標題: Titlebook: Endocrine FGFs and Klothos; Makoto Kuro-o Book 2012 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer S [打印本頁] 作者: FERN 時間: 2025-3-21 18:58
書目名稱Endocrine FGFs and Klothos影響因子(影響力)
書目名稱Endocrine FGFs and Klothos影響因子(影響力)學(xué)科排名
書目名稱Endocrine FGFs and Klothos網(wǎng)絡(luò)公開度
書目名稱Endocrine FGFs and Klothos網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Endocrine FGFs and Klothos被引頻次
書目名稱Endocrine FGFs and Klothos被引頻次學(xué)科排名
書目名稱Endocrine FGFs and Klothos年度引用
書目名稱Endocrine FGFs and Klothos年度引用學(xué)科排名
書目名稱Endocrine FGFs and Klothos讀者反饋
書目名稱Endocrine FGFs and Klothos讀者反饋學(xué)科排名
作者: Generic-Drug 時間: 2025-3-21 23:12
Wertgenerierende Faktoren im Bankensektor,ity of endocrine FGFs. Recent structural and biochemical studies have begun to shed light onto the molecular basis for the klotho-dependent endocrine mode of action of the FGF19 subfamily. Crystal structures of FGF19 and FGF23 show that the topology of the HS binding site (HBS) of FGF19 subfamily me作者: 痛苦一下 時間: 2025-3-22 03:55 作者: Arbitrary 時間: 2025-3-22 04:45 作者: 遠地點 時間: 2025-3-22 10:24
René K?nig und die "K?lner Schule"tients might benefit most from aggressive management of disordered phosphorus metabolism. It is also possible that markedly increased FGF23 levels in CKD could contribute directly to tissue injury in the heart, vessels and kidneys, an exciting question that is sure to be the topic of intense investi作者: 殘暴 時間: 2025-3-22 16:15
D. I. Hamilton,H. J. C. M. van de Waly from renal insults, preserve kidney function, and suppress renal fibrosis, in chronic kidney disease. Klotho is a highly promising candidate on the horizon as an early biomarker, and as a novel therapeutic agent for chronic kidney disease.作者: 殘暴 時間: 2025-3-22 20:58
Amy L. Ladd MD,Kristen Fleager MDpplied to the disease caused by loss of function of FGF23. Although these concepts still need to be proven with more detailed analyses, the latest knowledge on the FGF23-related diseases and the development of methods to appropriately regulate FGF23 actions may synergistically create novel therapeut作者: Spartan 時間: 2025-3-22 23:55
Complications of Transurethral Surgery,Rs, its physiological activities, and its differences from FGF21. The review also discusses strategies to separate the mitogenic and metabolic activities for the development of potential therapeutic molecules based on FGF19.作者: Binge-Drinking 時間: 2025-3-23 05:26 作者: BRAND 時間: 2025-3-23 06:03
FGF23 and Syndromes of Abnormal Renal Phosphate Handling,y, loss-of-function mutations in these genes underlie hypophosphatemic disorders that are either X-linked or autosomal recessive. Impaired O-glycosylation of FGF23 due to the lack of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase 3 (GALNT3) or due to certain homozy作者: 嚴峻考驗 時間: 2025-3-23 12:42
FGF23 and the Parathyroid,relates with the resistance of the parathyroid to FGF23. A further subject of great interest in this field is the effect of PTH to directly increase FGF23 expression by osteoblast like cells in culture and the observations that parathyroidectomy prevents and corrects the increased serum FGF23 level 作者: 鐵塔等 時間: 2025-3-23 14:27
FGF23 in Chronic Kidney Disease,tients might benefit most from aggressive management of disordered phosphorus metabolism. It is also possible that markedly increased FGF23 levels in CKD could contribute directly to tissue injury in the heart, vessels and kidneys, an exciting question that is sure to be the topic of intense investi作者: forecast 時間: 2025-3-23 20:58
Secreted Klotho and Chronic Kidney Disease,y from renal insults, preserve kidney function, and suppress renal fibrosis, in chronic kidney disease. Klotho is a highly promising candidate on the horizon as an early biomarker, and as a novel therapeutic agent for chronic kidney disease.作者: FRAX-tool 時間: 2025-3-24 00:17
FGF23 as a Novel Therapeutic Target,pplied to the disease caused by loss of function of FGF23. Although these concepts still need to be proven with more detailed analyses, the latest knowledge on the FGF23-related diseases and the development of methods to appropriately regulate FGF23 actions may synergistically create novel therapeut作者: Libido 時間: 2025-3-24 03:20 作者: Spinal-Fusion 時間: 2025-3-24 06:51
Book 2012However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endo作者: 細胞 時間: 2025-3-24 13:47
0065-2598 current knowledge on FGF19 and FGF21.Comprehensive in scopeFibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regu作者: dissent 時間: 2025-3-24 18:55 作者: 友好 時間: 2025-3-24 20:28
Ergebnisse der Performancemessung,rs and exert their biological activities. This chapter overviews function of Klotho family proteins as obligate coreceptors for endocrine FGFs and discusses potential link between Klothos and age-related diseases.作者: 行為 時間: 2025-3-25 00:06 作者: Mendacious 時間: 2025-3-25 05:16
Jeffrey M. Bumpous,Mary Worthenors is also different for this sub-family, requiring klotho protein cofactors rather than heparin sulfate proteoglycan. Mouse Fgf15 and human FGF19 play key roles in enterohepatic signaling, regulation of liver bile acid biosynthesis, gallbladder motility and metabolic homeostasis.作者: Comedienne 時間: 2025-3-25 11:00
,Klotho and βKlotho,rs and exert their biological activities. This chapter overviews function of Klotho family proteins as obligate coreceptors for endocrine FGFs and discusses potential link between Klothos and age-related diseases.作者: CUB 時間: 2025-3-25 12:10 作者: 逃避現(xiàn)實 時間: 2025-3-25 18:03 作者: Detoxification 時間: 2025-3-25 20:05 作者: 褪色 時間: 2025-3-26 00:47 作者: 修剪過的樹籬 時間: 2025-3-26 07:42
Evidence for FGF23 Involvement in a Bone-Kidney Axis Regulating Bone Mineralization and Systemic Phs through yet-to-be defined locally derived factors. In addition, FGF23 production is regulated by 1,25(OH)2D in a feedback loop where FGF23 stimulate Cyp24 mediated degradation of 1,25(OH)2D that serves to protect the organism from the toxic effects of vitamin D excess. In this chapter, we will review the regulation and function of FGF23.作者: 和音 時間: 2025-3-26 08:34
Book 2012 affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.作者: PRO 時間: 2025-3-26 15:07 作者: collateral 時間: 2025-3-26 17:51
https://doi.org/10.1007/978-3-662-33866-7 and lack of apparent side effects in a variety of animal models. Thus, FGF21 represents a novel and appealing therapeutic reagent for Type 2 diabetes mellitus, obesity, dyslipidemia, cardiovascular and fatty liver diseases. The in vitro biology, genetic animal models and in vivo pharmacology of FGF21 will be discussed in this chapter.作者: Vasoconstrictor 時間: 2025-3-26 23:09
FGF23, Klotho and Vitamin D Interactions:, D can induce the expression of both FGF23 and klotho while, FGF23 can suppress renal expression of 1α(OH)ase to reduce 1,25(OH).D activity. In this brief chapter, I will summarize the possible in vivo interactions of FGF23, klotho and vitamin D, in the light of recent mouse genetics studies.作者: 種族被根除 時間: 2025-3-27 04:11 作者: CONE 時間: 2025-3-27 09:15 作者: septicemia 時間: 2025-3-27 10:18
Endocrine FGFs and Klothos978-1-4614-0887-1Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: ARIA 時間: 2025-3-27 14:57 作者: 發(fā)生 時間: 2025-3-27 19:38
Ergebnisse der Performancemessung,estine upon feeding and acts on liver to suppress bile acid synthesis. FGF21 is secreted from liver upon fasting and acts on adipose tissue to promote lipolysis and responses to fasting. FGF23 is secreted from bone and acts on kidney to inhibit phosphate reabsorption and vitamin D synthesis. One cri作者: Jargon 時間: 2025-3-28 00:36 作者: Free-Radical 時間: 2025-3-28 03:59 作者: Eulogy 時間: 2025-3-28 10:15 作者: judicial 時間: 2025-3-28 13:44
Balihar Sanghera,Elmira Satybaldievahe parathyroid. FGF23 acts on the parathyroid to decrease PTH mRNA and serum PTH levels. It does this by activating the MAPK pathway. In chronic kidney disease there are very high levels of serum FGF23 together with increased serum PTH levels, implying resistance of the parathyroid to the action of 作者: 人類學(xué)家 時間: 2025-3-28 18:40 作者: 含糊 時間: 2025-3-28 19:58
René K?nig und die "K?lner Schule"ered mineral metabolism and particularly, disordered phosphorus metabolism appears to be a contributing factor. Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Its levels increase progressively beginning in early CKD, presumably as a physiological adaptation to mai作者: Missile 時間: 2025-3-29 02:15 作者: Keratectomy 時間: 2025-3-29 05:33 作者: 完成才會征服 時間: 2025-3-29 11:11 作者: Esalate 時間: 2025-3-29 14:52 作者: 玩笑 時間: 2025-3-29 17:01 作者: 牽索 時間: 2025-3-29 21:23
https://doi.org/10.1007/978-3-662-33866-7and safer drugs. Large molecule therapy has played an important role in diabetes since the discovery of insulin. This legacy was continued upon the introduction of Humulin (first recombinant insulin), Humalog (first engineered insulin) and Byetta (first incretin mimetic). Several other protein thera作者: 新星 時間: 2025-3-30 03:40
https://doi.org/10.1007/978-1-4614-0887-1Endocrine; FGF; Fibroblast growth factor; Klotho; Kuro-o; gene expression作者: ineluctable 時間: 2025-3-30 05:38 作者: depreciate 時間: 2025-3-30 10:03 作者: Type-1-Diabetes 時間: 2025-3-30 13:30
The Structural Biology of the FGF19 Subfamily, subfamilies known for their paracrine functions during embryonic development. Compared to the members of paracrine FGF subfamiles, the three members of the FGF19 subfamily, namely FGF19, FGF21 and FGF23, have poor affinity for heparan sulfate (HS) and therefore can diffuse freely in the HS-rich ext作者: Cerumen 時間: 2025-3-30 19:03
,Klotho and βKlotho,estine upon feeding and acts on liver to suppress bile acid synthesis. FGF21 is secreted from liver upon fasting and acts on adipose tissue to promote lipolysis and responses to fasting. FGF23 is secreted from bone and acts on kidney to inhibit phosphate reabsorption and vitamin D synthesis. One cri作者: Handedness 時間: 2025-3-30 21:16
