標(biāo)題: Titlebook: Endothelin and Its Inhibitors; Timothy D. Warner Book 2001 Springer-Verlag Berlin Heidelberg 2001 Circulation.Endothelin.Glatte Muskulatur [打印本頁] 作者: 閘門 時(shí)間: 2025-3-21 20:02
書目名稱Endothelin and Its Inhibitors影響因子(影響力)
書目名稱Endothelin and Its Inhibitors影響因子(影響力)學(xué)科排名
書目名稱Endothelin and Its Inhibitors網(wǎng)絡(luò)公開度
書目名稱Endothelin and Its Inhibitors網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Endothelin and Its Inhibitors被引頻次
書目名稱Endothelin and Its Inhibitors被引頻次學(xué)科排名
書目名稱Endothelin and Its Inhibitors年度引用
書目名稱Endothelin and Its Inhibitors年度引用學(xué)科排名
書目名稱Endothelin and Its Inhibitors讀者反饋
書目名稱Endothelin and Its Inhibitors讀者反饋學(xué)科排名
作者: Neutral-Spine 時(shí)間: 2025-3-21 20:14
Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/e/image/309945.jpg作者: 加強(qiáng)防衛(wèi) 時(shí)間: 2025-3-22 01:41
https://doi.org/10.1007/978-3-642-56899-2Circulation; Endothelin; Glatte Muskulatur; Kreislauf; Peptide; Peptides; Smooth Muscle; endothelium; tissue作者: 放氣 時(shí)間: 2025-3-22 07:26 作者: 虛構(gòu)的東西 時(shí)間: 2025-3-22 10:03
Endothelins Within the Liver and the Gastrointestinal System,(GI) smooth muscle preparations, and the relationships of these responses to the expression (mRNA), synthesis, production, and degradation of the endothelins and the distribution of ET receptors. Attention is also given to the possible physiological and pathophysiological roles of ETs in the gastrointestinal tract and related organs.作者: inhumane 時(shí)間: 2025-3-22 16:00 作者: inhumane 時(shí)間: 2025-3-22 21:01
Endothelin and Its Inhibitors978-3-642-56899-2Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: Amendment 時(shí)間: 2025-3-22 23:53
https://doi.org/10.1007/978-3-642-99265-0overy of endothelium-derived relaxing factor (EDRF) ((Furchgott and Zawadzki 1980). EDRF was later proved to be a simple substance, nitric oxide (Palmer et al. 1987). At that time, numerous studies provided evidence of a role for arachidonic acid and its metabolites in the endothelium-dependent resp作者: glucagon 時(shí)間: 2025-3-23 02:46 作者: FEMUR 時(shí)間: 2025-3-23 07:58
Erich Schild,Rainer Oswald,Reinhard Lamersmino acid residues) which undergo selective proteolysis to yield the biologically inactive intermediates called big endothelins (Bloch et al. 1989a,b; Ohkubo et al. 1990; Yanagisawa et al. 1988). The human ET-1 gene encodes a 212 amino acid precursor, preproendothelin-1 (Bloch et al. 1989b). Removal作者: Tremor 時(shí)間: 2025-3-23 19:11
Jana Maeffert,Christiane Tennhardtroduced embryonic anomalies, few people anticipated a developmental role for ET-1, which was commonly regarded as a potent vasoconstrictor and pressor peptide mainly produced by vascular endothelial cells (Masaki 1995; Levin 1995). At that time only a few signaling molecules had been demonstrated id作者: Stress 時(shí)間: 2025-3-24 00:54 作者: AIL 時(shí)間: 2025-3-24 03:57
Koichi Kato,Eva L. Feldman,Jiro Nakamurauce intense vasoconstriction of the underlying smooth muscle and so maintain endogenous vascular tone. ET-l released from other epithelial cells situated at the interface between biological compartments may have a range of actions in humans as well as functioning as a neuropeptide in the brain. Over作者: lipids 時(shí)間: 2025-3-24 07:36 作者: 射手座 時(shí)間: 2025-3-24 13:28 作者: Atrium 時(shí)間: 2025-3-24 16:30
,Crowdfunding in der Europ?ischen Union,nglasting hypertensive response when administered intravenously in most animal species (Table 1). The characteristic biphasic response to endothelin-1 was early on explained by Warner et al. (1989). That group suggested that the biphasic response to the peptide may be due to concomitant activation o作者: 清唱?jiǎng)?nbsp; 時(shí)間: 2025-3-24 20:46
General Framework of Preconditionerssidues (Yanagisawa et al. 1988). Three distinct members of the ET family, namely ET-1, ET-2, and ET-3, have been identified in humans through cloning (Inoue et al. 1989). The effects of ETs on mammalian organs and cells are initiated by their binding to high affinity G-protein linked receptors (see 作者: CURT 時(shí)間: 2025-3-25 02:36 作者: 悶熱 時(shí)間: 2025-3-25 05:08 作者: 無法取消 時(shí)間: 2025-3-25 09:53
https://doi.org/10.1007/978-3-322-97136-4ficient gas exchange. One critical aspect of pulmonary vascular physiology is the ability of the lung circulation to adapt to large variations in cardiac output with minimal impedance to blood flow at all levels (Voelkel and Weir 2000). In patients with PH, this ability is compromised, usually becau作者: armistice 時(shí)間: 2025-3-25 13:34
,Die ?konomisierung der Sozialen Arbeit,ctile responses that were both sustained and extremely resistant to wash-out (Yanagisawa et al. 1988). Subsequently, ET-1 has been shown to contract both resistance arterioles and venous tissue in addition to conduit arteries (venous tissue generally being more sensitive than arterial vessels; Brain作者: 休閑 時(shí)間: 2025-3-25 17:58
,Soziale Arbeit – was ist das eigentlich?,(GI) smooth muscle preparations, and the relationships of these responses to the expression (mRNA), synthesis, production, and degradation of the endothelins and the distribution of ET receptors. Attention is also given to the possible physiological and pathophysiological roles of ETs in the gastroi作者: 阻止 時(shí)間: 2025-3-25 21:55
https://doi.org/10.1007/978-3-658-32100-0d by a variety of cell types within the kidney including vascular and glomerular endothelium, mesangial cells and tubular epithelial cells. Sites of synthesis are in close proximity to receptors. ET-1 can produce a variety of responses through both ET. and ET. receptor subtypes located throughout th作者: 藝術(shù) 時(shí)間: 2025-3-26 01:52 作者: 體貼 時(shí)間: 2025-3-26 04:23
0171-2004 xicology of endothelin antagonists and endothelin-converting enzyme inhibitors, with mention of all the important members of these drug classes. This leads to well-rounded discussions of the potential therapeutic benefit of endothelin inhibitors.978-3-642-63237-2978-3-642-56899-2Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: 流浪者 時(shí)間: 2025-3-26 09:35
,Digitale Handlungsf?higkeit Erringen,f tissue), whereas the SRTXs are produced in large amounts in the venom of the snake (0.1 mmol/g). The SRTXs and ETs may be divided into two groups on the basis of their toxicity. The most lethal are ET1 and SRTX-b; ET-3 is less toxic, and SRTX-c and SRTX-e cause death only at very high doses, if at作者: 持續(xù) 時(shí)間: 2025-3-26 14:49
Erich Schild,Rainer Oswald,Reinhard LamersECE) was proposed (Yanagisawa et al. 1988). Most studies have concluded that proendothelin-1 is processed intracellularly to ET-1 prior to its release (Corder et al. 1995b; Harrison et al. 1993, 1995; Russell and Davenport 1999; Xu et al. 1994). This is also the case for ET-2 (Lambert et al. 2000), 作者: 潛伏期 時(shí)間: 2025-3-26 17:18 作者: poliosis 時(shí)間: 2025-3-26 23:40
Jana Maeffert,Christiane Tennhardtlopmental roles of the ET system. Following these studies mutations of the ET-3 and ET-B receptor genes were identified in patients with human Hirschsprung’s disease. Thus, gene knockout studies paved the way to a new era of research not only on the ET system but also in the broader field of develop作者: AFFIX 時(shí)間: 2025-3-27 03:41 作者: flaggy 時(shí)間: 2025-3-27 06:04
General Framework of Preconditionersned subtypes of ET. and ET. receptors have also been reported (Sudjarwo et al. 1994; Douglas et al. 1995). Various antagonists and agonists for ET receptors have been developed (Spellmeyer 1994; Warner 1994; Opgenorth 1995; Ohlstein et al. 1996; Wu-Wong et al. 1999; see Chaps 4, 9).作者: 有害 時(shí)間: 2025-3-27 10:19
Wie aus Gegens?tzen Optionen wurdenman and animal airway tissues established the presence of significant numbers of such receptors in several airway wall cell types in addition to airway and vascular smooth muscle (Henry et al. 1990; Goldie et al. 1995). Taken together, this information constituted a reasonable basis for speculating 作者: GEON 時(shí)間: 2025-3-27 14:26
https://doi.org/10.1007/978-3-658-32100-0 several mechanisms that are important in fluid volume homeostasis and arterial pressure regulation. Furthermore, the role of ET-1 in several forms of renal failure suggest potential therapeutic targets for endothelin receptor antagonists. This chapter reviews the localization of the endothelin syst作者: 外面 時(shí)間: 2025-3-27 20:01 作者: 里程碑 時(shí)間: 2025-3-28 00:55 作者: 潛伏期 時(shí)間: 2025-3-28 02:35
Endothelin Receptors,e likelihood that their activation is linked to the initiation, progression, and symptomology of various disease processes. These aspects of ET receptor biology have been excellently covered in earlier works (Huggins et al. 1993; Rubanyi and Polokoff 1994; Gray and Webb 1996), and detailed, up-to-da作者: 煤渣 時(shí)間: 2025-3-28 06:28
Lessons from Gene Deletion of Endothelin Systems,lopmental roles of the ET system. Following these studies mutations of the ET-3 and ET-B receptor genes were identified in patients with human Hirschsprung’s disease. Thus, gene knockout studies paved the way to a new era of research not only on the ET system but also in the broader field of develop作者: Intruder 時(shí)間: 2025-3-28 12:25 作者: confederacy 時(shí)間: 2025-3-28 15:01 作者: Condense 時(shí)間: 2025-3-28 19:53 作者: 努力趕上 時(shí)間: 2025-3-28 23:18
Endothelin and the Kidney, several mechanisms that are important in fluid volume homeostasis and arterial pressure regulation. Furthermore, the role of ET-1 in several forms of renal failure suggest potential therapeutic targets for endothelin receptor antagonists. This chapter reviews the localization of the endothelin syst作者: BRAVE 時(shí)間: 2025-3-29 04:31 作者: 間接 時(shí)間: 2025-3-29 08:47 作者: 任意 時(shí)間: 2025-3-29 12:56 作者: LUDE 時(shí)間: 2025-3-29 18:15
Endothelin Converting Enzymes and Endothelin Receptor Localisation in Human Tissues,is. Given the wide distribution and emerging multifunctional role of the peptide, determining the anatomical localisation of endothelin converting enzymes (ECE) is important in understanding the mechanism of production of ET and identification of the receptor sub-type interacting with the released peptide.作者: 褻瀆 時(shí)間: 2025-3-29 21:27 作者: 實(shí)現(xiàn) 時(shí)間: 2025-3-30 01:26 作者: BILL 時(shí)間: 2025-3-30 07:44 作者: muster 時(shí)間: 2025-3-30 09:00
,Die ?konomisierung der Sozialen Arbeit,nt the contractile actions of norepinephrine, 5-HT, and angiotensin II, it has been proposed that ET-1 also sensitizes vessels to the actions of other “classical” circulating neurohumoral factors (MacLean and McGrath 1990; Lerman et al. 1991; Nakayama et al. 1991).作者: 懸崖 時(shí)間: 2025-3-30 12:45
Historical Perspective and Introduction to the Endothelin Family of Peptides,sts. However, EDRF was not prostacyclin. Obviously, the regulatory mechanism of vascular tone involved several chemical substances, which are produced and released from endothelial cells in response to various physical and chemical stimuli and act on the underlying smooth muscle cells to elicit relaxation.作者: Inferior 時(shí)間: 2025-3-30 17:17 作者: 評論性 時(shí)間: 2025-3-30 21:30
The Involvement of Endothelins in Cerebral Vasospasm and Stroke,ible therapeutic potential. The isolation, purification and sequencing of the endothelins has since allowed the development of both peptide and non peptide antagonists selective for endothelin receptors (see Chap. 9).作者: 建筑師 時(shí)間: 2025-3-31 02:08
Vascular and Cardiac Effects of Endothelin,nt the contractile actions of norepinephrine, 5-HT, and angiotensin II, it has been proposed that ET-1 also sensitizes vessels to the actions of other “classical” circulating neurohumoral factors (MacLean and McGrath 1990; Lerman et al. 1991; Nakayama et al. 1991).作者: 骨 時(shí)間: 2025-3-31 09:03 作者: Medicaid 時(shí)間: 2025-3-31 13:16 作者: alliance 時(shí)間: 2025-3-31 16:26
Endothelin-1 and Pulmonary Hypertension,se of a narrowing or loss of pulmonary microvessels, due to an increase in vascular tone (i.e., vasoconstriction), remodelling, with hypertrophy of medial and intimal layers and muscularization of small arterioles (Voewkel and Weir 2000), or destruction of vascular channels.作者: gerontocracy 時(shí)間: 2025-3-31 20:13 作者: Aspiration 時(shí)間: 2025-4-1 01:38
Book 2001diseases. Attention is also paid to the development through chemistry, pharmacology and toxicology of endothelin antagonists and endothelin-converting enzyme inhibitors, with mention of all the important members of these drug classes. This leads to well-rounded discussions of the potential therapeutic benefit of endothelin inhibitors.作者: aerial 時(shí)間: 2025-4-1 04:23
Cell Signaling by Endothelin Peptides,by evoking a complex, integrated network of signaling pathways. ET signaling has emerged as an important model for understanding how G protein-coupled receptors function in physiology and pathophysiology, particularly for those signals that regulate the genome.作者: BOAST 時(shí)間: 2025-4-1 06:16
https://doi.org/10.1007/978-3-662-58961-8thy volunteers or patients. The reader should be appropriately skeptical, however, as endothelin antagonists are relatively new therapeutic entities and, as such, their toxicity spectrum could be broader and deeper than the literature would suggest at this point in time. Only wider preclinical and clinical experience can answer such questions.作者: 運(yùn)氣 時(shí)間: 2025-4-1 13:06 作者: Cougar 時(shí)間: 2025-4-1 17:08 作者: forthy 時(shí)間: 2025-4-1 22:14
0171-2004 amatic developments..Recent publications have addressed specRecent publications have addressed specific aspects of the endothelins, such as their roles in disease or the importance of endothelin receptors. However, in this book the entire field of endothelins is covered. This includes the pathways o作者: nonchalance 時(shí)間: 2025-4-1 22:44 作者: Commission 時(shí)間: 2025-4-2 05:43 作者: exquisite 時(shí)間: 2025-4-2 10:30
