標題: Titlebook: EGF Receptor in Tumor Growth and Progression; R. B. Lichtner,R. N. Harkins Conference proceedings 1997 Springer-Verlag Berlin Heidelberg 1 [打印本頁] 作者: Addiction 時間: 2025-3-21 17:32
書目名稱EGF Receptor in Tumor Growth and Progression影響因子(影響力)
書目名稱EGF Receptor in Tumor Growth and Progression影響因子(影響力)學科排名
書目名稱EGF Receptor in Tumor Growth and Progression網(wǎng)絡公開度
書目名稱EGF Receptor in Tumor Growth and Progression網(wǎng)絡公開度學科排名
書目名稱EGF Receptor in Tumor Growth and Progression被引頻次
書目名稱EGF Receptor in Tumor Growth and Progression被引頻次學科排名
書目名稱EGF Receptor in Tumor Growth and Progression年度引用
書目名稱EGF Receptor in Tumor Growth and Progression年度引用學科排名
書目名稱EGF Receptor in Tumor Growth and Progression讀者反饋
書目名稱EGF Receptor in Tumor Growth and Progression讀者反饋學科排名
作者: 鋸齒狀 時間: 2025-3-21 23:46 作者: lipids 時間: 2025-3-22 02:57 作者: 火花 時間: 2025-3-22 07:52
Epidermal Growth Factor Receptor Expression in Head and Neck Tumorigenesis and Saturation of EGFR wrials is the understanding that the whole epithelial lining of the tract shares a common carcinogenic exposure, resulting in an increased cancer risk throughout the exposed epithelum. This entire epithelium was first described as “condemned mucosa” associated with “field cancerization” by Slaughter 作者: RADE 時間: 2025-3-22 10:44
The Role of Estrogen in the Regulation of EGFR Expression,987). Moreover, many cell regulators such as EGF, 12-O-tetradecanoyl phorbol acetate (TPA), and sodium butyrate have opposite effects on the expression of the two receptors (Lee et al. 1989; Secada et al. 1991; De Fazio et al. 1992). This well-established inverse correlation between EGFR and ER expr作者: Magnitude 時間: 2025-3-22 15:16
Conference proceedings 1997poptosis, cell migration, and cell shape. Activation of autocrine growth loops, consisting in solid human tumors of upregulated expression of EGFR together with increased production of ligands suggested its crucial role in autonomous tumor growth.作者: Magnitude 時間: 2025-3-22 17:38
0947-6075 tiation, apoptosis, cell migration, and cell shape. Activation of autocrine growth loops, consisting in solid human tumors of upregulated expression of EGFR together with increased production of ligands suggested its crucial role in autonomous tumor growth.978-3-662-03393-7978-3-662-03391-3Series ISSN 0947-6075 作者: Hectic 時間: 2025-3-22 23:40
Michal Borkovec,Ger J. M. Koperts with transgenic mice suggest that an autocrine mechanism involving the EGFR could be expected to play a role in the initiation and/or progression of tumors. Transgenic mice expressing transforming growth factor-α (TGF-α) were reported to develop mammary and hepatocellular carcinoma as well as pan作者: magnanimity 時間: 2025-3-23 03:22
ptide substrate and the ATP binding sites. In the phosphorylated form it is expected to become disengaged from the active center and to allow access of the substrates. In terms of homology it is possible that such a mechanism might operate similarly in other RTK. (2) Autophosphorylation creates bind作者: Notify 時間: 2025-3-23 09:17 作者: 半球 時間: 2025-3-23 09:50
House Church Christianity in Chinarials is the understanding that the whole epithelial lining of the tract shares a common carcinogenic exposure, resulting in an increased cancer risk throughout the exposed epithelum. This entire epithelium was first described as “condemned mucosa” associated with “field cancerization” by Slaughter 作者: 協(xié)迫 時間: 2025-3-23 17:48 作者: PON 時間: 2025-3-23 21:20
0947-6075 and progression of cancer. Early breakthroughs defining growth control pathways came via studies of oncogenes, mutated signaling molecules that have lost the capacity to tum off their proliferative signal. Oncogenes with diverse growth-promoting activities have been discovered, covering the gamut fr作者: Restenosis 時間: 2025-3-24 01:52 作者: Epidural-Space 時間: 2025-3-24 04:15 作者: encyclopedia 時間: 2025-3-24 06:49
Real Sandpiles and Landscape Formation,nt toxin constructs are currently being tested in cancer therapy. The new strategies still employ the two original principles: (1) they rely on the enhanced expression of cell surface molecules in tumor cells when compared to normal cells, and (2) they utilize bifunctional molecules combining a tumor cell recognition domain and a toxic domain.作者: 猛然一拉 時間: 2025-3-24 13:32
ainsbury et al. 1985; Harris et al. 1989), and lung (Veale et al. 1987; Hendler et al. 1989). Furthermore, EGF receptor activation has been implicated in autocrine stimulation of cell growth in many experimental studies (Mendelsohn 1990). Therefore, the EGF receptor appears to be an excellent target for antitumor therapy (Mendelsohn 1989).作者: 平項山 時間: 2025-3-24 17:12
EGF Receptors as a Target for Therapy and Interactions with Angiogenesis,nd in vivo assays and commonly unregulated in cancer with a poor prognosis, its potential as a therapy target has been investigated and clinical trials are now in progress. This article reviews the clinical background and some recent developments with implications for therapy.作者: SEMI 時間: 2025-3-24 21:11
erbB Signalling and Endocrine Sensitivity of Human Breast Cancer, loss of suppressor gene function (Walker and Varley 1993), ultimately alter the phenotype of cancer cells and allow them to thrive under conditions in which their normal counterparts remain severely growth restrained (Gee et al. 1996; Nicholson and Gee 1996).作者: 通情達理 時間: 2025-3-24 23:29 作者: prodrome 時間: 2025-3-25 03:55
EGF Receptor Inhibition by Antibody as Anticancer Therapy,ainsbury et al. 1985; Harris et al. 1989), and lung (Veale et al. 1987; Hendler et al. 1989). Furthermore, EGF receptor activation has been implicated in autocrine stimulation of cell growth in many experimental studies (Mendelsohn 1990). Therefore, the EGF receptor appears to be an excellent target for antitumor therapy (Mendelsohn 1989).作者: 加劇 時間: 2025-3-25 09:34 作者: 高歌 時間: 2025-3-25 12:01
A Difference That Makes No Difference,aselga and Mendelsohn 1994; Eccles et al. 1995). The cell surface location of these molecules renders them attractive targets for a variety of immunotherapeutic strategies, some of which are showing promise in preclinical and early clinical trials.作者: Rotator-Cuff 時間: 2025-3-25 19:53
The Role of Epidermal Growth Factor Receptor in the Initiation and Progression of Malignancy,actically demonstrated in the case of avian erythroblastosis by functional replacement of v-erbB through human EGFR (Khazaie et al. 1988). Oncogenes and deregulation of cell proliferation provided a powerful tool for explaining cancer at the molecular level (Sinn et al. 1987).作者: Mettle 時間: 2025-3-25 23:50
Preclinical Studies with Human Tumour Xenografts Using Rat Monoclonal Antibodies Directed Against taselga and Mendelsohn 1994; Eccles et al. 1995). The cell surface location of these molecules renders them attractive targets for a variety of immunotherapeutic strategies, some of which are showing promise in preclinical and early clinical trials.作者: emulsify 時間: 2025-3-26 02:54 作者: oxidant 時間: 2025-3-26 07:58 作者: CHASE 時間: 2025-3-26 11:52
Michal Borkovec,Ger J. M. Koperst studied receptor signaling systems from this family is the epidermal growth factor receptor (EGFR). The EGFR is widely expressed in mammals and has been implicated in various stages of embryonic development. Recently, EGFR knockout mice by targeted disruption of exon 1 (Sibilia and Wagner 1995) o作者: 容易懂得 時間: 2025-3-26 14:01
iple tyrosine residues. This process, commonly designated as “autophosphorylation” is the initial and a crucial event of growth factor signaling, which is followed by initiation of a multitude of downstream signaling chains (Ullrich and Schlessinger 1990; Fantl et al. 1993). RTK autophosphorylation 作者: Obstacle 時間: 2025-3-26 20:19
Phase-transfer catalyzed reactions,crophages (Besner et al. 1990) and subsequently cloned and sequenced from the human macrophage-like cell line U-937 (Higashiyama et al. 1991). HB-EGF was considered to be a member of the family of EGF-like growth factors based on its primary structure containing six conserved cysteine residues (Higa作者: 豐富 時間: 2025-3-27 00:58 作者: 過份 時間: 2025-3-27 02:37 作者: 孤獨無助 時間: 2025-3-27 05:31
ocesses of cellular survival, proliferation and differentiation. Such changes, which are likely to occur through both oncogenic activation and via the loss of suppressor gene function (Walker and Varley 1993), ultimately alter the phenotype of cancer cells and allow them to thrive under conditions i作者: Thrombolysis 時間: 2025-3-27 11:51 作者: 食品室 時間: 2025-3-27 16:49 作者: 出處 時間: 2025-3-27 21:37 作者: Magnificent 時間: 2025-3-28 01:45 作者: 瑣事 時間: 2025-3-28 04:37 作者: 左右連貫 時間: 2025-3-28 10:09 作者: Blood-Clot 時間: 2025-3-28 13:40 作者: 信徒 時間: 2025-3-28 18:38 作者: 職業(yè)拳擊手 時間: 2025-3-28 21:47 作者: HALO 時間: 2025-3-29 00:22 作者: 保留 時間: 2025-3-29 06:20
Signal Transduction by EGF Receptor Tyrosine Kinase,st studied receptor signaling systems from this family is the epidermal growth factor receptor (EGFR). The EGFR is widely expressed in mammals and has been implicated in various stages of embryonic development. Recently, EGFR knockout mice by targeted disruption of exon 1 (Sibilia and Wagner 1995) o作者: MENT 時間: 2025-3-29 08:52 作者: 燈泡 時間: 2025-3-29 12:05 作者: 前面 時間: 2025-3-29 17:14 作者: 都相信我的話 時間: 2025-3-29 22:44 作者: Truculent 時間: 2025-3-30 03:45 作者: duplicate 時間: 2025-3-30 04:48
The Role of Estrogen in the Regulation of EGFR Expression, al. 1984; Sainsbury et al. 1985; Koenders et al. 1991; Sharma et al. 1992). While expression of ER usually predicts for responsiveness to endocrine therapy and overall good prognosis (Osborne et al. 1980), EGFR expression (independent of ER) correlates with lack of response to endocrine therapy, hi作者: SNEER 時間: 2025-3-30 12:14
The Role of Epidermal Growth Factor Receptor in the Initiation and Progression of Malignancy,ral simian sarcoma virus (SSV) v-sis (Doolittle et al. 1984; Waterfield et al. 1983) and avian erythroblastosis virus (AEV) v-erbB (Downward et al. 1984b) putative oncogenes provided strong support for the notion that deregulation of cellular growth control may form the basis for cancer. This was pr
