作者: 機(jī)構(gòu) 時(shí)間: 2025-3-21 23:13
Detection, Elimination, Mitigation, and Prediction of Drug-Induced Liver Injury in Drug Discovery major hurdle and is recognized to be a major cause of drug attrition and market withdrawal. DILI impacts many different sectors of society including patients, public health systems, health insurers and the pharmaceutical industry. Animal models are very efficient at detecting direct, dose-dependent作者: 恃強(qiáng)凌弱 時(shí)間: 2025-3-22 01:07 作者: 方舟 時(shí)間: 2025-3-22 07:09
Physicochemical Properties and Structural Alertsm the market. Significant efforts are being made to utilize existing knowledge of chemical and biological mechanisms that have been linked with causing DILI. These mechanisms are often varied and can include overt chemical reactivity or bioactivation to reactive metabolites; unintended interactions 作者: critic 時(shí)間: 2025-3-22 09:11 作者: 別名 時(shí)間: 2025-3-22 14:03 作者: 別名 時(shí)間: 2025-3-22 19:23
Prediction of Human Liver Toxicity Using In Vitro Assays: Limitations and Opportunitiess. Simple single cell-type in vitro cytotoxicity assays may fail to predict complex in vivo interconnected mechanism-based toxicities. Additionally, the lack of standardization of in vitro assays complicates data interpretation and makes assay comparison difficult. The selection of a given assay may作者: APNEA 時(shí)間: 2025-3-22 21:39
Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injurycytes. Multiple hepatocyte derived cellular carcinoma cell lines, such as HepG2, Huh7, and HepaRG cells, have been established over the years, and they display distinct characteristics regarding the expression and activity levels of drug-metabolizing enzymes and other hepatocyte-specific factors. Th作者: 提煉 時(shí)間: 2025-3-23 01:36
Evaluation of Drug-Induced Liver Injuries (DILI) with Human Hepatocytes: Scientific Rationale and Ex. Here the Human Cell Paradigm, namely, that human-specific drug properties can be obtained with in vitro human-based experimental systems is proposed. The success of the Human Cell Paradigm depends on the physiological relevance of the in vitro system, namely, the retention of human-specific and or作者: MUT 時(shí)間: 2025-3-23 07:08
Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testingon reasons given for drug attrition or withdrawal; this occurs for a multitude of reasons among which is certainly the lack of adequate models able to recapitulate hepatotoxicity in vitro. The loss of compounds in late-stage testing or after marketing is a major financial burden for the pharmaceutic作者: Ventilator 時(shí)間: 2025-3-23 09:51 作者: 暗指 時(shí)間: 2025-3-23 17:23 作者: 評(píng)論性 時(shí)間: 2025-3-23 19:32
Reactive Metabolite Assessment in Drug Discovery and Development in Support of Safe Drug Designnowledged as an important determinant of drug failure. Reasons for individual susceptibilities of patients that result in various forms and severities of adverse drug reactions are manifold. They involve factors such as the underlying diseases, individual genotypes of the immune system, and drug spe作者: engender 時(shí)間: 2025-3-23 22:23
High Content Screening for Prediction of Human Drug-Induced Liver Injurycombines automated imaging with image analysis to assess cell health and customized parameters in a multiparametric fashion, enabling coverage over several mechanisms important for DILI. In simple two-dimensional cell models, various HCS assays typically show a sensitivity of ~50% with a high specif作者: 死亡 時(shí)間: 2025-3-24 02:21
1557-2153 s, from basic research through to clinical actionThis book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into作者: Baffle 時(shí)間: 2025-3-24 07:57
Sensors,tigate these hazards. Alternatively, these stress responses may predict the development of idiosyncratic drug-induced liver injury (IDILI). Current evidence supports the hypothesis that IDILI is often mediated by adaptive immunity in genetically susceptible individuals which is modulated by the robustness of immune tolerance.作者: 厭惡 時(shí)間: 2025-3-24 13:17
Adaptive Reactive Rich Internet ApplicationsILI has lately expanded into complex three-dimensional models to further improve predictivity. The wealth of HCS data make it particularly amenable for machine learning and systems biology approaches for building rational models for prediction of DILI.作者: 翅膀拍動(dòng) 時(shí)間: 2025-3-24 17:00 作者: Microgram 時(shí)間: 2025-3-24 22:59 作者: 褻瀆 時(shí)間: 2025-3-25 00:38
Overview of Mechanisms of Drug-Induced Liver Injury (DILI) and Key Challenges in DILI Researchtigate these hazards. Alternatively, these stress responses may predict the development of idiosyncratic drug-induced liver injury (IDILI). Current evidence supports the hypothesis that IDILI is often mediated by adaptive immunity in genetically susceptible individuals which is modulated by the robustness of immune tolerance.作者: 下邊深陷 時(shí)間: 2025-3-25 06:59
Drug-Induced Liver Toxicity978-1-4939-7677-5Series ISSN 1557-2153 Series E-ISSN 1940-6053 作者: CONE 時(shí)間: 2025-3-25 09:36
Minjun Chen,Yvonne WillIncludes cutting-edge techniques for the study of DILI.Contains key implementation advice from the experts.Features detail essential for labs, from basic research through to clinical action作者: ineffectual 時(shí)間: 2025-3-25 15:34 作者: 受辱 時(shí)間: 2025-3-25 18:33
Sensors,me cases parent drug, elicit a variety of biochemical consequences such as covalent binding and oxidative stress which trigger signal transduction, transcription factors, mitochondrial and endoplasmic reticulum (ER) stress which can lead directly to cell death or activate adaptive responses which mi作者: CLAP 時(shí)間: 2025-3-25 20:55
Background Agents and Local Notifications, major hurdle and is recognized to be a major cause of drug attrition and market withdrawal. DILI impacts many different sectors of society including patients, public health systems, health insurers and the pharmaceutical industry. Animal models are very efficient at detecting direct, dose-dependent作者: 激怒 時(shí)間: 2025-3-26 01:05 作者: endarterectomy 時(shí)間: 2025-3-26 07:23 作者: 爭(zhēng)論 時(shí)間: 2025-3-26 11:56
Brain Injury and Work Performanceation groups, and difficulty in annotation of drugs, especially for the drugs that have been on the market for a short period of time. DILI remains a challenge for the industry and regulatory agencies. Assessing DILI risk in humans is important to assist drug development for the industry and to info作者: 梯田 時(shí)間: 2025-3-26 15:30 作者: Harbor 時(shí)間: 2025-3-26 18:48 作者: Nonconformist 時(shí)間: 2025-3-27 00:16
Service Integration in Supported Employmentcytes. Multiple hepatocyte derived cellular carcinoma cell lines, such as HepG2, Huh7, and HepaRG cells, have been established over the years, and they display distinct characteristics regarding the expression and activity levels of drug-metabolizing enzymes and other hepatocyte-specific factors. Th作者: Dignant 時(shí)間: 2025-3-27 04:07 作者: oblique 時(shí)間: 2025-3-27 07:35
Danica Damljanovi?,Kalina Bontchevaon reasons given for drug attrition or withdrawal; this occurs for a multitude of reasons among which is certainly the lack of adequate models able to recapitulate hepatotoxicity in vitro. The loss of compounds in late-stage testing or after marketing is a major financial burden for the pharmaceutic作者: 薄荷醇 時(shí)間: 2025-3-27 11:07 作者: 脆弱吧 時(shí)間: 2025-3-27 13:40 作者: 箴言 時(shí)間: 2025-3-27 19:33 作者: HATCH 時(shí)間: 2025-3-28 01:22
Adaptive Reactive Rich Internet Applicationscombines automated imaging with image analysis to assess cell health and customized parameters in a multiparametric fashion, enabling coverage over several mechanisms important for DILI. In simple two-dimensional cell models, various HCS assays typically show a sensitivity of ~50% with a high specif作者: Incompetent 時(shí)間: 2025-3-28 04:01
https://doi.org/10.1007/978-1-4939-7677-5Acute liver failure; Drug development; Regulatory processes; Preclinical and clinical studies; Hepatotox作者: Cumulus 時(shí)間: 2025-3-28 10:11 作者: Flavouring 時(shí)間: 2025-3-28 11:12
Background Agents and Local Notifications,phases of drug development. Considerable efforts are dedicated to the detection and understanding of idiosyncratic DILI, and to the prediction of intrinsic DILI. Ever more complex and biologically relevant in vitro models are emerging for compound prescreening purposes. These data are also being use作者: 半導(dǎo)體 時(shí)間: 2025-3-28 17:21
Introduction to the Windows Phone SDK,such an integrative predictor, we present four different classification schemes, i.e., an FDA labeling data-based approach (DILIrank dataset), a clinical evidence-based approach (LiverTox dataset), literature-based approaches (Greene and Xu datasets), and a registry-based approach (Suzuki dataset). 作者: projectile 時(shí)間: 2025-3-28 20:40
E. Sally Rogers,Kim L. MacDonald-Wilsons to disrupt a biological process. Whereas the concentration of a drug in the liver is highly dependent on its physicochemical properties as these influence many pharmacokinetic characteristics. However, despite the ability to assess compounds for their potential to cause DILI using in silico method作者: ANT 時(shí)間: 2025-3-29 01:47 作者: STIT 時(shí)間: 2025-3-29 06:14 作者: Interdict 時(shí)間: 2025-3-29 10:37
Anxiety Disorders and Work Performanceded to illustrate how the in vitro assays can help to derisk preclinical in vivo toxicity findings and to better predict clinical human liver toxicity outcomes. Opportunities in the DILI field are also discussed, in particular the need to use more relevant in vitro models to better mimic the in vivo作者: 厭煩 時(shí)間: 2025-3-29 14:57
Service Integration in Supported Employmentave contributed significantly to mechanistic studies of DILI, and various underlying signaling pathways and signatures of DILI have been identified. In this chapter, we first introduce the major hepatic lines (e.g., HepG2, Huh7, HepaRG, Hep3B, BC2, THLE, and Fa2N-4 cells), including their origins, c作者: GET 時(shí)間: 2025-3-29 18:59 作者: 愛花花兒憤怒 時(shí)間: 2025-3-29 22:31
Danica Damljanovi?,Kalina Bontchevall-derived hepatocyte-like cells (PSC-HLCs) are a developing model which show promise for hepatotoxicity testing. However, the current phenotype of PSC-HLCs is closer to a fetal hepatocyte than an adult hepatocyte. The methodologies for generating mature PSC-HLCs close to an idealized hepatotoxicity作者: amplitude 時(shí)間: 2025-3-30 00:02
Milan Stankovi?,Jelena Jovanovi?folds, and bioprinting enable precise control over the cellular microenvironment for enhancing and stabilizing hepatic functions in the presence of NPC types, including those derived from the liver towards determining their impact on DILI progression. The introduction of induced pluripotent stem cel作者: Detoxification 時(shí)間: 2025-3-30 07:42 作者: 弓箭 時(shí)間: 2025-3-30 11:34
Danica Damljanovi?,Kalina Bontchevaation and drug-induced liver injury. Many of these failed. The main two reasons are: (1) Methods are overly sensitive or unspecific and flag many drugs that show a safe history of use in a large population. (2) Reactive metabolite screening methods are too generic and fail to detect drug-specific bi作者: heterodox 時(shí)間: 2025-3-30 13:34 作者: Eeg332 時(shí)間: 2025-3-30 20:11
In Vitro Assessment of Mitochondrial Toxicity to Predict Drug-Induced Liver Injury作者: 案發(fā)地點(diǎn) 時(shí)間: 2025-3-30 22:08 作者: 離開真充足 時(shí)間: 2025-3-31 04:37
Detection, Elimination, Mitigation, and Prediction of Drug-Induced Liver Injury in Drug Discoveryphases of drug development. Considerable efforts are dedicated to the detection and understanding of idiosyncratic DILI, and to the prediction of intrinsic DILI. Ever more complex and biologically relevant in vitro models are emerging for compound prescreening purposes. These data are also being use作者: 不可知論 時(shí)間: 2025-3-31 06:31 作者: 誤傳 時(shí)間: 2025-3-31 10:22 作者: 執(zhí) 時(shí)間: 2025-3-31 14:28
