作者: 換話題 時間: 2025-3-31 23:19
Consideration of the Unbound Drug Concentration in Enzyme Kineticsombinant enzyme systems utilized in drug metabolism, each of these has different components which can influence the free drug concentration. The physicochemical properties of the test compound are also paramount in determining the influential factors in any deviation between true and apparent kineti
