作者: athlete’s-foot 時(shí)間: 2025-3-21 22:32 作者: Innovative 時(shí)間: 2025-3-22 03:17
Keith Kroll,James Bassingthwaighteever, studies of new agents have taught us important lessons regarding normal lipid and lipoprotein metabolism. In this presentation I wish to take up three “case histories” in the latter category: (1) bile acid sequestrants; (2) inhibitors of cholesterol biosynthesis, particularly inhibitors of HMG CoA reductase; (3) probucol.作者: 脫毛 時(shí)間: 2025-3-22 07:42
Understanding Measures of Landscape Patternrowth. Specifically, in tissues such as the kidney, cell replication is very slow and such tissues have low rates of cholesterol synthesis. By contrast, baby brain and intestine replicate at rapid rates and have active cholesterol synthesis. As we showed some years ago, the very rapid cell growth of作者: Ergots 時(shí)間: 2025-3-22 11:59 作者: tackle 時(shí)間: 2025-3-22 14:57
A Spatial View of Population Dynamicsolesterol 7α-hy-droxylase, which catalyzes the introduction of the hydroxyl group in the 7α-position of the cholesterol molecule, is a mixed-function oxidase, cytochrome P 450-dependent and is located in the smooth endoplasmic reticulum of the liver cell (Myant and Mitropoulos 1977).作者: tackle 時(shí)間: 2025-3-22 18:47
Frames and Riesz bases: a short surveyn of the EHC can be achieved in several ways, but the usual means is by use of resins (sequestrants) that bind bile acids in the intestine and prevent their reabsorption. The bile acid sequestrants most commonly used are cholestyramine and colestipol. Cholestyramine was the drug used in the Lipid Re作者: 搜集 時(shí)間: 2025-3-22 22:21 作者: 悄悄移動(dòng) 時(shí)間: 2025-3-23 03:22 作者: magenta 時(shí)間: 2025-3-23 05:41
Luis Guarracino,Juan Enrique Santospoprotein AI gene which was not present in normolipidaemic individuas (Rees et al. 1983). This RFLP arises because of the existence of a polymorphic nucleotide in the 3’ non-coding region of the linked apo-CIII gene that creates an additional cleavage site for the restriction enzyme SacI (Shoulders 作者: GIBE 時(shí)間: 2025-3-23 09:57 作者: DRILL 時(shí)間: 2025-3-23 15:41
Keith Kroll,James Bassingthwaighteever, studies of new agents have taught us important lessons regarding normal lipid and lipoprotein metabolism. In this presentation I wish to take up three “case histories” in the latter category: (1) bile acid sequestrants; (2) inhibitors of cholesterol biosynthesis, particularly inhibitors of HMG作者: cylinder 時(shí)間: 2025-3-23 20:21
Keith Kroll,James Bassingthwaightely hypertriglyceridemia (HTG) (1). These studies, recently published (2,3), can be summarized as follows: HTG states are associated with excessive lipid transfer reactions (4). The lipids that are transferred are the hydrophobic cholesteryl ester (CE) and triglyceride (TG) molecules. The reaction th作者: 豐滿中國 時(shí)間: 2025-3-23 23:59
Keith Kroll,James Bassingthwaightets between lipoprotein particles, and receptor-mediated uptake of lipoprotein particles in various organs. Three lipases, hormone-sensitive lipase (HSL), lipoprotein lipase (LPL), and hepatic lipase (HL) represent important points of regulation in lipoprotein metabolism and are consequently major de作者: entail 時(shí)間: 2025-3-24 06:04 作者: Bouquet 時(shí)間: 2025-3-24 09:43 作者: Confound 時(shí)間: 2025-3-24 14:04 作者: 僵硬 時(shí)間: 2025-3-24 16:39
,Dietary and Pharmacological Control of Cholesterol 7α-Hydroxylase,olesterol 7α-hy-droxylase, which catalyzes the introduction of the hydroxyl group in the 7α-position of the cholesterol molecule, is a mixed-function oxidase, cytochrome P 450-dependent and is located in the smooth endoplasmic reticulum of the liver cell (Myant and Mitropoulos 1977).作者: commune 時(shí)間: 2025-3-24 22:54 作者: Limerick 時(shí)間: 2025-3-25 03:14
https://doi.org/10.1007/978-3-642-71702-4Lipid; Lipoprotein; development; drug; lipide; metabolism; protein; research作者: 招人嫉妒 時(shí)間: 2025-3-25 05:12
978-3-642-71704-8Springer-Verlag Berlin Heidelberg 1987作者: Ointment 時(shí)間: 2025-3-25 10:55
Proceedings in Life Scienceshttp://image.papertrans.cn/e/image/283179.jpg作者: 哀悼 時(shí)間: 2025-3-25 15:02
A Spatial View of Population Dynamics3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (E.C. 1.1.1.34) in most metabolic contexts is the limiting step in cholesterol formation in mammalian liver and other tissues. The properties and significance of this enzyme have been extensively reviewed (Gibson 1985; Kennelly and Rodwell 1985).作者: 典型 時(shí)間: 2025-3-25 16:23
Eduardo P. Serrano,Marcela A. FabioAfter a number of years of being considered a well-established branch of biochemistry, we now have found that there is considerable less certainty about the pathways of bile acid synthesis from cholesterol, particularly in regard to human metabolism.作者: inquisitive 時(shí)間: 2025-3-25 23:24
Eduardo P. Serrano,Marcela A. FabioThe plasma apolipoproteins constitute a unique group of molecules which are now known to have multifunction relationships with plasma lipid transport. It is the purpose of this review to cover more recent aspects of research in which the structure of apolipoprotein B is related to its function.作者: CLAIM 時(shí)間: 2025-3-26 02:43 作者: figurine 時(shí)間: 2025-3-26 07:33
Keith Kroll,James BassingthwaighteAdipose tissue plays a major role in caloric homeostasis by shifting between lipid mobilization and storage. Its primary functions can be summarized as follows:作者: 暴行 時(shí)間: 2025-3-26 10:53
Turnover of HMG CoA Reductase is Influenced by Phosphorylation,3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (E.C. 1.1.1.34) in most metabolic contexts is the limiting step in cholesterol formation in mammalian liver and other tissues. The properties and significance of this enzyme have been extensively reviewed (Gibson 1985; Kennelly and Rodwell 1985).作者: 協(xié)議 時(shí)間: 2025-3-26 13:27
Recent Advances in Metabolic Pathways of Bile Acid Synthesis,After a number of years of being considered a well-established branch of biochemistry, we now have found that there is considerable less certainty about the pathways of bile acid synthesis from cholesterol, particularly in regard to human metabolism.作者: 口訣 時(shí)間: 2025-3-26 18:00
The Structure of ApoB-100: Structure-Function Studies,The plasma apolipoproteins constitute a unique group of molecules which are now known to have multifunction relationships with plasma lipid transport. It is the purpose of this review to cover more recent aspects of research in which the structure of apolipoprotein B is related to its function.作者: thalamus 時(shí)間: 2025-3-26 21:28
Cellular and Molecular Biology of Apolipoproteins: Receptor-Mediated Regulation of Cholesterol MetaLipoprotein receptors, especially those within the liver, play a central role in the regulation of cholesterol metabolism. Specific apolipoproteins (apo-) serve as the ligands for these receptors (for review, see Brown and Goldstein 1983, 1986; Mahley and Innerarity 1983; Mahley et al. 1984).作者: macular-edema 時(shí)間: 2025-3-27 01:22
Lipolysis and Antilipolytic Drugs at Different Ages,Adipose tissue plays a major role in caloric homeostasis by shifting between lipid mobilization and storage. Its primary functions can be summarized as follows:作者: confide 時(shí)間: 2025-3-27 05:39
0172-6625 opment of this area. After the publication and wide acceptance of the results of the cholestyramine study by the Lipid Clinics in the USA, showing for the first time a direct association between drug induced reduction of plasma levels of total and LDL cholesterol and coronary heart disease in a high作者: 聲明 時(shí)間: 2025-3-27 11:00
Understanding Measures of Landscape Patternt, baby brain and intestine replicate at rapid rates and have active cholesterol synthesis. As we showed some years ago, the very rapid cell growth of regenerating liver is accompanied by one of the highest rates of cholesterolgenesis seen in mammalian cells (1).作者: 衍生 時(shí)間: 2025-3-27 17:41
Keith Kroll,James Bassingthwaightenificantly decreased in different group populations including survivors of myocardial infarction, subjects with angina pectoris, and others with coronary artery disease as documented by angiography (1–4). In one study, apoA-I was found to be a superior predictor of CAD in individual patients compared to concentrations of HDL cholesterol (4,5)作者: 軍械庫 時(shí)間: 2025-3-27 21:03
Keith Kroll,James BassingthwaighteL), lipoprotein lipase (LPL), and hepatic lipase (HL) represent important points of regulation in lipoprotein metabolism and are consequently major determinants for the concentrations of plasma-lipoproteins.作者: 兵團(tuán) 時(shí)間: 2025-3-28 01:40 作者: unstable-angina 時(shí)間: 2025-3-28 04:34
APOA-I and APOA-II Metabolism and Coronary Artery Disease,nificantly decreased in different group populations including survivors of myocardial infarction, subjects with angina pectoris, and others with coronary artery disease as documented by angiography (1–4). In one study, apoA-I was found to be a superior predictor of CAD in individual patients compared to concentrations of HDL cholesterol (4,5)作者: 采納 時(shí)間: 2025-3-28 07:39
Lipolysis and Lipoprotein Metabolism,L), lipoprotein lipase (LPL), and hepatic lipase (HL) represent important points of regulation in lipoprotein metabolism and are consequently major determinants for the concentrations of plasma-lipoproteins.作者: agonist 時(shí)間: 2025-3-28 13:42 作者: ASSET 時(shí)間: 2025-3-28 15:22 作者: DOSE 時(shí)間: 2025-3-28 18:53
Regulation of ACAT,ions with respect to acyl-CoA but at the concentration of non-esterified cholesterol in the environment of the enzyme in endoplasmic reticular membrane vesicles. The rate at which this activity changes can, hence, be useful as an index of the rate at which cholesterol gets transferred to the immediate environment of the enzyme.作者: 發(fā)微光 時(shí)間: 2025-3-29 01:18 作者: OGLE 時(shí)間: 2025-3-29 05:42
Conference proceedings 1987this area. After the publication and wide acceptance of the results of the cholestyramine study by the Lipid Clinics in the USA, showing for the first time a direct association between drug induced reduction of plasma levels of total and LDL cholesterol and coronary heart disease in a high risk popu作者: 殘酷的地方 時(shí)間: 2025-3-29 07:37 作者: conception 時(shí)間: 2025-3-29 14:48
Keith Kroll,James Bassingthwaighte; Glatz et al. 1985a). FABPs occur in the rat in at least three tissue-specific forms (liver, intestinal and heart FABP), but two distinct forms may be present in one tissue (e.g. liver and intestinal forms in intestine). Liver FABP was also named Z-protein or protein A.作者: landfill 時(shí)間: 2025-3-29 19:04
Regulation of Lipoprotein Lipase Activity: Its Role in Lipid-Lowering Therapies,ar mechanisms involved in its regulation. The aim of this chapter is to outline present information in the area. Space is limited; we have therefore chosen to present a few extreme examples to illustrate the principles.作者: 群居動(dòng)物 時(shí)間: 2025-3-29 22:09 作者: 陳列 時(shí)間: 2025-3-30 00:17
Frames and Riesz bases: a short surveyof the plasma cholesterol will decrease the risk for CHD. Furthermore, analysis of the trial results provided no consistent evidence that lowering of plasma cholesterol by bile acid sequestrants is accompanied by significant side effects. On the other hand, despite the success of the CPPT, doubts re作者: Aqueous-Humor 時(shí)間: 2025-3-30 04:32
Luis Guarracino,Juan Enrique Santostudies showing that HDL can act as an acceptor of cholesterol from cells overloaded with cholesterol [reviewed by Reichl and Miller (2)]. On the other hand, lipoprotein-deficient serum or even serum albumin alone can also facilitate the removal of cholesterol from cholesterol-loaded cells. Studies b作者: Foregery 時(shí)間: 2025-3-30 08:41 作者: 無聊點(diǎn)好 時(shí)間: 2025-3-30 13:01
Keith Kroll,James Bassingthwaighte150% more CE molecules than present in LDL, and pointed out that such particles cannot complete the VLDL → LDL conversion cascade. Hence, in HTG, “remnants” of these VLDL populations must be cleared from the plasma independently of the LDL pathway (1,5). HTG-LDL is CE-poor, TG-rich, small and dense 作者: 宣傳 時(shí)間: 2025-3-30 17:10
Basic relations of wavelet theory,demic drugs and phthalic acid esters. This chapter will discuss aspects of our current knowledge regarding the mechanisms and significance of the interaction of the latter group of agents with the FABPs.作者: Eosinophils 時(shí)間: 2025-3-31 00:34
Bile Acid Sequestrants: Do They Have a Future?,of the plasma cholesterol will decrease the risk for CHD. Furthermore, analysis of the trial results provided no consistent evidence that lowering of plasma cholesterol by bile acid sequestrants is accompanied by significant side effects. On the other hand, despite the success of the CPPT, doubts re作者: 有毒 時(shí)間: 2025-3-31 03:17 作者: Optimum 時(shí)間: 2025-3-31 05:10 作者: 線 時(shí)間: 2025-3-31 10:53
Hypotriglyceridemic Drugs and Lipoprotein Catabolism,150% more CE molecules than present in LDL, and pointed out that such particles cannot complete the VLDL → LDL conversion cascade. Hence, in HTG, “remnants” of these VLDL populations must be cleared from the plasma independently of the LDL pathway (1,5). HTG-LDL is CE-poor, TG-rich, small and dense 作者: Flat-Feet 時(shí)間: 2025-3-31 14:42 作者: 概觀 時(shí)間: 2025-3-31 19:02
Conference proceedings 1987great effect on plasma lipid levels after oral administration. These new advances, together with the combined efforts of cell biologists and lipoprotein chemists, have set the pace for an exciting period of research and clinical applications of diets and drugs af- fecting lipids. This volume, which 作者: 諂媚于人 時(shí)間: 2025-3-31 22:50
Rodolfo Paoletti (Dean),David Kritchevsky (Associa作者: 擁護(hù)者 時(shí)間: 2025-4-1 05:52
0172-6625 lipoprotein chemists, have set the pace for an exciting period of research and clinical applications of diets and drugs af- fecting lipids. This volume, which 978-3-642-71704-8978-3-642-71702-4Series ISSN 0172-6625 作者: SEED 時(shí)間: 2025-4-1 09:36 作者: 簡略 時(shí)間: 2025-4-1 11:25
