作者: 單色 時(shí)間: 2025-3-21 21:21 作者: STERN 時(shí)間: 2025-3-22 00:23
Influence of Atherogenic Lipoproteins on The Thrombotic Potential of Endothelial Cells,ata in the literature indicate that LDL as well as modified LDL influence a variety of functional aspects of endothelial cells, that include adhesive properties for monocytes/macrophages and regulation of vascular tone. In addition these lipoproteins influence the capacity of endothelial cells both 作者: 下船 時(shí)間: 2025-3-22 08:35 作者: hurricane 時(shí)間: 2025-3-22 11:52
Three Liver-Enriched Transcription Factors: HNF-1, C/EBP, and Protein II are Required to Enhance Tr is found in B 443 base pair (bp) fragment (+621 to +1064) that is located entirely within the second intron of the gene. Within this fragment, a 147-bp region (+806 to +952) containing a single 97-bp DNasel footprint exhibits significant enhancer activity. We now report that this footprint contains作者: HPA533 時(shí)間: 2025-3-22 16:02
Structure-Function Relationships of Apolipoprotein B-100,es, such as investigations in cultured cells, and in human subjects with specific apoB mutations also have their limitations a novel approach using transgenic mice has yielded interesting information on the low density lipoprotein-associating function of apoB-100. In future, transgenic animals expre作者: HPA533 時(shí)間: 2025-3-22 17:49
Contribution of Helix-Helix Interactions to the Stability of Apolipoprotein-Lipid Complexes,zed. In discoidal lipid-apoprotein complexes, these helixes are oriented parallel to the phospholipid acyl chains around the edge of the disc, and antiparallel to each other. The residues on the side of the contiguous helixes are in close vicinity and can form salt bridges. Computer modeling of apo 作者: Airtight 時(shí)間: 2025-3-22 23:22 作者: 自戀 時(shí)間: 2025-3-23 05:24 作者: Coronation 時(shí)間: 2025-3-23 09:01
Lipoprotein Assembly: A Potential Target for Drugs Affecting Lipid Metabolism,h the liver and intestine. The gene responsible for this disease does not co-segregate with the apo a gene suggesting it is caused by the loss of some gene product. To gain an understanding of the apparently unique process necessary for apo a secretion, plasmids expressing apo a were transfected int作者: giggle 時(shí)間: 2025-3-23 12:27
Structural Features that Determine the Functional Properties of the Loop Region of Human Lipoproteind site specific mutagenesis of lipoprotein lipase and hepatic lipase demonstrate an Asp-His-Ser catalytic triad covered by a peptide loop bounded by a conserved disulfide bridge. Substitution of the loop of lipoprotein lipase with either six or twenty-two residues of the hepatic lipase loop gives m作者: 要素 時(shí)間: 2025-3-23 15:14 作者: Priapism 時(shí)間: 2025-3-23 21:50 作者: 傻瓜 時(shí)間: 2025-3-23 23:43 作者: Assault 時(shí)間: 2025-3-24 02:23 作者: 1FAWN 時(shí)間: 2025-3-24 06:38 作者: obsession 時(shí)間: 2025-3-24 13:01
,The Expression and Regulation of Cholesterol 7α-Hydroxylase,liver cholesterol 7α-hydroxylase, obtained a specific antibody, cloned the cDNA and expressed an active enzyme in E. Coli. Using these reagents, we studied the regulation of 7α-hydroxylase by cholesterol, oxysterols, bile acids, hormones and other drugs. All results indicate that 7α-hydroxylase is r作者: 松軟 時(shí)間: 2025-3-24 16:16
Cholesterol Metabolism in Normo and Genetically Hyperlipidemic Rats in Aging,train). Plasma and hepatic lipid levels and the activity of HMGCoA reductase, cholesterol 7α-hydroxylase were measured at the age of 2, 6 and 18 months. The effect of cholestyramine and simvastatin was also considered. Plasma cholesterol and triglyceride levels were higher in Yoshida and increased w作者: Accessible 時(shí)間: 2025-3-24 20:30
The Way They Were,The Way We Ares on the mechanisms that may be involved in cell-catalyzed oxidation of LDL are reviewed and discussed. Finally, the pros and cons of undertaking clinical testing of the oxidative modification hypothesis are presented.作者: Mendicant 時(shí)間: 2025-3-24 23:51
Which Way Down the Slippery Slope?he rat 7α-hydroxylase gene was cloned and several liver specific and ubiquitous regulatory elements were found in the 5’-upstream sequence of the rat gene. Possible mechanisms of regulation of 7α-hydroxylase are proposed.作者: Glossy 時(shí)間: 2025-3-25 05:26 作者: 沒有準(zhǔn)備 時(shí)間: 2025-3-25 08:11
,The Expression and Regulation of Cholesterol 7α-Hydroxylase,he rat 7α-hydroxylase gene was cloned and several liver specific and ubiquitous regulatory elements were found in the 5’-upstream sequence of the rat gene. Possible mechanisms of regulation of 7α-hydroxylase are proposed.作者: 確定 時(shí)間: 2025-3-25 14:48
0928-9550 lipoproteins and coronary heart disease. However, asusually happens in research, many more interesting issues are beingstudied, opening new fields of research for the future. These newadvances, together with the combined efforts of cell biologists andlipoprotein chemists, have set the pace for an e作者: Transfusion 時(shí)間: 2025-3-25 18:54
Ahmed I. Zayed,Gilbert G. Walteransgenic mice has yielded interesting information on the low density lipoprotein-associating function of apoB-100. In future, transgenic animals expressing site-specific mutant apoB molecules will be a valuable tool to study the structure-function relationship of this complex but functionally important protein in lipid metabolism.作者: Malfunction 時(shí)間: 2025-3-25 21:55
The Way They Were,The Way We Areerogenic potential. Increased shunting of cholesteryl esters into triglyceride-rich lipoproteins appears to be related to impaired triglyceride metabolic capacity which is indicated by the fasting lipoprotein constellation most frequently associated with coronary artery disease: low HDL cholesterol and a preponderance of small-sized HDL and LDL.作者: Armada 時(shí)間: 2025-3-26 00:53
The Way They Were,The Way We Areegion of the LPL gene of the propositus revealed a G→C transversion at the 5’ donor splice site of intron 1. We suggest that this mutation is not compatible with normal mRNA processing and it is responsible for the defect in our patient.作者: Incumbent 時(shí)間: 2025-3-26 06:30 作者: kidney 時(shí)間: 2025-3-26 08:51
Influence of Atherogenic Lipoproteins on The Thrombotic Potential of Endothelial Cells,to generate and to remove fibrin. The data so far available indicate that atherogenic lipoproteins influence both tissue factor expression and the release of plasminogen activator inhibitor type a by endothelial cells, thus increasing the prothrombotic potential of vascular endothelium.作者: 我不重要 時(shí)間: 2025-3-26 15:11
Contribution of Helix-Helix Interactions to the Stability of Apolipoprotein-Lipid Complexes,A-I- and apo A-IV-DPPC discoidal complexes, by energy minimisation procedures, suggests that electrostatic interactions between charged residues can significantly contribute to the stability of the apoprotein-lipid complexes.作者: 間接 時(shí)間: 2025-3-26 17:13
Book 1993ng world labortories, represents an authoritative and up-to-dateappraisal of the status of the art and a stimulus to future researchat the laboratory and clinical level in a fascinating area of clinicaland preventive medicine..作者: arbiter 時(shí)間: 2025-3-27 00:41
0928-9550 f theleading world labortories, represents an authoritative and up-to-dateappraisal of the status of the art and a stimulus to future researchat the laboratory and clinical level in a fascinating area of clinicaland preventive medicine..978-94-010-4746-3978-94-011-1703-6Series ISSN 0928-9550 作者: GIBE 時(shí)間: 2025-3-27 04:02
Theory of Subband Decompositionhologically these areas showed the presence of deeply-seated cholesterol crystals with no accompanying tissue necrosis. The superficial layers represented a new intima probably constituted in the process of repair when the previously present fatty streaks regressed.作者: deviate 時(shí)間: 2025-3-27 09:04
Which Way Down the Slippery Slope?cal region as structural features of lipoprotein lipase that distinguish it from hepatic and pancreatic lipase and may account for the much greater hydrolytic activity of lipoprotein lipase on a triolein substrate.作者: 光亮 時(shí)間: 2025-3-27 12:39
Which Way Down the Slippery Slope?r fasting conditions the major donor of triglycerides to LDL and HDL are the VLDL. Therefore, factors that affect fasting triglycerides are likely to have an effect on metabolism of all lipoproteins including the chylomicrons.作者: 頂點(diǎn) 時(shí)間: 2025-3-27 15:13 作者: 你敢命令 時(shí)間: 2025-3-27 18:23
Regression of Human Aortic Fatty Streaks of Early Life,hologically these areas showed the presence of deeply-seated cholesterol crystals with no accompanying tissue necrosis. The superficial layers represented a new intima probably constituted in the process of repair when the previously present fatty streaks regressed.作者: Exaggerate 時(shí)間: 2025-3-27 22:13
Structural Features that Determine the Functional Properties of the Loop Region of Human Lipoproteical region as structural features of lipoprotein lipase that distinguish it from hepatic and pancreatic lipase and may account for the much greater hydrolytic activity of lipoprotein lipase on a triolein substrate.作者: guardianship 時(shí)間: 2025-3-28 05:45
Modulation of Triglyceride Metabolism by Diet and Drugs,r fasting conditions the major donor of triglycerides to LDL and HDL are the VLDL. Therefore, factors that affect fasting triglycerides are likely to have an effect on metabolism of all lipoproteins including the chylomicrons.作者: 有限 時(shí)間: 2025-3-28 06:20 作者: NICE 時(shí)間: 2025-3-28 10:34
Structure-Function Relationships of Apolipoprotein B-100,ansgenic mice has yielded interesting information on the low density lipoprotein-associating function of apoB-100. In future, transgenic animals expressing site-specific mutant apoB molecules will be a valuable tool to study the structure-function relationship of this complex but functionally important protein in lipid metabolism.作者: Coterminous 時(shí)間: 2025-3-28 17:16
Postprandial Hyperlipidemia and Coronary Artery Disease,erogenic potential. Increased shunting of cholesteryl esters into triglyceride-rich lipoproteins appears to be related to impaired triglyceride metabolic capacity which is indicated by the fasting lipoprotein constellation most frequently associated with coronary artery disease: low HDL cholesterol and a preponderance of small-sized HDL and LDL.作者: heterodox 時(shí)間: 2025-3-28 22:07 作者: 預(yù)防注射 時(shí)間: 2025-3-28 23:39 作者: thalamus 時(shí)間: 2025-3-29 04:52
Which Way Down the Slippery Slope?A-I- and apo A-IV-DPPC discoidal complexes, by energy minimisation procedures, suggests that electrostatic interactions between charged residues can significantly contribute to the stability of the apoprotein-lipid complexes.作者: 領(lǐng)先 時(shí)間: 2025-3-29 09:01 作者: Conjuction 時(shí)間: 2025-3-29 12:08 作者: 靈敏 時(shí)間: 2025-3-29 16:05
Mark A. Kon,Louise Arakelian Raphaelata in the literature indicate that LDL as well as modified LDL influence a variety of functional aspects of endothelial cells, that include adhesive properties for monocytes/macrophages and regulation of vascular tone. In addition these lipoproteins influence the capacity of endothelial cells both 作者: 暫時(shí)別動(dòng) 時(shí)間: 2025-3-29 23:26
Cristian Pérez,Reinhold Schneideriabetes” (1). From the observations made in our patients we concluded for the existence of “a plurimetabolic syndrome including hyperlipemia, obesity and diabetes”. Moreover, we stated that “the development of ischemic heart disease and, less frequently, of arterial hypertension is often found in th作者: agitate 時(shí)間: 2025-3-30 02:43
Osiris Wavelets and the Dipole Gas is found in B 443 base pair (bp) fragment (+621 to +1064) that is located entirely within the second intron of the gene. Within this fragment, a 147-bp region (+806 to +952) containing a single 97-bp DNasel footprint exhibits significant enhancer activity. We now report that this footprint contains作者: inflame 時(shí)間: 2025-3-30 05:12
Ahmed I. Zayed,Gilbert G. Walteres, such as investigations in cultured cells, and in human subjects with specific apoB mutations also have their limitations a novel approach using transgenic mice has yielded interesting information on the low density lipoprotein-associating function of apoB-100. In future, transgenic animals expre作者: FLASK 時(shí)間: 2025-3-30 08:35 作者: 獨(dú)特性 時(shí)間: 2025-3-30 13:06
The Way They Were,The Way We Areso been clearly demonstrated that oxidative modification does occur . and that administration of some antioxidant compounds slows the progression of atherosclerosis in LDL receptor-deficient rabbits and in cholesterol-fed rabbits. Whether the antiathero-sclerotic effect of these compounds is limited作者: 易于 時(shí)間: 2025-3-30 18:27
The Way They Were,The Way We Are because it provides the opportunity for cholesteryl esters to be transferred from LDL and HDL into triglyceride-rich particles conferring on them atherogenic potential. Increased shunting of cholesteryl esters into triglyceride-rich lipoproteins appears to be related to impaired triglyceride metabo作者: 蛤肉 時(shí)間: 2025-3-30 21:09
The Meaning of the Holocaust for Bioethicsh the liver and intestine. The gene responsible for this disease does not co-segregate with the apo a gene suggesting it is caused by the loss of some gene product. To gain an understanding of the apparently unique process necessary for apo a secretion, plasmids expressing apo a were transfected int作者: defeatist 時(shí)間: 2025-3-31 03:48 作者: 無畏 時(shí)間: 2025-3-31 07:53
The Way They Were,The Way We Areresult in a milder clinical phenotype. The clue to detection of these changes in the LPL gene might be to be to investigate patients who present with chylomicronemia when exposed to specific environmental stresseswhile continuing with only moderate hypertriglyceridemia in the resting state.作者: confide 時(shí)間: 2025-3-31 10:15
The Way They Were,The Way We Areerchylomicronemia and recurrent episodes of acute pancreatitis..Analysis of the complete coding sequence, with intronic boundaries, and the promoter region of the LPL gene of the propositus revealed a G→C transversion at the 5’ donor splice site of intron 1. We suggest that this mutation is not comp作者: GEM 時(shí)間: 2025-3-31 15:27 作者: 移動(dòng) 時(shí)間: 2025-3-31 18:36
The Way They Were,The Way We Areliver. High density lipoproteins (HDL) are the vehicle of cholesterol in this reverse transport, a function believed to explain the inverse correlation between plasma HDL levels and atherosclerosis. An attempt to stimulate, by the use of drugs, this transport process may hold promise in the preventi作者: 慢跑鞋 時(shí)間: 2025-3-31 22:19
Multidimensional Wavelets and Applications the epidemiologic observation that HDL-cholesterol and apolipoprotein (apo) A-I are inversely correlated with the risk for coronary artery disease. More recent data indicate that HDL is involved in several other mechnisms such as coagulation, immunomodulation, cell proliferation, and detoxification作者: Spongy-Bone 時(shí)間: 2025-4-1 02:22 作者: aggressor 時(shí)間: 2025-4-1 08:10 作者: 萬神殿 時(shí)間: 2025-4-1 13:24
