標題: Titlebook: Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3; Kenneth V. Honn,Lawrence J. Marnett,Patrick Y.-K. [打印本頁] 作者: 威風 時間: 2025-3-21 17:01
書目名稱Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3影響因子(影響力)
書目名稱Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3影響因子(影響力)學科排名
書目名稱Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3網(wǎng)絡公開度
書目名稱Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3網(wǎng)絡公開度學科排名
書目名稱Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3被引頻次
書目名稱Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3被引頻次學科排名
書目名稱Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3年度引用
書目名稱Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3年度引用學科排名
書目名稱Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3讀者反饋
書目名稱Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3讀者反饋學科排名
作者: 打包 時間: 2025-3-21 23:50 作者: 極大的痛苦 時間: 2025-3-22 01:50
Wendelyn H. Inman,Graham Carpenter vitronectin, thrombospondin, and von Willebrand factor.. Cells expressing these receptors have an advantage to adhere to a variety of basement membrane proteins and thereby generate different matrix driven cellular responses.作者: Inexorable 時間: 2025-3-22 04:35 作者: TOXIN 時間: 2025-3-22 08:54 作者: 故意釣到白楊 時間: 2025-3-22 14:18 作者: 故意釣到白楊 時間: 2025-3-22 19:44
Human and Rat Cyclooxygenases are Pharmacologically Distinctmpounds. The active compounds are subsequently evaluated mostly using rat or mouse in vivo models. Unless the COX enzymes used for the in vitro screening is pharmacologically identical to the COX enzyme of the in vivo model, the in vivo results may be misleading.作者: 啞巴 時間: 2025-3-22 21:14
Effects of Secretory PLA2 on Rat Peritoneal Mast Cells Activated by Different Secretagoguesis enzyme in non-digestive organs suggested that it may play a role in cell proliferation and in smooth muscle contraction.. The concentration of sPLA.-II is increased in synovial fluids and plasma of patients with diverse inflammatory diseases.. The sPLA.-II may hence play important roles in the pathogenesis of these inflammatory diseases.作者: 中子 時間: 2025-3-23 01:26
Function of Calcium-Independent Phospholipase A2 in Arachidonic Acid Metabolism in P388D1 Macrophagetely 14 kDa), the structurally unrelated Ca.-dependent, high molecular mass enzymes (85 kDa), and the recently described Ca.-independent enzymes.. All three families have been implicated in AA release in a variety of cells, their relative contribution being dependent on the agonist and cell type considered.作者: macrophage 時間: 2025-3-23 07:51 作者: minimal 時間: 2025-3-23 12:47 作者: 閑蕩 時間: 2025-3-23 16:34
https://doi.org/10.1007/978-94-009-6729-8ain more than one enzyme, each of which is regulated independently and has distinct functions. Thus, cytosolic PLA. (cPLA.) and two types of secretory PLA.s (type I and type II) are the best characterized members of a still expanding large family of mammalian PLA. s..作者: PAGAN 時間: 2025-3-23 19:15
Víctor Ramiro Fernández,Gabriel Brondinothe formation of different eicosanoids (2). This eventually would lead to the differing biological responses. This paper focuses on the differential activation of different forms of PLA. and identifies and characterizes two forms of PLA., namely the cytosolic (cPLA.) and secretory (sPLA.) forms in mouse epidermal keratinocytes.作者: Atmosphere 時間: 2025-3-24 01:05
Oxidized Low Density Lipoprotein Stimulates Protein Kinase C (PKC) Activity and Expression of PKC-Isenase/cyclooxygenase inhibitor ML 3000 and by treatment with N-(2-cyclohexy-loxy-4-nitrophenyl)methane sulfonamide (NS-398). Thesse results suggest a predominantly COX 2-dependent and isotype-specific effect of modified (lipo)proteins on PKC.作者: 輕快帶來危險 時間: 2025-3-24 03:40
Characterization and Molecular Cloning of Mouse Type II Phospholipase A2ain more than one enzyme, each of which is regulated independently and has distinct functions. Thus, cytosolic PLA. (cPLA.) and two types of secretory PLA.s (type I and type II) are the best characterized members of a still expanding large family of mammalian PLA. s..作者: 杠桿 時間: 2025-3-24 10:18 作者: ALB 時間: 2025-3-24 11:00
EGF-Receptor Tyrosine Kinase and 12-Lipoxygenase Activity Regulate Expression of 12-Lipoxygenase in LOX and the arachidonate metabolite generated via 12-LOX activity, 12(.)-HETE, have been shown to contribute to the metastatic potential of tumor cells in vivo and in vitro 4. Most recently, elevated expression of 12-LOX mRNA in prostate epithelial cells was demonstrated to correlate with poor prognosis in human prostate cancer..作者: aesthetician 時間: 2025-3-24 15:43
Disruption of the Mouse Cyclooxygenase 1 Genehapter will summarize the known characteristics of COX-1 deficient mice and describe some future studies utilizing these mice which will lead to a better understanding of the physiological functions of the COX’s and their roles in the therapeutic and toxic effects of NSAIDs (non-steroidal anti-inflammatory drugs).作者: Enthralling 時間: 2025-3-24 20:02
Amita Singh,Milap Punia,Thiyam Bharat Singhate LTA. into the proinflammatory compound LTB., 5(S), 12(R)-dihydroxy-6, 14-.-8, 10-.-eicosa-tetraenoic acid (For reviews see Refs. 1 and 2). Sequence comparisons of LTA. hydrolase with certain zinc containing proteases and peptidases led to the discovery of a zinc binding motif in the primary stru作者: monopoly 時間: 2025-3-25 01:09 作者: refraction 時間: 2025-3-25 07:06
Rucong Yu,Tianjun Zhou,Guangqing Zhouhas demonstrated the occurrence of two isoforms of 12-lipoxygenase (platelet-type and leukocyte-type) which were distinguished in terms of substrate specificity, the cross-reactivity of their antibodies and the homology of their amino acid sequences.. The leukocyte-type 12-lipoxy-genases have been d作者: monopoly 時間: 2025-3-25 10:15
Development and Implementation of Ship BWMSts occurrence correlates to the presence and the amount of subarachnoid clot. It is different from ordinary constriction of vessel, since the cerebral vasospasm is delayed onset and long lasting contraction of the vessel which also involves histological changes. Although almost all substances which 作者: Slit-Lamp 時間: 2025-3-25 11:54
https://doi.org/10.1007/978-94-017-1237-8nd lipoproteins (Belkner et al., 1993). The enzyme is expressed in high yield in rabbit reticulocytes, in human airway epithelial cells and eosinophils and in smaller amounts in other mammalian cells (for review see Ford-Hutchinson, 1991a). In contrast to the 5-lipoxygenase which is involved in the 作者: TRACE 時間: 2025-3-25 17:39
Mark W. Barnett,Ruth F. Watson,Peter C. Kindly regulate cell growth. To date, a number of tumor suppressor genes (e. g., RB, p53, DCC, APC/MCC, NF1, NF2, WT1, VHL, BRCA1, MST1, and WAF1/CIP1 genes) have been identified and have been shown to be important in a variety of human malignancies such as cancers of the colon, lung, breast, and esopha作者: orient 時間: 2025-3-25 20:28
Wendelyn H. Inman,Graham Carpenters, endothelial cells, etc.) in addition to tumor cell interactions with the extracellular matrix. These interactions are mediated by a variety of cell surface receptors including cadherins, CAMs, selectins, and integrins.. To date a number of integrin receptors have been shown to be critically invol作者: 星星 時間: 2025-3-26 02:38
W. Hoffmann,A. K?nigstorfer,S. Sterrertors (1). One of these genes encodes the inducible form of prostaglandin synthase (2), now known as PGS-2 or cyclooxygenase 2 (COX-2). We demonstrated that the product of the PGS-2 gene has both cyclooxygenase and hydroperoxidase activities (3); that PGS-2 is a functional prostaglandin synthase. At 作者: 粗魯?shù)娜?nbsp; 時間: 2025-3-26 07:24
Werner A. Mueller,Monika Hassel,Maura Grealymmatory stimuli. are about 63% identical in their primary amino acid sequence and >90% of the putative “active site” amino acids are conserved.. Despite this similarity, recent studies have shown that these enzymes are pharmacologically distinct.. Similarly, COX-1 and COX-2 from different species sh作者: COLON 時間: 2025-3-26 10:39 作者: 取消 時間: 2025-3-26 13:55 作者: 陰郁 時間: 2025-3-26 20:37 作者: 鐵塔等 時間: 2025-3-26 21:40 作者: opinionated 時間: 2025-3-27 03:53 作者: chassis 時間: 2025-3-27 06:38
Development for Sustainable Agriculturend at the .-2 position of phospholipid molecules. Arachidonic acid released by PLA. from mammalian cells is then further metabolized by cyclooxgenase or lipoxygenase to form eicosanoids. At least three mammalian PLA. have been identified:. two are 14-kDa secretory enzymes and one is an 85-kDa in-tra作者: 不滿分子 時間: 2025-3-27 11:16
https://doi.org/10.1007/978-94-009-6729-8ransduction. PLA. also provides precursors for eicosanoid generation when the cleaved fatty acid is arachidonic acid, or platelet-activating factor (PAF) formation when the .-1 position of the phosphatidylcholine (PC) contains an alkyl ether linkage. Recent advances in molecular and cellular biology作者: Defense 時間: 2025-3-27 14:29 作者: Engaged 時間: 2025-3-27 18:06
Guidi Caterina Francesca,Alessandro Petretto Beyond its antioxidative property, vitamin E has been shown to inhibit the proliferation of smooth muscle cells by modulating protein kinase C.. The regulatory role of vitamin E in the production of certain lipid mediators has also been demonstrated. For instance, vitamin E was found to enhance the作者: Cantankerous 時間: 2025-3-27 23:32 作者: Fibrillation 時間: 2025-3-28 03:32 作者: OATH 時間: 2025-3-28 07:25 作者: justify 時間: 2025-3-28 13:21 作者: HEDGE 時間: 2025-3-28 17:42
0065-2598 Overview: 978-1-4899-1815-4978-1-4899-1813-0Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: 溺愛 時間: 2025-3-28 19:51
Bernd Pelster,Warren W. BurggrenLOX and the arachidonate metabolite generated via 12-LOX activity, 12(.)-HETE, have been shown to contribute to the metastatic potential of tumor cells in vivo and in vitro 4. Most recently, elevated expression of 12-LOX mRNA in prostate epithelial cells was demonstrated to correlate with poor prognosis in human prostate cancer..作者: MILK 時間: 2025-3-28 23:48
https://doi.org/10.1007/978-1-349-02062-1hapter will summarize the known characteristics of COX-1 deficient mice and describe some future studies utilizing these mice which will lead to a better understanding of the physiological functions of the COX’s and their roles in the therapeutic and toxic effects of NSAIDs (non-steroidal anti-inflammatory drugs).作者: AER 時間: 2025-3-29 04:00
Studies on the Active Site of Leukotriene A4 Hydrolaseate LTA. into the proinflammatory compound LTB., 5(S), 12(R)-dihydroxy-6, 14-.-8, 10-.-eicosa-tetraenoic acid (For reviews see Refs. 1 and 2). Sequence comparisons of LTA. hydrolase with certain zinc containing proteases and peptidases led to the discovery of a zinc binding motif in the primary stru作者: 合乎習俗 時間: 2025-3-29 08:10
EGF-Receptor Tyrosine Kinase and 12-Lipoxygenase Activity Regulate Expression of 12-Lipoxygenase in LOX and the arachidonate metabolite generated via 12-LOX activity, 12(.)-HETE, have been shown to contribute to the metastatic potential of tumor cells in vivo and in vitro 4. Most recently, elevated expression of 12-LOX mRNA in prostate epithelial cells was demonstrated to correlate with poor progn作者: anesthesia 時間: 2025-3-29 11:54 作者: LAVA 時間: 2025-3-29 17:28
Role of 12-HPETE in the Pathogenesis of Cerebral Vasospasmts occurrence correlates to the presence and the amount of subarachnoid clot. It is different from ordinary constriction of vessel, since the cerebral vasospasm is delayed onset and long lasting contraction of the vessel which also involves histological changes. Although almost all substances which 作者: humectant 時間: 2025-3-29 19:59 作者: 課程 時間: 2025-3-30 00:29
Involvement of the Multiple Tumor Suppressor Genes and 12-Lipoxygenase in Human Prostate Cancerly regulate cell growth. To date, a number of tumor suppressor genes (e. g., RB, p53, DCC, APC/MCC, NF1, NF2, WT1, VHL, BRCA1, MST1, and WAF1/CIP1 genes) have been identified and have been shown to be important in a variety of human malignancies such as cancers of the colon, lung, breast, and esopha作者: 細胞學 時間: 2025-3-30 07:57 作者: FOIL 時間: 2025-3-30 09:58
Function and Regulation of Prostaglandin Synthase-2tors (1). One of these genes encodes the inducible form of prostaglandin synthase (2), now known as PGS-2 or cyclooxygenase 2 (COX-2). We demonstrated that the product of the PGS-2 gene has both cyclooxygenase and hydroperoxidase activities (3); that PGS-2 is a functional prostaglandin synthase. At 作者: Crohns-disease 時間: 2025-3-30 15:18 作者: 舊病復發(fā) 時間: 2025-3-30 19:25 作者: groggy 時間: 2025-3-30 23:01 作者: 泥瓦匠 時間: 2025-3-31 01:33 作者: 獸皮 時間: 2025-3-31 07:47 作者: flavonoids 時間: 2025-3-31 09:27 作者: 我要威脅 時間: 2025-3-31 15:25 作者: 彩色的蠟筆 時間: 2025-3-31 17:50
Characterization and Molecular Cloning of Mouse Type II Phospholipase A2ransduction. PLA. also provides precursors for eicosanoid generation when the cleaved fatty acid is arachidonic acid, or platelet-activating factor (PAF) formation when the .-1 position of the phosphatidylcholine (PC) contains an alkyl ether linkage. Recent advances in molecular and cellular biology作者: Sedative 時間: 2025-3-31 22:18
Differential Activation of Keratinocyte Phospholipase A2S by Tumor Promoters and other Irritantsransduction and tumor promotion. The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) and other irritants, including the calcium ionorphore A23187, elicit the release of the fatty acids from which these compounds are derived (1). Phospholipase A. (PLA.) plays a key role in regulating the re作者: Virtues 時間: 2025-4-1 05:25
Vitamin E (α-Tocopherol) Enhances Arachidonic Acid Release in Rat Heart Myoblastic Cells Through the Beyond its antioxidative property, vitamin E has been shown to inhibit the proliferation of smooth muscle cells by modulating protein kinase C.. The regulatory role of vitamin E in the production of certain lipid mediators has also been demonstrated. For instance, vitamin E was found to enhance the作者: delegate 時間: 2025-4-1 09:56
Studies on the Active Site of Leukotriene A4 Hydrolaseinc atom was bound to His-295, His-299, and Glu-318, in accordance with previous predictions, and that replacements of either of these three residues led to enzymatically inactive proteins which did not contain zinc..作者: 黑豹 時間: 2025-4-1 10:37
Tissue Distribution and Subcellular Localization of Platelet-Type Arachidonate 12-Lipoxygenase and the distribution of the enzyme by immunohistochemical study. However, the purification of platelet-type 12-lipoxygenase as antigen was difficult, and no polyclonal antibody with a high affinity for platelet-type enzyme was available until recently. Therefore, in this study we attempted to purif作者: 使虛弱 時間: 2025-4-1 16:08
Role of 12-HPETE in the Pathogenesis of Cerebral Vasospasm (12-HPETE) injected into canine major cistern was produced delayed onset and long lasting vasospasm comparable to the canine SAH model. The injected 12-HPETE into the canine major cistern was decreased rapidly and disappeared from cerebrospinal fluid (CSF) at 6 hours after its injection.. It was in作者: exclusice 時間: 2025-4-1 20:44
Subcellular Localization of the 15-Lipoxygenase in Mammalian Cellse in atherogenesis has been suggested (Yl?-Herttuala et al., 1991). The human 5-lipoxygenase which is synthesized as a cytosolic protein in resting white blood cells translocates to the nuclear envelope when the cells were stimulated with calcium ionophore (Woods et al., 1993). In the translocation
