標(biāo)題: Titlebook: Endoplasmic Reticulum Stress in Health and Disease; Patrizia Agostinis,Samali Afshin Book 2012 Springer Science+Business Media Dordrecht 2 [打印本頁] 作者: 斷巖 時(shí)間: 2025-3-21 18:53
書目名稱Endoplasmic Reticulum Stress in Health and Disease影響因子(影響力)
書目名稱Endoplasmic Reticulum Stress in Health and Disease影響因子(影響力)學(xué)科排名
書目名稱Endoplasmic Reticulum Stress in Health and Disease網(wǎng)絡(luò)公開度
書目名稱Endoplasmic Reticulum Stress in Health and Disease網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Endoplasmic Reticulum Stress in Health and Disease被引頻次
書目名稱Endoplasmic Reticulum Stress in Health and Disease被引頻次學(xué)科排名
書目名稱Endoplasmic Reticulum Stress in Health and Disease年度引用
書目名稱Endoplasmic Reticulum Stress in Health and Disease年度引用學(xué)科排名
書目名稱Endoplasmic Reticulum Stress in Health and Disease讀者反饋
書目名稱Endoplasmic Reticulum Stress in Health and Disease讀者反饋學(xué)科排名
作者: Heretical 時(shí)間: 2025-3-21 22:07 作者: 古董 時(shí)間: 2025-3-22 01:37 作者: 指派 時(shí)間: 2025-3-22 04:51 作者: 被告 時(shí)間: 2025-3-22 12:40
https://doi.org/10.1007/978-3-319-44657-8 development of obesity, diabetes, and hepatic steatosis, has been demonstrated. In the present chapter, the role of ER stress/UPR activation and alterations in specific UPR genes in the context of obesity, lipid metabolism, and fatty liver will be discussed.作者: 靈敏 時(shí)間: 2025-3-22 15:25
https://doi.org/10.1007/978-81-322-2401-3ansporters, as a transcriptional target of the UPR and its possible link to the decreased sensitivity of tumor cells to chemotherapeutic drugs; and finally, the UPR’s ability to decrease translation via mTOR signaling and the mechanisms that tumor cells may use to elude this translational block of critical proteins to continue their growth.作者: 靈敏 時(shí)間: 2025-3-22 18:15
Biology of the Endoplasmic Reticulumture of the protein folding process in the ER enables this organelle to act as a sensor of a broad range of cellular stresses. Signals emanating from the stressed ER play central roles in differentiation processes, cellular homeostasis and cell death.作者: 喊叫 時(shí)間: 2025-3-23 00:36
A Tight-Knit Group: Protein Glycosylation, Endoplasmic Reticulum Stress and the Unfolded Protein Resruction of improperly folded proteins in the ER associated degradation (ERAD) process. This chapter explores the interdependence of ER stress and glycosylation during protein quality control and cellular response to physiological stress.作者: esthetician 時(shí)間: 2025-3-23 05:11
Regulation of ER Stress Responses by microRNAsvere ER stress that is not resolved, the UPR switches to initiation of apoptosis. Here we have discussed the role of miRNAs in determining cell fate during conditions of ER stress. This chapter will provide novel insights into regulation of UPR signaling by miRNAs.作者: 寄生蟲 時(shí)間: 2025-3-23 08:31
ER Stress As Modulator of Autophagy Pathwaysath promoting mechanism. In this chapter we will review some of the mechanisms that have been proposed to participate in the regulation of autophagy by ER stress and the UPR. Likewise, we will discuss the potential therapeutic implications of the coordinated regulation of these two cellular mechanisms in cancer and cancer treatments.作者: EXPEL 時(shí)間: 2025-3-23 10:05
Endoplasmic Reticulum Stress and the Unfolded Protein Response in Lipid Metabolism and Obesity development of obesity, diabetes, and hepatic steatosis, has been demonstrated. In the present chapter, the role of ER stress/UPR activation and alterations in specific UPR genes in the context of obesity, lipid metabolism, and fatty liver will be discussed.作者: Harpoon 時(shí)間: 2025-3-23 14:15 作者: nitroglycerin 時(shí)間: 2025-3-23 21:56
Falsifying Economic Theories (II), cellular life and death decisions. In this chapter, we address the transition from the physiological ER stress response to the pathological response and explore the mechanisms of ER stress-mediated dysfunction and death of neurons during the progression of neurodegenerative diseases and psychiatric illness.作者: Spina-Bifida 時(shí)間: 2025-3-23 22:58 作者: hair-bulb 時(shí)間: 2025-3-24 03:43 作者: BUOY 時(shí)間: 2025-3-24 09:50 作者: AROMA 時(shí)間: 2025-3-24 12:01 作者: antecedence 時(shí)間: 2025-3-24 17:04
Role of ER Stress in Dysfunction of the Nervous System cellular life and death decisions. In this chapter, we address the transition from the physiological ER stress response to the pathological response and explore the mechanisms of ER stress-mediated dysfunction and death of neurons during the progression of neurodegenerative diseases and psychiatric illness.作者: champaign 時(shí)間: 2025-3-24 22:44
Immersive Ruin: Chernobyl and Virtual Decayell fate may play a part in disease development and response to stress signals in conflicting ways. The lethal arm of the UPR may contribute to pathologies that are linked to unscheduled cell death, like diabetes and certain neurodegenerative diseases such as Alzheimer‘s and Parkinson’s, or be utili作者: Provenance 時(shí)間: 2025-3-25 00:31 作者: 解開 時(shí)間: 2025-3-25 06:01 作者: catagen 時(shí)間: 2025-3-25 09:53 作者: 豎琴 時(shí)間: 2025-3-25 14:29 作者: Obituary 時(shí)間: 2025-3-25 19:05 作者: libertine 時(shí)間: 2025-3-25 21:41 作者: BRIEF 時(shí)間: 2025-3-26 03:15 作者: Terminal 時(shí)間: 2025-3-26 05:46
also developed strategies to get around UPR-induced death signals. In the present chapter, we describe how cancer cells use the UPR or have altered the UPR signaling machinery to gain selective advantage over surrounding cells. We also discuss how UPR signaling is connected to classical carcinogenic作者: 案發(fā)地點(diǎn) 時(shí)間: 2025-3-26 12:21 作者: 清洗 時(shí)間: 2025-3-26 14:38 作者: Airtight 時(shí)間: 2025-3-26 20:51
ER Stress and UPR Through Dysregulated ER Ca2+ Homeostasis and Signaling and –release mechanisms by ER chaperones and the main controller of the ER-stress sensors, GRP78/BiP. Furthermore, recently identified Ca.-transport systems also seem to target ER-stress proteins. Overall, it is clear that altered Ca. signaling and UPR during ER stress are closely related through d作者: 小母馬 時(shí)間: 2025-3-27 00:48
Physiological ER Stress: The Model of Insulin-Secreting Pancreatic b-Cellses give rise to a peculiar pattern of acute regulation of the UPR by nutrients. At low non-stimulatory glucose concentrations, when intracellular ATP, [Ca.]. and protein synthesis are low, the IRE1-XBP1 branch of the UPR is at its lowest level of activation while the PERK-eIF2α-ATF4 branch of the UP作者: 牽索 時(shí)間: 2025-3-27 02:03
Pathological ER Stress in β Cellsological to pathological UPR and proapoptotic signaling in a variety of environmental and genetic diabetic conditions are addressed. In addition, therapeutic approaches to modulate the level of β cell ER stress and mitigate UPR activation are discussed. Finally, we propose that the identification of作者: disparage 時(shí)間: 2025-3-27 09:14 作者: CHIDE 時(shí)間: 2025-3-27 09:41 作者: resuscitation 時(shí)間: 2025-3-27 16:11
Cardiovascular Disease and Endoplasmic Reticulum Stress ER-associated degradation (ERAD) of mis-folded proteins. The UPR can also trigger apoptosis if the insult is prolonged or severe. The cardiovascular system has recently been linked to ER stress with an ability to protect the heart, but is also observed to be pathologically damaging. Suppression of 作者: 轉(zhuǎn)折點(diǎn) 時(shí)間: 2025-3-27 21:46 作者: 涂掉 時(shí)間: 2025-3-28 01:23
Book 2012ria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carci作者: 吼叫 時(shí)間: 2025-3-28 02:56
Endoplasmic Reticulum Stress in Health and Disease作者: minaret 時(shí)間: 2025-3-28 07:07 作者: 召集 時(shí)間: 2025-3-28 13:10 作者: 最有利 時(shí)間: 2025-3-28 16:34
Biology of the Endoplasmic Reticulumrly studies focused on the structure, which was then followed by biochemical and functional studies associated with calcium storage and release from the ER, protein folding and secretion, ER associated degradation (ERAD) and ER stress responses. Currently there is a significant interest in the role 作者: 過分 時(shí)間: 2025-3-28 20:10
A Tight-Knit Group: Protein Glycosylation, Endoplasmic Reticulum Stress and the Unfolded Protein Resc reticulum (ER), details concerning the interconnected nature of pathways associated with protein glycosylation, ER stress and the unfolded protein response are only now beginning to come to light. Changes in glycosylation may induce ER stress or may be induced by ER stress. It has been established作者: 鞭子 時(shí)間: 2025-3-29 01:53 作者: originality 時(shí)間: 2025-3-29 05:51
Endoplasmic Reticulum-mitochondria connections, calcium cross-talk and cell fate: a closer inspectiohighly interconnected structures that are physically based on the most abundant intracellular membranes: ., those forming the endoplasmic reticulum (ER) and the mitochondrial networks. Main hubs of these infra-structures are the Mitochondria-Associated Membranes (MAMs), ER and mitochondria juxtapose作者: keloid 時(shí)間: 2025-3-29 07:32
ER Stress and UPR Through Dysregulated ER Ca2+ Homeostasis and Signalingre filling is critical for proper protein folding. In many occasions, ER stress is tightly linked to disruption of ER Ca. homeostasis, causing the activation of an integrated signaling pathway, the unfolded protein response (UPR). In this book chapter, we will review the ER as a dynamic intracellula作者: arrhythmic 時(shí)間: 2025-3-29 14:11
Regulation of ER Stress Responses by microRNAsirect posttranscriptional regulation of gene expression, typically by binding to 3’ UTR of cognate mRNAs and inhibiting their translation and/or stability. Hundreds of miRNAs, many of them evolutionarily conserved, have been identified in mammals, but their physiological functions are just beginning作者: fallible 時(shí)間: 2025-3-29 16:44 作者: 易受騙 時(shí)間: 2025-3-29 21:58 作者: 愛花花兒憤怒 時(shí)間: 2025-3-29 23:52
Pathological ER Stress in β Cellstancy. The reduction in functional β cell mass due to increased β cell apoptosis and decreased β cell proliferation is a crucial factor in the pathogenesis of diabetes mellitus. Mounting clinical and experimental research findings suggest that endoplasmic reticulum (ER) stress and activation of the 作者: GRAVE 時(shí)間: 2025-3-30 04:39 作者: –LOUS 時(shí)間: 2025-3-30 12:05
ER Stress and Inflammationrocesses, such as the acute-phase response (APR) and those instigated by transcriptional factors like NF-κB and AP-1. ER stress-mediated inflammation has been found to be associated with several diseases, such as obesity, type 2 diabetes, intestinal bowel disease and cancer. The role of ER stress-me作者: Oration 時(shí)間: 2025-3-30 15:42
ER Stress in Intestinal Inflammatory Diseaseus attention on intestinal epithelial cells (IEC) which are unique as they are highly secretory cells that are exposed to a great number of ER stress inducers such as bacteria, xenobiotics, toxins, and hypoxia amongst many other factors (Kaser and Blumberg, Mucosal Immunol 3:11–16, 2010). At the sam作者: Excitotoxin 時(shí)間: 2025-3-30 16:52 作者: 極微小 時(shí)間: 2025-3-30 22:00
Endoplasmic Reticulum (ER) Stress in Amyotrophic Lateral Sclerosis (ALS)with the identification of mutations in 4 key genes, TARDBP, FUS, VCP and VAPB that cause familial ALS. The strong association of TDP-43 with ubiquitinated protein aggregates in motor neurons, a hallmark of ALS in sporadic cases of ALS, clearly demonstrates the importance of these findings for under作者: 輕觸 時(shí)間: 2025-3-31 01:37 作者: 糾纏 時(shí)間: 2025-3-31 05:17
Signaling the Unfolded Protein Response in cancernmental challenges such as hypoxia, nutrient deprivation, remodeling of the environmental space or presence of chemotherapeutic agents. Moreover cancer cells also have to cope with elevated oxidative stress, high DNA replication and protein synthesis rates. As a consequence cancer cells must show hi作者: 監(jiān)禁 時(shí)間: 2025-3-31 12:29 作者: hair-bulb 時(shí)間: 2025-3-31 14:19
Rheinisch-Westf?lischen Kohlen-Syndikatrly studies focused on the structure, which was then followed by biochemical and functional studies associated with calcium storage and release from the ER, protein folding and secretion, ER associated degradation (ERAD) and ER stress responses. Currently there is a significant interest in the role 作者: glomeruli 時(shí)間: 2025-3-31 20:43 作者: 小平面 時(shí)間: 2025-3-31 22:16
Immersive Ruin: Chernobyl and Virtual Decayd degradation of terminally misfolded proteins. Different physiological as well as pathological stress conditions however, can lead to an imbalance between the ER protein folding capacity and protein load, giving rise to an accumulation of misfolded proteins in the ER lumen, a condition dubbed as ‘E
