標(biāo)題: Titlebook: Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments; Anne C. La Flamme,Jacqueline Monique Orian Book 2015 The E [打印本頁(yè)] 作者: fibrous-plaque 時(shí)間: 2025-3-21 19:22
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作者: enflame 時(shí)間: 2025-3-21 21:19 作者: Transfusion 時(shí)間: 2025-3-22 01:47
Sex-Based Differences in Multiple Sclerosis (MS): Part II: Rising Incidence of Multiple Sclerosis iirected toward understanding why this is the case. Past research has revealed a number of sex differences in autoimmune responses that can account for the female bias in MS. However, much less is known about why the incidence of MS has increased exclusively in women over the past half century. The r作者: GLIDE 時(shí)間: 2025-3-22 08:03 作者: ETCH 時(shí)間: 2025-3-22 10:20 作者: Hot-Flash 時(shí)間: 2025-3-22 16:17 作者: Hot-Flash 時(shí)間: 2025-3-22 21:06 作者: 神圣不可 時(shí)間: 2025-3-22 21:25 作者: 胰島素 時(shí)間: 2025-3-23 03:11
Helminth Therapy for MS,ping world; this proposal has been termed the hygiene or old friends hypothesis. The epidemiology of MS shows an inverse correlation with helminth infections. Positive effects of helminths in animal models of MS and observational studies in people with MS naturally infected with helminths suggest th作者: conifer 時(shí)間: 2025-3-23 06:08 作者: 前兆 時(shí)間: 2025-3-23 10:38
Open Foresight und Unternehmenskulturinate in the induction of regulatory cells in distant tissues. Each and every one of the immune suppressive cells and molecules activated by UV exposure are potential targets for treating and preventing MS. A thorough understanding of the mechanisms involved is therefore required if we are to realise the therapeutic potential of photoimmunology.作者: Inflamed 時(shí)間: 2025-3-23 16:27
Jizhe Xia,Qunying Huang,Zhipeng Gui,Wei Tuwe discuss the development of neurofilaments as surrogate outcomes of disability in MS. The validation and qualification are vital steps in biomarker development and to gaining acceptance in scientific community, and the pitfalls leading up to this are also discussed.作者: Mobile 時(shí)間: 2025-3-23 19:12
Photoimmunology and Multiple Sclerosis,inate in the induction of regulatory cells in distant tissues. Each and every one of the immune suppressive cells and molecules activated by UV exposure are potential targets for treating and preventing MS. A thorough understanding of the mechanisms involved is therefore required if we are to realise the therapeutic potential of photoimmunology.作者: 有罪 時(shí)間: 2025-3-24 01:37
Developing Biomarkers for MS,we discuss the development of neurofilaments as surrogate outcomes of disability in MS. The validation and qualification are vital steps in biomarker development and to gaining acceptance in scientific community, and the pitfalls leading up to this are also discussed.作者: adequate-intake 時(shí)間: 2025-3-24 03:38 作者: Rodent 時(shí)間: 2025-3-24 09:30
https://doi.org/10.1007/978-1-4615-1475-6anisms that are thought to lead to the initiation of this disease and then honing in on how these mechanisms differ between the sexes. Finally, we review what is known about the hormonal and genetic basis of these sex differences in CNS autoimmunity.作者: Tincture 時(shí)間: 2025-3-24 13:50
Interesting Classes of Surfaces,y with high parasite load. This chapter focuses on intestinal worms as they are the current choice as a therapeutic strategy in a number of autoimmune diseases, including MS. Here we review current data regarding the rationale and the current state of research in the field of helminth therapies in MS.作者: 縮短 時(shí)間: 2025-3-24 17:00
Sex-Based Differences in Multiple Sclerosis (Part I): Biology of Disease Incidence,anisms that are thought to lead to the initiation of this disease and then honing in on how these mechanisms differ between the sexes. Finally, we review what is known about the hormonal and genetic basis of these sex differences in CNS autoimmunity.作者: agnostic 時(shí)間: 2025-3-24 21:22
Helminth Therapy for MS,y with high parasite load. This chapter focuses on intestinal worms as they are the current choice as a therapeutic strategy in a number of autoimmune diseases, including MS. Here we review current data regarding the rationale and the current state of research in the field of helminth therapies in MS.作者: Hyperlipidemia 時(shí)間: 2025-3-25 01:41
Book 2015ogenesis and treatment. While some of these advances have been through new approaches and ideas that have emerged in the last decade such as the newly identified protective role that amyloid proteins may play in MS or the use of helminths to treat autoimmune diseases, others have evolved from previo作者: 牢騷 時(shí)間: 2025-3-25 06:09
1866-3370 g of the underlying pathobiology of Multiple Sclerosis.This Over the past decade, we have made great advances in the field of multiple sclerosis (MS) research, and this book focuses on those advances in MS pathogenesis and treatment. While some of these advances have been through new approaches and 作者: ABIDE 時(shí)間: 2025-3-25 09:37
Scott Hawken,Hoon Han,Christopher Pettit. However, other HLA molecules have also been linked to the development of MS. In this chapter, the association between different HLA types and susceptibility to MS will be reviewed, and other linkages between the carriage of specific HLA molecules and clinical and experimental findings in MS will be considered.作者: 連鎖,連串 時(shí)間: 2025-3-25 15:43 作者: follicle 時(shí)間: 2025-3-25 18:55 作者: abolish 時(shí)間: 2025-3-25 22:50 作者: PLE 時(shí)間: 2025-3-26 03:30
https://doi.org/10.1007/978-3-319-32170-7irected toward understanding why this is the case. Past research has revealed a number of sex differences in autoimmune responses that can account for the female bias in MS. However, much less is known about why the incidence of MS has increased exclusively in women over the past half century. The r作者: Inveterate 時(shí)間: 2025-3-26 07:57
Toichiro Asada,Carl Chiarella,Reiner Frankeing MS in relatives of affected individuals gives solid evidence for a genetic base for susceptibility, whereas the modest familial risk, most strikingly demonstrated in the twin studies, is a very strong argument for an important role of lifestyle/environmental factors in determining the risk of MS作者: MEET 時(shí)間: 2025-3-26 10:56
Open Field Magnetic Resonance Imagingrisk. A substantial evidence base now exists supporting an association between vitamin D and MS, primarily illustrated by a latitudinal gradient of MS prevalence, a month of birth effect, an interaction of vitamin D with MS-associated genes and the fact that high vitamin D levels have been associate作者: HEED 時(shí)間: 2025-3-26 13:54
Open Foresight und Unternehmenskulturn cancer, it is also associated with protection against a range of autoimmune diseases, particularly multiple sclerosis (MS). Although the precise mechanism by which sunlight affords protection from MS remains to be determined, some have hypothesised that UV immunosuppression explains the “l(fā)atitude-作者: 增強(qiáng) 時(shí)間: 2025-3-26 20:02
Ausgangssituation und Problemstellung,, and its pathophysiology is poorly understood. Moreover, the last two decades have witnessed a dramatic revision of the long-held view of MS as an inflammatory demyelinating white matter disease. Instead, it is now regarded as a global central nervous system (CNS) disorder with a neurodegenerative 作者: Encoding 時(shí)間: 2025-3-27 00:07
Jizhe Xia,Qunying Huang,Zhipeng Gui,Wei Tuover, it is extremely difficult to measure clinical disability in patients, which is often a retrospective assessment, and definitely not within the time frame of a clinical trial. Biomarkers, conversely are more specific for a pathologic process and if used correctly can prove invaluable in the dia作者: 音樂(lè)等 時(shí)間: 2025-3-27 03:49
Interesting Classes of Surfaces,ping world; this proposal has been termed the hygiene or old friends hypothesis. The epidemiology of MS shows an inverse correlation with helminth infections. Positive effects of helminths in animal models of MS and observational studies in people with MS naturally infected with helminths suggest th作者: 心神不寧 時(shí)間: 2025-3-27 07:49 作者: Gingivitis 時(shí)間: 2025-3-27 12:45 作者: 出來(lái) 時(shí)間: 2025-3-27 15:43
978-3-319-34846-9The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl作者: 致敬 時(shí)間: 2025-3-27 19:33
Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments978-3-319-25543-9Series ISSN 1866-3370 Series E-ISSN 1866-3389 作者: 郊外 時(shí)間: 2025-3-28 00:48 作者: Fissure 時(shí)間: 2025-3-28 05:54 作者: Culmination 時(shí)間: 2025-3-28 08:08
Sex-Based Differences in Multiple Sclerosis (MS): Part II: Rising Incidence of Multiple Sclerosis ine mechanisms to contribute to the preferential rise in MS incidence in women. Despite the strong female bias in MS incidence, culminating evidence from natural history studies, and imaging and pathology studies suggests that males who develop MS may exhibit a more rapid decline in disability and co作者: Feigned 時(shí)間: 2025-3-28 11:38
The Role of Environment and Lifestyle in Determining the Risk of Multiple Sclerosis,UVR) exposure habits/vitamin D status, and smoking. We have also reviewed a number of additional environmental factors, published in the past 5?years, that have been described to influence MS risk. Independent replication, preferably by a variety of methods, may give still more firm evidence for the作者: habile 時(shí)間: 2025-3-28 16:16 作者: agitate 時(shí)間: 2025-3-28 21:42
Modelling MS: Chronic-Relapsing EAE in the NOD/Lt Mouse Strain,anized versions. Nonetheless, EAE is a distinct disease, and each variant models only certain facets of MS. Whilst the search for more refined MS models must continue, it is important to further explore where mechanisms underlying EAE provide proof-of-principle for those driving MS pathogenesis. EAE作者: 周興旺 時(shí)間: 2025-3-29 02:27
Self-Assembling Peptides Form Immune Suppressive Amyloid Fibrils Effective in Autoimmune Encephalomtive transfer of Th1 lymphocytes. However, type 1 IFN is known to exacerbate EAE with adoptive transfer of Th17 lymphocytes. Indeed, the amyloid fibril-forming peptide Tau 623–628 was therapeutic in Th1 adoptively transferred EAE, but ineffective in Th17 adoptively transferred EAE. However, the ther作者: 只有 時(shí)間: 2025-3-29 05:48
1866-3370 in elucidation of the factors regulating susceptibility or disease progression, identification of new ways to monitor or predict MS pathology, and development of new strategies for treating MS.978-3-319-34846-9978-3-319-25543-9Series ISSN 1866-3370 Series E-ISSN 1866-3389 作者: Cognizance 時(shí)間: 2025-3-29 07:41 作者: insipid 時(shí)間: 2025-3-29 11:26 作者: aggressor 時(shí)間: 2025-3-29 18:13 作者: 極端的正確性 時(shí)間: 2025-3-29 23:22
Open Field Magnetic Resonance Imagingand unanswered questions exist. Most notably, future work will need to establish appropriate dosing, timing and method of vitamin D supplementation in optimising any potential clinical benefit. In this chapter, we discuss the strong epidemiological and growing mechanistic evidence supporting an asso作者: CURB 時(shí)間: 2025-3-30 03:15
Ausgangssituation und Problemstellung,anized versions. Nonetheless, EAE is a distinct disease, and each variant models only certain facets of MS. Whilst the search for more refined MS models must continue, it is important to further explore where mechanisms underlying EAE provide proof-of-principle for those driving MS pathogenesis. EAE
