標(biāo)題: Titlebook: Drugs and a Methodological Compendium; From bench to bedsid Vikrant Singh Rajput,Ashish Runthala Book 2023 The Editor(s) (if applicable) an [打印本頁(yè)] 作者: ACRO 時(shí)間: 2025-3-21 16:27
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作者: 量被毀壞 時(shí)間: 2025-3-21 21:02
Bioactivity-Guided Fractionation and Identification of Bioactive Molecules: A Basic Method in Drug orefront over the decades. Bioassay-guided fractionation and isolation are still the basic procedures for identifying new natural product-based scaffolds with defined biological activity. Historically, drugs were discovered serendipitously through the accidental identification of active ingredients 作者: 舊石器 時(shí)間: 2025-3-22 03:41 作者: 糾纏,纏繞 時(shí)間: 2025-3-22 04:43 作者: 露天歷史劇 時(shí)間: 2025-3-22 11:06 作者: recession 時(shí)間: 2025-3-22 14:52 作者: recession 時(shí)間: 2025-3-22 18:03 作者: HERE 時(shí)間: 2025-3-23 00:08
Nanoparticles for Targeted Drug Delivery Systems with Cancer Therapy in Perspective,liver it specifically to the target size, either by passive or by active targeting, and reduce the drug-associated toxicity. Conjugation of specific ligands on the surface of NPs can enhance therapeutic efficacy and reduce unwanted side effects of the drug.作者: 不真 時(shí)間: 2025-3-23 05:06 作者: Extemporize 時(shí)間: 2025-3-23 08:36 作者: G-spot 時(shí)間: 2025-3-23 11:25
macological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.978-981-19-7954-5978-981-19-7952-1作者: DRAFT 時(shí)間: 2025-3-23 14:59 作者: Cupidity 時(shí)間: 2025-3-23 21:17
O,l molecules usually utilized for drug discovery. Nevertheless, natural products retain unique features that differentiate them from conventional and outdated small-molecule drug leads, demanding novel techniques and access for evaluating their therapeutic capability. In this chapter, we scrutinize a作者: forecast 時(shí)間: 2025-3-23 23:58 作者: 形容詞 時(shí)間: 2025-3-24 02:30
Q,oxicokinetics using complex mathematical models. Despite significant breakthroughs in the field of in vitro test systems including 3D cell and organ culture techniques, the translational value of these systems is limited, and still mankind needs to traverse a long road ahead in this field. Undoubted作者: 失眠癥 時(shí)間: 2025-3-24 09:06
L,dies that includes animal models and toxicology testing methodologies to identify a safe, potent, and efficacious drug. This chapter also highlights the importance of predictive and validated animal models for absorption, distribution, metabolism, and excretion (ADME) studies, along with the disease作者: 慢跑鞋 時(shí)間: 2025-3-24 11:18 作者: 珊瑚 時(shí)間: 2025-3-24 18:33 作者: 泰然自若 時(shí)間: 2025-3-24 22:15 作者: 致命 時(shí)間: 2025-3-25 01:58 作者: micronized 時(shí)間: 2025-3-25 05:37
Q,x modelling, understanding side effects, off-target predictions and also target identification. To improve virtual screening, pharmacophores are frequently paired with molecular docking and MD simulations. This chapter offers case studies for developing new tuberculosis (TB) inhibitors based on cofa作者: impale 時(shí)間: 2025-3-25 09:39
R, key enzyme that plays a crucial role in facilitating viral replication and transcription. Considering the significance of these two proteins in the viral infection, these were chosen as the potential drug target against SARS-CoV-2 infection. This chapter emphasizes the need for an additional antivi作者: CLASH 時(shí)間: 2025-3-25 13:56 作者: Rheumatologist 時(shí)間: 2025-3-25 19:00
In Vitro Methodologies for the Safety Assessment of Drugs,作者: 埋葬 時(shí)間: 2025-3-25 21:51 作者: Contracture 時(shí)間: 2025-3-26 00:27
Vikrant Singh Rajput,Ashish RunthalaExplores the most-updated techniques and procedures utilized for drug discovery and development.Provides a meticulous view of the methodologies involved using illustrative examples.Features the finest作者: daredevil 時(shí)間: 2025-3-26 08:06
http://image.papertrans.cn/e/image/283207.jpg作者: 愛(ài)得痛了 時(shí)間: 2025-3-26 10:00
https://doi.org/10.1007/978-981-19-7952-1Drug discovery and development; Computational drug designing; Pharmacology and Pharmaceutics; Drug safe作者: accordance 時(shí)間: 2025-3-26 13:20 作者: mercenary 時(shí)間: 2025-3-26 20:05 作者: 潛伏期 時(shí)間: 2025-3-26 23:14
P,t in the drug development. Different methodologies have been applied in drug discovery time to time..Drug discovery has started with the usage of herbal extracts for different ailments, which were termed as traditional medicine. The knowledge, skills and practice of holistic health care, recognized 作者: pessimism 時(shí)間: 2025-3-27 03:54
Q,ates. These drugs are tested for pharmacological as well as toxicological evaluations to uncover their therapeutic applications for a particular disease. These tests followed by clinical trials allow studying the safety, efficacy and pharmacology of that molecule. These tests are conducted on a wide作者: 團(tuán)結(jié) 時(shí)間: 2025-3-27 07:00
L,ion, preclinical evaluation, and finally human clinical trials. Once a new chemical entity (NCE) is discovered, it progresses toward the development process that includes preclinical and clinical pharmacology. Preclinical research includes in silico, in vitro, ex vivo, and in vivo studies using cell作者: Neuropeptides 時(shí)間: 2025-3-27 12:37 作者: 裙帶關(guān)系 時(shí)間: 2025-3-27 15:28 作者: macrophage 時(shí)間: 2025-3-27 18:29
M,entry of novel drug molecules into the pharmaceutical market. This situation mandates the initiation of contemporary drug repurposing research strategies to reconnoiter the hidden off-label indications of de-risked compounds or existing approved drugs with established safety profile. This chapter le作者: omnibus 時(shí)間: 2025-3-28 01:02 作者: POINT 時(shí)間: 2025-3-28 02:09 作者: ARBOR 時(shí)間: 2025-3-28 09:12 作者: CODE 時(shí)間: 2025-3-28 10:28 作者: VOK 時(shí)間: 2025-3-28 16:53 作者: BROTH 時(shí)間: 2025-3-28 21:53 作者: Acetabulum 時(shí)間: 2025-3-29 02:10 作者: 彩色的蠟筆 時(shí)間: 2025-3-29 03:07
ies involved using illustrative examples.Features the finestThis?book provides a meticulous view on methodological drug discovery and development insights from bench to bedside. The current book threads almost each step encompassing drug the discovery and development of a molecule. The chapters focu作者: 芭蕾舞女演員 時(shí)間: 2025-3-29 09:08 作者: TOXIC 時(shí)間: 2025-3-29 13:45 作者: MUTE 時(shí)間: 2025-3-29 17:37
P,inside the host during infection are the major challenges in anti-TB drug discovery. Therefore, various high-throughput screening (HTS) methods that mimic closely to the host conditions during . infection can be used to identify novel drug molecules. This chapter summarizes these HTS methods for discovering novel anti-TB molecules.作者: 潛移默化 時(shí)間: 2025-3-29 20:57 作者: Outmoded 時(shí)間: 2025-3-30 03:16 作者: 震驚 時(shí)間: 2025-3-30 07:08
George Deacon,William Rainey,Herbert Rabine in vivo, the challenge lies in supplying the appropriate dose at the injured site for an increased period. To overcome the challenge, various biomimetic materials are being employed for delivering drugs in a controlled manner, which includes porous materials, hydrogels, nanofibrous scaffolds, etc. made from natural and synthetic polymers.作者: 滋養(yǎng) 時(shí)間: 2025-3-30 12:10
S,dentified. As a result, drug development has shifted from serendipity/whole-cell screening of vast libraries to a new era of target-focused investigations, in which the method is more systematic and based on parasite genome knowledge. In this chapter, we discuss the current methodologies in antimalarial drug discovery.作者: 剛毅 時(shí)間: 2025-3-30 13:51
Biomimetic Approach for the Controlled Drug Delivery through 3D Bioactive Scaffolds: A Novel Stratee in vivo, the challenge lies in supplying the appropriate dose at the injured site for an increased period. To overcome the challenge, various biomimetic materials are being employed for delivering drugs in a controlled manner, which includes porous materials, hydrogels, nanofibrous scaffolds, etc. made from natural and synthetic polymers.作者: Aids209 時(shí)間: 2025-3-30 19:03 作者: 險(xiǎn)代理人 時(shí)間: 2025-3-30 23:19
RETRACTED CHAPTER: Computational and Informatics Methodologies in Drug Discovery, with Focus on Nate for scientific, economic, and social progress. The precision of drug discovery and development approaches can be enhanced by efficient computational methodologies. Developments in the computational biology and informatics algorithms have greatly augmented the efficiency of the drug discovery strat作者: epicardium 時(shí)間: 2025-3-31 01:41
Bioactivity-Guided Fractionation and Identification of Bioactive Molecules: A Basic Method in Drug t in the drug development. Different methodologies have been applied in drug discovery time to time..Drug discovery has started with the usage of herbal extracts for different ailments, which were termed as traditional medicine. The knowledge, skills and practice of holistic health care, recognized 作者: deficiency 時(shí)間: 2025-3-31 05:30 作者: fibroblast 時(shí)間: 2025-3-31 10:29
