標(biāo)題: Titlebook: Emerging Targets in Antibacterial and Antifungal Chemotherapy; Joyce A. Sutcliffe,Nafsika H. Georgopapadakou Book 1992 Routledge, Chapman [打印本頁] 作者: Scuttle 時(shí)間: 2025-3-21 16:18
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書目名稱Emerging Targets in Antibacterial and Antifungal Chemotherapy讀者反饋學(xué)科排名
作者: MORPH 時(shí)間: 2025-3-21 22:47 作者: 音樂會(huì) 時(shí)間: 2025-3-22 00:23 作者: 啜泣 時(shí)間: 2025-3-22 07:29
Achin Chakraborty,Subrata Mukherjeeication in bacteria is a complex process; in . , over 30 proteins are required. It has been established biochemically and genetically that many replication genes encode products that are essential for replication (Table 3.1) Temperature-sensitive mutations in each of these genes are conditionally le作者: Ankylo- 時(shí)間: 2025-3-22 11:32 作者: 思考而得 時(shí)間: 2025-3-22 14:32 作者: 思考而得 時(shí)間: 2025-3-22 17:31 作者: 帶來的感覺 時(shí)間: 2025-3-22 22:21 作者: ineptitude 時(shí)間: 2025-3-23 01:59
Andrea Daley,Merrick D. Pillingal component which gives the cell wall its rigid structure. Peptidoglycan is composed of glycan chains with alternating N-acetylglucosamine and N-acetylmuramic acid residues that are cross-linked through a peptide bridge (.). As shown in Figure 8.1, crosslinking occurs via nucleophilic attack of the作者: 古董 時(shí)間: 2025-3-23 06:22
Alexander M. Stoner,Andony Melathopoulosllin (.). This epoch-making discovery ushered in a new era of fruitful research culminating in the identification of the bacterial cell wall as the target of this β-lactam (.). Penicillin was found to act by inhibiting the cross-linking enzymes involved in the biosynthesis of peptidoglycan (PG), the作者: Dissonance 時(shí)間: 2025-3-23 10:46 作者: 與野獸博斗者 時(shí)間: 2025-3-23 14:07 作者: 充氣球 時(shí)間: 2025-3-23 20:21
Echo Questions and Grammatical Constraints,ly diverse and progressively expanding population of immunocompromised patients. Those with the acquired immune deficiency syndrome (AIDS) constitute the most rapidly growing group of patients at risk for life-threatening mycoses, especially cryptococcal meningitis [., .], disseminated histoplasmosi作者: Paraplegia 時(shí)間: 2025-3-23 22:23
Interrupt Handling Architectures, is involved in various cellular processes (., ., .). These topological forms of DNA may arise as a result of it being in a closed, circular form (rings or loops) such as in plasmid, viral, phage, or bacterial genomic DNA. Alternatively, the genomic DNA of eukaryotes may be complexed with proteins a作者: Fluctuate 時(shí)間: 2025-3-24 06:11
Italian and Italian American Studiesngal sterols. The characteristics of these agents have been studied extensively in recent years, but their precise mechanisms in altering fungal growth are only poorly understood. Our research on . has produced evidence that there are multiple functions for sterols in this organism. It seems logical作者: 爭(zhēng)吵加 時(shí)間: 2025-3-24 08:34 作者: 一窩小鳥 時(shí)間: 2025-3-24 12:59 作者: Albumin 時(shí)間: 2025-3-24 18:35 作者: DIS 時(shí)間: 2025-3-24 19:33 作者: exhilaration 時(shí)間: 2025-3-24 23:09
https://doi.org/10.1007/978-3-319-75217-4ntibiotics, however, declined, sharply thereafter, precipitating strategic changes. Mechanism-based or target-directed screening, utilization of rare microorganisms and unusual culture conditions, and introduction of gene technology to modify antibiotic productivity have been among the major changes; these topics will be reviewed in this chapter.作者: Proponent 時(shí)間: 2025-3-25 05:56 作者: 正常 時(shí)間: 2025-3-25 09:11 作者: fleeting 時(shí)間: 2025-3-25 11:45 作者: 蚊子 時(shí)間: 2025-3-25 19:50
Bacterial Cell Divisione mechanisms employed by eukaryotic cells. Although this lack of similarity may be a result of our lack of knowledge about these processes it may also be that different mechanisms are involved. If so, it would make cell division a selective target for antimicrobial agents.作者: FADE 時(shí)間: 2025-3-25 23:42 作者: archenemy 時(shí)間: 2025-3-26 00:09 作者: Consequence 時(shí)間: 2025-3-26 06:25 作者: 修飾 時(shí)間: 2025-3-26 08:27 作者: nonradioactive 時(shí)間: 2025-3-26 13:40 作者: 絕食 時(shí)間: 2025-3-26 20:51 作者: scrape 時(shí)間: 2025-3-27 00:26
Investing in Youth Health Assetscade saw the introduction of carbapenem antibiotics (imipenem/cilastatin), enzyme inhibitors combined with older beta-lactams, such as ticarcillin/clavulanate and ampicillin/ sulbactam, and last, but certainly not least, fluoroquinolone antimicrobials.作者: Hamper 時(shí)間: 2025-3-27 02:26
Achin Chakraborty,Subrata Mukherjeethal. Thus, blocking any of these essential proteins with chemotherapeutic agents should block cell proliferation. Because the replication system of . is well characterized, I will focus on it throughout this review. Similar enzymes and genes have also been identified in widely divergent bacteria including gram-positive species..作者: Detain 時(shí)間: 2025-3-27 05:21 作者: Rinne-Test 時(shí)間: 2025-3-27 12:15 作者: 無力更進(jìn) 時(shí)間: 2025-3-27 14:19 作者: DNR215 時(shí)間: 2025-3-27 20:15
DNA Replicationthal. Thus, blocking any of these essential proteins with chemotherapeutic agents should block cell proliferation. Because the replication system of . is well characterized, I will focus on it throughout this review. Similar enzymes and genes have also been identified in widely divergent bacteria including gram-positive species..作者: Robust 時(shí)間: 2025-3-27 22:58
Protein secretion in bacteria: a chemotherapeutic target?tudies. All proteins destined for the outer membrane or periplasmic space are first synthesized as precursors bearing an amino-terminal signal sequence of about 20 amino acids. Cleavage of the signal sequence by signal peptidase at the outer face of the inner membrane precedes proper localization of these exported protein.作者: Ringworm 時(shí)間: 2025-3-28 02:25 作者: BIDE 時(shí)間: 2025-3-28 10:00 作者: 盡忠 時(shí)間: 2025-3-28 12:52
Italian and Italian American Studies. Once these functions and physiological processes are identified, they may be of value in the biorational design of specific inhibitors and agents that are targeted to essential functions in fungi. Such agents might be effective in smaller amounts and have less deleterious effects on the host than those presently in use.作者: 制定 時(shí)間: 2025-3-28 15:50
Cytosolic Enzymes in Peptidoglycan Biosynthesis as Potential Antibacterial Targetsate proteins present in the cell membrane which catalyze transpeptidation and D,D-carboxypeptidation of the peptidoglycan. (For review, see ..) Inability to crosslink the different glycan chains leads to cell wall degradation by bacterial autolysins, thus leading to cell death.作者: transplantation 時(shí)間: 2025-3-28 21:19 作者: Lipohypertrophy 時(shí)間: 2025-3-29 00:22
rely new classes of drugs. The authors emphasize newtopicsrather than review work on known antibacterials andantifungals, andidentify new targets--either the rate-limitingcomponent of abiochemical pathway or a component of the pathway thatis susceptibleto a ``screening‘‘ or ``rational drug design‘‘a(chǎn)作者: achlorhydria 時(shí)間: 2025-3-29 05:22 作者: intrigue 時(shí)間: 2025-3-29 11:13
Being Heard: A Māori Community Narrativepecific sterol biosynthetic enzymes by mechanism-based inhibitors. Because sterol biosynthesis and its regulation vary among animals, plants, and fungi, this approach offers significant prospects for the rational design of chemotherapeutic agents aimed at the control of disease states ranging from arteriosclerosis to fungal infections.作者: obnoxious 時(shí)間: 2025-3-29 15:22 作者: florid 時(shí)間: 2025-3-29 18:03
Rationally Designed Inhibitors of Sterol Biosynthesispecific sterol biosynthetic enzymes by mechanism-based inhibitors. Because sterol biosynthesis and its regulation vary among animals, plants, and fungi, this approach offers significant prospects for the rational design of chemotherapeutic agents aimed at the control of disease states ranging from arteriosclerosis to fungal infections.作者: 無能的人 時(shí)間: 2025-3-29 23:31 作者: bonnet 時(shí)間: 2025-3-30 00:53 作者: projectile 時(shí)間: 2025-3-30 04:02
Echo Questions and Grammatical Constraints, occurred with similar frequency in both populations, being found in 15.4% of 350 children (age <13 years) with AIDS in comparison to 10.6% of all AIDS patients and 8.5–16.8% of various subpopulations of adults with AIDS.作者: BROW 時(shí)間: 2025-3-30 10:05
Interrupt Handling Architectures,d type II based on their ability to catalyse single- or double-strand cleavages, respectively; in addition type II enzymes have an energy requirement satisfied by ATP. In bacteria, topoisomerase II is often referred to as bacterial gyrase. . contains two type I topoisomerases, the TopA and TopB prot作者: 受人支配 時(shí)間: 2025-3-30 16:27 作者: ethnology 時(shí)間: 2025-3-30 19:46 作者: 異教徒 時(shí)間: 2025-3-30 21:24 作者: Emg827 時(shí)間: 2025-3-31 03:05 作者: 蝕刻術(shù) 時(shí)間: 2025-3-31 05:48
Emerging Targets in Antibacterial and Antifungal Chemotherapy作者: APEX 時(shí)間: 2025-3-31 10:33
Emerging Targets in Antibacterial and Antifungal Chemotherapy978-1-4615-3274-3作者: 天然熱噴泉 時(shí)間: 2025-3-31 13:22 作者: Recess 時(shí)間: 2025-3-31 18:30 作者: ESPY 時(shí)間: 2025-4-1 00:02
Historical Perspectives of Approaches to Antibiotics Discoveryntibiotics, however, declined, sharply thereafter, precipitating strategic changes. Mechanism-based or target-directed screening, utilization of rare microorganisms and unusual culture conditions, and introduction of gene technology to modify antibiotic productivity have been among the major changes作者: Frenetic 時(shí)間: 2025-4-1 04:23
Bacterial Pathogens for the 1990s: A Case for New Drug Development was dominated by the introduction of multiple new beta-lactams, both extended-spectrum penicillins ( . , mezlocillin, piperacillin, and azlocillin) and third-generation cephalosporins (cefotaxime, moxalactam, cefoperazone, ceftazidime, ceftizoxime, ceftriaxone, . ). The mid to latter part of the de作者: A簡(jiǎn)潔的 時(shí)間: 2025-4-1 09:45
DNA Replicationication in bacteria is a complex process; in . , over 30 proteins are required. It has been established biochemically and genetically that many replication genes encode products that are essential for replication (Table 3.1) Temperature-sensitive mutations in each of these genes are conditionally le作者: intimate 時(shí)間: 2025-4-1 10:21
RNA Synthesis in Bacteria: Mechanism and Regulation of Discrete Biochemical Events at Initiation andthat catalyzes transcription, locates and binds a specific promoter sequence on the template DNA, unwinds a small region surrounding a specific start site, initiates the synthesis of an RNA chain, elongates the chain to a definite stop site, and finally releases the completed transcript and dissocia
