標題: Titlebook: Electrical Diseases of the Heart; Genetics, Mechanisms Ihor Gussak (Deputy Therapeutic Area Head, Profess Book 20081st edition Springer-Ver [打印本頁] 作者: 力學 時間: 2025-3-21 17:06
書目名稱Electrical Diseases of the Heart影響因子(影響力)
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書目名稱Electrical Diseases of the Heart被引頻次學科排名
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書目名稱Electrical Diseases of the Heart讀者反饋學科排名
作者: Receive 時間: 2025-3-21 20:53
Mechanisms of Cardiac Arrhythmiadisturbances may be relatively benign, as in the case of premature ventricular contractions (PVC), whereas others are malignant, as in the case of ventricular fibrillation, capable of leading to sudden death. The most prevalent sustained arrhythmia in the clinic is atrial fibrillation.作者: 高調(diào) 時間: 2025-3-22 01:12
K, Channelopathies (,, and ,,) Opening of ion channels allows ions to move along their electrochemical gradient thus either depolarizing the membrane or repolarizing it and creating electrical patterns such as the action potential (see Chapter 9 and Figure 11-1).作者: 散布 時間: 2025-3-22 06:31
Comparisons of Substrates Responsible for Atrial Versus Ventricular Fibrillationure 16-1A). can underlie fibrillation. In the latter two cases, although the primary source may be firing regularly, the inability of tissues to follow 1∶1 causes wave breakup and fibrillation. Ironically, these recent ideas echo notions first put forward in the early twentieth century..作者: Melanocytes 時間: 2025-3-22 11:09
https://doi.org/10.1007/978-3-322-91686-0it that stabilizes the closed state of the channel to prevent aberrant calcium (Ca.) leak from the SR.. Direct targeting of several protein kinases and phosphatases to the type 2 cardiac RyR channel (RyR2) allows for rapid and localized modulation of SR Ca. release in response to extracellular signals..作者: Monotonous 時間: 2025-3-22 14:50 作者: Monotonous 時間: 2025-3-22 17:16
Grundsicherungsarbeit in der Wissenschaft,disturbances may be relatively benign, as in the case of premature ventricular contractions (PVC), whereas others are malignant, as in the case of ventricular fibrillation, capable of leading to sudden death. The most prevalent sustained arrhythmia in the clinic is atrial fibrillation.作者: 啞巴 時間: 2025-3-23 00:43 作者: 種屬關(guān)系 時間: 2025-3-23 02:27 作者: maroon 時間: 2025-3-23 05:56
Calcium Release Channels (Ryanodine Receptors) and Arrhythmogenesisit that stabilizes the closed state of the channel to prevent aberrant calcium (Ca.) leak from the SR.. Direct targeting of several protein kinases and phosphatases to the type 2 cardiac RyR channel (RyR2) allows for rapid and localized modulation of SR Ca. release in response to extracellular signals..作者: 使閉塞 時間: 2025-3-23 12:35
Grundri? zum Studium der Zahnheilkunderdial perfusion through effects on coronary vascular function and platelet aggre- gability (Figure 4-1). Neural influences may also be arrhythmogenic in patients with channelopathies, including the long QT and Brugada syndromes, as discussed in detail in other chapters.作者: EXTOL 時間: 2025-3-23 16:12 作者: 表示問 時間: 2025-3-23 19:14 作者: Inflamed 時間: 2025-3-24 00:12
L-type Calcium Channel Diseasend distinctive dysmorphic features. So far TS is the only inherited arrhythmogenic disorder linked to cardiac calcium channel mutations. In this chapter, we will briefly review the structure, physiology, and pathophysiology of the cardiac Cav1.2 encoded by the . gene.作者: Lumbar-Stenosis 時間: 2025-3-24 03:01 作者: 概觀 時間: 2025-3-24 08:00
Verfügungsrecht über die Bodensch?tzestanding of cardiac electricity and outline some of the key questions that I think we must address. Although my personal career goal has been how we can now exploit this basic science for clinical care, more than ever basic understanding is the framework for our future advances.作者: 砍伐 時間: 2025-3-24 14:43 作者: anniversary 時間: 2025-3-24 18:45
https://doi.org/10.1007/978-3-322-81717-4n to structural cardiac defects, notably cardiac fibrosis, dilated cardiomyopathy, and, possibly, arrhythmogenic right ventricular cardiomyopathy. These structural changes may also be conducive to (reentrant) arrhythmias.作者: Criteria 時間: 2025-3-24 19:57 作者: abnegate 時間: 2025-3-25 00:33
Anatomic and Histopathological Characteristics of the Conductive Tissues of the Heartity between atrial and ventricular myocardium, allowing atrial impulses to be conveyed to the ventricles in an orderly fashion. In this chapter, we will deal with normal and pathological features of the conductive tissue of the heart.作者: 初學者 時間: 2025-3-25 06:03 作者: KEGEL 時間: 2025-3-25 10:47
Basic Physiology of Ion Channel Functionl to generate action potentials and is also summed up in time and space to generate a surface electrocardiogram (EKG) signal. Thus cardiac electrophysiology offers the unique opportunity to obtain different levels of view of the same phenomenon either nanoscopically (at the level of a channel pore) 作者: 燈絲 時間: 2025-3-25 12:50 作者: 凹處 時間: 2025-3-25 17:12
Mechanisms of Action of Antiarrhythmic Drugsecently treatment of atrial tachyarrhythmias such as atrial fibrillation is also one of the major interests. However, its application may cause serious adverse effects.. Since usage of antiarrhythmic drugs tended to rely on clinicians’ experience and to be based on clinical practice, the effects of 作者: 挑剔小責 時間: 2025-3-25 21:05
The Role of Cellular Sodium and Calcium Loading in Cardiac Energetics and Arrhythmogenesis: Contribu The mechanisms and consequences of sodium and calcium overload are the subject of this review. Evidence supporting a role for the late sodium current (late . .) as a mechanism of calcium overloading and cardiac dysfunction is emphasized.作者: 沒血色 時間: 2025-3-26 01:41 作者: inveigh 時間: 2025-3-26 06:54
Senescence and Arrhythmogenesise in understanding the pathogenesis of age-related cardiac diseases and therapies are being developed for these diseases, advanced age by itself poses significant dilemmas in therapy due to the lack of a full understanding of the molecular basis for the aging-associated increase in the susceptibilit作者: 暗諷 時間: 2025-3-26 10:34 作者: Scintillations 時間: 2025-3-26 15:24 作者: squander 時間: 2025-3-26 19:16 作者: microscopic 時間: 2025-3-26 21:05 作者: monogamy 時間: 2025-3-27 03:18 作者: MITE 時間: 2025-3-27 08:19 作者: GRIN 時間: 2025-3-27 09:27 作者: 名字 時間: 2025-3-27 14:28
H. W. Haupt,Verlag Dr. Th. Gablerg treatment with cardiac and noncardiac drugs, is still a major challenge for physicians. Recent advances in the knowledge of the genomic and physiological regulation of myocardial repolarization suggest that common alterations of cardiac (ion channel) genes are associated with slight electrophysiol作者: parasite 時間: 2025-3-27 19:56 作者: BROW 時間: 2025-3-27 22:22 作者: delta-waves 時間: 2025-3-28 05:09 作者: Insatiable 時間: 2025-3-28 07:51 作者: ARM 時間: 2025-3-28 13:54
Anatomic and Histopathological Characteristics of the Conductive Tissues of the Heartogical staining. They are located in specific regions of the heart to form the sinus node and the atrioventricular (AV) node, which then extend into the AV bundle and bundle branches. Both cardiac nodes are sited in the atria with working atrial myocardium in between (so called internodal preferenti作者: 侵略 時間: 2025-3-28 15:59
Neural Regulation of the Heart in Health and Diseasework of intrinsic cardiac nerves, and autonomic reflexes, all of which interact with a cardiac substrate altered by advancing age and disease. In patients with ischemic heart disease, which is the major factor underlying risk for sudden cardiac death (SCD),. neural influences can predispose to arrhy作者: reception 時間: 2025-3-28 21:57 作者: 太空 時間: 2025-3-29 01:28
Mechanisms of Action of Antiarrhythmic Drugs clinics for a long time. Arrhythmias refer to changes from the normal sequence of electrical impulses and conduction, causing abnormal heart rhythms. They can be classified into two categories: bradyarrhythmias and tachyarrhythmias. Both can make the heart pump less effectively and, more seriously,作者: 失望昨天 時間: 2025-3-29 05:44 作者: Aerate 時間: 2025-3-29 10:46
The Role of Cellular Sodium and Calcium Loading in Cardiac Energetics and Arrhythmogenesis: Contribuum (Figure 8-1).. Reperfusion of the ischemic heart may further exacerbate an ischemia-induced loss of ionic homeostasis. Ischemia and ischemic metabolites can increase the influx of sodium into myocytes..–. Concurrent reduction of sodium efflux during ischemia, as a consequence of reductions of cel作者: 采納 時間: 2025-3-29 12:19
Sodium Ion Channelopathies rapid impulse conduction through cardiac tissue. Therefore, Na. channel function plays a major role in initiation, propagation, and maintenance of the normal cardiac rhythm. Mutations in SCN5A, the gene encoding for the α-subunit of the cardiac Na. channel, the so-called “inherited sodium channelop作者: legislate 時間: 2025-3-29 15:32
L-type Calcium Channel Diseaseciated with mutations in several genes that control cardiac excitability. Among the most recent findings, the voltage-gated L-type cardiac calcium channel (Cav1.2) has been involved in the pathogenesis of Timothy syndrome (TS). TS is a variant of the long QT syndrome (also LQT8) and it is a rare and作者: 不連貫 時間: 2025-3-29 21:00 作者: 意外的成功 時間: 2025-3-30 01:05
Channelopathies of Cardiac Inwardly Rectifying Potassium Channelsstanding the molecular basis of an ion channel disease has provided new opportunities for screening, early diagnosis, and therapy of these commonly life-threatening conditions. ., . A case in point is the identification of molecular genetic defects in inwardly rectifying potassium (Kir, .) channels.作者: 知識分子 時間: 2025-3-30 07:13 作者: doxazosin 時間: 2025-3-30 09:31
Caveolae and Arrhythmogenesispace. However, unlike the historical model of the “fluid mosaic” for the plasma membrane, in which integral membrane proteins are evenly distributed and free to diffuse, current knowledge suggests a more heterogeneous view of the plasma membrane in which proteins and lipids are clustered within spec作者: FAZE 時間: 2025-3-30 13:19
Senescence and Arrhythmogenesisage..–. The increased susceptibility to both ventricular and atrial arrhythmias in the senescent heart occurs despite the absence of apparent disease and is exaggerated in the presence of underlying comorbidities..,. Cardiac dysrhythmias not only adversely affect the quality of life but also contrib作者: 尖酸一點 時間: 2025-3-30 19:43
Comparisons of Substrates Responsible for Atrial Versus Ventricular FibrillationC) has been challenged by recent ideas suggesting that in some cases a single high-frequency rotor (Figure 16-1B). or even a rapidly firing focus (Figure 16-1A). can underlie fibrillation. In the latter two cases, although the primary source may be firing regularly, the inability of tissues to follo作者: 單調(diào)性 時間: 2025-3-31 00:27 作者: 幼稚 時間: 2025-3-31 03:28 作者: 殺菌劑 時間: 2025-3-31 07:34
Ihor Gussak (Deputy Therapeutic Area Head, ProfessProvides a perspective on primary (heritable) electrical disease of the heart and sudden cardiac death in cardiology, neurology, nephrology, endocrinology by emphasizing the clinical and basic aspects作者: AWL 時間: 2025-3-31 12:54 作者: 發(fā)怨言 時間: 2025-3-31 14:06
Verfügungsrecht über die Bodensch?tzey in lethal cardiac arrhythmia, and equally frustrated by the paucity of basic understanding of cardiac electricity upon which better treatment could be based. What a remarkable change has occurred since that time; there have been extraordinary advances in both the science and clinical care. I will
