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標(biāo)題: Titlebook: Endothelial Mechanisms of Vasomotor Control; With special Referen H. Drexler,A. M. Zeiher,H. Just Conference proceedings 1991 Dr. Dietrich [打印本頁]

作者: 機會    時間: 2025-3-21 16:09
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作者: cuticle    時間: 2025-3-21 23:40

作者: entitle    時間: 2025-3-22 01:24
https://doi.org/10.1007/978-3-531-90867-0d with the maintenance of the liquidity of the blood. Only in 1976, when Moncada et al. discovered prostacyclin (17), and 1980, when Furchgott and Zawadzki (7) described the essential role of the intact endothelium for the vasodilatory action of acetylcholine, was the significance of this organ for vasomotor control recognized.
作者: 顯微鏡    時間: 2025-3-22 04:53
Introductiond with the maintenance of the liquidity of the blood. Only in 1976, when Moncada et al. discovered prostacyclin (17), and 1980, when Furchgott and Zawadzki (7) described the essential role of the intact endothelium for the vasodilatory action of acetylcholine, was the significance of this organ for vasomotor control recognized.
作者: implore    時間: 2025-3-22 11:33
978-3-642-72463-3Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1991
作者: cardiac-arrest    時間: 2025-3-22 14:20
https://doi.org/10.1007/978-3-531-90867-0d with the maintenance of the liquidity of the blood. Only in 1976, when Moncada et al. discovered prostacyclin (17), and 1980, when Furchgott and Zawadzki (7) described the essential role of the intact endothelium for the vasodilatory action of acetylcholine, was the significance of this organ for
作者: cardiac-arrest    時間: 2025-3-22 20:17

作者: CHOP    時間: 2025-3-23 00:15
https://doi.org/10.1007/978-3-322-95063-5e nitrosothiol S-nitroso-.-cysteine. EDRF was produced from endothelial cells by basal release or by stimulation with the calcium ionophore A23187. Biological activity was measured as relaxation of porcine coronary arteries preconstricted with prostaglandin F., and chemical analysis was made of the
作者: 勤勞    時間: 2025-3-23 03:05

作者: Mets552    時間: 2025-3-23 07:48

作者: 甜瓜    時間: 2025-3-23 11:11

作者: 雄偉    時間: 2025-3-23 15:34

作者: heterodox    時間: 2025-3-23 20:45

作者: 雜色    時間: 2025-3-24 00:19

作者: 瘙癢    時間: 2025-3-24 06:00

作者: ANTIC    時間: 2025-3-24 09:58
Wilhelm Bleek,Hans J. Lietzmannnd tissue oxygenation were studied. Experiments were performed in isolated perfused rabbit hearts as well as in rabbit hindlimbs in vivo. In isolated hearts, perfusion with hemoglobin (6 μM) or N.-nitro-.-arginine (30 μM) significantly increased vascular resistance. The cGMP level in platelets passi
作者: Engulf    時間: 2025-3-24 11:05

作者: 鋼筆尖    時間: 2025-3-24 18:20
Untersuchungsmethoden und -designortic endothelial cells (PAEC) and reperfused ischemic Langendorff hearts of rabbits. Using cGMP as an index of NO generation and 6-oxo-PGF. as an index for PGI. production in endothelial cells, it is demonstrated that the two metabolic pathways for NO and prostacyclin formation act independent of e
作者: guzzle    時間: 2025-3-24 20:57
Fallstudien in der Lehrerausbildung — wozu?muscle tone. Native (n) LDL, isolated from fresh human plasma, was oxidized by Cu.-incubation. EDRF released from cultured endothelial cells was inactivated by both n-LDL and ox-LDL (1 mg/ml) as detected in a bioassay system. n-LDL reduced the EDRF-mediated vasodilations of the detector segments by
作者: 伴隨而來    時間: 2025-3-24 23:27

作者: jungle    時間: 2025-3-25 04:12

作者: 浮雕寶石    時間: 2025-3-25 11:32

作者: Servile    時間: 2025-3-25 12:26
https://doi.org/10.1007/978-3-322-95063-5wed more vasodilation per amount of contained NO than did authentic NO. Solutions containing EDRF (basal release or by stimulation with A23187) subjected to the same analysis appeared similar to nitrosocysteine, and were distinct from solutions of NO. These experiments show that nitrosyl compounds o
作者: 蚊子    時間: 2025-3-25 18:28

作者: Cloudburst    時間: 2025-3-25 20:00
,überg?nge nach der Berufslehre,of NO-formation correlates with the number of nitrate ester groups and proceeds with a simultaneous nitrite formation (with a ratio of 1: 14 in the presence of cysteine). Nitrosamines such as molsidomine do not need thiol compounds for bioactivation. They directly liberate NO from the ring-open A-fo
作者: 缺乏    時間: 2025-3-26 01:06

作者: 商議    時間: 2025-3-26 05:29

作者: BANAL    時間: 2025-3-26 09:25

作者: bleach    時間: 2025-3-26 14:49

作者: 改革運動    時間: 2025-3-26 20:32
Shiva Stucki-Sabeti,Barbara Bonhagesensitivity and circulating levels of endothelin-1, on the other hand, are reduced in this experimental model of hypertension. In the porcine coronary circulation, oxidized low-density lipoproteins selectively reduce endothelium-dependent relaxations to aggregating platelets, serotonin, and thrombin
作者: 下級    時間: 2025-3-26 21:26

作者: CHIP    時間: 2025-3-27 04:41

作者: Criteria    時間: 2025-3-27 07:20

作者: Ganglion    時間: 2025-3-27 11:33
Molecular mechanisms of nitrovasodilator bioactivationof NO-formation correlates with the number of nitrate ester groups and proceeds with a simultaneous nitrite formation (with a ratio of 1: 14 in the presence of cysteine). Nitrosamines such as molsidomine do not need thiol compounds for bioactivation. They directly liberate NO from the ring-open A-fo
作者: 勛章    時間: 2025-3-27 16:06
Endothelium-mediated regulation of coronary tonethe double product of heart rate and blood pressure dropped by only 8±2% (p = 0.05). The maximal coronary conductance during peak reactive hyperemia (after 20 s ischemia) indicating complete coronary dilation was diminished by 48% after .-NNA..The severe drop in resting myocardial perfusion and O.-s
作者: Prologue    時間: 2025-3-27 18:04
Impaired tissue perfusion after inhibition of endothelium-derived nitric oxide vascular resistance and abolition of the increase in platelet cGMP induced by intraarterial infusion of acetylcholine. In addition, the oxygen uptake of the hindlimb (?46%) and the skeletal muscle pO. were significantly reduced. It is concluded that continuously released EDRF has a functional role
作者: insomnia    時間: 2025-3-28 00:52

作者: NAV    時間: 2025-3-28 02:46

作者: ANN    時間: 2025-3-28 10:08

作者: dura-mater    時間: 2025-3-28 11:09
Conference proceedings 1991 as well as the development of new modalities of pharmacotherapy will have to be discussed. The topic addressed by the 1990 Gargellen Conference: Endothelial Mechanisms of Vasomotor Control, clearly is of interest for both basic scientists and clinicians. It has been the aim of the organizers, the S
作者: CRACY    時間: 2025-3-28 14:35
on- cepts, as well as the development of new modalities of pharmacotherapy will have to be discussed. The topic addressed by the 1990 Gargellen Conference: Endothelial Mechanisms of Vasomotor Control, clearly is of interest for both basic scientists and clinicians. It has been the aim of the organizers, the S978-3-642-72463-3978-3-642-72461-9
作者: 并入    時間: 2025-3-28 18:47
https://doi.org/10.1007/978-3-531-91812-9ted). An important principle in the development of collaterals is the remodeling of pre-existing small vessels into the much larger vascular structure. To accomodate new cells old structures have to be removed by controlled proteolysis (tPA, uPA, elastase).
作者: 偶然    時間: 2025-3-29 00:57

作者: 運動的我    時間: 2025-3-29 05:20

作者: 山間窄路    時間: 2025-3-29 09:58
Endothelium and blood flow mediated vasomotion in the conscious dogendothelium, through elaboration of constricting factors, e. g., endothelin, can also induce potent vasoconstriction. In the conscious animal endothelin elicits markedly differing degrees of vasoconstriction among the various regional vascular beds.
作者: 分離    時間: 2025-3-29 14:32

作者: Memorial    時間: 2025-3-29 15:40
Schulentwicklung durch Beratungfusion. No significant changes in EDR, MPO or cardiac necrosis occurred during the 90 min of ischemia. Thus, endothelial dysfunction is an early and specific marker of reperfusion injury preceding neutrophil involvement and cardiac necrosis. Superoxide radicals appear to play a key role in the decreased EDR observed early after reperfusion.
作者: Fresco    時間: 2025-3-29 22:02
Maximilian Hettmann,Kerstin Tiedemannthat seen in patients with variant angina, and that coronary spasm can produce sudden progression of coronary atherosclerotic obstruction due to intramural hemorrhage. Establishment of various animal models to elucidate mechanisms related to various stages of ischemic heart disease are needed.
作者: Offset    時間: 2025-3-30 02:48
Blood flow and optimal vascular topography: role of the endotheliumol value but was restored towards 3, both by basal and by acetylcholine-stimulated EDRF activity. In contrast, endothelin-1 caused a dose-dependent reduction in the junction exponent from its optimal value 3. This suggests that the endothelium helps to optimise microvascular function through EDRF but not endothelin-1 release.
作者: 農(nóng)學(xué)    時間: 2025-3-30 07:13
Endothelial dysfunction in myocardial ischemia and reperfusion: role of oxygen-derived free radicalsfusion. No significant changes in EDR, MPO or cardiac necrosis occurred during the 90 min of ischemia. Thus, endothelial dysfunction is an early and specific marker of reperfusion injury preceding neutrophil involvement and cardiac necrosis. Superoxide radicals appear to play a key role in the decreased EDR observed early after reperfusion.
作者: Glower    時間: 2025-3-30 08:24

作者: BABY    時間: 2025-3-30 14:51

作者: 失望昨天    時間: 2025-3-30 18:33
Role of EDRF and endothelin in coronary vasomotor controlugh ET is possibly the most potent constrictor of coronary arteries yet described, its role in physiological regulation of coronary vasomotor tone is less certain. Interactions between EDRF and ET in the coronary circulation are highlighted and a schema of regulation of release of endothelium-derived vasoactive factors is proposed.
作者: FEMUR    時間: 2025-3-30 23:37

作者: PHON    時間: 2025-3-31 04:24
(and organ perfusion) in health and disease. Physiology, pharmacology, and molecular biology have uncovered a wealth of information on structure and function of this heretofore largely neglected "organ". Clinical medicine is now called upon to define the clinical significance of these observa- tions
作者: Anonymous    時間: 2025-3-31 08:28
Introductiond with the maintenance of the liquidity of the blood. Only in 1976, when Moncada et al. discovered prostacyclin (17), and 1980, when Furchgott and Zawadzki (7) described the essential role of the intact endothelium for the vasodilatory action of acetylcholine, was the significance of this organ for
作者: Ibd810    時間: 2025-3-31 09:30

作者: 小官    時間: 2025-3-31 15:59

作者: 草率女    時間: 2025-3-31 18:48
Does EDRF/NO regulate its own release by increasing endothelial cyclic GMP?se cells contain considerable amounts of soluble guanylyl cyclase. The increase in cyclic GMP in these cells provided a sensitive bioassay for EDRF/NO activity. Bovine aortic endothelial cells released a material that markedly enhanced cyclic GMP in RFL-6 cells. The synthesis of this substance could
作者: 阻礙    時間: 2025-3-31 22:43
Molecular mechanisms of nitrovasodilator bioactivationprodrugs or carriers of the active principle NO, responsible for endothelial controlled vasodilation. The rate of NO-formation strongly correlates with the activation of the soluble guanylate cyclase in vitro, resulting in a stimulation of cGMP synthesis. Nitrovasodilators thus are therapeutic subst




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