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標(biāo)題: Titlebook: Drugs Targeting B-Cells in Autoimmune Diseases; Xavier Bosch,Manuel Ramos-Casals,Munther A Khamash Book 2014 Springer Basel 2014 Cryoglobu [打印本頁]

作者: commotion    時間: 2025-3-21 18:39
書目名稱Drugs Targeting B-Cells in Autoimmune Diseases影響因子(影響力)




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書目名稱Drugs Targeting B-Cells in Autoimmune Diseases讀者反饋學(xué)科排名





作者: Tdd526    時間: 2025-3-21 20:57

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Targeting B Cells in ANCA-Associated Vasculitides,mall and medium-sized vessels. Glomerulonephritis in AAV is typified by focal necrosis, crescent formation, and few or no immunoglobulin deposits. In vitro and animal evidence suggests that ANCA play a pathogenic role in AAV. Specific gene expression signatures are reported to predict long-term prog
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Targeting B Cells in Neurological Autoimmune Diseases,the activation-dependent release of cytokines and the mutual activation of T cells, B-cell-directed therapy has emerged as a promising tool in the therapeutic strategies of a range of autoimmune neurological diseases, such as multiple sclerosis (MS), neuromyelitis optica, autoimmune encephalitis, ch
作者: 火車車輪    時間: 2025-3-23 19:52
Targeting B Cells in Other Systemic Autoimmune Diseases,ditions, evidence on the use of these therapies is restricted to rituximab and it mainly relies on individual case reports or short series. In general, the underlying pathophysiology of the disease and/or the successful use of biological agents with a different mechanism of action seem to justify th
作者: 狂怒    時間: 2025-3-24 00:21

作者: ABOUT    時間: 2025-3-24 06:26
The Future Potential of Biosimilars Targeting B-Cells,pire, leaving open the potential for development and regulatory approval of 1 or more “similar” versions of these biologic therapies, termed biosimilars in Europe (BS)—the term that will be used in this chapter—subsequent entry biologics in Canada, or follow-on-biologics in the USA. The development
作者: Exposition    時間: 2025-3-24 10:30
Natural Resource Management and Policyand for therapeutic uses. The initial drive to specifically target B cells was part of the effort to develop more effective and safer therapeutic agents to treat B-cell malignancies. Anti-idiotype antibodies were effective but a different antibody needed to be developed for each patient, contributin
作者: right-atrium    時間: 2025-3-24 14:34
Water Development and Poverty Reductionmune disease. The last decade has witnessed substantial growth in the number of therapeutic agents that target B cells themselves, or molecules key to B cell survival or function. In order to understand, develop, and eventually predict the outcomes of B cell targeted therapies, a thorough understati
作者: Mediocre    時間: 2025-3-24 17:33
Ryan Hill,Yemi Katerere,Tabeth Matiza-Chiutanoclonal antibody rituximab for the treatment of B cell malignancies and reassurance about the overall safety of B cell depletion, the field of anti-B cell therapies has expanded over the last decade to the treatment of multiple autoimmune diseases. Moreover, growing knowledge of the biology of B ce
作者: iodides    時間: 2025-3-24 21:39
?. H. Olcay ünver,Rajiv K. Gupta disease have led to a growing evidence of the importance of B-cells in the origins of the disease. Two main therapeutic approaches targeting B-cells have emerged: one directed against B-cell specific molecules and the other directed against B-cell survival factors. We will discuss below the differe
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Daniel B. Cornfield,Randy Hodsonidisciplinary therapeutic approach. Treatment of sicca manifestations is symptomatic (topical therapies like saliva substitutes and preservative-free artificial tears), while the management of extraglandular features is tailored to the specific organs involved. The use of biological drugs targeting
作者: 矛盾    時間: 2025-3-25 11:59

作者: 拘留    時間: 2025-3-25 17:02
Nadya Araujo Guimar?es,Marcia de Paula Leitedous interest around the role of B-cells in the early inflammation, autoimmunity, and subsequent fibrosis both in animal and human models. There have been promising results from B-cell depletion therapy in clinical trials in both SSc and IIM. This review will concentrate on the role of B-cells in pa
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Building an International Sociology of Workditions, evidence on the use of these therapies is restricted to rituximab and it mainly relies on individual case reports or short series. In general, the underlying pathophysiology of the disease and/or the successful use of biological agents with a different mechanism of action seem to justify th
作者: Assignment    時間: 2025-3-26 16:13
Nadya Araujo Guimar?es,Marcia de Paula Leiteiseases such as SLE. Rituximab also has a longer established role in the treatment of B-cell lymphoproliferative disorders and rheumatoid arthritis. In this chapter we review the available data on the safety aspects of B-cell targeted therapies. A common adverse event with this family of agents is i
作者: 牲畜欄    時間: 2025-3-26 18:35
Daniel B. Cornfield,Randy Hodsonpire, leaving open the potential for development and regulatory approval of 1 or more “similar” versions of these biologic therapies, termed biosimilars in Europe (BS)—the term that will be used in this chapter—subsequent entry biologics in Canada, or follow-on-biologics in the USA. The development
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Daniel B. Cornfield,Randy Hodsonease has long been regarded as very unlikely to be successful. In 2002 the first report was published in a case series of five patients that advocated B cells as a therapeutic target, spurred by a report of Takemura et al., who even suggested that the activation of T cells in the rheumatoid synovium was B cell-dependent.
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Building an International Sociology of Workditions such as steroid-resistant and dependent sarcoidosis, Beh?et disease with retinal vasculitis, chronic hepatitis C virus-associated polyarteritis nodosa, highly active refractory Takayasu arteritis, and Henoch–Sch?nlein purpura nephritis.
作者: Outwit    時間: 2025-3-28 06:35
B-Cell Targeted Therapies in Rheumatoid Arthritis,ease has long been regarded as very unlikely to be successful. In 2002 the first report was published in a case series of five patients that advocated B cells as a therapeutic target, spurred by a report of Takemura et al., who even suggested that the activation of T cells in the rheumatoid synovium was B cell-dependent.
作者: 蘑菇    時間: 2025-3-28 11:21
,B-Cell Targeted Therapies in Primary Sj?gren Syndrome,the evidence from controlled trials has suggested that tumour necrosis factor blockers are not efficacious in primary SS, the use of B-cell targeted agents (rituximab, epratuzumab, belimumab) may be more promising therapies. However, the potential risks and benefits of these new agents must be always weighted carefully.
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B-Cell Targeted Therapies in Cryoglobulinemia,ntext of these three concomitant biologic events linked one to each other, i.e., chronic infection, autoimmunity, and B-cell lymphoproliferation. Since rituximab is used for B-cell depletion in CV, this drug will be herein discussed.
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Book 2014 arthritis, systemic lupus erythematosus, Sj?gren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell
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作者: 怪物    時間: 2025-3-29 07:22
Book 2014ed evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases..
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Arne L. Kalleberg,Kevin T. Leichtd trials. Belimumab has been licensed for use in SLE in 2011 by the FDA and European Medicines Agency. Forthcoming years will show the real value of B-cell targeted therapies, including the off-label use of rituximab and especially the licensed use of belimumab, as part of the standard of care in patients with SLE.
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B-Cell Targeted Therapies in Autoimmune Cytopenias and Thrombosis,penic purpura. This chapter presents a historical perspective reviewing the various studies that have been published in this field. In addition, it offers a current assessment of the evidence regarding the use of B-cell depleting agents in the aforementioned conditions.
作者: 捕鯨魚叉    時間: 2025-3-30 18:02
Targeting B Cells in Neurological Autoimmune Diseases,etrospective, and with a few exceptions, e.g. MS, randomized controlled trials are lacking. In this article, we review and discuss the available literature on B cell-targeted therapies in autoimmune neurologic diseases.
作者: Chandelier    時間: 2025-3-30 23:53
2296-6056 n for scientists, clinicians and pharmaceutical companies.Im.This book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sj?gren syndrome, ANCA-associated vasculitis and




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