標題: Titlebook: Drugs Affecting Leukotrienes and Other Eicosanoid Pathways; B. Samuelsson,F. Berti,G. P. Velo Book 1985 Plenum Press, New York 1985 Acetyl [打印本頁] 作者: GLOAT 時間: 2025-3-21 17:17
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作者: Temporal-Lobe 時間: 2025-3-21 22:49
978-1-4684-7843-3Plenum Press, New York 1985作者: 粗魯?shù)娜?nbsp; 時間: 2025-3-22 02:40
Overview: 978-1-4684-7843-3978-1-4684-7841-9作者: 深淵 時間: 2025-3-22 05:20 作者: CHOIR 時間: 2025-3-22 09:50
Hypotheses, Questions, and Evidence,The interest in the biological influence of prostaglandins on different physiological and pathophysiological conditions in man has led to the development of several methods for measuring prostaglandins in biological materials.作者: 發(fā)展 時間: 2025-3-22 14:06 作者: 發(fā)展 時間: 2025-3-22 19:43
Syntheses and Biological Effects of Leukotrienes and Analogs,the prostaglandin, the thromboxanes and the prostacyclins. These compounds are formed via the 5-Lipoxygenase pathway and play a major role as biolohical mediators on ommediate hypersensitivity reactions and inflammation ..作者: Alcove 時間: 2025-3-22 21:33
NATO Science Series A:http://image.papertrans.cn/e/image/283176.jpg作者: 裝勇敢地做 時間: 2025-3-23 03:19 作者: 牛的細微差別 時間: 2025-3-23 05:59 作者: Servile 時間: 2025-3-23 12:21
Hypotheses, Questions, and Evidence,wo major complementary methods were selected by the scientists: gas-chromatography combined with mass spectrometry and radioimmunoassay (RIA) techniques. Both methods were improved throughout the years in regard of their specificity and sensitivity. The introduction of deuterated carriers for the fi作者: 遭遇 時間: 2025-3-23 16:02
Sri Kurniawan,Andrew Arch,Sean-Ryan Smiththe prostaglandin, the thromboxanes and the prostacyclins. These compounds are formed via the 5-Lipoxygenase pathway and play a major role as biolohical mediators on ommediate hypersensitivity reactions and inflammation ..作者: Odyssey 時間: 2025-3-23 20:27 作者: 使厭惡 時間: 2025-3-23 23:13 作者: Irritate 時間: 2025-3-24 05:10
Jane Seale,Sheryl Burgstahler,Bj?rn Fisselertrating a broad range of activities. They all derive from some closely related polyunsaturated fatty acids, particularly arachidonic acid, which may be oxidized and further transformed in reactions initiated either by a fatty acid cyclooxygenase or, alternatively by a number of lipoxygenases. Prosta作者: 戰(zhàn)勝 時間: 2025-3-24 10:19 作者: 禍害隱伏 時間: 2025-3-24 11:42 作者: implore 時間: 2025-3-24 16:49
Franz Hlawatsch,Georg Taub?ck,Teresa Twarochnction and vascular tone (see ref. 1 for a review) has prompted attempts to develop selective pharmacologic tools affecting their production with the aim of under standing their pathophysiologic role and possibly treating human disease states. Two different approaches have been followed; 1) differen作者: MANIA 時間: 2025-3-24 22:52
Prashant Sansgiry,Ioana Mihaila and to some extent PGE. are proaggregatory, whereas prostacyciin (PGI.) and PGD. inhibi platelet activation. Attempts to change the balance in favour of the antiaggregatory PG’s therefore could be of benefit in thrombotic situations, and can be done at different levels: selective in- hibition of pl作者: Observe 時間: 2025-3-24 23:38
Prashant Sansgiry,Ioana Mihailalavonoids interact with many macromolecules in animal cells, change the activity of mammalian enzymes and influence permeability of cell membranes. Controlled trials on the therapeutical efficacy of flavonoids were relatively few, although flavonoids were consistently claimed to show anti-bleeding, 作者: canvass 時間: 2025-3-25 03:33
Prashant Sansgiry,Ioana Mihailae isolated and purified by RP-HPLC and SPHPLC. GC/MS analysis revealed that the three metabolites were: 8,15-dihydroxyeicosapentaenoic acid, 14,15-dihydroxyeicosapentaenoic acid and 15-hydroxyeicosapentaenoic acid. In addition, the non-enzymatic generation of an allylic hydroxy-epoxide metabolite (1作者: 大都市 時間: 2025-3-25 09:56
Theory of Subband Decompositionhidonic acid (AA) was extensively converted to mono-HETEs and DHETEs in these cell types. These mono-HETEs and DHETEs were identified as oxidative products of AA via the 12- and 15-lipoxygenase pathways and DHETEs were exclusively generated from 15-lipoxygenase pathway. Incubation of AA or 12-L.-hyd作者: 信任 時間: 2025-3-25 13:36
Applied and Numerical Harmonic Analysisdroxy-eicosatetraenoic acids. The epoxygenase activity was found to be located predominantly in the renal cortex. This renal epoxygenase pathway also transformed PGI. to a new, previously unreported, metabolite. This metabolite was isolated and identified by radio gas chromatography and gas chromato作者: 擁護者 時間: 2025-3-25 18:23
Applied and Numerical Harmonic Analysisa return to a new sodium balance. This latter phenomenon, known as escape from the sodium-retaining effects of mineralocorticoids, is characterized by an increased urinary volume and sodium excretion. At the same time increased renal blood flow, glomerular filtration rate and reduced renal vascular 作者: Bouquet 時間: 2025-3-25 21:14
Time-Frequency Analysis of Signalsumans with atherosclerosis (D’Angelo et al. 1978, Sinzinger et al. 1979) or with an exposure to risk factors (Silberbauer et al. 1979, Dadak et al. 1981) the generation of a prostacyclin-like activity is severely suppressed. On the other hand it has been recently reported that the urine excretion of作者: medium 時間: 2025-3-26 04:05
https://doi.org/10.1007/978-1-4612-0113-7s., suggesting an important role for LTs in the allergic bronchoconstriction.. On the other hand anaphylactic shock is accompanied by increase in pulmonary vascular resistance. and both specific antigen-challenge and LTs “in vitro” induce a vasoconstriction of pulmonary vessels of different animal s作者: DUST 時間: 2025-3-26 05:24
Hypotheses, Questions, and Evidence,ortant areas in this development (1). The new knowledge has formed the basis for understanding the role of prostaglandins in many pathophysiological processes and for the therapeutic use of prostaglandins in various diseases.作者: 闖入 時間: 2025-3-26 10:31
Sri Kurniawan,Andrew Arch,Sean-Ryan Smithrs, has been proposed as an important mediator of bronchoconstriction in man. These LTs display pronounced spasmogenic and vasoactive properties in various preparations and possess unprecedented potencies in respiratory smooth muscle in particular..作者: deadlock 時間: 2025-3-26 13:20
Prashant Sansgiry,Ioana Mihaila of the antiaggregatory PG’s therefore could be of benefit in thrombotic situations, and can be done at different levels: selective in- hibition of platelet cyclooxygenase, stimulation of the PGI. synthesis, inhibition of TXA. synthesis or blockage of the TXA. receptor.作者: 江湖郎中 時間: 2025-3-26 19:15
Applied and Numerical Harmonic Analysis an increased urinary volume and sodium excretion. At the same time increased renal blood flow, glomerular filtration rate and reduced renal vascular resistance are observedl. Besides the haemodynamic factors, prostaglandins (PGs) and kallikreinkinin system have been suggested as being responsible, at least partly, for the escape phenomenon.作者: adequate-intake 時間: 2025-3-27 00:45
Hypotheses, Questions, and Evidence,o explain such differences between studies where identical assay methods have been used (for example a commercially available TXB. radioimmunoassay); that is, if the obtained data really reflect the endogenous situation.作者: 誘惑 時間: 2025-3-27 02:39
Sri Kurniawan,Andrew Arch,Sean-Ryan Smithhe same molecule, the goal of the studies to be reported here is the development of selective inhibitors of the formation of the leukotrienes in the hope that these agents might then be useful in providing the remaining needed element of proof for the role of the leukotrienes in disease.作者: 沉著 時間: 2025-3-27 08:38 作者: Brittle 時間: 2025-3-27 13:30 作者: Expediency 時間: 2025-3-27 17:22 作者: 咆哮 時間: 2025-3-27 21:29 作者: notion 時間: 2025-3-28 01:24
Introduction,ortant areas in this development (1). The new knowledge has formed the basis for understanding the role of prostaglandins in many pathophysiological processes and for the therapeutic use of prostaglandins in various diseases.作者: Spina-Bifida 時間: 2025-3-28 04:17
Comparative Effects of Leukotrienes in Respiratory Tissue of Various Species,rs, has been proposed as an important mediator of bronchoconstriction in man. These LTs display pronounced spasmogenic and vasoactive properties in various preparations and possess unprecedented potencies in respiratory smooth muscle in particular..作者: 糾纏 時間: 2025-3-28 06:17 作者: 割讓 時間: 2025-3-28 13:09
,The Effect of 9α-Fluorohydrocortisone on the Urinary Excretion of 6-KETO-PGF1α in Man, an increased urinary volume and sodium excretion. At the same time increased renal blood flow, glomerular filtration rate and reduced renal vascular resistance are observedl. Besides the haemodynamic factors, prostaglandins (PGs) and kallikreinkinin system have been suggested as being responsible, at least partly, for the escape phenomenon.作者: AGONY 時間: 2025-3-28 18:12 作者: 幾何學家 時間: 2025-3-28 22:36 作者: groggy 時間: 2025-3-29 02:18 作者: 吝嗇性 時間: 2025-3-29 05:32 作者: 赤字 時間: 2025-3-29 08:27 作者: 代替 時間: 2025-3-29 14:11 作者: intolerance 時間: 2025-3-29 15:49
Sri Kurniawan,Andrew Arch,Sean-Ryan Smithnd to a minor extent TX are formed ubiquitarily, whereas the synthesis of LTs seems to require a considerable cellular specificity (4) (5): all of them are formed by normal and asthmatic human lung where they may play a role as potent bronchoconstrictors as well as primary mediators of airway hyperreactivity (6).作者: 小卷發(fā) 時間: 2025-3-29 20:04
Theory of Subband Decomposition, 8, 10, 14-eicosatetraenoic acid (12, 20-DHETE). The structure of this new metabolite was assigned by physical methods and by chemical degradation. Thus, during platelet and leukocyte interaction, “transcellular metabolism” of various lipoxygenase products of AA may generate new compounds of biological importance.作者: heterodox 時間: 2025-3-30 00:44
Modulation of the Release of Leukotrienes and Prostaglandins and of their Functional Effects in Humnd to a minor extent TX are formed ubiquitarily, whereas the synthesis of LTs seems to require a considerable cellular specificity (4) (5): all of them are formed by normal and asthmatic human lung where they may play a role as potent bronchoconstrictors as well as primary mediators of airway hyperreactivity (6).作者: florid 時間: 2025-3-30 06:49 作者: 消毒 時間: 2025-3-30 09:17
Hypotheses, Questions, and Evidence,ently range from 50–200 Ci/mmole. In 1975, we introduced the 125. labeling of these substances after coupling of their carboxyle to the amino group of a potential iodine receptor (e.g. histamine, tyramine or tyrosylmethyl ester) (2). Such an approach allowed us to reach for these tracers the theoret作者: 善于 時間: 2025-3-30 15:36
Sri Kurniawan,Andrew Arch,Sean-Ryan Smithneration of the leukotriene compounds could have a significant effect in down-regulating a variety of inflammatory events has been strongly suggested by several types of data developed over the past 5 years, with regard to the breadth of proinflammatory effects manifested by these compounds, indicat作者: Infirm 時間: 2025-3-30 20:07 作者: 步兵 時間: 2025-3-30 21:07 作者: Spirometry 時間: 2025-3-31 04:44
https://doi.org/10.1007/978-1-4612-0113-7the pathogenesis of bronchial hyperreactivity.; in addition to this, Creese and Bach. have shown in guinea-pig tracheal smooth muscle a clear cut potentiating action of LTD. on histamine and acetylcholine induced contractions.作者: 吸氣 時間: 2025-3-31 07:18 作者: Contort 時間: 2025-3-31 12:34
Pharmacologic Modulation of Leukotriene Biosynthesis by Incorporation of Alternative Unsaturated Faneration of the leukotriene compounds could have a significant effect in down-regulating a variety of inflammatory events has been strongly suggested by several types of data developed over the past 5 years, with regard to the breadth of proinflammatory effects manifested by these compounds, indicat作者: 屈尊 時間: 2025-3-31 14:26
Pulmonary and Vascular Effects of Leukotrienes: Involement in Asthma and Inflation,nd related non-steroidal antiinflammatory drug (NSAID:s). is well established, and apparently correlates with the capacity to inhibit the formation of cyclooxygenase products, notably PGE., PGD2, and PGI2. Although these three substances are considered proinflammatory and potently enhance the respon作者: 自戀 時間: 2025-3-31 20:07 作者: 無節(jié)奏 時間: 2025-3-31 23:23 作者: 亞當心理陰影 時間: 2025-4-1 02:37
Drugs Affecting Leukotrienes and Other Eicosanoid Pathways作者: Nebulizer 時間: 2025-4-1 07:01
Drugs Affecting Leukotrienes and Other Eicosanoid Pathways978-1-4684-7841-9作者: GRILL 時間: 2025-4-1 10:27
Introduction,the prostaglandin system as well as advances concerning the biological effects and physiological roles of prostaglandins and related compounds are important areas in this development (1). The new knowledge has formed the basis for understanding the role of prostaglandins in many pathophysiological p作者: 調(diào)色板 時間: 2025-4-1 14:26
Measurement of Thromboxane Production in Vivo: Metabolic and Analytical Aspects,dogenous thromboxane production. Since TXA. is difficult to measure as such, a common approach in such studies is to monitor its stable hydrolysis product, TXB., instead, and to compare obtained TXB. levels in, for example, plasma samples in patient and control groups. Numerous such studies have bee
